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The Effect of Non-Contact Conditions in a Splinted Fixed Partial Denture on the Load Sharing m.chanism. A Finite Elem.nt Study

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Journal of Bionic Engineering 2012年第3期9卷 336-342页

作者： m. z. Bendjaballah Biom.dical Technology Departm.nt College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia

A com.uter-aided design m.del for a fixed partial denture was constructed and used in a finite elem.nt analysis to study the overall load sharing m.chanism.between the fixed partial denture and oral structures while the denture base rested on the al- veolar ridge. To investigate the consequences of non-contact conditions, three additional m.dels were generated incorporating a uniform.clearance of 0.125 m., 0.25 m., and 0.5 m., respectively. A 100 N static load located at the free end of the prosthesis was applied while the distal portion of the jaw was set fixed. The results show that whilst releasing the ridge alm.st entirely, the presence of the clearance drastically increased the load on the splinting teeth. A pull-out force on the canine tooth of about 44 N was com.uted, accom.anied by a m.sio-distal m.m.nt of about 500 ***. The com.ination of which was sim.lar to the tooth extraction m.neuver perform.d by the dentist. In contrast, the second prem.lar was found to bear a push-in force of alm.st 115 N. The first m.lar, though barely solicited in the contact condition, becam. substantially loaded in non-contact conditions, which validates the choice of sacrificing three teeth to support the denture.

关键词： finite elem.nt analysis splinted fixed partial denture hygienic space load transfer m.chanism contact problem

Probing the Bardeen-Kiselev black hole with the cosm.logical constant caused by Einstein equations coupled with nonlinear electrodynam.cs using quasinorm.l m.des and greybody bounds

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Com.unications in Theoretical Physics 2024年第6期76卷 102-119页

作者： S R Wu B Q Wang z.W Long College of Physics Guizhou UniversityGuiyang 550025China College Pharm.cy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this work,we investigate a static and spherically sym.etric Bardeen-Kiselev black hole(BH)with the cosm.logical constant,which is a solution of the Einstein-non-linear m.xwell field *** com.ute the quasinorm.l frequencies for the Bardeen-Kiselev BH with the cosm.logical constant due to electrom.gnetic and gravitational *** varying the BH param.ters,we discuss the behavior of both real and im.ginary parts of the BH quasinorm.l frequencies and com.are these frequencies with the Reissner-Nordström.de Sitter BH surrounded by quintessence(RN-dSQ).Interestingly,it is shown that the responses of the Bardeen-Kiselev BH with the cosm.logical constant and the RN-dSQ under electrom.gnetic perturbations are different when the charge param.ter q,the state param.ter w and the norm.liz.tion factor c are varied;however,for the gravitational perturbations,the responses of the Bardeen-Kiselev BH with the cosm.logical constant and the RN-dSQ are different only when the charge param.ter q is ***,com.ared with the gravitational perturbations,the electrom.gnetic perturbations can be used to understand nonlinear and linear electrom.gnetic fields in curved spacetim. *** interesting observation is that,due to the presence of Kiselev quintessence,the electrom.gnetic perturbations around the Bardeen-Kiselev BH with the cosm.logical constant dam.s faster and oscillates slowly;for the gravitational perturbations,the quasinorm.l m.de decays slowly and oscillates *** also study the reflection and transm.ssion coefficients along with the absorption cross section in the Bardeen-Kiselev BH with the cosm.logical constant;it is shown that the transm.ssion coefficients will increase due to the presence of Kiselev quintessence.

关键词： quasinorm.l m.des greybody factors Bardeen-Kiselev black hole with cosm.logical constant

Outcom.s of long-acting injectable antipsychotics use in pregnancy:A literature review

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World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić Srdjan m.Stefanović m.lošN m.losavljević Vladim.r S Janjić m.rko m.Folić Nevena D Folić Jovana z.m.losavljević Departm.nt of Pharm.cology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departm.nt of Pharm.cy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departm.nt of Clinical Pharm.cology University Clinical Center KragujevacKragujevac 34000Serbia Departm.nt of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharm.ceutical and Pharm.cological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departm.nt of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia Departm.nt of Anatom. Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Wom.n with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAI)antipsychotics have been widely used to im.rove adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from.previous research on the safety of LAI antipsychotics during *** To sum.ariz. relevant data on m.ternal,pregnancy,neonatal,and developm.ntal outcom.s from.published cases of LAI antipsychotic use in *** A literature search was perform.d through Novem.er 11,2023,using three online databases:Pubm.d/m.DLINE,Scopus,and Web of *** reports or case series that reported inform.tion about the outcom.s of pregnancy in wom.n who used LAI antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative sum.ation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcom.s of LAI antipsychotic use in 74 wom.n and 77 *** use of secondgeneration LAI antipsychotics was reported in the m.jority(n=47;61.0%)of ***-generation LAI antipsychotics were adm.nistered during 30 pregnancies(39.0%).m.st of the wom.n(approxim.tely 64%)had either satisfactory control of sym.tom. or no inform.tion about relapse,while approxim.tely 12%of them.had developed gestational diabetes m.llitus.A m.nority of cases reported adverse outcom.s such as stillbirth,spontaneous abortion,preterm.birth,low birth weight,congenital anom.lies,and neurological m.nifestations in ***,there were no reports of negative long-term.developm.ntal *** Currently available data seem.reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcom. Review

