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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGhAR z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(hAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Microstructural Evolution and Mechanical Properties of Laminated CuAl Composites Processed by Accumulative Roll-Bonding and Annealing

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Acta Metallurgica Sinica(English Letters) 2021年第7期34卷 925-931页

作者： h.R.lin Y.z.Tian S.J.Sun z.F.zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Nano structured Cu-/Al-laminated composites were processed by accumulative roll-bonding(ARB)technique for four *** evolutions inside the Cu and Al layers and the interfacial reactions were revealed after annealing at different *** and recrystallization occurred in the Cu and Al layers at low annealing temperatures,and three kinds of intermetallic compounds formed near the *** mechanical properties of these composites after annealing were investigated by tensile tests,and the variation of strength-ductility synergy was comprehensively discussed by considering the roles of constituent and the intermetallic compounds.

关键词： CuAl composites Accumulative roll-bonding(ARB) Annealing Intermetallic compounds Ductility

Gyrokinetic Particle Simulation of Compressional Electromagnetic Modes

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Communications in Computational Physics 2008年第8期4卷 519-536页

作者： h.Qu z.lin Department of Physics and Astronomy University of CaliforniaDivineCA 92697USA

A gyrokinetic particle simulation model is developed for simulations of the compressional electromagnetic turbulence driven by the mirror *** of the linear simulations of mirror modes agree well with the analytic dispersion *** simulations of a single mode find that the mirror instability saturates via a phase-space trapping due to the nonlinear wave-particle interaction when the instability drive is weak.

关键词： Mirror instability compressional electromagnetic turbulence particle-in-cell simulation

Fatigue behavior of CoCrFeMnNi high-entropy alloy under fully reversed cyclic deformation

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Journal of Materials Science & Technology 2019年第3期35卷 334-340页

作者： Y.z.Tian S.J.Sun h.R.lin z.F.zhang Materials Fatigue and Fracture Division Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China

Bulk ultrafine-grained(UFG) CoCrFeMnNi high-entropy alloy(hEA) with fully recrystallized microstructure was processed by cold rolling and annealing treatment. The high-cycle fatigue behaviors of the UFG hEA and a coarse-grained(CG) counterpart were investigated under fully reversed cyclic *** fatigue strength of the UFG hEA can be significantly enhanced by refining the grain size. however,no grain coarsening was observed in the UFG hEA during fatigue tests. Mechanisms for the superior mechanical properties of the UFG hEA were explored.

关键词： high-entropy alloy(hEA) Ultrafine-grain(UFG) high-cycle fatigue Recrystallization Grain size Fatigue strength

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

WORKING WITh AND LEARNING FROM BRIT

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Journal of Innovative Optical health Sciences 2011年第4期4卷 479-482页

作者： lin z.LI Molecular Imaging Lab Department of Radiology Britton Chance Lab of Redox Imaging Eldridge Reeves Johnson Research Foundation Department of Biochemistry and Biophysics Perelman School of MedicineUniversity of Pennsylvania PhiladelphiaPA 19014USA

I had been closely working with *** Chance from 2005-2010 on imaging mitochondrial redox state in cancer and stem cells.I had also learned much from him in daily work and personal *** I would like to share some of my memories and experiences including(1)Great science is not necessarily done with top-grade expensive instruments;(2)Brit was genuinely interested in and dedicated to science;(3)Brit's attention to detail and timely action;(4)Brit's open-mindedness;and(5)Brit being modest,appreciative,and caring for others.

关键词： Britton Chance mitochondria redox state cancer stem cell

RESEARCh ON ThE SELECTION OF FRICTION MODELS IN ThE FINITE ELEMENT SIMULATION OF WARM EXTRUSION

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Acta Metallurgica Sinica(English Letters) 2003年第2期16卷 90-96页

作者： X.B.lin h.S.Xiao z.L.zhang National Die and Mold CAD Engineering Research Center Shanghai Jiao Tong University1954 Hua Shan RoadShanghai 200030ChinaNational Die and Mold CAD Engineering Research CenterShanghai Jiao Tong University1954 Hua Shan RoadShanghai 200030ChinaNational Die and Mold CAD Engineering Research CenterShanghai Jiao Tong University1954 Hua Shan RoadShanghai 200030China

During the process of finite element simulation of precision warm forging, the selection of friction models has a direct effect on the precision accuracy of finite element simulation results. Among all the factors which influence the selection of friction models, the distribution rule of normal stress at the tool-workpiece interface is a key one. To find out the distribution rule of normal stress at the tool-workpiece interface, this paper has made a systematic research on three typical plastic deformation processes: forward extrusion, backward extrusion, and lateral extrusion by a method of finite element simulation. Then on the base of synthesizing and correcting traditional friction models, a new general friction model which is fit for warm extrusion is developed at last.

关键词： friction model warm extrusion finite element simulation

Decorating crystalline YFe_(2-x)Al_(x) on the Mg_(60)La_(10)Ni_(20)Cu_(10) amorphous alloy as “hydrogen pump” to realize fast de/hydrogenation

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Journal of Materials Science & Technology 2024年第6期173卷 72-79页

作者： L.J.huang h.Wang L.z.Ouyang M.zhu h.J.lin School of Materials Science and Engineering Key Laboratory of Advanced Energy Storage Materials of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510641China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China

Mg-based amorphous alloys are one of the potential hydrogen storage materials but suffer from sluggish dehydrogenation/hydrogenation(de/hydrogenation)*** this work,as a new strategy,a hydrogen pump is built on the surface of amorphous alloys to solve this *** milling crystalline YFe_(2-x)Al_(x) hydrogen storage alloy with Mg_(60)La_(10)Ni_(20)Cu_(10) amorphous alloy,fine crystalline particles were seeded on amorphous alloy powder to form a“strawberry”*** to the TEM observation,a metallurgical bonding boundary formed between the Mg-based amorphous matrix and the Y-Fe-Al crystalline *** microstructure and de/hydrogenation kinetics investigation,the“hydrogen pump”effect of the seeded crystalline alloy was confirmed,which makes it much easier for the hydrogen to dissociate on and diffuse through the surface of the Mg-based amorphous *** such effect,the h absorption rate of Mg_(60)La_(10)Ni_(20)Cu_(10) amorphous alloy became almost eight times faster and it absorbs ~2.8 wt.% in 1 h at 130℃ under 4.5 MPa-h_(2).Further,fast hydrogenation can even achieve at 70℃ and the low-temperature dehydrogenation kinetics of the amorphous hydride can be also greatly *** present work proves that surface modification is of great importance for obtaining Mg-based amorphous alloy with ideal hydrogen storage performance.

关键词： hydrogen storage Mg-based amorphous alloy hydrogen pump Composite structure