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Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing Shanshan Yang Lingling Geng Yupeng Yan Fangshuo zheng Fang Cheng Weiqi zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(msCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human mSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKzF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

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轨道阱边缘场效应及其补偿方法的研究

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质谱学报 2024年第2期45卷 237-245页

作者：王俊恬任熠黄正旭陈政阁丁力暨南大学质谱仪器与大气环境研究所广东广州510632 广东省麦思科学仪器创新研究院广东广州510530 广州禾信仪器股份有限公司广东广州510530 宁波大学材料科学与化学工程学院浙江宁波315211

静电轨道阱(Orbitrap)自推出以来已被证明是一款强大的离子分析器,其分辨率受电极结构中边缘场的影响。因此,亟需研究由离子入射孔和外电极间隙共同导致的畸变场对分辨率的影响,并提出边缘场效应的解决方法。本实验利用离子光学仿真软件... 详细信息

静电轨道阱(Orbitrap)自推出以来已被证明是一款强大的离子分析器,其分辨率受电极结构中边缘场的影响。因此,亟需研究由离子入射孔和外电极间隙共同导致的畸变场对分辨率的影响,并提出边缘场效应的解决方法。本实验利用离子光学仿真软件(SImION)分别建立了理想、畸变和矫正3种结构模型,以测量不同初始轴向振幅和不同轨道半径对应的轴向振动周期分散来衡量轨道阱可以达到的极限分辨率。通过对比理想模型的实验结果与理论结果,验证了仿真参数选取和离子运动计算方法的可靠性;在畸变模型实验中,探究外电极间隙和离子入射孔导致的边缘场效应引起的离子轴向运动周期分散情况,及其对分辨率产生的影响;在矫正模型实验中证明了可以通过调节2个补偿电极的电压来修正畸变场,从而克服离子入射孔和外电极间隙共同产生的边缘场效应,乃至其他缺陷所引起的场畸变问题,仿真得到轨道阱对m/z 100离子的极限质量分辨率可达2500000。

关键词：轨道阱边缘场补偿电极分辨率仿真模拟

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An integrated microfluidic platform for nucleic acid testing

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microsystems & Nanoengineering 2024年第3期10卷 181-194页

作者： Antao Sun Petra Vopařilová Xiaocheng Liu Bingqian Kou TomášŘezníček TomášLednický Sheng Ni JiříKudr Ondřej zítka zdenka Fohlerová Petr Pajer Haoqing zhang Pavel Neužil ministry of Education Key Laboratory of micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072P.R.China Department of Chemistry and Biochemistry Mendel University in BrnoZemědělská161300 BrnoCzech Republic ITD Tech s.r.o Osvoboditelů100573581 BohumínCzech Republic Central European Institute of Technology Brno University of TechnologyPurkyňova 123Brno 61200Czech Republic Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Department of microelectronics Faculty of Electrical Engineering and CommunicationBrno University of TechnologyTechnická3058/10Brno 61600Czech Republic military Health Institute U Vojenskénemocnice 120016200 Praha 6Czech Republic The Key Laboratory of Biomedical Information Engineering of ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049P.R.China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049P.R.China

This study presents a rapid and versatile low-cost sample-to-answer system for SARS-CoV-2 *** system integrates the extraction and purification of nucleic acids,followed by amplification via either reverse transcriptionquantitative polymerase chain reaction(RT–qPCR)or reverse transcription loop-mediated isothermal amplification(RT–LAmP).By meeting diverse diagnostic and reagent needs,the platform yields testing results that closely align with those of commercial RT-LAmP and RT‒qPCR *** advantages of our system include its speed and *** assay is completed within 28 min,including sample loading(5 min),ribonucleic acid(RNA)extraction(3 min),and RT-LAmP(20 min).The cost of each assay is≈$9.5,and this pricing is competitive against that of Food and Drug Administration(FDA)-approved commercial *** some RNA loss during on-chip extraction is observed,the platform maintains a potential limit of detection lower than 297 *** makes the system particularly useful in environments where centralized laboratories are either unavailable or inconveniently *** key feature is the platform’s versatility,allowing users to choose between RT‒qPCR or RT‒LAmP tests based on specific requirements.

