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China Communications 2024年第1期21卷 279-296页

作者： Junhui z.ao z.yang zhang z.enghao Yi Xiaoting Ma Qingmiao zhang School.of El.ctronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School.of Information Engineering East China Jiaotong UniversityNanchang 330013China

Edge computing paradigm for 5G architecture has been considered as one of the most effective ways to real.z. l.w l.tency and highl. rel.abl. communication,which brings computing tasks and network resources to the edge of *** depl.yment of edge computing nodes is a key factor affecting the service performance of edge computing *** this paper,we propose a method for depl.ying edge computing nodes based on user *** the combination of Simul.tion of Urban Mobil.ty(SUMO)and Network Simul.tor-3(NS-3),a simul.tion pl.tform is buil. to generate data of hotspot areas in Io T *** effectivel. using the data generated by the communication between users in Io T scenario,the l.cation area of the user terminal.can be *** this basis,the depl.yment probl.m is expressed as a mixed integer l.near probl.m,which can be sol.ed by Simul.ted Anneal.ng(SA)*** anal.sis of the resul.s shows that,compared with the traditional.method,the proposed method has faster convergence speed and better performance.

关键词： depl.yment probl.m edge computing internet of things machine l.arning

Unveil.ng the mechanisms of Fe(Ⅲ)-l.aded chitosan composite(CTS-Fe)in enhancing anaerobic digestion of waste activated sl.dge

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Journal.of Environmental.Sciences 2024年第4期138卷 200-211页

作者： Boaiqi zhang z.wen z.ao RuiMa Nan Chen z.e Kong z.ongfang l.i z.enya zhang Graduate School.of l.fe and Environmental.Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8572Japan The Key l.boratory of Water and Sediment Sciences Ministry of Education/State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems/College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China South China Institute of Environmental.Sciences Ministry of Ecology and EnvironmentGuangzhou 510345China School.of Water Resources and Environment China University of Geosciences(Beijing)Beijing 100083China School.of Environmental.Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China

Anaerobic digestion(AD)of waste activated sl.dge(WAS)is usual.y l.mited by the l.w generation efficiency of ***(Ⅲ)-l.aded chitosan composite(CTS-Fe)have been reported to effectivel. enhanced the digestion of WAS,but its rol. in promoting anaerobic sl.dge digestion remains *** present study,the effects of CTS-Fe on the hydrol.sis and methanogenesis stages of WAS anaerobic digestion were *** addition of CTSFe increased methane production potential.by 8%-23%under the tested conditions with the addition of 5-20 g/l.***,the resul.s demonstrate that the addition of CTS-Fe coul. effectivel. promote the hydrol.sis of WAS,evidenced by l.wer protein or pol.saccharides concentration,higher sol.bl. organic carbon in rector adding CTS-Fe,as wel. as the increased activity of extracel.ul.r hydrol.se with higher CTS-Fe ***,the enrichment of Cl.stridia abundance(iron-reducing bacteria(IRBs))was observed in CTS-Fe adding reactor(8.9%-13.8%),which was higher than that in the control.reactor(7.9%).The observation further suggesting the accel.ration of hydrol.sis through dissimil.tory iron reduction(DIR)process,thus providing abundant substrates for ***,the presence of CTS-Fe was inhibited the acetocl.stic and hydrogenotrophic methanogenesis process,which coul. be ascribed to the Fe(Ⅲ)act as el.ctron acceptor coupl.d to methane for anaerobic ***,coenz.me F420 activity in the CTS-Fe added reactor was 34.9% l.wer than in the bl.nk,al.o abundance of microorganisms invol.ed in hydrogenotrophic methanogenesis was *** from this study coul. provide theoretical.support for the practical.appl.cations of CTS-Fe.

关键词： Chitosan-Fe(Ⅲ)composite Methanogenesis Dissimil.tory iron reduction Enz.me activity Microbial.community structure

Unveil.ng a novel.metal.to-metal.transition in l.H_(2):Critical.y chal.enging superconductivity cl.ims in l.tetium hydrides

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Matter and Radiation at Extremes 2024年第3期9卷 65-73页

作者： Dong Wang Ningning Wang Caoshun zhang Chunsheng Xia Weicheng Guo Xia Yin Kejun Bu Takeshi Nakagawa Jianbo zhang Federico Gorel.i Phil.p Dal.aday-Simpson Thomas Meier Xujie l. l.l.ng Sun Jinguang Cheng Qiaoshi z.ng Yang Ding Ho-kwang Mao Center for High-Pressure Science and Technol.gy Advanced Research Beijing 100094China Beijing National.l.boratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Shanghai Key l.boratory of Material.Frontiers Research in Extreme Environments(MFree) Shanghai Advanced Research in Physical Sciences(SHARPS)Shanghai 201203China

Fol.owing the recent report by Dasenbrock-Gammon et al.[Nature 615,244–250(2023)]of near-ambient superconductivity in nitrogendoped l.tetium trihydride(l.H_(3-δ)N_(ε)),significant debate has emerged surrounding the composition and interpretation of the observed sharp resistance ***,we meticul.usl. revisit these cl.ims through comprehensive characteriz.tion and *** definitivel. identify the reported material.as l.tetium dihydride(l.H_(2)),resol.ing the ambiguity surrounding its *** simil.r conditions(270–295 K and 1–2 GPa),we repl.cate the reported sharp decrease in el.ctrical.resistance with a 30%success rate,al.gning with the observations by Dasenbrock-Gammon et ***,our extensive investigations reveal.this phenomenon to be a novel.pressure-induced metal.to-metal.transition intrinsic to l.H_(2),distinct from ***,nitrogen doping exerts minimal.impact on this *** work not onl. el.cidates the fundamental.properties of l.H_(2)andl.H_(3),but al.o critical.y chal.enges the notion of superconductivity in these l.tetium hydride *** findings pave the way for future research on l.tetium hydride systems,whil. emphasiz.ng the crucial.importance of rigorous verification in cl.ims of ambient-temperature superconductivity.

关键词： resistance hydride superconductivity

Phosphoryl.tion Promotes the Accumul.tion of PERIOD Protein Foci

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Research 2024年第1期2023卷 59-69页

作者： Mengna l. Shujing l. l.oying zhang Key l.boratory of Mol.cul.r Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074China Department of l.fe Sciences Bengbu Medical CollegeBengbuAnhui 233030China Hubei Province Key l.boratory of Oral.and Maxil.ofacial.Devel.pment and Regeneration WuhanHubei 430022China

Circadian cl.ck drives the 24-h rhythm in our behavior and *** mol.cul.r cl.ck consists of a series of transcriptional.transl.tional.feedback l.ops operated by a number of cl.ck genes.A very recent study reported that the cl.ck protein PERIOD(PER)is organiz.d into discrete foci at the nucl.ar envel.pe in fl. circadian neurons,which is bel.eved to be important for control.ing the subcel.ul.r l.cal.z.tion of cl.ck *** of inner nucl.ar membrane protein l.min B receptor(l.R)l.ads to disruption of these foci,but how they are regul.ted is yet ***,we found that PER foci are l.kel. phase-separated condensates,the formation of which is mediated by intrinsical.y disordered region in *** promotes the accumul.tion of these *** phosphatase 2A,which is known to dephosphoryl.te PER,hampers the accumul.tion of the *** the other hand,the circadian kinase DOUBl.TIME(DBT)which phosphoryl.tes PER enhances the accumul.tion of the *** l.kel. facil.tates PER foci accumul.tion by destabil.z.ng the catal.tic subunit of protein phosphatase 2A,MICROTUBUl. STAR(MTS).In concl.sion,here,we demonstrate a key rol. for phosphoryl.tion in promoting the accumul.tion of PER foci,whil. l.R modul.tes this process by impinging on the circadian phosphatase MTS.

关键词： concl.sion separated transl.tional

Nutrient transport fol.owing water transfer through the worl.'s l.rgest water diversion channel

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Journal.of Environmental.Sciences 2024年第1期135卷 703-714页

作者： Yuanhui Cheng Hong zhang Wei Yin State Key l.boratory of Environmental.Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085 China Changjiang Water Resources Protection Institute Wuhan 430051China University of Chinese Academy of Sciences Beijing 100049China

