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The new era of cardiovascular research:revolutionizing cardiovascular research with 3. models in a dish

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Medical Review 2024年第1期4卷 68-85页

作者： Yuan Yang hao Yang Fedir N.Kiskin Joe z.zhang Institute of Neurological and Psychiatric Disorders Shenzhen Bay LaboratoryShenzhenGuangdong ProvinceChina Institute of Neurological and Psychiatric Disorders Shenzhen Bay LaboratoryShenzhen 518132Guangdong ProvinceChina

Cardiovascular research has heavily relied on studies using patient samples and animal ***,patient studies often miss the data from the crucial early stage of cardiovascular diseases,as obtaining primary tissues at this stage is *** animal models can offer some insights into disease mechanisms,although they usually do not fully recapitulate the phenotype of cardiovascular diseases and their *** recent years,a promising breakthrough has emerged in the form of in vitro three-dimensional(3.)cardiovascular models utilizing human pluripotent stem *** innovative models recreate the intricate 3. structure of the human heart and vessels within a controlled *** advancement is pivotal as it addresses the existing gaps in cardiovascular research,allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin *** this review,we first outline various approaches employed to generate these *** then comprehensively discuss their applications in studying cardiovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular condi***,we highlight the potential of these 3. models serving as a platform for drug testing to assess drug efficacy and *** their immense potential,challenges persist,particularly in maintaining the complex structure of 3. heart and vessel models and ensuring their function is comparable to real ***,overcoming these challenges could revolutionize cardiovascular *** has the potential to offer comprehensive mechanistic insights into human-specific disease processes,ultimately expediting the development of personalized therapies.

关键词： pluripotent stem cells three-dimensional(3.)models cardiac microtissues cardiac organoids vessel organoids organ-on-a-chip

Effects of friction stir processing and nano-hydroxyapatite on the microstructure,hardness,degradation rate and in-vitro bioactivity of WE43.alloy for biomedical applications

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Journal of Magnesium and Alloys 2024年第1期12卷 209-224页

作者： Bo Wu Farazila Yusof Fuguo Li huan Miao A.R.Bushroa Mohd Ridha Bin Muhamad Irfan Anjum Badruddin Mahmoud z.Ibrahim Department of Mechanical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur 50603Malaysia Centre of Advanced Manufacturing and Material Processing(AMMP Centre) Universiti MalayaKuala Lumpur 50603Malaysia Center of Foundation studies in Science Universiti MalayaKuala Lumpur 50603Malaysia State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Mechanical Engineering Department College of EngineeringKing Khalid UniversityAbha 61421Saudi Arabia Design and Production Engineering Faculty of EngineeringAin Shams UniversityCairo 11517Egypt

Nowadays,magnesium alloys are emerging in biomedical implants for their similar properties to natural ***,the rapid degradation of magnesium alloys in biological media hinders successful *** of microstructure,as well as reinforcement particles can significantly improve the degradation *** this work,multi-pass friction stir processing(FSP)was proposed to synthesize WE43.nano-hydroxyapatite(n hA)surface composite,the microstructure,reinforced particle distribution,micro-hardness,corrosion behavior and in-vitro bioactivity were *** subsequent FSP passes of WE43.alloy and WE43.n hA composite refined the grain size which was reduced by 94.29%and 95.92%(2.63.and 1.88μm,respectively)compared to base metal after three *** resulted in increasing the microhardness by 120%(90.86 hV0.1)and 13.%(105.59 hV0.1)for the WE43.and WE43.n hA,*** is found that increasing FSP passes improved the uniform distribution of n hA particles within the composite matrix which led to improved corrosion resistance and less degradation *** corrosion rate of the FSPed WE43.n hA composite after three passes was reduced by 3..2%(4.13.mm/year)and the degradation rate was reduced by 69.7%(2.87 mm/y).This is attributed to secondary phase(Mg24Y5and Mg41Nd5)particle fragmentation and redistribution,as well as a homogeneous distribution of n ***,the growing Ca-P and Mg(Oh)2layer formed on the surface represented a protective layer that reduced the degradation *** wettability test revealed a relatively hydrophilic surface with water contact angle of 49.1±2.2°compared to 71.2±2.1°for base ***,biomineralization test showed that apatite layer grew after immersion 7d in simulated body fluid with atomic ratio of Ca/P 1.60 approaching the stoichiometric ratio(1.67)indicating superior bioactivity of FSPed WE43.n hA composite after three *** results raise that the grain refinement by FSP and introduction of n hA partic