关键词： testing maintain versatile

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Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative medicine and Stem Cell Research&manufacturing(LivmedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-mSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of mSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-mSCs at a target dose of 1×106/kg for each application *** was assessed using the modified Ashworth scale(mAS),motor function according to the medical Research Council muscle Strength Scale,quality of life was assessed by the Functional Independence measure(FIm)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(Pm scale includes both motor scores(Pmance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation mesenchymal stem cell

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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher michael J.Lamonte Andrea z.LaCroix Eleanor m.Simonsick Steven P.Hooker Humberto Parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(mL),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several mL VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVm)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:measured VO_(2max)is a strong predictor of *** mL can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology mortality

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Influence of a liquid-filled compartment structure on the incoming shaped charge jet stability

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Defence Technology（防务技术） 2021年第2期17卷 571-582页

作者： X.D.zu z.X.Huang z.W.Guan X.C.Yin Y.m.zheng School of mechanical Engineering Nanjing University of Science and TechnologyXiaolingwei 200Nanjing 210094China School of Engineering University of LiverpoolLiverpoolL693GQUK Department of mechanics and Engineering Science Nanjing University of Science and TechnologyNanjing 210094China

Liquid-filled compartment structure consists of a bulk steel plate with matrix blind holes which are filled with liquid and a steel front plate to seal up the liquid with rings and *** liquid-filled compartment structure can resist the shaped charge warhead *** paper presents experimental and theoretical investigations of the penetration ability of the residual shaped charge jet emerging from the liquid-filled compartment structure after the penetration process at different impact *** the basis of shock wave propagation theory,the influence of the liquid-filled compartment structure on jet stability is *** interferences of the liquid backflow caused by a reflected shock wave and a back plate on jet stability under different impact angles are also *** addition,the range of the disturbed velocity segments of the jet at different impact angles and the penetration ability of the residual jet are obtained.A theoretical model is validated against the experimental penetration depths.

关键词： Compartment structure Shaped charge jet Shock wave Disturbance Stability

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EXPERImENTAL RESEARCH AND NUmERICAL SImULATION OF mOLD TEmPERATURE FIELD IN CONTINUOUS CASTING OF STEEL

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Acta metallurgica Sinica(English Letters) 2006年第3期19卷 176-182页

作者： X.S. zheng m.H. Sha J.z. Jin Research Center of Foundry Engineering Dnlian University of Technology Dalian 116024 China School of materials Science and Engineering Anshan University of Science and Technology Anshan 114044 China

mold is the heart of the continuous casting machine. Heat transfer and solidification in a water- cooled mold are the most important factors during the continuous casting of steel. For studying the temperature distribution of a mold wall, a simulated apparatus of mold was designed and experiments were performed by it. The measured results indicated that the mold wall temperature approaches the temperature of cooling-water. An equivalent thermal-conductivity coefficient was proposed and deduced on the basis of the conclusion of the experiments. This coefficient was applied to solve the heat transfer between the melt and cooling water, and to characterize the heat transfer capacity of the mold. By this equivalent thermal-conductivity coefficient, it is very easy and convenient to numerically simulate the solidification process of continuous casting. And the calculation results are in agreement with the experiments. The effects of custing speed and water flow rate on the mold temperature field were also discussed.

关键词： continuous casting mold temperature field numerical simulation

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Theoretical study on the effective thermal conductivity of silica aerogels based on a cross-aligned and cubic pore model

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Chinese Physics B 2024年第6期33卷 28-36页

作者：郑坤灿李震东曹豫通刘犇胡君磊 School of Energy and Environment Inner Mongolia University of Science and TechnologyBaotou 014010China Inner mongolia Key Laboratory of Efficient and Clean Combustion Baotou 014010China