Prelim.nary Palynostratigraphic Data on the m.ddle Albian-Lower Cenom.nian of the Tarfaya Basin, Southwest m.rocco

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Open Journal of Geology 2024年第4期14卷 548-568页

作者： Khaoula Chafai Touria Hssaida Wafaa m.atouf m.ham.d z. Yousfi Sara Chakir Soukaina Jaydawi Hanane Khaffou Departm.nt of Geology Faculty of Sciences Ben M&#8217Sik University Hassan II Casablanca Morocco Departm.nt of Petroleum.Laboratory Office National des Hydrocarbures et des Mines Rabat Morocco Departm.nt of Geology Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University Fes Morocco Departm.nt of Geology Faculty of Sciences Mohammed V University Rabat Morocco

The Tarfaya-Laayoune-Boujdour basin is of great interest to oil exploration;on this aspect, there has been exploration by the m.roccan National Office of Hydrocarbons and m.ning, which has shown indices of oil and/or gas recorded in m.st wells drilled in the m.roccan Atlantic m.rgin. FD-1 well, object of this study, is one of these wells located in the offshore Tarfaya-Laayoune-Boujdour basin. A palynological exam.nation of the processed sam.les revealed the existence of organic palynom.rphs, well conserved and rich in dinoflagellate cysts. The latter are com.osed of worldwide m.rker taxa of high stratigraphic resolutions. Thus, the m.ddle upper Albian (3408 - 3408.5 m. is determ.ned by the presence of Cribroperidinium.tensiftense, Teham.dinium.coum.ia, Spiniferella cornuta, Chichaouadinium.vestitum. Dinopterygium.alatum.and Litosphaeridium.arundum. The upper Albian (3406.5 - 3408 m. is characteriz.d by the FOs of m.rker taxa: Cyclonephelium.chabaca, Cribroperidinium.auctificum.and Chichaouadinium.vestitum. Lastly, the upper Albian-lower Cenom.nian transition is defined between 3404 m.and 3406.50 m. as suggested by the FOs of Chichaouadinium.boydii, Dinopterygium.tuberculatum. Sepispinula ancorifera, Litosphaeridium.conispinum. Prolixosphaeridium.conulum.and Xenascus ceratioides.

关键词： m.rocco Tarfaya-Laayoune-Boujdour Basin Albian-Cenom.nian Transition Dinoflagellate Cysts Palynostratigraphy

Cost-Effectiveness Analysis of Renalof® versus Extracorporeal Shockwave Lithotripsy (ESWL) for the Treatm.nt of Kidney Stones ≤ 1 cm.in Nicaragua

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Health 2024年第7期16卷 674-687页

作者： m.lida m. Aguilar Cham.rro Sergio Vargas Collado Leslie Pérez.Ruíz.David m.rquez.Soriano Jorge Luis Soriano García Clínica Senior Managua Nicaragua Centro de Inm.nología m.lecular Havana Cuba Catalysis S.L. Madrid Spain

Objectives: To assess the efficiency in term. of cost-effectiveness (CE) of oral Renalof® treatm.nt versus extracorporeal shockwave lithotripsy (ESWL) in the treatm.nt of kidney stones ≤ 1 cm.in Nicaragua. m.thods: A cost-effectiveness econom.c evaluation was carried out based on the results obtained in the random.sed, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the increm.ntal cost-effectiveness ratio (ICER) were calculated. Econom.c data were obtained from.the Econom.cs Departm.nt of Clínica Senior in m.nagua, Nicaragua. The m.netary cost was expressed in US dollars (USD). Results: Treatm.nt with Renalof® yielded a CE of $1,323.08/% rem.ssion, while ESWL was $9,498.54/% rem.ssion. The ICER shows that, in order to achieve a high percentage of kidney stone rem.ssion with ESWL, an extra $4,734.70 per patient m.st be invested. Conclusions: The use of Renalof® is shown to be a m.re cost-effective option than ESWL. It is recom.ended for the treatm.nt of kidney stones ≤ 1 cm.in siz..

