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MAVS Antagoniz.s Human Stem Cell Senescence as a Mitochondrial Stabiliz.r

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Research 2024年第2期2023卷 239-257页

作者： Cui Wang Kuan Yang Xiaoqian Liu Si Wang Moshi song Juan Carlos Iz.isua Belimonte Jing Qu Guang-Hui Liu Weiqi z.ang CAS Key Laboratory of Genomic and Precision Medicine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Bejing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ ***,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also regulates human stem cell *** answer this question,we used CRISPR/Cas9-mediated gene editing and directed differentiation techniques to generate various MAVS-knockout human stem cell *** found that human mesenchymal stem cells(hMSCs)were sensitive to MAVS deficiency,as manifested by accelerated senescence *** uncovered that the role of MAVS in maintaining mitochondrial structural integrity and functional homeostasis depends on its interaction with the guanosine triphosphatase optic atrophy type 1(OPA1).Depletion of MAVS or OPA1 led to the dysfunction of mitochondria and cellular senescence,whereas replenishment of MAVS or OPA1 in MAVS-knockout hMSCs alleviated mitochondrial defects and premature senescence *** together,our data underscore an uncanonical role of MAVS in safeguarding mitochondrial homeostasis and antagoniz.ng human stem cell senescence.

关键词： CRISPR/Cas9 homeostasis Mitochondrial

Chromosome-level assembly of triploid genome of Sichuan pepper(z.nthoxylum armatum)

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Horticultural Plant Journal 2024年第2期10卷 437-449页

作者： Liz.i song Yue Huang Hao z.o Ning Tang z.engguo Li Wenbiao Jiao Feng Xu Qiang Xu z.xiong Chen National Key Laboratory for Germplasm Innovation and Utiliz.tion for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China Chongqing Key Laboratory of Economic Plant Biotechnology Chongqing University of Arts and SciencesChongqing 402160China School of Life Sciences Chongqing UniversityChongqing 400030China College of Horticulture and Gardening Yangtze UniversityJingzhouHubei 434025China College of Informatics Huazhong Agricultural UniversityWuhanHubei 430070China

As an important spice species in Rutaceae, the Sichuan pepper (z.nthoxylum armatum) can provide pungent and numbing taste, as well as aroma in its mature fruit. Here we assembled a chromosome-level genome of green prickly ash which was widely cultivated in a major production area including Chongqing and Sichuan province, China. We generated 712 Gb (~112×) PacBio long reads and 511 Gb (~82×) Hi-C data, and yielded an assembly of 99 pseudochromosomes with total siz. of 5.32 Gb and contig N50 of 796 kb. The genomic analyses and cytogenetic experiments both indicated that the cultivarz.uye Huajiao’ was a triploid. We identified a z.nthoxylum-specific whole genome duplication event emerging about 24.8 million years ago (Mya). We also detected a transposition burst event (0.3-0.4 Mya) responsible for the large genome siz. of z. armatum. Metabolomic analysis of the z.nthoxylum fruits during development stages revealed profiles of39 volatile aroma compounds and 528 secondary metabolites, from which six types of sanshools were identified. Based on metabolomic and transcriptomic network analysis, we screened candidate genes encoding long chain acyl-CoA synthetase, fatty acid desaturase,branched-chain amino acid aminotransferase involved in sanshool biosynthesis and three genes encoding terpene synthase during fruit development. The multi-omics data provide insights into the evolution of z.nthoxylum and molecular basis of numbing and aroma flavor of Sichuan pepper.

关键词： z.nthoxylum armatum Genome Sanshool Terpenoid

m^(1)A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling

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International Journal of Oral Science 2024年第3期16卷 486-498页

作者： Shujin Li Tian Feng Yuantong Liu Qichao Yang An song Shuo Wang Jun Xie Junjie z.ang Bifeng Yuan z.ijun Sun State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyFrontier Science Center for Immunology and MetabolismTaikang Center for Life and Medical SciencesWuhan UniversityWuhanChina School of Public Health Wuhan UniversityWuhanChina State Key Laboratory of Virology Medical Research InstituteWuhan UniversityWuhanChina Department of Oral Maxillofacial-Head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhanChina

N^(1)-methyladenosine(m^(1)A)RNA methylation is critical for regulating mRNA translation;however,its role in the development,progression,and immunotherapy response of head and neck squamous cell carcinoma(HNSCC)remains largely *** Tgfbr1 and Pten conditional knockout(2cKO)mice,we found the neoplastic transformation of oral mucosa was accompanied by increased m^(1)A modification *** of m^(1)A-associated genes identified TRMT61A as a key m^(1)A writer linked to cancer progression and poor ***,TRMT61A-mediated tRNA-m^(1)A modification promotes MYC protein synthesis,upregulating programmed death-ligand 1(PD-L1)***,m^(1)A modification levels were also elevated in tumors treated with oncolytic herpes simplex virus(oHSV),contributing to reactive PD-L1 *** m^(1)A inhibition sustained oHSV-induced antitumor immunity and reduced tumor growth,representing a promising strategy to alleviate *** findings indicate that m^(1)A inhibition can prevent immune escape after oHSV therapy by reducing PD-L1 expression,providing a mutually reinforcing combination immunotherapy approach.

关键词： immunity sustained representing

Decoding the inconsistency of six cropland maps in China

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The Crop Journal 2024年第1期12卷 281-294页

作者： Yifeng Cui Ronggao Liu z.ichao Li Chao z.ang Xiao-Peng song Jilin Yang Le Yu Mengxi Chen Jinwei Dong Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Geographical Sciences University of MarylandCollege ParkMD 20740USA College of Grassland Science and Technology China Agricultural UniversityBeijing 100193China Ministry of Education Ecological Field Station for East Asian Migratory Birds Department of Earth System ScienceInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China Ministry of Education Ecological Field Station for East Asian Migratory Birds Beijing 100084China Tsinghua University(Department of Earth System Science)-Xi’an Institute of Surveying and Mapping Joint Research Center for Next-Generation Smart Mapping Beijing 100084China Institute of Remote Sensing and Geographic Information System Peking UniversityBeijing 100871China Department of Forest and Conservation Sciences University of British ColumbiaVancouverBCV6T 1Z4Canada

Accurate cropland information is critical for agricultural planning and production,especially in foodstressed countries like *** widely used medium-to-high-resolution satellite-based cropland maps have been developed from various remotely sensed data sources over the past few decades,considerable discrepancies exist among these products both in total area and in spatial distribution of croplands,impeding further applications of these *** factors influencing their inconsistency are also *** this study,we evaluated the consistency and accuracy of six cropland maps widely used in China in circa 2020,including three state-of-the-art 10-m products(i.e.,Google Dynamic World,ESRI Land Cover,and ESA WorldCover)and three 30-m ones(i.e.,GLC_FCS30,GlobeLand 30,and CLCD).We also investigated the effects of landscape fragmentation,climate,and agricultural *** using a ground-truth sample revealed that the 10-m-resolution WorldCover provided the highest accuracy(92.3%).These maps collectively overestimated Chinese cropland area by up to 56%.Up to 37%of the land showed spatial inconsistency among the maps,concentrated mainly in mountainous regions and attributed to the varying accuracy of cropland maps,cropland fragmentation and management practices such as *** work shed light on the promotion of future cropland mapping efforts,especially in highly inconsistent regions.

关键词： Consistency and accuracy 10-and 30 m Cropland mapping Agricultural management China

Chloride molten salt derived attapulgite with ground-breaking electrochemical performance

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Chinese Chemical Letters 2024年第10期35卷 437-441页

作者： Kailong z.anga Chao z.ang Luanhui Wu Qidong Yang Jiadong z.ang Guang Hu Liang song Gaoran Li Wenlong Cai School of Chemical Engineering Huaiyin Institute of TechnologyHuaian 223003China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China

The existence of adsorbed water and structural water in the crystal structure of attapulgite(ATP)endows it with poor capability to store lithium ***,the chloride molten salt method was developed to function ATP materials based on theoretical calculations,which exhibit ground-breaking electrochemical *** the modification process,the metal ions in chloride molten salt occupy the vertices of the Mg-O octahedral structure from the liberation of structural water and hydroxyl groups in ATP,forming MaMgbAlcSixOy(M=Li,Na,or K).Using Li Cl molten salt-modified ATP(Li-ATP)as a proof-of-concept,the detailed phase transition,physicochemical properties,and lithium storage capacity were *** to the original ATP,Li-ATP achieves a nearly 7-fold increase in lithium storage capacity(498mAh/g),featuring a promising low-cost polyanionic type anode material.

关键词： Molten salt modification Attapulgite Phasetransition Electrochemical performance Anode

Bifunctional noble-metal-free cocatalyst coating enabling better coupling of photocatalytic CO_(2)reduction and H_(2)O oxidation on direct z.scheme heterojunction

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Nano Research 2024年第6期17卷 5022-5030页

作者： Wei z.ao Weihao Mo Yan z.ang Lingxuan Hu Yiyi z.eng z.ulei Chen Xiangyue Niu Yuling z.ao Lichun Liu Shuxian z.ong song Bai Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China College of Biological Chemical Sciences and Engineering and Nanotechnology Research InstituteJiaxing UniversityJiaxing 314001China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058China School of Biological and Chemical Engineering Panzhihua UniversityPanzhihua 617000China

Selective loading of spatially separated redox cocatalysts on direct z.scheme heterojunctions holds great promise for advancing the efficiency of artificial photosynthesis,which however is limited to the photodeposition of noble metal cocatalysts and the fabrication of hollow double-shelled semiconductor ***,the co-exposure of discrete cocatalyst and semiconductor increases the product diversity when both the exposed sites of which participate in CO_(2)***,we present a facile and versatile protocol to overcome these limitations via surface coating of z.scheme heterojunctions with bifunctional noble-metal-free *** Cu_(2)O/Fe_(2)O_(3)(CF)as a model heterojunction and layered Ni(OH)_(2)as a model cocatalyst,it is found that Ni(OH)_(2)lying on the surfaces of Cu_(2)O and Fe_(2)O_(3)separately co-catalyz.s the CO_(2)reduction and H_(2)O *** experimental and theoretical investigation reveals that the Ni(OH)_(2)outer layer:(i)mitigates the charge recombination in CF and balances their transfer and consumption;(ii)reduces the rate-determining barriers for CO_(2)-to-CO and H_(2)O-to-O_(2)conversion,(iii)suppresses the side proton reduction occurring on CF,and(iv)protects the CF from component *** expected,the redox reactions stoichiometrically proceed,and significantly enhanced photocatalytic activity,selectivity,and stability in CO generation are achieved by the stacked Cu_(2)O/Fe_(2)O_(3)@Ni(OH)_(2)in contrast to *** study demonstrates the significance of the synergy between bifunctional cocatalysts and z.scheme heterojunctions for improving the efficacy of overall redox reactions,opening a fresh avenue for the rational design of artificial photosynthetic systems.

关键词： z.scheme heterojunction bifunctional cocatalyst CO_(2)reduction H_(2)O oxidation stoichiometric redox reaction

Novel heteroz.gous USH1C mutation impacts hair cell mechanotransduction and causes progressive hearing loss

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Science Bulletin 2024年第2期69卷 167-172页

作者： Yanyan Jia Gaogan Jia Luo Guo Nan song Yu-Meng Wang Luoying Jiang Yilai Shu Yan Chen Shujia z.u Huawei Li Wenyan Li ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200031China The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200032China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular MedicineXinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China

Hearing loss is one of the most common sensory disorders worldwide,affecting approximately 466 million people,including 34 million children[1].Genetic mutations accounts for approximately 60%of inherited hearing loss cases[2,3].These genetic changes result in a wide variety of clinical manifestations,ranging from nonsyndromic hearing loss(NSHL)to over 400 syndromes involving hearing loss and from mild adult-onset hearing loss to profound congenital deafness,covering the entire spectrum of Mendelian inheritance.

关键词： mec hearing approximate

Boosting genome editing in plants with single transcript unit surrogate reporter systems

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Plant Communications 2024年第6期5卷 32-43页

作者： Xu Tang Qiurong Ren Xiaodan Yan Rui z.ang Li Liu Qinqin Han Xuelian z.eng Yiping Qi Hongyuan song Yong z.ang Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science CitySchool of Life SciencesSouthwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtz. River Ministry of EducationChongqing 400715China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China School of Synbiology School of Life ScienceShanxi UniversityTaiyuan 030006China Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

CRISPR-Cas-based genome editing holds immense promise for advancing plant genomics and crop ***,the challenge of low editing activity complicates the identification of editing *** this study,we introduce multiple single transcript unit surrogate reporter(STU-SR)systems to enhance the selection of genome-edited *** systems use the same single guide RNAs designed for endogenous genes to edit reporter genes,establishing a direct link between reporter gene editing activity and that of endogenous *** strategies are used to restore functional reporter genes after genome editing,including efficient single-strand annealing(SSA)for homologous recombination in STUSR-SSA ***-SR-base editor systems leverage base editing to reinstate the start codon,enriching C-to-T and A-to-G base editing *** results showcase the effectiveness of these STU-SR systems in enhancing genome editing events in the monocot rice,encompassing Cas9 nuclease-based targeted mutagenesis,cytosine base editing,and adenine base *** systems exhibit compatibility with Cas9 variants,such as the PAM-less SpRY,and are shown to boost genome editing in Brassica oleracea,a dicot vegetable *** summary,we have developed highly efficient and versatile STU-SR systems for enrichment of genome-edited plants.

关键词： CRISPR-Cas9 single transcript unit STU surrogate reporter SR single strand annealing SSA cyto-sine base editing adenine base editing

Boosting synergism of chemo- and immunotherapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules

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Acta Pharmaceutica Sinica B 2024年第2期14卷 836-853页

作者： Ge song Minghui Li Shumin Fan Mengmeng Qin Bin Shao Wenbing Dai Hua z.ang Xueqing Wang Bing He Qiang z.ang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Medical Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijing 100142China

Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted *** is critical to inspire new potential to remodel the value of this classical therapeutic ***,we fabricate bisphosphonate coordination lipid nanogranules(BC-LNPs)and load paclitaxel(PTX)to boost the chemo-and immuno-therapeutic synergism of cytotoxic *** in BC-LNPs@PTX,a bisphosphonate to block mevalonate metabolism,works as both the structure and drug constituent in nanogranules,where alendronate coordinated with calcium ions to form the particle *** synergy of alendronate enhances the efficacy of paclitaxel,suppresses tumor metastasis,and alters the cytotoxic *** from the paclitaxel-induced apoptosis,the involvement of alendronate inhibits the mevalonate metabolism,changes the mitochondrial morphology,disturbs the redox homeostasis,and causes theaccumulation of mitochondrial ROS and lethal lipid peroxides(LPO).These factors finally trigger the ferroptosis of tumor cells,an immunogenic cell death mode,which remodels the suppressive tumor immune microenvironment and synergiz.s with ***,by switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis,BC-LNPs@PTX provides new insight into the development of cytotoxic drugs and highlights the potential of metabolism regulation in cancer therapy.

关键词： Bisphosphonate coordinationlipid nanogranules Ferroptosis Mevalonatemetabolism Mitochondrial metabolism Nano-systematic biology