Aerogel nanoporous materials possess high porosity, high specific surface area, and extremely low density due to their unique nanoscale network structure. moreover, their effective thermal conductivity is very low, making them a new type of lightweight and highly efficient nanoscale super-insulating material. However, prediction of their effective thermal conductivity is challenging due to their uneven pore size distribution. To investigate the internal heat transfer mechanism of aerogel nanoporous materials, this study constructed a cross-aligned and cubic pore model(CACPm) based on the actual pore arrangement of SiO_(2) aerogel. Based on the established CACPm, the effective thermal conductivity expression for the aerogel was derived by simultaneously considering gas-phase heat conduction, solid-phase heat conduction, and radiative heat transfer. The derived expression was then compared with available experimental data and the Wei structure model. The results indicate that, according to the model established in this study for the derived thermal conductivity formula of silica aerogel, for powdery silica aerogel under the conditions of T = 298 K, a_(2)= 0.85, D_(1)= 90 μm, ρ = 128 kg/m^(3), within the pressure range of 0–10^(5)Pa, the average deviation between the calculated values and experimental values is 10.51%. In the pressure range of 10^(3)–10^(4)Pa, the deviation between calculated values and experimental values is within 4%. Under these conditions, the model has certain reference value in engineering verification. This study also makes a certain contribution to the research of aerogel thermal conductivity heat transfer models and calculation formulae.

关键词： silica aerogel effective thermal conductivity two pore-size structure model porous medium heat transfer

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东亚地区栓皮栎叶片表皮毛空间变异特征及其与气孔的协同关系

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Journal of Plant Ecology 2024年第3期17卷 153-161页

作者： Yanhua zhu Ji zheng Hongzhang Kang Nan Hui Shan Yin zhicheng Chen Baoming Du Chunjiang Liu School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China School of Design Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Urban Forest Ecosystem Research Station State Forestry AdministrationShanghai 200240China Shanghai Yangtze River Delta Ecoenvironmental Change and management Observation and Research Station Ministry of Science and TechnologyShanghai 200240China Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijing 100091China

理解植物功能性状的地理变异对预测全球气候变化下的植物响应至关重要。叶片表皮毛由表皮细胞发育而来,具有调节叶片温度和控制气体交换的功能,然而大的地理尺度上叶片表皮毛如何变异,以及它们与气孔之间的关系仍不清楚。本研究以栓皮栎... 详细信息

理解植物功能性状的地理变异对预测全球气候变化下的植物响应至关重要。叶片表皮毛由表皮细胞发育而来,具有调节叶片温度和控制气体交换的功能,然而大的地理尺度上叶片表皮毛如何变异,以及它们与气孔之间的关系仍不清楚。本研究以栓皮栎(Quercus variabilis)为研究对象,分析了东亚地区44个种群叶片表皮毛密度,并评估了它们与气候因子和气孔等性状之间的相关性。同时,为了进一步检测环境变化下的表皮毛响应特征以及与气孔之间的协同关系,本研究利用其中15个种群开展了同质园试验。研究结果发现,栓皮栎叶片表皮毛密度平均值为459.78个mm^(−2),变异范围为325.79–552.38 mm^(−2)。表皮毛密度会随纬度增加而增加,随经度减少而减少,并且与温度和降水呈负相关。同时发现,无论是在野外还是在同质园,叶片表皮毛密度均与气孔密度呈正相关,并且两者均会随干旱强度的增加而增加。这些结果表明,面对环境变化叶片表皮毛密度具有高度的适应性变异,并且可与气孔协同适应这种变化。该研究结果对加深理解气候变化下植物适应策略以及叶片功能性状之间的协同互作具有重要意义。

关键词：叶片功能性状表皮毛气孔性状-性状关系性状-环境关系气候变化

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： m.Ablikim m.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen m.L.Chen S.J.Chen S.L.Chen S.m.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen z.J.Chen z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng z.Y.Deng A.Denig I.Denysenko m.Destefanis F.De mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer m.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge z.W.Ge C.Geng E.m.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong m.Y.Dong X.Dong m.C.Du S.X.Du z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna m.Greco m.H.Gu Y.T.Gu C.Y.Guan z.L.Guan A.Q.Guo L.B.Guo m.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou z.L.Hou B.Y.Hu H.m.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche m.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao z.Jiao S.Jin Y.Jin m.Q.Jing X.m.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei z.H.Lei H.Leithoff m.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.m.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li m.H.Li P.R.Li Q.m.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COmSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner mongolia University Hohhot 010021China Institute of modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKm angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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