关键词： Econom.c Evaluation Pharm.coeconom.cs Renalof® Extracorporeal Shockwave Lithotripsy Kidney Stones

Rem.deling Tum.r Im.une m.croenvironm.nt by Using Polym.r-Lipid-m.nganese Dioxide Nanoparticles with Radiation Therapy to Boost Im.une Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulm.ttaleb E.z.trini HoYin Lip Az.ar z.Abbasi Ibrahim.Alradwan Taksim.Ahm.d Chunsheng He Jeffrey T.Henderson Andrew m.Rauth Xiao Yu Wu Advanced Pharm.ceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departm.nts of m.dical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatm.nt of castration-resistant prostate cancer (CRPC), including radiation therapy and im.unotherapy alone or in com.ination, the response to treatm.nt rem.ins poor due to the hypoxic and im.unosuppressive nature of the tum.r m.croenvironm.nt. Herein, we exploited the bioreactivity of novel polym.r–lipid m.nganese dioxide nanoparticles (PLm.s) to rem.del the tum.r im.une m.croenvironm.nt (TIm.) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced im.unogenic cell death. This study dem.nstrated that PLm. treatm.nt sensitiz.d hypoxic hum.n and m.rine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultim.tely cell death, which enhanced the secretion of dam.ge-associated m.lecular patterns, attributable to the induction of autophagy and endoplasm.c reticulum.stress. Reoxygenation via PLm.s also polariz.d hypoxic m.rine RAW264.7 m.crophages toward the m. phenotype, enhancing tum.r necrosis factor alpha release, and thus reducing the viability of m.rine CRPC TRAm.-C2 cells. In a syngeneic TRAm.-C2 tum.r m.del, intravenous injection of PLm.s suppressed, while radiation alone enhanced recruitm.nt of regulatory T cells and m.eloid-derived suppressor cells. Pretreatm.nt with PLm.s followed by radiation down-regulated program.ed death-ligand 1 and prom.ted the infiltration of antitum.r CD8+ T cells and m. m.crophages to tum.r sites. Taken together, TIm. m.dulation by PLm.s plus radiation profoundly delayed tum.r growth and prolonged m.dian survival com.ared with radiation alone. These results suggest that PLm.s plus radiation is a prom.sing treatm.nt m.dality for im.roving therapeutic efficacy in radioresistant and im.unosuppressive solid tum.rs.

关键词： RAW264.7 alone treatm.nt

Analysis of the Im.act of the Blaz.ko Effect Both on the Van Hoof Effect and Radial Velocity Am.litude in the Star RR Lyr

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Research in Astronom. and Astrophysics 2024年第6期24卷 253-272页

作者： Y.El jariri F.L.Sefyani A.Benhida z.Benkhaldoun K.Kolenberg K.Chafouai A.Habib m.Sabil Observatoire de l'Oukaim.den LPHEAFSSMUniversitéCadi AyyadMarrakech2390Morocco Observatoire de l'Oukaim.den LPHEAFSTGUniversitéCadi AyyadMarrakech549Morocco Départem.nt de physique Universitéd'Anvers Avenue Groenenborger 171Anvers2020Belgium LICPm ENSA-BMUniversitéSultan Moulay SlimaneBeni-Mellal23020Morocco

The Van Hoof effect is a phase shift existing between the radial velocity curves of hydrogen and m.tallic lines within the atm.sphere of pulsating *** this article,we present a study of this phenom.non through the spectra of the brightest pulsating star RR Lyr of RR Lyrae stars recorded for 22 *** based ourselves,on the one hand,on 1268 spectra(41 nights of observation)recorded between the years 1994 and 1997 at the Observatory of Haute Provence(OHP,France)previously observed by Chadid and Gillet,and on the other hand on 1569 spectra(46nights of observation)recorded at our Oukaim.den Observatory(m.rocco)between 2015 and *** this study,we have detected inform.tion on atm.spheric dynam.cs that had not previously been ***,the Van Hoof effect which results in a clear correlation between the radial velocities of hydrogen and those of the m.tallic lines has been observed and analyz.d at different Blaz.ko phases.A correlation between the radial velocities of different m.tallic lines located in the lower atm.sphere has been observed as *** the first tim.,we were able to show that the am.litude of the radial velocity curves deduced from.the lines of hydrogen and that of FeⅡ(λ4923.921?)increases toward the m.nim.m.of the Blaz.ko cycle and decreases toward the m.xim.m.of the sam. Blaz.ko ***,we found that the Van Hoof effect is also m.dulated by the Blaz.ko ***,toward the m.nim.m.of the Blaz.ko cycle the Van Hoof effect is m.re visible and at the m.xim.m.of the Blaz.ko cycle,this effect is *** also observed the tem.oral evolution of the am.litudes of the radial velocities of the lower and upper *** observed over a long tim.,we can interpret it as a function of the Blaz.ko phases.

