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OXIDATION BEHAVIOR OF KOVAR ALLOY IN CONTROLLED ATMOSPHERE

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Acta Metallurgica Sinica(English Letters) 2008年第6期21卷 409-418页

作者： D. W. luo z.S. Shen School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Controlled oxidation experiments were performed on Kovar alloy by changing oxidation atmosphere, temperature, and exposure time to produce films with different oxide type and thickness. The results indicated that single Fe3O4 and single FeO were respectively obtained when Kovar alloy was oxidized in N2-2.31%H2O-0.95%H2 at 500℃ and in N2-2.31%H2O-0.5%H2 at 1000℃, and all kinetic curves followed linear relation; mixed oxides of FeO and Fe3O4 formed when Kovar was oxidized in N2-2.31%H2O at 1000℃and parabolic kinetics were obeyed. Analysis of metallographic cross section of oxides indicated that oxygen diffusion inward through the oxide scale is responsible for intergranular oxide, which had formed beneath the oxide scales when the oxide products were mixed oxides of FeO and Fe3O4, and which did not occur when the oxide was single FeO or Fe3O4. The oxidation model was also established.

关键词： Kovar alloy, Oxidation Controlled atmosphere H2-H2O-N2

小分子药物TD-198946促进大鼠骨髓间充质干细胞的成骨分化

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中国组织工程研究 2025年第13期29卷 2648-2654页

作者：杨超罗宗平苏州大学附属第一医院骨科苏州大学骨科研究所江苏省苏州市215006

背景:小分子药物TD-198946是一种能诱导干细胞形成软骨的高效软骨生成剂,但目前尚不清楚其对成骨分化的作用。目的:探讨小分子药物TD-198946促进大鼠骨髓间充质干细胞成骨分化的效果及其作用机制。方法:提取SD大鼠骨髓间充质干细胞,利用... 详细信息

背景:小分子药物TD-198946是一种能诱导干细胞形成软骨的高效软骨生成剂,但目前尚不清楚其对成骨分化的作用。目的:探讨小分子药物TD-198946促进大鼠骨髓间充质干细胞成骨分化的效果及其作用机制。方法:提取SD大鼠骨髓间充质干细胞,利用CCK-8法评估不同浓度TD-198946对骨髓间充质干细胞增殖的影响,确定TD-198946的最佳使用浓度;然后加入最适浓度TD-198946和成骨分化培养基对骨髓间充质干细胞进行成骨诱导;成骨诱导第3天用qRT-PCR检测碱性磷酸酶、Runt相关转录因子2、骨桥蛋白、骨钙蛋白、Ⅰ型胶原基因表达;成骨诱导第7天进行碱性磷酸酶染色,Western blot检测Runt相关转录因子2、Ⅰ型胶原、AKT、p-AKT、PI3K、p-PI3K蛋白表达;成骨诱导第21天进行茜素红染色。结果与结论:①CCK-8实验结果显示,100 nmol/L TD-198946能促进骨髓间充质干细胞增殖;②碱性磷酸酶染色及茜素红染色结果显示,TD-198946能促进大鼠骨髓间充质干细胞的成骨分化;③qRT-PCR结果显示,TD-198946可促进成骨相关基因碱性磷酸酶、Runt相关转录因子2、骨桥蛋白、骨钙蛋白、Ⅰ型胶原的表达;④Western blot结果显示,TD-198946可促进Runt相关转录因子2、Ⅰ型胶原以及p-PI3K、p-AKT蛋白表达。结果表明,小分子药物TD-198946可能通过激活PI3K/AKT信号通路,诱导大鼠骨髓间充质干细胞成骨分化。

关键词：骨髓间充质干细胞 TD-198946 成骨分化 PI3K/AKT信号通路 AKT p-AKT

Intestinal glucagon-like peptide-1:A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus

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World Journal of Diabetes 2025年第1期16卷 217-221页

作者： Le-Rong Liu Yuan-Yuan luo Pei-zhu Su Cong zhang zhao-Tao Li Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endocrinology Chongqing University Three Gorges HospitalChongqing 404100China Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases Chongqing University Three Gorges HospitalChongqing 404100China Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400013China Department of Gastroenterology The First People's Hospital of FoshanFoshan 528000Guangdong ProvinceChina

In this article,we review the study by Jin et al,which examined the role of intestinal glucagon-like peptide-1(GLP-1)in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus(T1DM).With the global rise of T1DM,there is an increased burden on society and healthcare *** to insulin therapy and islet dysfunction,T1DM patients are highly vulnerable to severe hypoglycemia,a leading cause of *** healthy individuals,counterregulatory mechanisms restore blood glucose during hypoglycemia,but repeated episodes impair these *** et al demonstrated that overexpression of GLP-1 attenuates the sympathetic-adrenal reflex and disrupts the secretion of counterregulatory hormones such as glucagon during hypoglycemia,leading to counterregulatory *** findings highlight the critical role of GLP-1 in the impaired counterregulatory response to hypoglycemia in T1DM patients and provide new insights into the potential application of GLP-1-related therapies in T1DM patients.

关键词： Glucagon-like peptide-1 Impaired counterregulation Type 1 diabetes mellitus Sympathetic-adrenal reflex Glucagon

Asymmetrical Fault Current Calculation Method and Influencing Factors Analysis of Droop-Controlled Inverters

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 562-573页

作者： Huimin zhao zhikang Shuai Jun Ge An luo Weimin Wu z.John Shen College of Electrical and Information Engineering Hunan UniversityChangsha 410006China Electrical Engineering Department Shanghai Maritime UniversityShanghai 201306China Department of Electrical and Computer Engineering Ilinois Institute of TechnologyChicagoIL 60616 USA

Since the fault dynamic of droop-controlled inverter is different from synchronous generators (SGs), protection devices may become invalid, and the fault overcurrent may damage power electronic devices and threaten the safety of the microgrid. Therefore, it is imperative to conduct a comprehensive fault analysis of the inverter to guide the design of protection schemes. However, due to the complexity of droop control strategy, existing literatures have simplified asymmetric fault analysis of droop-controlled inverters to varying degrees. Therefore, accurate fault analysis of a droop-controlled inverter is needed. In this paper, by analyzing the control system, an accurate fault model is established. Based on this, a calculation method for instantaneous asymmetrical fault current is proposed. In addition, the current components and current characteristics are analyzed. It was determined that fault currents are affected by control loops, fault types, fault distance and nonlinear limiters. In particular, the influences of limiters on the fault model, fault current calculation and fault current characteristics were analyzed. Through detailed analysis, it was found that dynamics of the control loop cannot be ignored, the fault type and fault distance determine fault current level, and part of the limiters will totally change the fault current trend. Finally, calculation and experimental results verify the correctness of the proposed method.

关键词： Asymmetrical fault analysis droop control fault current calculation method limiter transient fault characteristics

Effect of Rotation Rate on Microstructures and Mechanical Properties of FSW Mg-zn-Y-zr Alloy Joints

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Journal of Materials Science & Technology 2011年第12期27卷 1157-1164页

作者： G.M. Xie z.Y. Ma z.A. luo P. Xue G.D. Wang The State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110819 China Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China

Friction stir welding （FSW） of Mg-zn-Y-zr plates with 6 mm in thickness was successfully carried out under a wide range of rotation rates of 600-1200 r/rain with a constant traverse speed of 100 mm/min. After FSW, the coarse grains in the parent material （PM） were changed into fine equiaxed recrystallized grains at the＇nugget zone （Nz）. Furthermore, the coarse Mg-zn-Y particles （W-phase） were broken up and dispersed homogenously into the Mg matrix. With increasing rotation rates, the size of the W-phase particles at the Nz significantly decreased, but the recrystallized grain size tended to increase. The hardness values of the Nzs for all the FSW joints were higher than those of the PM, and the lowest hardness values were detected in the heat affected zone （HAz）. The fracture occurred in the thermo-mechanical affected zone （TMAz） on the advancing side for all the FSW joints in the tensile test, due to the incompatibility of the plastic deformation between the Nz and TMAz caused by remarkably different orientation of grains and W-phase particles. The strength of FEW ioint reaches 90% of that of its PM

