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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece TüsüzÖnata ÖnerÖzdemir Division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMT)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(T helper 1/T helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMT in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

Diameter distributions in Pinus sylvestris ***:evaluating modelling approaches including a machine learning technique

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Journal of Forestry Research 2023年第6期34卷 1829-1842页

作者： Şükrü Teoman Güner Maria J.Diamantopoulou Ramazan Özçelik Department of Forestry Ulus Vocational SchoolBartın University74600 UlusBartınTurkey Faculty of Agriculture Forestry and Natural EnvironmentSchool of Forestry and Natural EnvironmentAristotle University of Thessaloniki54124 ThessalonikiGreece Faculty of Forestry Isparta University of Applied ScienceEast Campus32260 IspartaTurkey

The diameter distribution of trees in a stand provides the basis for determining the stand’s ecological and economic value,its structure and stability and appropriate management *** pine(Pinus sylvestris L.)is one of the most common and important conifers in Turkey,so a well-planned management schedule is *** distribution models to accurately describe the stand structure help improve management strategies,but developing reliable models requires a deep understanding of the growth,output and constraints of the *** most important information derived by diameter distribution models is primary data on horizontal stand structure for each diameter class of trees:basal area and volume per unit *** predictions are required to estimate the range of products and predicted volume and yield from a forest ***,to construct an accurate,reliable diameter distribution model for natural Scots pine stands in the Türkmen Mountain region,we used Johnson’s SBdistribution to represent the empirical diameter distributions of the stands using ground-based measurements from 55 sample plots that included1219 trees in natural distribution zones of the *** an alternative,nonparametric approach,which does not require any predefined function,an artificial intelligence model was constructed based on support vector machine *** error index was calculated to evaluate the ***,both Johnson’s SB probability density function with a three-parameter recovery approach and the support vector regression methodology provided reliable estimates of the diameter distribution of these stands.

关键词： Diameter distribution Johnson’s S_(B) Support vector regression Scots pine Türkmen mountains

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen zhou Cathy z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Grids of stellar models including second harmonic and colors:solar composition(z = 0.0172,X = 0.7024)

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Research in Astronomy and Astrophysics 2015年第12期15卷 2244-2262页

作者： Mutlu Y?ld?z Ege University Department of Astronomy and Space Sciences

Grids of stellar evolution omy/astrophysics, such as planet hosting are required in many fields of astron- stars, binaries, clusters, chemically peculiar stars, etc. In this study, a grid of stellar evolution models with updated ingredients and recently determined solar abundances is presented. The solar values for the initial abundances of hydrogen, heavy elements and mixing-length parameter are 0.0172, 0.7024 and 1.98, respectively. The mass step is small enough （0.01 M） that interpolation for a given star mass is not required. The range of stellar mass is 0.74 to 10.00M. We present results in different forms of tables for easy and general appli- cation. The second stellar harmonic, required for analysis of apsidal motion of eclips- ing binaries, is also listed. We also construct rotating models to determine the effect of rotation on stellar structure and derive fitting formulae for luminosity, radius and the second harmonic as a function of rotational parameter. We also compute and list colors and bolometric corrections of models required for transformation between theo- retical and observational results. The results are tested for the Sun, the Hyades cluster, the slowly rotating chemically peculiar Am stars and eclipsing binaries with apsidal motion. The theoretical and observational results along isochrones are in good agree- ment. The grids are also applicable to rotating stars provided that equatorial velocity is given.

关键词： stars: interior -- stars: evolution -- binaries: eclipsing -- stars: chemi-cally peculiar

Automatic route planning for GPS art generation

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Computational Visual Media 2019年第3期5卷 303-310页

作者： Andre Waschk Jens krüger University of Duisburg-Essen

In this paper, we present a novel approach to automated route generation of global positioning system(GPS) artwork. The term GPS artwork describes the generation of drawings by leaving virtual traces on digital maps. Until now, the creation of these images has required a manual planning phase in which an artist designs the route by hand. Once the route for this artwork has been planned, GPS devices have been used to track the movement. Using our solution, the lengthy planning phase can be significantly shortened,thereby opening art creation to a broader public.

关键词： GPS art walking routing shape detection navigation

Conformable fractional heat equation with fractional translation symmetry in both time and space

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Chinese Physics B 2023年第4期32卷 125-129页

作者： W S Chung A Gungor J krız B C Lutfuoglu H Hassanabadi Department of Physics and Research Institute of Natural Science College of Natural ScienceGyeongsang National UniversityJinju 660-701Korea Mechanical Engineering Akdeniz UniversityAntalyaTurkey Department of Physics University of Hradec KraloveRokitanskeho 6250003 Hradec KraloveCzech Republic Department of Physics Akdeniz UniversityAntalyaTurkey Faculty of Physics Shahrood University of TechnologyShahroodIran

We investigate the fractional heat equation with fractional translation in both time and position with different fractional *** examples,we consider a rod and anα-disk with an initial constant temperature and discuss... 详细信息

关键词： fractional derivative heat equation conformable symmetry