Nutrient l.vel. in the artificial.channel.constructed for the Middl. Route Project are significant indicators of water qual.ty safety and aquatic ecol.gical.integrity for this l.rge,interbasin ***,the distribution and transport of nutrients al.ng the channel.were poorl. *** on a time-series dataset as wel. as mass bal.nce and material.fl.w anal.sis methods,the water and nutrient transport fl.xes in the Middl. Route of the South-to-North Water Diversion Project were identified in this *** resul.s indicate that the nutrient concentrations varied considerabl. with time,but there was no significant difference among the 30 stations of the main *** temperature difference was the major factor in the l.rge fl.ctuations of water qual.ty indicators over *** nutrient l.adings varied with the water vol.me outputs from the main channel.to the waterreceiving *** deposition was an important source of nutrients in the main channel.accounting for 9.13%,20.6%,and 0.635%of the nitrogen,phosphorus,and sul.ur input from the Danjiangkou Reservoir,*** 2021,a net accumul.tion of 988 tons of N,29 tons of P,and 2,540 tons of S,respectivel.,were present in the main *** increase of these external.and internal.nutrient l.adings woul. cause water qual.ty fl.ctuation and deterioration in some l.cal.sections of the main *** study quantified the spatial.and temporal.patterns of nutrient transport in the Middl. Route and reveal.d the ecol.gical.effects on the aquatic environment,assisting authorities on the project to devel.p effective water conservation strategies.

关键词： Nutrient transport Spatiotemporal.patterns The Middl. Route The South-to-North Diversion Project Hydro-ecol.gical.effects Water-receiving cities

Mul.i-functional.epoxides cross-l.nked col.agen sponges for tissue engineering scaffol.s

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Optimiz.tion of biofuel.suppl. chain integrated with petrol.um refineries under carbon trade pol.cy

胶原与皮革（英文） 2024年第1期6卷 127-140页

作者： Yuanz.i zhang Changkai Yang Min Gu Xiaoxia zhang Xueqing zhang Guoying l. National.Engineering l.boratory for Cl.an Technol.gy of l.ather Manufac-ture Sichuan UniversityChengdu 610065People's Republic of China Key l.boratory of l.ather Chemistry and Engineering(Sichuan University) Min-istry of EducationChengdu 610065People's Republic of China Max Pl.nck Institute for Pol.mer Research 55128 MainzGermany National.Engineering l.boratory for Cl.an Technol.gy of l.ather Manufac-ture Sichuan UniversityChengdu 610065People's Republic of China Key l.boratory of l.ather Chemistry and Engineering(Sichuan University) Min-istry of EducationChengdu 610065People's Republic of China

With the efficient cross-l.nking abil.ties and the fl.xibl. regul.tion abil.ties to the performances of cross-l.nked products,the mul.i-functional.al.phatic epoxides were once widel. used to cross-l.nk the col.agen-based material. in the l.st *** present work,the mul.i-functional.epoxides were used to construct and cross-l.nk col.agen sponges for tissue engineering scaffol.s,which was hoped to board the theoretical.system of epoxides and expl.re their potential. for modern *** bi-to tetra-functional.epoxides were used to cross-l.nk col.agen sol.-tions and establ.sh the gel.l.ke precursors,then using freez.-drying to form the final.*** SEM observed that the sponges had shown regul.r porous structures with a wide range of pore siz.s from 160 to 440 μ*** sponges had presented the resistance to enz.matic degradation,shape-remaining abil.ty,and reversibl. compress-ibil.ty in aqueous environments,which al. coul. be regul.ted through the functional.ties of *** regul.tion abil.ties of mul.i-functional.epoxides on the performances of sponges had been mainl. achieved through the cross-l.nking degrees that the higherfunctional.ty of epoxides woul. bring higher cross-l.nking *** higher cross-l.nking degrees coul. enhance the el.stic behaviors of gel.l.ke precursors,and improve the compressive strengths and thermal.stabil.ties of ***,the mul.i-functional.epoxides had barel. affected the safety of col.l.gen sponges at the cel.ul.r l.vel.according to the resul.s of CCK8 assay and the SEM and Cl.M images of l.29 fibrobl.sts cul.ured on the cross-sections of sponges.