关键词： Friction stir welding Magnesium alloys Microstructure Mechanical property

Revealing the high-frequency attenuation mechanism of polyurea-matrix composites

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Acta Mechanica Sinica 2020年第1期36卷 130-142页

作者： J.Cheng z.L.Liu C.C.luo T.Li z.J.Li Y.Kang z.zhuang Applied Mechanics Laboratory School of Aerospace EngineeringTsinghua UniversityBeijing100084China Key Laboratory of Advanced Materials of Ministry of Education Department of Chemical EngineeringTsinghua UniversityBeijing100084China School of Materials Science and Engineering Tsinghua UniversityBeijing100084China

In this paper,a method for analyzing the high-frequency attenuation property of polyurea-matrix composites is developed by combining experimental,computational and theoretical ***,the ultrasonic experimental platform is established by solving the difficulties of high-frequency ultrasonic testing as high-frequency signal distortion,insufficient driving voltage and sampling rate failure,to study the dynamic mechanical properties(1-5 MHz)of pure polyurea and polyurea-matrix ***,the influences of composite parameters including the size and volume fraction of inclusions on wave attenuation performance under different frequencies are obtained and further verified by numerical ***,the contribution of inclusions to the wave attenuation performance is also theoretically *** is found that the increase of inclusion volume fraction and inclusion diameter will increase the attenuation coefficient of the *** the attenuation of composites with the inclusions of a 150-μm diameter and 30%as volume fraction can be 82%higher than pure *** amplifying attenuation effect of inclusions is mainly attributed to the scattering effect,which is verified by comparing numerical and theoretical results.

关键词： Polyurea Viscoelastic Dynamic mechanical properties Ultrasound

Cutting Behavior of Cortical Bone in Different Bone Osteon Cutting Angles and Depths of Cut

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 80-91页

作者： Yuanqiang luo Yinghui Ren Yang Shu Cong Mao zhixiong zhou z.M.Bi College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-performance Mechanical Equipment Changsha University of Science and TechnologyChangsha 410114China Department of Civil and Mechanical Engineering Purdue University Fort WayneFort WayneIN 46805USA

Cortical bone is semi-brittle and anisotropic,that brings a challenge to suppress vibration and avoid undesired fracture in precise cutting process in *** this paper,a novel analytical model is proposed to represent cortical bone cutting *** model is utilized to predict the chip formations,material removal behavior and cracks propagation under varying bone osteon cutting angles and *** of orthogonal cutting experiments were conducted on cortical bone to investigate the impact of bone osteon cutting angle and depth of cut on cutting force,crack initialization and *** observed chip morphology highly agreed with the prediction of chip formation based on the analytical *** curly,serrated,grainy and powdery chips formed when the cutting angle was set as 0°,60°,90°,and 120°,*** bone were removed dominantly by shearing at a small depth of cut from 10 to 50μm,and by a mixture of pealing,shearing,fracture and crushing at a large depth of cut over 100μm at different bone osteon ***,its fracture toughness was calculated based on measured cutting *** is found that the fluctuation of cutting force is suppressed and the bone material becomes easy to remove,which attributes to lower fracture toughness at bone osteon cutting angle 0°.When the cutting direction develops a certain angle to bone osteon,the fracture toughness increases then the crack propagation is inhibited to some extent and the fluctuation of cutting force comparatively *** is a theoretical and practical significance for tools design and operational parameters choice in surgeries.

关键词： Bone cutting surgery Orthogonal cutting models Anisotropic materials Chip formation Crack initialization and propagation Fracture toughness

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen zhou Cathy z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen zhongcheng Fan zhiwen luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise