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Predicting factors for the need of extracorporeal membrane oxygenation for suicide attempts by cardiac medication:a single-center cohort study

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World Journal of Emergency medicine 2022年第4期13卷 283-289页

作者： David vandroux Thomas Aujoulat Bernard-Alex gaüz.re Bérénice Puech Bertrand Guihard Olivier martinet Intensive Care Unit Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance Cardiosurgical Intensive Care Unit Dupuytren II HospitalUniversity Teaching Hospital of Limoges87042 LimogesFrance UmR 1094 Neuro-épidémiologie Tropicale University of Limoges87042 LimogesFrance Cardiovascular Anesthesia Department Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance Service d’Aide médicale d’Urgence Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance

BACKGROUND:Severe poisoning due to the overdosing of cardiac drugs can lead to cardiovascular *** order to decrease the mortality rate,the most severe patients should be transferred as quickly as possible to an extracorporeal membrane oxygenation(ECmO)***,the predictive factors showing the need for venous-arterial ECmO(va-ECmO)had never been ***:A retrospective,descriptive,and single-center cohort *** consecutive patients admitted in the largest ICU of Reunion Island(Indian Ocean)between January 2013 and September 2018 for beta-blockers(BB),calcium channel blockers(CCB),renin-angiotensin-aldosterone system blockers,digoxin or anti-arrythmic intentional poisonings were *** implementation was the primary ***:A total of 49 consecutive admissions were *** patients had ECmO,39 patients did not have *** patients in ECmO group died,while no patients in the conventional group *** most relevant ECmO-associated factors were pulse pressure and heart rate at first medical contact and pulse pressure,heart rate,arterial lactate concentration,liver enz.mes and left ventricular ejection fraction(LVEF)at *** pulse pressure at first medical contact and LVEF were significant after logistic ***:A transfer to an ECmO center should be considered for a pulse pressuremmHg at first medical contact or LVEFmission to ICU.

关键词： Extracorporeal membrane oxygenation Implementation Cardiac medication Overdose Predicting factor

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measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev m.m.Aggarwal z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied m.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz.L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunz.rov T.P.Burton X.z.Cai H.Caines m.Calderon de la Barca Sanchez.D.Cebra R.Cendejas m.C.Cervantes z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng m.Cherney A.Chikanian K.E.Choi W.Christie P.Chung m.J.m.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souz. L.Didenko P.Djawotho S.m.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov m.Elnim J.Engelage G Eppley m.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.gagliardi D.R.gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.m.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle m.Heinz.S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kiz.a A.G.Knospe D.D.Koetke T.Kollegger J.Konz.r I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger m.Krus L.Kumar P.Kurnadi m.A.C.Lamont J.m.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight m.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li z.m.Li m.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.ma Y.G.mai D.P.mahapatra R.majka O.I.mall L.K.mangotra R.manweiler S.margetis C.markert H.masui H.S.matis Yu.A.matulenko D.meDonald T.S.mcShane A.meschanin R.milner N.G.minaev S.miodusz.wski A.mischke m.K.mitrovski B.mohanty m.m.mondal B.moroz.v D.A.moroz.v m.G.munhoz.m Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA University of Califomia BerkeleyCaliformnia 94720USA University of California DavisCalifornia 95616USA University of Califormnia Los AngelesCalifomia 90095USA Universidade Estadual de Campinas Sao PauloBrazil University of Illinois at Chicago ChicagoIlinois 60607USA Creighton University OmahaNebraska 68178USA Cz.ch Technical University in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA massachusetts Institute of Technology CambridgeMA 02139-4307USA mx-Planck-Institut fir Physik MunichGermany michigan State University East LansingMichigan 48824USA moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of China Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron az.muthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron az.muthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron az.muthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's az.muthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The az.muthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming z.ro Yield At minimum(z.Am),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

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The comparative efficacy of ez.timibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years

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Journal of Geriatric Cardiology 2011年第1期8卷 1-11页

作者： Ori Ben-Yehuda Nanette K. Wenger Christian Constance Franklin z.eve mary E. Hanson Jian-Xin Lin Arvind K. Shah Charlotte Jones-Burton Andrew m. Tershakovec University of California San Diego 200 West Arbor Drive La Jolla CA 92103 USA Emory University School of medicine 49 Jess Hill Jr Dr SE Atlanta GA 30303 USA SHopital maisonneuve-Rosemont Recherche Clinique/Polyclinique 5415 Boulevard de l＇Assomption Suite 295 Montreal Quebec QC H1T2M4 Canada mcGuire va medical Center 1201 Broad Rock Blvd （151） Richmond VA 23249 USA merck-Sharp ＆ Dohme One Merck Drive Whitehouse Station NJ 08889 USA

Background Coronary heart disease （CHD） risk increases with age; yet lipid-lowering therapies are significantly under-utiliz.d in patients 〉 65 years. The objective was to evaluate the safety and efficacy of lipid-lowering therapies in older patients treated with atorvastatin 10 nag ＋ ez.timibe 10 mg （Ez.Atorva） vs. increasing the atorvastatin dose to 40 mg, methods Patients 〉 65 years with atherosclerotic vascular disease （LDL-C ≥1.81 mmol/L） or at high risk for coronary heart disease （LDL-C 〉 2.59 mmol/L） were randomiz.d to Ez.Atorva for 12 wk vs. uptitration to atorvastatin 20 nag for 6 wk followed by atorvastatin 40 nag for 6 wk. The percent change in LDL-C and other lipid parameters and percent patients achieving prespecified LDL-C levels were assessed after 12 wk. Results Ez.Atorva produced greater reductions in most lipid parameters vs. uptitration of atorvastatin in patients 〉 75 years （n = 228）, generally consistent with patients 65-74 years （n = 812）. more patients achieved LDL-C targets with combination therapy vs. monotherapy in both age groups at 6 wk and in patients 〉 75 years at 12 wk. At 12 wk, more patients 〉 75 years achieved LDL-C targets with monotherapy vs. combination therapy. Ez.Atorva produced more favorable improvements in most lipids vs. doubling or quadrupling the atorvastatin dose in patients 〉 75 years, generally consistent with the findings in patients 65-74 years. Conclusions Our results extended previous findings demonstrating that ez.timibe added to a statin provided a generally well-tolerated therapeutic option for improving the lipid profile in patients 65 to 74 years and 〉 75 years of age.

关键词： cholesterol absorption inhibitor LDL-C hypercholesterolemia statin

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STATUS OF HIGGS BOSON PHYSICS

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Chinese Physics C 2014年第9期38卷 161-213页

作者： K.A.Olive K.Agashe C.Amsler m.Antonelli J.-F.Arguin D.m.Asner H.Baer H.R.Band R.m.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller V.Burkert m.A.Bychkov R.N.Cahn m.Carena A.Ceccucci A.Cerr D.Chakraborty m.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu m.Doser m.Drees H.K.Dreiner D.A.Edwards S.Eidelman J.Erler V.V.Ez.ela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.gaisser H.gallagher L.garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala m.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom m.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes m.Heffner B.Heltsley J.J.Hernandez.Rey K.Hikasa A.Hocker J.Holder A.Holtkamp J.Huston J.D.Jackson K.F.Johnson T.Junk m.Kado D.Karlen U.F.Katz.S.R.Klein E.Klempt R.V.Kowalewski F.Krauss m.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle z.Ligeti C.-J.Lin T.m.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.maltoni T.mannel A.V.manohar W.J.marciano A.D.martin A.masoni J.matthews D.milstead P.molaro K.monig F.moortgat m.J.mortonson H.murayama K.Nakamura m.Narain P.Nason S.Navas m.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock m.Pennington S.T.Petcov Kavli IPmU A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharma S.R.Sharpe m.Silari T.Sjostrand P.Skands J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sumiyoshi m.J.Syphers F.Takahashi m.Tanabashi J.Terning L.Tiator m.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.valencia G.Venanz.ni m.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg m.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Womersley C.L. University of minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland Lab.Naz.onali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest National Laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COmPAS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance max-Planck-Institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-maximilians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA Kavli Institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

Written November 2013 by m. Carena （Fermi National Accelerator Laboratory and the University of Chicago）, C. Grojean （ICREA at IFAE, Universitat Autbnoma de Barcelona）, m, Kado （Laboratoire de l＇Accelerateur Lin... 详细信息

关键词： STATUS OF HIGGS BOSON PHYSICS Sm LHC QCD

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神经精神药理学治疗药物监测共识指南:2017版

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实用药物与临床 2022年第1期25卷 1-20页

作者： C.Hiemke N.Bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts m.Gerlach C.Greiner G.Gründer E.Haen U.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.messer R.m ssner m.J.müller m.Paulz.n B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis m.Schwarz.m.Silva Gracia B.Stegmann W.Steimer J.C.Stingl m.Uhr S.Ulrich S.Unterecker R.Waschgler G.z.rnig G.z.rek P.Baumann 李文标(主译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(审校) 王传跃(审校) 王刚(审校) Department of Psychiatry and Psychotherapy University Medical Center of MainzMainzGermany Institute of Clinical Chemistry and Laboratory medicine University Medical Center of MainzMainzGermany Kitz.erg Hospitals Center for Psychosomatic Medicine and PsychotherapyBad MergentheimGermany Department of Child and Adolescent Psychiatry University of FreiburgFreiburgGermany Serviz.o Psichiatrico del Comprensorio Sanitario di Bolz.no BolzanoItaly Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WürzburgGermany Department of Psychiatry and Psychotherapy Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Psychiatric Hospital KaufbeurenGermany Department of Child and Adolescent Psychiatry Psychosomatics and PsychotherapyCenter of Mental HealthUniversity Hospital of WürzburgGermany Federal Institute for Drugs and medical Devices(BfArm) BonnGermany Department of Psychiatry Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenand JARA–Translational Brain MedicineAachenGermany Clinical Pharmacology Department of Psychiatry and Psychotherapy and Department of Pharmacology and ToxicologyUniversity of RegensburgRegensburgGermany Department of Psychiatry and Psychosomatics University of G ttingenG ttingenGermany Psychiatric Hospital Vitos KlinikEichbergEltvilleGermany Center of Epilepsy BielefeldGermany medical Laboratory Stein Limbach GroupM nchengladbachGermany Psychiatric Hospital K nigsfeldenBruggAargauSwitzerland Institute of Psychological medicine Haag in OberbayernGermany Danuviuskliniken Psychiatric HospitalPfaffenhofenGermany Department of Psychiatry and Psychotherapy University of TübingenTübingenGermany Psychiatric Hospitals Oberberggruppe BerlinGermany Psychiatric Hospital Weisser Hirsch DresdenGermany Experimental Psychiatry Unit Department of Psychiatry1Medical University of InnsbruckInnsbruckAustria kbo-Isar-Amper Klinikum münchen-Ost Psychiatric HospitalMunich-HaarGermany Department of

治疗药物监测(Therapeutic Drug monitoring,TDm)通过定量测定和解释血药浓度以优化药物治疗。TDm着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDm的主要患者群体包括少年儿童... 详细信息

治疗药物监测(Therapeutic Drug monitoring,TDm)通过定量测定和解释血药浓度以优化药物治疗。TDm着眼于药代动力学的个体差异,使个体化药物治疗成为可能。在精神病学和神经病学领域中,有可能明显获益于TDm的主要患者群体包括少年儿童、孕妇、老年患者、智障患者、药物滥用者、涉法精神病患者、已知或怀疑药代动力学异常的患者以及合并躯体疾病影响药代动力学的患者。常规剂量下治疗无效,用药依从性难以判断,药物耐受性不佳,以及可能存在药代动力学方面的药物-药物相互作用等情况都是治疗药物监测的典型指征。然而,只有将TDm充分整合到临床治疗过程中,才能发挥其优化药物治疗的潜在优势。为了向临床医生和实验室提供有效的TDm信息,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDm专家组在2004年发表了第一版《精神科治疗药物监测指南》。2011年进行了更新之后,现在再次更新。遵循新版指南,可能会改善神经精神药物治疗的效果,加快很多患者的康复,并降低医疗费用。

关键词：抗凝药物妊娠期静脉血栓栓塞疾病抗抑郁药抗癫痫药抗帕金森病药抗精神病药血药浓度共识指南药物分析基因型分析神经药物遗传药理学药代动力学表型分析血浆药物浓度精神药物参考范围血清药物浓度治疗药物监测治疗窗

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神经精神药理学治疗药物监测共识指南:2017版

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实用药物与临床 2022年第2期25卷 97-118页

作者： C.Hiemke N.Bergemann H.W.Clement A.Conca J.Deckert K.Domschke G.Eckermann K.Egberts m.Gerlach C.Greiner G.Gründer E.Haen U.Havemann-Reinecke G.Hefner R.Helmer G.Janssen E.Jaquenoud G.Laux T.messer R.m ssner m.Jmüller m.Paulz.n B.Pfuhlmann P.Riederer A.Saria B.Schoppek G.Schoretsanitis m.Schwarz.m.Silva Gracia B.Stegmann W.Steimer J.C.Stingl m.Uhr S.Ulrich S.Unterecker R.Waschgler G.z.rnig G.z.rek P.Baumann 李文标(译) 果伟(译) 贺静(译) 鲍爽(译) 路钊(译) 牛梦溪(译) 阮灿军(译) 臧彦楠(译) 王勇(译) 张玲(译) 刘辰庚(译) 李洁(译) 汤宜朗(译) 王传跃(译) 王刚(译) Department of Psychiatry and Psychotherapy University Medical Center of MainzMainzGermany Institute of Clinical Chemistry and Laboratory medicine University Medical Center of MainzMainzGermany Kitz.erg Hospitals Center for Psychosomatic Medicine and PsychotherapyBad MergentheimGermany Department of Child and Adolescent Psychiatry University of FreiburgFreiburgGermany Serviz.o Psichiatrico del Comprensorio Sanitario di Bolz.no BolzanoItaly Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WürzburgGermany Department of Psychiatry and Psychotherapy Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Psychiatric Hospital KaufbeurenGermany Department of Child and Adolescent Psychiatry Psychosomatics and PsychotherapyCenter of Mental HealthUniversity Hospital of WürzburgGermany Federal Institute for Drugs and medical Devices(BfArm) BonnGermany Department of Psychiatry Psychotherapy and PsychosomaticsRWTH Aachen UniversityAachenand JARA–Translational Brain MedicineAachenGermany Clinical Pharmacology Department of Psychiatry and Psychotherapy and Department of Pharmacology and ToxicologyUniversity of RegensburgRegensburgGermany Department of Psychiatry and Psychosomatics University of G ttingenG ttingenGermany Psychiatric Hospital Vitos KlinikEichbergEltvilleGermany Center of Epilepsy BielefeldGermany medical Laboratory Stein Limbach GroupM nchengladbachGermany Psychiatric Hospital K nigsfeldenBruggAargauSwitzerland Institute of Psychological medicine Haag in OberbayernGermany Danuviuskliniken Psychiatric HospitalPfaffenhofenGermany Department of Psychiatry and Psychotherapy University of TübingenTübingenGermany Psychiatric Hospitals Oberberggruppe BerlinGermany Psychiatric Hospital Weisser Hirsch DresdenGermany Experimental Psychiatry Unit Department of Psychiatry1Medical University of InnsbruckInnsbruckAustria kbo-Isar-Amper Klinikum münchen-Ost Psychiatric HospitalMunich-HaarGermany Department of

2.2剂量相关参考浓度范围对于TDm结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围。治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题。后者比较的是测得的... 详细信息

2.2剂量相关参考浓度范围对于TDm结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围。治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题。后者比较的是测得的药物浓度与理论预期药物浓度范围。参照药代动力学研究,优先考虑没有合并用药或药物基因组异常的患者群(“正常”患者),在日维持剂量(Daily maintenance dose,D m)、给药间隔(Dosing interval,d i)、总清除率(Total clearance,CL)和生物利用度(Bioavailability,F)已知情况下,某种药物在某个“正常”患者体内的预期平均稳态浓度(Average steady-state concentration,C av)可通过下面的公式计算。

关键词：治疗药物监测药效动力学给药间隔维持剂量生物利用度药物浓度药代动力学合并用药

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