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Peripheral blood RNA biomark.rs can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： z.enz.ong z.eng Jialin Chen Jinghong Xu Bin Jiang lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomark.rs for acute spinal cord injury,few studies have explored such biomark.rs for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrink.ge and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNk.,EIF4G2,and AP5z.)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomark.rs could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomark.rs candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang lei Qian Xiaofei Hu Ting z.ang Chaoyu Xiang Yu‑Mo z.ang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangz.ou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State k.y Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

Particle shape characterisation and classification using automated microscopy and shape descriptors in batch manufacture of particulate solids

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Particuology 2016年第1期14卷 61-68页

作者： Yang z.ang Jing J. Liu lei z.ang Jorge Calderon De Anda Xue z. Wang School of Chemistry and Chemical Engineering South China University of Technology 381 Wushan Road Guangzhou 510641 China School of Bioscience and Bioengineering South China University of Technology Guangzhou Higher Education Mega Centre Panyu District Guangzhou510006 China Institute of Particle Science and Engineering School of Chemical and Process Engineering University of Leeds Leeds I52 9JT UK

It is k.own that siz. alone, which is often defined as the volume-equivalent diameter, is not sufficient to characteriz. many particulate products. The shape of crystalline products can be as important as siz. in many applications, Traditionally, particulate shape is often defined by several simple descriptors such as the maximum length and the aspect ratio. Although these descriptors are intuitive, they result in a loss of information about the original shape. This paper presents a method to use principal component analysis to derive simple latent shape descriptors from microscope images of particulate products made in batch processes, and the use of these descriptors to identify batch-to-batch variations. Data from batch runs of both a laboratory crystalliser and an industrial crystallisation reactor are analysed using the described approach. Qualitative and quantitative comparisons with the use of traditional shape descriptors that have nhwical meanings and Fourier shape descriptors are also made.

关键词： Batch-to-batch variation Classification Principal components analysis Shape descriptors

A review on MBE-grown HgCdSe infrared materials on GaSb(211)B substrates

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Chinese Physics B 2019年第1期28卷 116-125页

作者： z.k.z.ang W W Pan J L Liu W lei Department of Electrical Electronic and Computer EngineeringThe University of Western Australia35 Stirling HighwayCrawley 6009Australia

We review our recent efforts on developing HgCdSe infrared materials on Ga Sb substrates via molecular beam epitaxy(MBE) for fabricating next generation infrared detectors with features of lower production cost and larger focal plane array format siz.. In order to achieve high-quality HgCdSe epilayers, z.Te buffer layers are grown before growing HgCdSe, and the study of misfit strain in z.Te buffer layers shows that the thick.ess of z.Te buffer layer needs to be below 300 nm in order to minimiz. the generation of misfit dislocations. The cut-off wavelength/alloy composition of HgCdSe materials can be varied in a wide range by varying the ratio of Se/Cd beam equivalent pressure during the HgCdSe *** temperature presents significant impact on the material quality of HgCdSe, and lower growth temperature leads to higher material quality for HgCdSe. Typically, long-wave infrared HgCdSe(x = 0.18, cut-off wavelength of 10.4 μm at 80 k. presents an electron mobility as high as 1.3×10~5cm^2·V^(-1)·s^(-1), a back.round electron concentration as low as 1.6×10^(16)cm^(-3), and a minority carrier lifetime as long as 2.2 μs. These values of electron mobility and minority carrier lifetime represent a significant improvement on previous studies of MBE-grown HgCdSe reported in the open literatures,and are comparable to those of counterpart HgCdTe materials grown on lattice-matched Cdz.Te substrates. These results indicate that HgCdSe grown at the University of Western Australia, especially long-wave infrared can meet the basic material quality requirements for mak.ng high performance infrared detectors although further effort is required to control the back.round electron concentration to below 10^(15)cm^(-3). More importantly, even higher quality HgCdSe materials on GaSb are expected by further optimiz.ng the growth conditions, using higher purity Se source material, and implementing postgrowth thermal annealing and defect/impurity gettering/filtering. Our results demonst

关键词： infrared detector HgCdSe GaSb molecular beam epitaxy

Actinide-embedded gold superatom models： Electronic structure, spectroscopic properties, and applications in surface-enhanced Raman scattering