关键词： Friction stir processing Magnesium-based composite Nano-hydroxyapatite Corrosion behavior In-vitro bioactivity

Compressive property and energy absorption characteristic of interconnected porous Mg-zn-Y alloys with adjusting Y addition

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Journal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： J.A.Liu S.J.Liu B.Wang W.B.Sun X.J.Liu z.W.han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China Weihai Institute for Bionics-Jilin University Weihai 264205PR China

In this study,interconnected porous Mg-2zn-xY alloys with different phase compositions were prepared by various Y additions(x=0.4,3.and 6 wt.%)to adjust the compressive properties and energy absorption *** characterization methods were then applied to identify the microstructure of the porous Mg-zn-Y and describe the details of the second *** tests were performed at room temperature(RT),200℃,and 3.0℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results showed that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-zn-Y ternary phases appear:I-phase(Mg_(3.zn_(6)Y),W-phase(Mg_(3.zn_(3.Y_(2)),and LPSO phase(Mg_(12)znY).When the Y content ranges between 0.4%and 6%,the compressive strength increases from 6.3.MPa to 9.23.MPa,and the energy absorption capacity increases from 7.3. MJ/m^(3.to 10.97 MJ/m^(3.at RT,which is mainly attributed to the phase composition and volume fraction of the second ***,the average energy absorption efficiency is independent of the Y *** addition,the compressive deformation behaviors of the porous Mg-zn-Y are altered by the testing *** compressive strength and energy absorption capacity of the porous Mg-zn-Y decrease due to the softening effect of the high temperature on the *** deformation behaviors at different temperatures are finally observed to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements Microstructure Compressive behavior Energy absorption characteristic

On building automation system security

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High-Confidence Computing

high-Confidence Computing 2024年第3期4卷 103-122页

作者： Christopher Morales-Gonzalez Matthew harper Michael Cash Lan Luo zhen Ling Qun z.Sun Xinwen Fu Department of Computer Science University of Massachusetts LowellLowell 01854USA Department of Electrical and Computer Engineering University of Central FloridaOrlando 32816USA School of Computer Science and Technology Southeast UniversityMa’anshan 243032China School of Computer Science and Engineering Anhui University of TechnologyNanjing 211189China

Building Automation Systems(BASs)are seeing increased usage in modern society due to the plethora of benefits they provide such as automation for climate control,hVAC systems,entry systems,and lighting *** BASs in use are outdated and suffer from numerous vulnerabilities that stem from the design of the underlying BAS *** this paper,we provide a comprehensive,up-to-date survey on BASs and attacks against seven BAS protocols including BACnet,EnOcean,KNX,LonWorks,Modbus,zigBee,and *** studies of secure BAS protocols are also presented,covering BACnet Secure Connect,KNX Data Secure,KNX/IP Secure,ModBus/TCP Security,EnOcean high Security and z-Wave *** and zigBee do not have security *** point out how these security protocols improve the security of the BAS and what issues remain.A case study is provided which describes a real-world BAS and showcases its vulnerabilities as well as recommendations for improving the security of *** seek to raise awareness to those in academia and industry as well as highlight open problems within BAS security.

关键词： Building automation system BAS protocols Security Attack

DFT investigation of half-metallic ferromagnetic rare earth based spinels Mgho_(2)z_(4)(z=S,Se)

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Journal of Rare Earths 2024年第1期42卷 121-128,I0005页

作者： Maiza zanib Mumtaz Manzoor N.A.Noor M.Waqas Iqbal Mazia Asghar h.h.hegazy A.Laref Department of Physics Riphah International UniversityLahore CampusPakistan Research Centre for Advanced Materials Science King Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Department of Physics and Astronomy College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

half-metallic ferromagnetism,mechanical as well as thermoelectric properties for rare earth-based spinels Mgho_(2)z_(4)(z=S,Se)were investigated using density functional theory(DFT).Structural optimization was done with Perdew-Burke-Ehrenzorf(PBE)sol-generalized gradient approximation(GGA)to calculate the lattice constant of both spinels comparable to experimental *** addition,Born stability criteria and negative formation energy show that our studied spinels are also structurally and dynamically stable in the cubic *** ferromagnetic(FM)state stability,we also calculated the energy differences among FM,antiferromagnetic(AFM),and non-magnetic(NM)***,Curie temperatures of ferromagnetic phases were also *** used Trans-Blaha improved BeckeJohnson(TB-mBJ)potential functional for electronics as well as magnetic characteristics,which lead to the consistent explanation of half-metallic ferromagnetism,representing the whole band-occupancy in material with exact detail of density of states(DOS).The stable FM state was examined in spinels due to the exchange splitting of ho cation consisting of p-d hybridizations compatible with the result achieved for electronics band structure and ***,spin magnetic moment was explained in terms of anion,cation,and sharing charge on studied *** addition,the calculated thermoelectric properties clearly show that operation range of these systems may be utilized by future experimental works for identifying the potential applications of these systems.

关键词： ho-based spinels DFT simulations Mechanical parameters Electronic properties hM ferromagnetism Figure of merit

China-Caribe:más cerca que nunca

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今日中国（西文版） 2024年第3期 34-35页

作者： MIChAEL zÁRATE 不详

China-Uruguay: la defensa del libre comercio

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今日中国（西文版） 2024年第1期 44-45页

作者： MlChAEL zÁRATE

Erratum to “Plant Defense against Necrotrophic Pathogens” [American Journal of Plant Sciences 11(12) (2020) 2122-213.]

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American Journal of Plant Sciences 2024年第2期15卷 122-138页

作者： Mahmoud h. Ghozlan Nikita Gambhir Eman EL-Argawy Serkan Tokgöz Dilip K. Lakshman Amitava Mitra University of Nebraska Lincoln NE USA USDA-ARS Beltsville MD USA

The original online version of this article (Ghozlan, M.h., EL-Argawy, E., Tokgöz, S., Lakshman, D.K. and Mitra, A. (2020) Plant Defense against Necrotrophic Pathogens. American Journal of Plant Sciences, 11, 2122-213.. https://***/10.423./ajps.2020.1112149) was published mistakenly without another co-author, Nikita Gambhir. In this regard, we revise authors and “how to cite” sections by adding her name.

关键词： Effectors host Immunity Signaling P/MAMP ETI Disease Resistance

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古北口长城景观视觉感知区位数据集

全球变化数据学报（中英文） 2024年第1期8卷 32-41,V0032-V0041页

作者：李照航李仁杰孙宝磊李家慧河北师范大学地理科学学院石家庄050024 河北师范大学地理计算与规划研究中心石家庄050024 河北省环境变化遥感识别技术创新中心石家庄050024

长城是具有历史文化、形态美学等多重意义的重要视觉景观资源,视觉感知计算分析是挖掘长城景观资源价值,呈现和阐释长城多维意义的重要路径。通过设计长城景观系统的语义特征点提取和编码规则,基于古北口长城资源本体和ALOS 12.5 m DEM... 详细信息

长城是具有历史文化、形态美学等多重意义的重要视觉景观资源,视觉感知计算分析是挖掘长城景观资源价值,呈现和阐释长城多维意义的重要路径。通过设计长城景观系统的语义特征点提取和编码规则,基于古北口长城资源本体和ALOS 12.5 m DEM数据生成了景观语义特征点,并对每个特征点进行视域分析得到可视域栅格;以景观视觉感知区位信息模型(LVPLM)为基础,选择NetCDF多维数据格式建立了古北口长城景观视觉感知区位数据集。数据集包括3.分:(1)人工选择语义特征点数据子集;(2)程序自动选择语义特征点数据子集;(3.验证点数据。(1)和(2)数据子集内容包括:(a)古北口长城本体要素与语义特征点矢量数据;(b)古北口长城景观视觉感知区位数据。数据集存储为.shp和.nc格式,由64个数据文件组成,数据量为6.58 GB(压缩为1个文件,63.8 MB)。

关键词：视觉感知区位景观语义特征点长城 NetCDF