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胫神经MRT2值可作为诊断糖尿病周围神经病变的潜在无创性定量生物标志物

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国际医学放射学杂志 2018年第3期 365-365页

作者： D.Wang C.Wang X.Duan z.Yang z.bai H.Hu 史洪建 Department of Radiology Sun Yat-Sen Memorial Hospital Sun Yat-Sen University

摘要目的探讨定量T2值在糖尿病周围神经病变(DPN)的胫神经诊断中的作用。方法对22例糖尿病伴DPN病人、20例无DPN的糖尿病病人及20例正常对照组行胫神

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High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

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Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng bai Yi Li Yabo Xie Qiancheng Chen Xin zhang Jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao bai Yuan zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin zhang baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Numerical Simulation of Solidification of Work Roll in Centrifugal Casting Process

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Journal of Materials Science & Technology 2012年第2期28卷 147-154页

作者： Nannan Song Yikun Luan Yunlong bai z.A. Xu Xiuhong Kang Dianzhong Li Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China SIRRIS the Collective Center for the Belgian Technological Industry Technologiepark 915 9052 Zwijnaarde Belgium

A program on the solidification process of horizontal centrifugal casting coupled with eutectic carbides segregation has been developed in this paper. Due to the geometrical features of work roll, a cylindrical coordinate system was used. The temperature field of the outer layer at the end of filling process was imported as the initial temperature condition for the solidification process. The model of eutectic carbides segregation caused by different densities between eutectic MC and the molten steel was coupled in the program. The temperature field of the outer layer of work roll during horizontal centrifugal casting process was investigated. Results show that the outer layer has a ＂sandwich shape＂ solid fraction manner. Results also indicate that the segregation of eutectic MC is quite severe during centrifugal casting process. It forms four zones of different content of carbides in radial direction. The simulated results of MC carbides segregation phenomenon agree with the experimental observations.

关键词： Numerical simulation Horizontal centrifugal casting MC segregation Work roll

Grain refinement mechanism of Mg-3Sn-1Mn-1La alloy during accumulative hot rolling

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Journal of Materials Science & Technology 2021年第32期91卷 251-261页

作者： z.Y.zhao R.G.Guan Y.F.Shen P.K.bai School of Materials Science and Engineering North University of ChinaTaiyuan 030051China bEngineering Research Center of Continuous Extrusion Ministry of EducationDalian Jiaotong UniversityDalian 116028China Key Laboratory for Anisotropy and Texture of Materials Northeastern UniversityShenyang 110004China

We elucidate the effect of lanthanum(La) on the grain refinement of Mg-3 Sn-1 Mn alloy during accumulative hot rolling. The lath-shaped Mg_(2) Sn phase in the Mg-3 Sn-1 Mn alloy is firstly broken and spheroidized,and then the size increases and coarsens with the increase of rolling reduction, most of Mg_(2) Sn move from grain boundary to grain and are homogeneously distributed within the matrix. However, the plate-shaped Mg Sn La compound in Mg-3 Sn-1 Mn-1 La gradually becomes fine, spheroidized, and homogeneously distributed. The grain sizes of Mg-3 Sn-1 Mn and Mg-3 Sn-1 Mn-1 La alloys become fine through dynamic recrystallization(DRX), though the grain refinement of Mg-3 Sn-1 Mn-1 La alloy is better compared to the Mg-3 Sn-1 Mn alloy. A large number of uniformly distributed spherical Mg Sn La compounds pin the dislocations, thus increasing the dislocation density. Hence, the driving force for DRX increases and promotes the formation of deformation bands and more twins, providing the sites for DRX nucleation and growth.

关键词： Mg alloy Grain refinement Dynamic recrystallization Accumulative hot rolling

Effect of icosahedral clusters on β-relaxations in metallic glasses

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Chinese Physics B 2017年第1期26卷 86-90页

作者： X Q Gao Y T Sun z Wang M z Li H Y bai Institute of Physics Chinese Academy of Sciences Beijing 100190 China Department of Physics Renmin University of China Beijing 100872 China

The most pronounced β-relaxation was found in the Y-based binary metallic glasses（MGs）. The correlation betweenβ-relaxation and local atomic structure was studied. The dynamic mechanical measurements were performed for three chosen binary systems： zr-, Ti-, and Y-based MGs. The experimental results show that, in each system,the larger negative enthalpy of mixing（？Hm） between the component elements makes β-relaxation become more pronounced. The less negative value of ？Hm facilitates the formation of icosahedral clusters, which have a pinning effect on the excitation of β-relaxations and correspondingly make the β-relaxation become less pronounced. These chemical effects on β-relaxations can only be compared in the same MG system, and it is not suitable for the comparison between different systems due to the different features of the major metallic elements.

关键词： metallic glass β-relaxation enthalpy of mixing icosahedral clusters

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面向航拍路面裂缝检测的AC-YOLO

计算机工程与应用 2025年第1期61卷 153-164页

作者：白锋马庆禄赵敏重庆交通大学土木工程学院重庆400074 重庆交通大学交通运输学院重庆400074 重庆大学自动化学院重庆400044

针对当前道路巡检智能化程度不足以及效率低等现状,为提高利用无人机道路巡检检测效率与检测精度,在YOLOv8s的基础上针对无人机航拍场景提出改进模型AC-YOLO,在主干网络引入动态大卷积核注意机制LSK-attention来扩展模型的感受野,提高... 详细信息

针对当前道路巡检智能化程度不足以及效率低等现状,为提高利用无人机道路巡检检测效率与检测精度,在YOLOv8s的基础上针对无人机航拍场景提出改进模型AC-YOLO,在主干网络引入动态大卷积核注意机制LSK-attention来扩展模型的感受野,提高对路面裂缝范围检测的准确性。在颈部结构设计多尺度特征融合策略,融入BiFPN网络,改善对细小裂缝的检测。替换损失函数为WIoUv3,优化梯度分配策略,使模型更加关注裂缝主体。在数据集UAV-PDD2023上进行实验验证,改进后AC-YOLO精准度达到0.895,较原模型提高0.128,mAP50达到0.791,提高0.071,F1得分提高0.051,模型大小减小8.5%,FPS达到了129,提高4%。同时采用不同任务验证了模型泛化性能,实验结果证明AC-YOLO具有更强的检测性能,能有效应用于无人机视角下的路面裂缝检测。

关键词：道路巡检裂缝检测航拍裂缝增强感知特征融合

Dislocation self-interaction in TiAl:Evolution of super-dislocation dipoles revealed by atomistic simulations

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Journal of Materials Science & Technology 2021年第10期69卷 138-147页

作者： z.zhen H.Wang C.Y.Teng C.G.bai D.S.Xu R.Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of China.Shenyang 110016China School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Laboratory of Fundamental Research AVIC China Aero-Polytechnology EstablishmentBeijing 100028.China

As one of the fundamental outcomes of dislocation self-interaction,dislocation dipoles have an important influence on the plastic deformation of materials,especially on fatigue and *** this work,superdislocation dipoles inγ-TiAl andα_(2)-Ti_(3)Al were systematically investigated by atomistic simulations,with a variety of dipole heights,orientations and annealing tempe *** results indicate that non-screw super-dipoles transform into locally stable dipolar or reconstructed cores at low temperature,while into isolated or interconnected point defect clusters and stacking fault tetrahedra at high temperature via short-range diffu ***-screw super-dipoles inγ-TiAl andα_(2)-Ti_(3)Al exhibit similar features as fcc and hcp metals,***,over long-term annealing where diffusion is significant,60°superdipoles inγ-TiAl are stable,whereas the stability of super-dipoles inα2-Ti3 Al increases with dipole height and orientation *** influence on mechanical properties can be well evaluated by integrating these results into mesoscale or constitutive models.

关键词： TiAl Dislocation Dipole Mechanical property Atomistic simulation

BRIGHT LONG AFTERGLOW PHOSPHORESCENCE GLASS MADE OF SrAl_(2)O_(4): Eu^(2+), Dy^(3+) AND GLASS FRITS

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Acta Metallurgica Sinica(English Letters) 2005年第6期18卷 736-740页

作者： X. Y. zhang z. F. Cao L.P. Lu z.H. bai W.z. Wang X. C. Wang Department of Materials Science and Engineering Changchun University of Science and Technology Changchun 130022 China

Bright long afterglow phosphorescence glasses were prepared by using SrAl2O4： Eu^2＋, Dy^3＋ phosphors and suitable glass frits together. The SrAl2O4： Eu^2＋, Dy^3＋ phosphors were initially prepared by the solid reaction method. Three kinds of glass frits were prepared to match the SrAl2O4： Eu^2＋, Dy^3＋ phosphors. Effects of the compositions of the glass frits, the ratios of the phosphors to the frits us well us the firing temperature and firing times on the properties of the samples were discussed. XRD analysis indicated the samples exhibited the typical diffraction peaks of SrAlwO4： Eu^2＋, Dy^3＋. The emission spectra of the samples showed broad bands peaking at *** excitation spectra of the samples showed broad bands ranging from 300 to 480hm. These are believed due to the 5d4f-4f transitions of Eu^2＋ in the SrAl2O4： Eu^2＋, Dy^3＋ phosphors. The afterglow luminescence of the samples excited by a 40W fluorescence lamp for 30min can be observed in the dark for more lOh with the naked eyes. It can find wide applications in many fields.

关键词： long afterglow phosphorescence glass StAl2O4 :Eu^2+ Dy^3+,glass frit