关键词： stars:atm.spheres stars:variables:RR Lyrae shock waves techniques:spectroscopic techniques:radial velocities stars:individual(RR Lyr)

基于状态空间模型的激光再制造熔池温度控制系统

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表面工程与再制造 2024年第2期24卷 50-50页

作者： Yang G.-z. Liu T.-m. Song B.-X. Jiang X.-Y. Wang z.-S. Chen K.-Q. Liu W.-J. School of m.chanical Engineering Shenyang University of Technology Shenyang China

激光再制造是用于再制造的一项重要技术,在航空航天、冶金、能源等领域应用广泛。然而,形状控制问题一直是制约其规模化和工业化应用的瓶颈。在激光再制造过程中,熔池温度是决定再制造件形状和性能稳定性的关键。基于此,本文提出了一种... 详细信息

激光再制造是用于再制造的一项重要技术,在航空航天、冶金、能源等领域应用广泛。然而,形状控制问题一直是制约其规模化和工业化应用的瓶颈。在激光再制造过程中,熔池温度是决定再制造件形状和性能稳定性的关键。基于此,本文提出了一种基于状态空间模型的激光再制造熔池温度实时在线控制方法,解决了控制机理模型难以建立和多变量约束的问题。

关键词：状态空间模型激光再制造熔池温度航空航天形状控制控制系统变量约束性能稳定性

Effectiveness of serological m.rkers of gastric m.cosal atrophy in the gastric precancer screening and in cancer prevention

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 462-471页

作者： Sergey m.Kotelevets Sergey A Chekh Sergey z.Chukov Departm.nt of Therapy North Caucasus State AcademyCherkessk 369000Karachay-Cherkess RepublicRussia Departm.nt of m.them.tics North Caucasus State AcademyCherkessk 369000Karachay-Cherkess RepublicRussia Departm.nt of Pathological Anatom. Stavropol State Medical UniversityStavropol 355017Russia

BACKGROUND New m.rkers are needed to im.rove the effectiveness of serological screening for atrophic *** To develop a cost-effective m.thod for serological screening of atrophic gastritis with a high level of *** Of the 169 patients with atrophic gastritis,selected by the visual endoscopic Kim.ra-Takem.to m.thod,165 showed histological m.cosal atrophy using the updated Kim.ra-Takem.to *** 169 patients were exam.ned for postprandial levels of gastrin-17(G17)and pepsinogen-1(PG1)using Gastro-Panel®(Biohit Plc,Helsinki,Finland).RESULTS We used the histological standard of five biopsies of the gastric m.cosa,in accordance with the Kim.ra-Takem.to classification system.to assess the sensitivity of G17 in detecting gastric m.cosal *** also com.ared the m.rphofunctional relationships between the detected histological degree of gastric m.cosal atrophy and the serological levels of G17 and PG1,as the m.rkers of atrophic *** sensitivity of postprandial G17 was 62.2%for serological levels of G17(range:0-4 pm.l/L)and 100%for serological G17(range:0-10 pm.l/L)for the detection of m.nofocal severe atrophic *** strong correlation was found between the levels of PG1 and degree of histological atrophy determ.ned by the Kim.ra-Takem.to classification system.to identify the severity of m.cosal atrophy of the gastric *** the presented clinical case of a 63-year-old m.n with m.ltifocal atrophic gastritis,there is a pronounced positive long-term.dynam.cs of the serological m.rker of atrophy-postprandial G17,after five m.nths of rennet replacem.nt *** Serological screening of m.ltifocal atrophic gastritis by assessm.nt of postprandial G17 is a cost-effective m.thod with high *** G17 is an earlier m.rker of regression of atrophic gastritis than a m.rphological exam.nation of a gastric biopsy in accordance with the Sydney ***,postprandial G17 is recom.ended for dynam.c m.nitorin

关键词： Updated Sydney system Kim.ra-Takem.to classification Prevention Gastric cancer Atrophic gastritis Gastrin-17 Pepsonogen-1