检索结果-南通市图书馆

Accelerating Alz.eimer’s pathogenesis by GRK5 deficiency via cholinergic dysfunction

在线全文

学校读者我要写书评

暂无评论

Advances in Alz.eimer's Disease 2013年第4期2卷 148-160页

作者： William z. suo Laboratory for Alz.eimer’s Disease & Aging Research Veteran Affairs Medical Center Kansas City USA

G protein-coupled receptors (GPCRs) mediate a wide variety of physiological function. GPCR signaling is negatively regulated by the receptor desensitiz.tion, a procedure initiated by a group of kinases, including GPCR kinases (GRKs). Studies using genetargeted mice revealed that deficiency of a particular GRK member led to dysfunction of a highly selective group of GPCRs. In particular, for example, GRK5 deficiency specifically disrupts M2/M4-mediated muscarinic cholinergic function. Emerging evidence indicates that ?-amyloid accumulation may lead to GRK5 deficiency, while the latter impairs desensitiz.tion of M2/M4 receptors. Within memory circuits, M2 is primarily presynaptic autoreceptor serving as a negative feedback to inhibit acetylcholine release. The impaired desensitiz.tion of M2 receptor by GRK5 deficiency leads to hyperactive M2, which eventually suppresses acetylcholine release and results in an overall cholinergic hypofunctioning. Since the cholinergic hypofunctioning is known to cause ?-amyloid accumulation, the GRK5 deficiency appears to connect the cholinergic hypofunctioning and ?-amyloid accumulation together into a self-amplifying cycle, which accelerates both changes. Given that the ? -amyloid accumulation and the cholinergic hypofucntioning are the hallmark changes in the ?-amyloid hypothesis and the cholinergic hypothesis, respectively, the GRK5 deficiency appears to bring the two major hypotheses in Alz.eimer’s disease together, whereas the GRK5 deficiency is the pivotal link. Therefore, any strategies that can break this cycle would be therapeutically beneficial for Alz.eimer’s patients.

关键词： G Protein Receptor Kinase Cholinergic Alz.eimer Pathogenesis

Accelerating Alz.eimer’s pathogenesis by GRK5 deficiency via cholinergic dysfunction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Facile low-temperature supercritical carboniz.tion method to prepare high-loading nickel single atom catalysts for efficient photodegradation of tetracycline

Advances in Alz.eimer's Disease（阿尔茨海默氏病研究进展） 2013年第4期

作者： William z. suo

来源：评论

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第4期138卷 373-384页

作者： Han Qiao Lirong z.eng Shiwen Hu Gang Tang Hongri suo Chongxuan Liu School of Environment Harbin Institute of TechnologyHarbin 150090China State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Beijing Synchrotron Radiation Facility(BSRF) Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Environmental photocatalysis is a promising technology for treating antibiotics in *** this study,a supercritical carboniz.tion method was developed to synthesiz. a single-atom photocatalyst with a high loading of Ni(above 5 wt.%)anchored on a carbonnitrogen-silicate substrate for the efficient photodegradation of a ubiquitous environmental contaminant of tetracycline(TC).The photocatalyst was prepared from an easily obtained metal-biopolymer-inorganic supramolecular hydrogel,followed by supercritical drying and carboniz.tion *** low-temperature(300℃)supercritical ethanol treatment prevents the excessive structural degradation of hydrogel and greatly reduces the metal clustering and aggregation,which contributed to the high Ni *** characteriz.tions confirmed that Ni was present at isolated sites and stabiliz.d by Ni-N and Ni-O bonds in a Ni-(N/O)_(6)-C/SiC configuration.A 5%Ni-C-Si catalyst,which performed the best among the studied catalysts,exhibited a wide visible light response with a narrow bandgap of 1.45 eV that could efficiently and repeatedly catalyz. the oxidation of TC with a conversion rate of almost 100% within 40 *** reactive species trapping experiments and electron spin resonance(ESR)tests demonstrated that the h+,and·O_(2)-were mainly responsible for TC *** TC degradation mechanism and possible reaction pathways were provided ***,this study proposed a novel strategy to synthesiz. a high metal loading singleatom photocatalyst that can efficiently remove TC with high concentrations,and this strategy might be extended for synthesis of other carbon-based single-atom catalysts with valuable properties.

关键词： Carbon-based single-atom catalyst Nickel Photocatalytic degradation Tetracycline Visible light

Quantitative Precipitation Estimation Using X-band Phased Array Weather Radar

在线全文

学校读者我要写书评

暂无评论

Meteorological and Environmental Research 2024年第4期15卷 29-31页

作者： Shaoyu HOU Xuejiao CHEN Chunnan suo Xiangfeng HU Hebei Provincial Weather Modification Center Shijiazhuang 051432China China Meteorological Administration Xiong an Atmospheric Boundary Layer Key Laboratory Xiong an New Area 071000China Hebei Xiong an New Area Meteorological Service Xiong an New Area 070001China Hebei Cangz.ou Meteorological Observatory Cangzhou 061000China Hebei Key Laboratory of Meteorology and Ecological Environment Shijiazhuang 050021China

This study utiliz.d data from an X-band phased array weather radar and ground-based rain gauge observations to conduct a quantitative precipitation estimation(QPE)analysis of a heavy rainfall event in Xiong an New Area from 20:00 on August 21 to 07:00 on August 22,*** analysis applied the z.R relationship method for radar-based precipitation estimation and evaluated the QPE algorithm s performance using scatter density plots and binary classification *** results indicated that the QPE algorithm accurately estimates light to moderate rainfall but significantly underestimates heavy *** study identified disparities in the predictive accuracy of the QPE algorithm across various precipitation intensity ranges,offering essential insights for the further refinement of QPE techniques.

关键词： X-band phased array radar Quantitative precipitation estimation

基于平扫和不同期相增强CT预测胃肠道间质瘤高Ki-67增殖指数

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2024年第3期 376-377页

作者： z.Xie S.suo W.z.ang Q.z.ang Y.Dai Y.Song 余翔玲

摘要目的评估和分析基于平扫和对比增强不同期相CT的影像组学模型，以预测经病理证实的胃肠道间质瘤（GIST）病人的Ki-67增殖指数（PI）。方法将383例经病理

关键词：

“一个连续过程”与“三个阶段”:抑郁青少年情绪失调的原因探析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

心理科学进展 2024年第6期32卷 928-938页

作者：詹紫薇王梦梦索涛蒋艳菊河南大学教育学部开封475004 浙大宁波理工学院商学院浙江宁波315100

当前抑郁逐渐低龄化使得青少年的情绪失调问题备受关注。情绪调节能力作为情绪稳定的关键因素,能够帮助青少年对自身情绪状态进行有效管理;而调节情绪的动态性和多阶段加工过程等特性则是情绪调节的重要组成部分,对其研究有利于系统地... 详细信息

当前抑郁逐渐低龄化使得青少年的情绪失调问题备受关注。情绪调节能力作为情绪稳定的关键因素,能够帮助青少年对自身情绪状态进行有效管理;而调节情绪的动态性和多阶段加工过程等特性则是情绪调节的重要组成部分,对其研究有利于系统地阐明抑郁青少年情绪失调的特征及原因。扩展过程模型将情绪调节过程分为识别、选择和执行三个阶段,强调阶段之间相互影响的关系,还原了情绪调节的动态过程。基于该模型对抑郁青少年在情绪调节三阶段的特征进行梳理,结果发现其在各阶段均存在缺陷。考虑到三阶段的整体性和连续性,为了明确抑郁青少年情绪失调是哪一阶段的受损或中断对后续阶段产生了影响、影响的程度如何以及采用指导性的干预是否可以改变这种影响,未来研究可以:1)通过脑电技术与漂移扩散模型相结合的方式还原情绪调节的动态变化过程;2)更为全面地研究不同抑郁症状水平青少年的特点;3)关注情绪反应性异常的双重性,更为系统地揭示抑郁青少年情绪失调的原因,以此来探究抑郁青少年情绪失调的干预路径和举措。

关键词：抑郁情绪调节青少年扩展过程模型

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

基于字形特征的中文医学命名实体识别方法

电子学报 2024年第6期52卷 1945-1954页

作者：孟伟伦郭景峰邢珂萱魏宁王巧梭刘滨燕山大学信息科学与工程学院河北秦皇岛066004 河北省虚拟技术与系统集成重点实验室河北秦皇岛066004 河北建材职业技术学院河北秦皇岛066000 河北科技大学大数据与社会计算研究中心河北石家庄050018

作为医学信息抽取的第一个关键环节,医学命名实体识别任务旨在从如电子医疗病例、中文医药说明书等非结构化文本中抽取出医学相关的实体.目前大多数中文医学命名实体识别工作通过在预训练模型上进行微调来获得文本表示向量,然后利用特... 详细信息

作为医学信息抽取的第一个关键环节,医学命名实体识别任务旨在从如电子医疗病例、中文医药说明书等非结构化文本中抽取出医学相关的实体.目前大多数中文医学命名实体识别工作通过在预训练模型上进行微调来获得文本表示向量,然后利用特征工程来提升模型在医疗领域上的性能.这些模型大部分源自在通用数据集上表现较好的模型,没有考虑中文医学数据集的语言特性.通过在多个医学数据集上进行统计分析,发现部分类型的医学实体在字形上具有共性,如在汉字中大部分表示疾病含义的字符都包含“疒”,大部分表示身体器官的字符都包含“月”.针对这些问题,本文提出了一种基于字形特征的中文医学命名实体识别方法,该方法通过在文本表示向量上融合字形向量以及进一步利用数据集中负样本来提升模型的准确度和泛化能力.在多个公共的中文医学数据集上的实验结果表明,该方法获得了比其他模型更好的效果,并且通过消融实验证明了融合字形特征和从负样本中学习对于该任务是有效的.

关键词：字形负样本两阶段医学信息命名实体识别深度学习

松辽盆地大情字井地区砂-页复合储层可压性评价

在线全文

学校读者我要写书评

暂无评论

岩石力学与工程学报 2024年第9期43卷 2140-2151页

作者：索彧苏显蘅何文渊付晓飞潘哲君东北石油大学石油工程学院黑龙江大庆163318 大庆油田股份有限公司博士后资源中心黑龙江大庆163318 东北石油大学陆相页岩油气成藏与高效开发教育部重点实验室黑龙江大庆163318 黑龙江省油气储层压裂与评价重点实验室黑龙江大庆163318 中国石油国际勘探开发有限公司北京100029

储层可压性评价是判断储层被有效改造的难易程度以及确定压裂“甜点”的有效方法。然而,目前国内外的储层可压性评价方法主要集中在单一岩性上,未考虑多岩性组合情况。选取松辽盆地大情字井地区青山口组砂-页夹层型储层为研究对象,通过... 详细信息

储层可压性评价是判断储层被有效改造的难易程度以及确定压裂“甜点”的有效方法。然而,目前国内外的储层可压性评价方法主要集中在单一岩性上,未考虑多岩性组合情况。选取松辽盆地大情字井地区青山口组砂-页夹层型储层为研究对象,通过对不同深度的砂岩和页岩进行X射线衍射和岩石力学实验,利用模糊层次分析法建立一种新的基于能量演化与应力-应变曲线中不同阶段脆性敏感指数的脆性评价方法。同时,对复合岩石脆性破坏程度进行分析和定量评价,将复合岩石脆性指数与矿物含量和黏聚力结合,建立多岩性复合储层的可压性评价体系。实验结果表明:复合岩样的单轴和三轴抗压强度随着页岩夹层厚度减少而降低,但脆性指数随页岩夹层厚度减少先降低后增加,可压性指数随围压增加而降低。基于连续取芯进行的力学实验和矿物含量实验,绘制可压性指数随埋深变化的曲线,将现场微地震监测结果与对应埋深储层段的可压性指数进行比较,验证了该可压性评价方法的准确性。研究结果为多岩性复合储层的压裂设计提供了关键参数和理论依据。

关键词：岩石力学多岩性储层脆性评价可压性评价复合岩石模糊层次分析法

同方期刊数据库

Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen suo Langda Peng Pu Xiaojia z.u Shiwei z.ou Peter Kalds Ke z.ang Meenu Bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran Wang Haolin z.u Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai Chong He Liming Wang Yu Jiang Jian-Lin Han Yulin Chen Ping z.ou Hubert Pausch Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland Institute of Animal Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life Sciences Shaanxi Normal UniversityXi’an 710119China z.ology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic Sciences Kashi UniversityKashi 844000China Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyz.d Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep