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Maternal High-Fat Diet Impairs Offspring glucose Metabolism and Programs Hepatic DNA Methylation linked to NK cell-Mediated cytotoxicity Signaling Pathway at weaning

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Food Science and Human wellness 2024年

作者： Sheng zheng ling zhang Shixuan zhang guanyu Hu Yikai li jia zheng Department of traditional chinese Orthopedics and traumatology， center for Orthopedic Surgery， the third Affiliated Hospital of Southern Medical University Department of Endocrinology， Peking University First Hospital

Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring. However， the precise epigenetic mechanisms governing these intergenerational effects， particularly during the early stages of offspring development， remain poorly understood. In this study， female c57bl/6J mice were randomly assigned to either a high-fat diet or normal chow diet throughout gestation and lactation. Methylated DNA immunoprecipitation (MeDIP) coupled with microarray analysis was employed to identify differentially methylated genes in the livers of offspring at weaning age. we found that maternal high-fat diet feeding predisposes offspring to obesity and impaired glucose metabolism as early as the weaning period. DNA methylation profile analysis unveiled a significant enrichment of differentially methylated genes within the natural killer (NK) cell-mediated cytotoxicity pathway. MeDIP-PcR validated reduced methylation levels of specific genes within this pathway， including tNFα， PI3K， and SHc1. consistently， the expressions of tNFα， PI3K， and SHc1 were significantly upregulated， accompanied by elevated serum tNFα and Il-6 levels in offspring from dams fed with high-fat diet. Moreover， we assessed the expressions of genes associated with NK cell activities， uncovering a notable rise in hepatic granzyme b levels and a trend towards increased cD107a expression in offspring from dams fed a high-fat diet. In addition， methylation levels of tNFα， PI3K， and SHc1 promoters were inversely correlated with glucose response during glucose tolerance testing. In conclusion， our findings underscore the critical role of the NK cell-mediated cytotoxicity signaling pathway in mediating DNA methylation patterns， thereby contributing to the programming effects of maternal high-fat diet consumption on offspring glucose metabolism as early as the weaning period.

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江汉平原地下水混合的^(14)c年龄曲线投影校正研究

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矿物岩石地球化学通报 2024年第3期43卷 479-488,I0001页

作者：查希茜毛绪美中国地质大学(武汉)环境学院武汉430074

地下水^(14)c年龄的分布可以指示地下水渗流的方向及其变化。经典校正模型可以消除水化学组成变化对^(14)c年龄的影响,但很难识别地下水混合,导致得到的^(14)c年龄代表的是地下水的混合年龄。本文根据地下水化学组分变化提出了识别混合... 详细信息

地下水^(14)c年龄的分布可以指示地下水渗流的方向及其变化。经典校正模型可以消除水化学组成变化对^(14)c年龄的影响,但很难识别地下水混合,导致得到的^(14)c年龄代表的是地下水的混合年龄。本文根据地下水化学组分变化提出了识别混合和校正a^(14)c值的方法,并以江汉平原为研究实例进行解剖。江汉平原地下水中硫酸盐矿物溶解导致SO_(4)^(2-)含量增加,且SO_(4)^(2-)含量与a^(14)c值的关系曲线可以识别混合,并利用曲线投影校正a^(14)c值,提出了混合-IAEA模型。IAEA年龄和混合-IAEA年龄的分布差异揭示出地下水渗流变化。年轻地下水混合区为年轻地下水的汇聚方向;老地下水混合区为老地下水的汇集方向。因此,对于大型沉积平原(或盆地)的地下水流系统,使用^(14)c定年时需要考虑地下水混合的影响,混合校正后的^(14)c年龄可以用来识别地下水渗流变化。

关键词： ^(14)c年龄混合校正水文地球化学地下水渗流江汉平原

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黄河下游叶蜡正构烷烃的物源指示意义

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中国科学：地球科学 2024年第6期54卷 2031-2049页

作者：张亮刘金召姜崇张飞安芷生西安交通大学人居环境与建筑工程学院西安710054 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710061 陕西黄土高原地球关键带国家野外科学观测研究站西安710061