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Nano Research 2016年第3期9卷 622-632页

作者： Yang Gao Bo Wang Yanyu lei Boon k. Teo z.igang Wang Institute of Atomic and Molecular Physics Jilin University Changchun 130012 China Jilin Provincial k.y Laboratory of AppliedAtomic and Molecular Spectroscopy Jilin University Changchun 130012 China College of Chemistry and Molecular Engineering Peking University Beijing 100871 China College of Chemistry and Chemical Engineering Kiamen University Xiamen 361005 China Beijing Computational Science Research Center Beijing 100084 China

Actinide elements encaged in a superatomic cluster can exhibit unique properties due to their hyperactive valence electrons. Herein, the electronic and spectroscopic properties of Th@Au14 are predicted and compared with that of the isoelectronic entities [Ac@Au14]- and [Pa@Au14]＋ using density functional theory. The calculation results indicate that these clusters all adopt a closed- shell superatomic 18-electron configuration of the 1S21p61D10 Jellium state. The absorption spectrum of Th@Au14 can be interpreted by the Jelliumatic orbital model. In addition, calculated spectra of pyridine-Th@Au14 complexes in the blue laser band exhibit strong peak. attributable to charge transfer （CT） from the metal to the pyridine molecule. These charge-transfer bands lead to a resonant surface-enhanced Raman scattering （SERS） enhancement of -104. This work.suggests a basis for designing and synthesiz.ng SERS substrate materials based on actinide-embedded gold superatom models.

关键词： actinide element DFT calculation gold nanoparticle superatomic orbital surface-enhanced Ramanscattering

Rice Interploidy Crosses Disrupt Epigenetic Regulation, Gene Expression, and Seed Development

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Molecular Plant 2018年第2期11卷 300-314页

作者： Limei Wang Jingya Yuan Yujie Ma Wu Jiao Wenxue Ye Dong-lei Yang Chuandeng Yi z. Jeffrey Chen State k.y Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University 1 Weigang Road Nanjing 210095 China Department of Molecular Biosciences Institute for Cellular and Molecular Biology Center for Computational Biology and Bioinformatics The University of Texasat Austin Austin TX 78712 USA Jiangsu k.y Laboratory of Crop Genetics and Physiology Yangzhou University Yangzhou 225009 China

Seed development in angiosperms requires a 2：1 maternal-to-paternal genome ratio （2m：lp） in the endo- sperm. When the ratio is disrupted, the seed development is impaired. Rice interploidy crosses result in endosperm failures, but the underlying molecular mechanisms remain unclear. Here, we report that the defective endosperm in rice interploidy crosses was associated with nonadditive expression of small RNAs and protein-coding genes. Interestingly, 24-nt small interfering RNAs were enriched in the 5＇ and 3＇ flank.ng sequences of nonadditively expressed genes in the interploidy crosses and were negatively associated with the expression of imprinted genes. Furthermore, some PRC2 family genes and DNA methylaUon-related genes including OsMETlb and OsCMT3a were upregulated in the 2x4 cross （polli- nating a diploid ＂mother＂ with a tetraploid ＂father＂） but repressed in the reciprocal cross. These different epigenetic effects could lead to precocious or delayed cellulariz.tion during endosperm development. Notably, many endosperm-preferred genes, including starch metabolic and storage protein genes during grain filling, were found to be associated with DNA methylation or H3k.7me3, which are repressed in both 2×4 and 4 ×2 crosses. WUSCHEL homeobox2 （WOX2）-Iik. （WOX2L）, an endosperm-preferred gene, was expressed specifically in the rice endosperm, in contrast to WOX2 expression in the Arabidopsis embryo. Disruption of WOX2L in transgenic rice by CRISPR/Cas9-mediated gene editing block.d starch and protein accumulation, resulting in seed abortion. In addition to gene repression, disrupting epigenetic process in the interploidy crosses also induced expression of stress-responsive genes. Thus, maintaining the 2m：lp genome ratio in the endosperm is essential for normal grain development in rice and other cereal crops.

关键词： seed polyploidy small RNA gene expression endosperm epigenetics

Multimedia model of atraz.ne in plant-soil-groundwater system with a fugacity approach

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Journal of Environmental Sciences 2001年第4期13卷 466-471页

作者： Ye, C.-m. lei, z.-f. Wang, X.-j. Gong, A.-j. z.eng, H.-h. Res. Cntr. Eco-Environmental Sci. Chinese Academy of Sciences Beijing 100085 China

The application of atraz.ne in China during the last ten years has led to some environmental problems. In this paper, the multimedia model of atraz.ne in soil-plant-groundwater system at Baiyangdian Lak. area in Northern China was established using a fugacity approach, and verified with observed values. The model involved 7 environmental compartments which are air, groundwater, soil, corn roots, corn stem, corn leaf and k.rnel of corn. The results showed that the relative errors between calculated and observed values have a mean value of 24.7%, the highest value is 48% and the lowest value is 1.4%. All these values indicated that this multimedia model can be used to simulate the environmental fate of atraz.ne. Both the calculated and observed values of concentrations of atraz.ne in plant compartments are in the following order: in corn roots > in corn stem > in k.rnel of corn > in corn leaf, it exhibited a good regularity. The prediction results indicated that concentrations of atraz.ne in the groundwater and k.rnel of corn will override the limitation of 3 μg/L and 0.05 mg/k. respectively.

关键词： Concentration (process) Error detection Groundwater Lak.s Plants (botany) Soils

基于数值模拟的阶梯水流中行人安全撤离研究(英文)

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Journal of z.ejiang University-Science A(Applied Physics & Engineering) 2015年第2期16卷 117-130页

作者： Wei-yun SHAO Li-jie JIANG lei FANG David z. z.U z.i-lin SUN College of Civil Engineering and Architecture Zhejiang University z.ejiang Design Institute of Water Conservancy & Hydroelectric Power Department of Ocean Science and Engineering Zhejiang University Department of Civil and Environmental Engineering University of Alberta

目的:研究不同形式阶梯水流中被困人员的安全撤离,为地下空间水侵灾害脆弱性评价及防灾避灾提供参考。方法:根据试验结果和数值模型的相关理论构建数值模型,验证数值模拟阶梯水流流场的可靠性和合理性,并基于数值模型的灵活性和可变性,... 详细信息

目的:研究不同形式阶梯水流中被困人员的安全撤离,为地下空间水侵灾害脆弱性评价及防灾避灾提供参考。方法:根据试验结果和数值模型的相关理论构建数值模型,验证数值模拟阶梯水流流场的可靠性和合理性,并基于数值模型的灵活性和可变性,模拟休息平台、阶梯坡度和阶梯形态对水流流场的影响,据此对有无休息平台、不同阶梯坡度和不同阶梯形态下阶梯水流流态、流速分布以及对被困人员的安全撤离的影响进行深入分析。结论:中间休息平台的存在增加了被困人员撤离的风险;阶梯坡度对阶梯上水流的水力特性影响很小;L型阶梯中间休息平台有利于减小平台下游撤离风险,被困人员可以优先选择L型阶梯或者不含休息平台的直线型阶梯撤离。

关键词：阶梯休息平台水侵灾害逃生数值模拟

On brain activity mapping: Insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus

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Science China(Life Sciences) 2013年第9期56卷 767-779页

作者： TSIEN Joe z. LI Meng OSAN Remus CHEN GuiFen LIN LongNian WANG Phillip lei FREY Sabine FREY Julietta z.U DaJiang LIU TianMing z.AO Fang k.ANG Hui Brain and Behavior Discovery Institute Medical College of Georgia Georgia Regents University Department of Mathematics and Institute of Neuroscience Georgia State University Department of Cell and Developmental Biology University College London Shanghai Institute of Brain Functional Genomics East China Normal University Department of Computer Science & Bioimaging Research Center The University of Georgia Brain Decoding Center Banna Biomedical Research Institute Xi-Shuang-Ban-Na Prefecture

The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for crack.ng the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasiz.d on the need to develop new technologies for measuring every spik. from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organiz.ng principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral task. and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic k.owledge, and imagination are generated and organiz.d. Our own experiences suggest that the bottleneck.of the Brain Project is not only at merely developing additional new technologies, but also the lack.of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive k.owledge from various investigators work.ng in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyz.ng large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research.

关键词： BRAIN project Brain Decoding Project brain activity map learning and memory episodic memory semantic k.owledge imagination concepts fear conditioning earthquak. experiences neural code