关键词： Mul.i-functional.epoxides Col.agen sponges Tunabl. porous structures Reversibl. compressibil.ty

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Frontiers of Chemical.Science and Engineering 2024年第3期18卷 113-122页

作者： Wenhui zhang Yiqing l.o Xigang Yuan Chemical.Engineering Research Center School of Chemical Engineering and TechnologyTianjin UniversityTianjin300350China State Key l.boratory of Chemical.Engineering Tianjin UniversityTianjin300350China

The use of fossil.fuel. resul.s in significant carbon dioxide *** have been increasingl. adopted as sustainabl. al.ernatives to fossil.fuel.to address this environmental.*** petrol.um refineries into biofuel.suppl. chains is an effective approach to mitigating greenhouse gas emissions and improving environmental.*** this study,an integrated suppl. chain optimiz.tion framework was establ.shed,considering the carbon trade *** addition,a mixed-integer nonl.near programming model.was devel.ped to optimiz. the sel.ction of biomass suppl.ers,construction of pretreatment pl.nts and biorefineries,integration of petrol.um refineries,and sel.ction of transportation routes with the objective of minimiz.ng the total.annual.*** exampl. is presented to il.ustrate the appl.cabil.ty of the *** optimiz.tion resul.s show that integrating petrol.um refineries into biofuel.suppl. chains effectivel. mitigates carbon *** trade pol.cies can have a direct impact on the total.annual.cost and carbon emissions of the suppl. chain.

关键词： renewabl. energy biofuel.suppl. chain carbon trade pol.cy

Efficacy and Safety of Bufei Jiedu Granul.s in Treating Mul.idrug-Resistant Pul.onary Tubercul.sis:A Mul.i-center,Doubl.-Bl.nded and Randomiz.d Control.ed Trial

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Chinese Journal.of Integrative Medicine 2024年第7期30卷 579-587页

作者： zhang Shao-yan QIU l.i zhang Shun-xian XIAO He-ping CHU Nai-hui zhang Xia zhang Hui-qiang z.ENG Pei-yong zhang Hui-yong l. z.en-hui Institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Cl.nical.Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tubercul.sis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tubercul.sis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tubercul.sis the Second Hospital of NanjingNanjing210003China Department of Tubercul.sis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granul.s as adjuvant therapy for patients with mul.idrug-resistant pul.onary tubercul.sis(MDR-PTB). Methods: A l.rge-scal., mul.i-center, doubl.-bl.nded, and randomiz.d control.ed trial.was conducted in 18 sentinel.hospital. in China from December 2012 to December 2016. A total.of 312 MDR-PTB patients were randoml. assigned to BFJD Granul.s or pl.cebo groups(1:1) using a stratified randomiz.tion method, which both received the l.ng-course chemotherapy regimen for 18 months(6 Am-l.x-P-z.Pto, 12 l.x-P-z.Pto). Meanwhil., patients in both groups al.o received BFJD Granul.s or pl.cebo twice a day for a total.of 18 months, respectivel.. The primary outcome was cure rate. The secondary outcomes incl.ded time to sputum-cul.ure conversion, changes in l.ng cavities and qual.ty of l.fe(Qol. of patients. Adverse reactions were monitored during and after the trial. Resul.s: A total.of 216 cases compl.ted the trial. 111 in the BFJD Granul.s group and 105 in the pl.cebo group. BFJD Granul.s, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the pl.cebo(58.4% vs. 44.8%, P=0.02), and accel.rated the median time to sputum-cul.ure conversion(5 months vs. 11 months). The cavity cl.sure rate of the BFJD Granul.s group(50.6%, 43/85) was higher than that of the pl.cebo group(32.1%, 26/81;P=0.02) in patients who compl.ted the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granul.s significantl. improved physical.functioning, general.heal.h, and vital.ty of patients rel.tive to the pl.cebo group(al. Pl., the death rates in the two groups were not significantl. different;5.1%(8/156) in the BFJD Granul.s group and 2.6%(4/156) in the pl.cebo group. Concl.sions: Suppl.menting BFJD Granul.s with the l.ng-course chemotherapy regimen significantl. increased the cure rate and cavity cl.sure rate, and rapidl. improved Qol.of pati

关键词： al.ernative medicine Chinese herbal.formul. Bufei Jiedu Granul.s mul.idrug-resistant tubercul.sis l.ng-course chemotherapy regimen randomiz.d control.ed trial

A coupl.d l.gendre-l.guerre pol.nomial.method with anal.tical.integration for the Rayl.igh waves in a quasicrystal.l.yered hal.-space with an imperfect interface

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Appl.ed Mathematics and Mechanics(Engl.sh Edition) 2024年第9期45卷 1539-1556页

作者： Bo zhang Honghang TU Weiqiu CHEN Jiangong YU l.El.AIMOUNI School.of Mechanical.and Power Engineering Henan Polytechnic University Henan International.Joint l.boratory of Advanced El.ctronic Packaging Material. Precision Forming Henan Polytechnic University Department of Engineering Mechanics Zhejiang University Pol.discipl.nary Facul.y of Ouarz.z.te Ibnou Zohr University

The l.guerre pol.nomial.method has been successful.y used to investigate the dynamic responses of a hal.-space. However, it fail. to obtain the correct stress at the interfaces in a l.yered hal.-space, especial.y when there are significant differences in material.properties. Therefore, a coupl.d l.gendre-l.guerre pol.nomial.method with anal.tical.integration is proposed. The Rayl.igh waves in a one-dimensional.1D) hexagonal.quasicrystal.QC) l.yered hal.-space with an imperfect interface are investigated. The correctness is val.dated by comparison with avail.bl. resul.s. Its computation efficiency is anal.z.d. The dispersion curves of the phase vel.city, displ.cement distributions, and stress distributions are il.ustrated. The effects of the phonon-phason coupl.ng and imperfect interface coefficients on the wave characteristics are investigated. Some novel.findings reveal.that the proposed method is highl. efficient for addressing the Rayl.igh waves in a QC l.yered hal.-space. It can save over 99% of the computation time. This method can be expanded to investigate waves in various l.yered hal.-spaces, incl.ding earth-l.yered media and surface acoustic wave(SAW) devices.

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Mol.cul.r Mechanisms of Intracel.ul.r Del.very of Nanoparticl.s Monitored by an Enz.me‑Induced Proximity l.bel.ng

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Nano-Micro l.tters 2024年第6期16卷 14-37页

作者： Junji Ren z.bin zhang Shuo Geng Yuxi Cheng Huiz. Han z.ipu Fan Wenbing Dai Hua zhang Xueqing Wang Qiang zhang Bing He Department of Pharmaceutics School.of Pharmaceutical.Sciences Peking University38 Xueyuan RdHaidian DistrictBeijing 100191People’s Republic of China

Achieving increasingl. finel. targeted drug del.very to organs,tissues,cel.s,and even to intracel.ul.r biomacromol.cul.s is one of the core goal. of *** the del.very destination is refined to cel.ul.r and subcel.ul.r targets,it is essential.to expl.re the del.very of nanomedicines at the mol.cul.r ***,due to the l.ck of technical.methods,the mol.cul.r mechanism of the intracel.ul.r del.very of nanomedicines remains uncl.ar to ***,we devel.p an enz.me-induced proximity l.bel.ng technol.gy in nanoparticl.s(nano-EPl.for the real.time monitoring of proteins that interact with intracel.ul.r ***(l.ctic-co-gl.col.c acid)nanoparticl.s coupl.d with horseradish peroxidase(HRP)were fabricated as a model.HRP(+)-PNPs)to eval.ate the mol.cul.r mechanism of nano del.very in *** adding the l.bel.ng probe biotin-phenol.and the catal.tic substrate H_(2)O_(2)at different time points in cel.ul.r del.very,nano-EPl.technol.gy was val.dated for the real.time in situ l.bel.ng of proteins interacting with ***-EPl.achieves the dynamic mol.cul.r profil.ng of 740 proteins to map the intracel.ul.r del.very of HRP(+)-PNPs in macrophages over *** on dynamic cl.stering anal.sis of these proteins,we further discovered that different organel.es,incl.ding endosomes,l.sosomes,the endopl.smic reticul.m,and the Gol.i apparatus,are invol.ed in del.very with distinct participation *** importantl.,the engagement of these organel.es differential.y affects the drug del.very efficiency,refl.cting the spatial.temporal.heterogeneity of nano del.very in *** summary,these findings highl.ght a significant methodol.gical.advance toward understanding the mol.cul.r mechanisms invol.ed in the intracel.ul.r del.very of nanomedicines.

关键词： Enz.me-induced proximity l.bel.ng Intracel.ul.r del.very Nano-protein interaction Dynamic mol.cul. profil.ng Macrophages