黄河作为输沙量和有机碳输送通量最大的河流之一,在区域生物地球化学及全球碳循环过程中发挥了至关重要的作用.目前,关于黄河总颗粒有机碳的通量、组成、来源及其季节变化已开展了大量研究,但针对不同时空尺度上分子生物标志物的研究仍... 详细信息

黄河作为输沙量和有机碳输送通量最大的河流之一,在区域生物地球化学及全球碳循环过程中发挥了至关重要的作用.目前,关于黄河总颗粒有机碳的通量、组成、来源及其季节变化已开展了大量研究,但针对不同时空尺度上分子生物标志物的研究仍然较少.本文重点研究了黄河下游不同季节(汛期、非汛期),不同类型载体中叶蜡正构烷烃的分子组成及氢同位素比值.结果表明:岸边表土中叶蜡正构烷烃的分子指标反映了其上覆植被的输入;汛期悬浮物的正构烷烃分子指标体现出黄土高原不同地质时期土壤的混合特征,而受水动力条件影响,非汛期悬浮物表现出相应的季节性差异;另外,考虑气候因素影响,利用正构烷烃氢同位素对汛期悬浮物中单子叶植物的输入进行了半定量化估算.本研究一定程度上为黄河有机质的物源研究中叶蜡指标的应用提供了新的见解.

关键词：分子组成氢同位素叶蜡正构烷烃悬浮物黄河下游

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Novel insight into dry sliding behavior of cu-Pb-Sn in-situ composite with secondary phase in different morphology

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Journal of Materials Science & technology 2020年第5期40卷 158-167页

作者： b.w.Dong S.H.wang z.z.Dong J.c.Jie t.M.wang t.J.li School of Material Science and Engineering Dalian University of TechnologyDalian 116024China

the cu-24 Pb-x Sn(wt%)(x=0,2,4,6)alloys with Pb-rich second-phase particles(SPPs)in different shapes show obviously differently mechanical and self-lubricating *** influence of the SPPs’shape difference on the alloys’mechanical and self-lubricating properties was ***-24 Pb alloy with continuously netty SPPs shows much more intensive stick-slip phenomenon during dry sliding than the other three alloys with independently rodlike *** is mainly due to insufficient lubrication resulted by the netty SPPs’splitting *** the SPPs transforming from netty to rodlike shape under the addition of Sn,the stick-slip phenomenon was notably weakened,which was proven to be related to the higher self-lubricating property of alloys with rodlike ***,the simultaneous increase of ductility and tensile strength was observed in the cu-24 Pb-x Sn alloys with increasing Sn content,which is because the netty SPPs’splitting behavior will be weakened with them replaced by the rodlike SPPs.

关键词： Second-phase particles Netty shape Rodlike shape Stick-slip Mechanical property Self-lubricating property

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Microstructure Evolution of in situ (ti3Alc+ti5Si3 )/ti3Al composite Sheet with a Novel Quasi-continuous chain Reinforcement Distribution Architecture Prepared by Using Roll bonding and Reaction Annealing

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Journal of Materials Science & technology 2013年第12期29卷 1191-1196页

作者： J.c.Pang g.H.Fan X.P.cui A.b.li l.geng z.z.zheng Q.w.wang School of Materials Science and Engineering Harbin Institute of Technology

the ti3Al matrix composite sheet with a novel quasi-continuous chain reinforcement distribution was prepared by using roll bonding and subsequent reaction annealing with pure ti and Sicp/Al *** (ti3Alc t ti5Si3) reinforcements were produced by in situ reaction of the as-rolled tie(Sic p/Al) laminated composite sheet after a two-stage annealing treatment including first annealing at 660 c and second annealing at 1250 *** microstructure evolution during the reaction annealing was *** the first reaction annealing,tiAl3was formed,and the Sic particles were pushed together due to the Kirkendall effect,and after the second reaction annealing,ti3Al,ti3Alc and ti5Si3were *** addition,the reinforcement distribution presents a quasi-continuous chain microstructure in ti3Al matrix composite sheet.

关键词： composite Intermetallic Fabrication Reaction synthesis

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Static spheroidization and its effect on superplasticity of fine lamellae in nugget of a friction stir welded ti-6Al-4V joint

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Journal of Materials Science & technology 2022年第24期119卷 1-10页

作者： c.l.jia l.H.wu P.Xue H.zhang D.R.Ni b.l.Xiao z.Y.Ma Shi-changxu Innovation center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Key laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

the spheroidization of the lamellar structure can greatly contribute to the superplasticity of the nugget zone(Nz)of ti alloy welds,which is the key to achieve the integral superplastic forming of welds for the fabrication of large-scale complex ***,the spheroidization process is complex and costly since it cannot be obtained generally,unless the lamellae suffers from a large *** this study,the static spheroidization was achieved for the fine lamellae structure in the nugget of a friction stir welded(FSw)ti-6Al-4V joint,particularly by the annealing without any *** specialα/βinterface obeying a burgers orientation relationship(bOR)after FSw was first time directly observed,whose effect on the spheroidization was discussed.A new static spheroidization mechanism with the gradual coalescence of the adjacent lamellae was discovered,which we named as“termination coalescence”.there was a slower coarsening rate in the lamellar structure than in the classical equiaxed one,due to the bOR in the lamellae,although both of them exhibited a volume diffusion character during ***,the similar superplasticity can be achieved for the base material and Nz after *** study can provide a new way to the spheroidization and a theoretical basis for the integral superplastic forming of welds during production.

关键词： Friction stir welding titanium alloys Spheroidization mechanism coalescence Superplasticity Static annealing

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Experimental methods for determination of mechanical behaviors of materials at high temperatures via the split Hopkinson bars

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Acta Mechanica Sinica 2020年第6期36卷 1275-1293,I0003页

作者： Q.b.Dou K.R.wu t.Suo c.zhang X.guo Y.z.guo w.g.guo Y.l.li School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Joint International Research laboratory of Impact Dynamics and its Engineering Application Xi’an710072China Shaanxi Key laboratory of Impact Dynamics and its Engineering Application Xi’an710072China State Key laboratory for Strength and Vibration of Mechanical Structures School of AerospaceXi’an Jiaotong UniversityXi’an710049China

Full understanding of the thermomechanical behaviors of materials at high strain rates and high temperatures are of great importance from not only scientific meaning but also practical value in engineering structure design and safety *** efforts have been made for abilities of operation the split Hopkinson bars,the most popular technique for experimental determination of mechanical behaviors of materials over the strain rates from 10^2 to 10^4 s^−1 over the past 70 years,at high temperatures since 1960s.A review of experiment work is presented in this paper to give an overview of the development of experimental techniques at high temperatures based on Hopkinson bar *** principles of the split Hopkinson bar requires the loading bars avoiding temperature gradient or keeping relatively low temperature when performing high temperature *** such as performing temperature gradient corrections,rapid heating or using special designed automatically assembled systems were proposed by researchers to enable the operation of the split Hopkinson bars at temperature as high as ***,to the application of high speed photographic technique for capturing the dynamic deformation process of the specimen in high temperature Hopkinson bar testing,some key issues of eliminating the strong thermal radiation induced lights oversaturation and de-blurring of images due to insufficient exposure at high temperature and high strain rate condition,as well as fabrication of high contrast speckle pattern for high temperature digital image correlation measurement were also *** technique can now enable the split Hopkinson bar testing to be performed at high temperature up to 1873 K under the loading conditions of compression or tension with the in situ observation and full field measurement of deformation as *** paper concludes with summaries of the most important achievements and highlighting of the prospects,trends and remaining challenge

关键词： Mechanical behaviors Split Hopkinson bar High strain rate High temperature

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人表皮生长因子受体2(HER2)低表达和HER2过表达乳腺癌的鉴别：4种MRI扩散模型的比较研究

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国际医学放射学杂志 2024年第3期 379-380页

作者： c.Mao l.Hu w.jiang Y.Qiu z.Yang Y.liu 余芸菲

摘要目的确定传统扩散加权成像（DwI）、连续时间随机游走（ctRw）、分数阶微积分（FROc）和拉伸指数模型（SEM）在识别乳腺癌的人表皮生长因子受体2(HER2)表达

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Influence of Angiotensin II on αb>1b>-Adrenergic Receptors Function in Rat Aorta and Expression in Vascular Smooth Muscle cells

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Journal of biosciences and Medicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina gallardo-Ortíz Juan Pablo de Jesús benítez-garrido Santiago c. Sigrist-Flores Juan Javier lópez-guerrero Enrique Hong Rafael Villalobos-Molina Unidad de biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico carrera de Enfermerí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Departamento de Farmacobiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico carrera de Mé dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on At1 and other At receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth fac... 详细信息

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on Atb>1b> and other At receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. the aim of this work was to examine the impact of Ang II on the expression and function of αb>1b>-adrenergic receptors (αb>1b>-ARs) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated wistar rat aorta was incubated for 24 h in DMEM at 37˚c, then subjected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10−5 M), and in some experiments, 5-Methylurapidil (αb>1Ab>-AR antagonist), AH11110A (αb>1bb>-AR antagonist), or bMY-7378 (αb>1Db>-AR antagonist), were used to identify the αb>1b>-AR involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation time, and by the Ang II action. αb>1Db>-AR was protected from desensitization by bMY-7378;while RS-100329 and prazosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and αb>1b>-ARs proteins were evaluated. αb>1Db>-AR increased at 30 and 60 min post Ang II exposure, the αb>1Ab>-AR diminished from 1 to 4 h, while αb>1bb>-AR remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of αb>1Db>-AR at short times, and bMY-7378 protected αb>1Db>-AR from desensitization.

关键词： Angiotensin II α1D-AR α1-AR Expression Rat aorta Smooth Muscle cells

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Vanadium(V) complexes containing Unsymmetrical N-Heterocyclic carbene ligands: Highly Efficient Synthesis and catalytic behavior towards Ethylene/Propylene copolymerization

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chinese Journal of Polymer Science 2024年第1期42卷 32-41,I0006页

作者： Yi-cong wang Hui zhat Pei-Yi cheng Shu zhang Xiang-wei liu Yi-Xian wu State Key laboratory of chemical Resource Engineering Beijing University of Chemical TechnologyBejing 100029China

the highly efficient method has been developed for the synthesis of NHc·VOcl_(3) containing symmetrical or unsymmetrical Nheterocyclic carbene(NHc) ligands by the transmetallation reaction of NHc·Agcl with VOcl_(3).the total isolated yield of VOcl_(3)[1,3-(2,4,6-Me_(3)c_(6)H_(2))_(2)(NcH=)_(2)c:](V4') reached 86% by transmetallation reaction,which is much higher than that(48%) by direct coordination *** methodology has also been used to synthesize the novel vanadium complexes containing unsymmetrical NHc ligands of VOcl_(3)[PhcH_(2)NcH=cHNR)c:](V5',R=2,4,6-Me_(3)c_(6)H_(2);V6',R=2,4-Me_(2)-6-Ph-c_(6)H_(2);V7',R=2,6-^(i)Pr_(2)-c_(6)H_(3)) with high yield,which could not be obtained by direct coordination *** catalytic activity and copolymerization ability would be improved by introducing unsymmetrical NHc ligands due to their less steric bulky *** vanadium complex V5' containing unsymmetrical NHc ligand exhibits higher catalytic activity(3.7×10^(5)g_(copolymer)·mol^(-1) of V·h^(-1)) than that of V4' containing symmetrical NHc ***,the higher propylene incorporation ratio(45.6 mol%) in the copolymers of ethylene with propylene could be obtained by using V5' than that(39.9%) by using V4'.the results would provide a highly efficient strategy for the synthesis of early transition metal complexes containing versitile NHc ligands,affording the catalyst with both high catalytic activity and copolymerization ability for the synthesis of high performance polyolefin elastomers.

关键词： Vanadium complex N-heterocyclic carbene ligand transmetallation reaction copolymerization of ethylene with propylene

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