检索结果-南通市图书馆

Astrocyte-derived estrogen enhances synapse formation and synaptic transmission between cultured neonatal rat cortical neurons

在线全文

cnki会议

学校读者我要写书评

暂无评论

Astrocyte-derived estrogen enhances synapse formation and sy...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： R.HU,W.Q.CAI,X.G.WU,z.yang Department of Neurobiology,The Third Military Medical University,Chongqing 400038,China

＜正＞Recent in vitro studies have found that astrocytes exert powerful control over the number of neuronal synapses, leading us to consider why glia can exert this control and what the underlying mechanism（s） may *** understand the potential possibility,we studied the formation of synapses and synaptic function in primary rat cortical *** found that primary cultured neonatal rat cortical astrocytes modulate synaptogenesis and synaptic function through producing and secreting estradiol into culture *** concentration of estradiol produced by pure cultured astrocytes increased in correspondence with the days of culture and the number of proliferating astrocytes,which peaked at 266±22 ng/1 around day 14 of *** astrocyte- conditioned medium（ACM） was added into pure cultured cortical neurons,the number of synapses formed between cortical neurons increased by nearly *** mean frequency and the amplitude of mini-postsynaptic currents（mPSCs） increased from 13±4 events/min and 20.5±2 pA to 73±16 events/min and 29.1±3 pA,*** the meantime,the level of estrogen receptor-α（ER-α） expressed on neonatal rat cortical neurons was significantly ***,the effect of ACM on synaptic formation and transmission was blocked by tamoxifen（estrogen receptor antagonist） in *** the treatment of tamoxifen,the number of synapses on neurons decreased from 79±9 to 32±*** mean amplitude and frequency of mPSCs were also dropped to 24.5±2 pA and 35±10/min,***,exogenic estradiol can mimic the effect of ACM on synaptic formation and ***,to understand whether astrocyte-derived estradiol regulates the synaptic transmission via presynapse, the release of presynaptic vesicle from neuron was monitored by FM 4-64 *** results showed that when ACM or exogenic estradiol was added into neurons,the kinetics of vesicle release speed are similar to that of neuronal cultured with astrocytes,which were fast

关键词： astrocyte-conditioned medium ACM estradiol cortical neuron estrogen receptor synaptogenesis synaptic transmission.

Precipitation of multi-type nano-quasicrystals in a Mg-zn-Y alloy

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第3期12卷 997-1008页

作者： W.z.Wang X.z.zhou L.F.zhang H.Q.Ye z.Q.yang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of ScienceShenyang 110016China Ji Hua Laboratory Foshan 528251China Foshan University Foshan 528231China

Mg-6zn-1Y(at.%)ribbons with strengthening precipitates of multi-type nanoquasicrystals were prepared by melt-spinning followed by aging *** evolution of the rapidly solidified ribbons during isothermal aging was comprehensively studied using various electron microscopy *** new kinds of decagonal quasicrystals were formed in aged ribbons,in addition to precipitation of nanometer icosahedral ***-resolution observations reveal that both decagonal quasicrystals can be modeled by quasiperiodic tiling with decagonal clusters of 2.5 nm in diameter,but overlap of neighboring clusters in both decagonal quasicrystals is different from the Gummelt model observed in other quasicrystals.A shell composed of complex Laves Mg-zn domains was formed surrounding each decagonal quasicrystal precipitate upon prolonged *** addition,all kinds of nanoprecipitates exhibit excellent structure and size stability at 573 *** findings may have implications for not only fundamental studies about quasicrystals,but also microstructural manipulation of high-performance Mg alloys.

关键词： Quasicrystal Mg alloys Rapid solidification Scanning-transmission electron microscopy.

同步多层加速分段读出平面回波成像技术诊断乳腺病变

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2021年第4期44卷 487-488页

作者： Y.Q.Hu C.zhan z.yang X.Y.zhang H.T.zhang W.Liu 边甜甜

摘要目的探讨同步多层(SMS)加速分段读出平面回波成像(rs-EPI)技术评估乳腺病变的可行性及其效能。方法本前瞻性研究经机构伦理委员会批准。共纳入 96 例病人,经

关键词：分段读出平面回波成像技术诊断乳腺病变

Regulation of energy expenditure by brain stem peptidergic neurons

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Regulation of energy expenditure by brain stem peptidergic n...

中国生理学会张锡钧基金第十五届全国青年优秀生理学学术论文交流及评奖会议;中国生理学会第十三届全国青年生理学工作者学术会议

作者： Wen z.yang Xiaosa Du Wen zhang Hengchang Xie Yan Xiao Xiaoning Jia Jiashu Liu Jianhui Xu Xin Fu Xinyan Ni Weizhe Hong Miao He Jiajun yang Haitao yang Xiao-hong Xu Wei L.Shen Shanghai Institute for Advanced Immunochemical Studies & School of Life Science and Technology Shanghaitech University CAS Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic ChemistryChinese Academy of Sciences Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Department of Neurology Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine & Health Science Thermoregulation and Inflammation Laboratory Chengdu Medical College Department of Biological Chemistry and Department of Neurobiology David Geffen School of MedicineUniversity of California Institutes of Brain Science State Key Laboratory of Medical NeurobiologyFudan University

Homeostatic control of body temperature and energy expenditure (EE) are crucial for the survival and fitness in mammals which are achieved by precise coordination between dedicated brain pathways and peripheral effector *** temperature signals to hypothalamic centers represent a key layer of thermal and energy ***,the mechanism by which these signals are transmitted into the hypothalamus remains poorly *** find that broad photoactivation of

关键词： PBN Regulation of energy expenditure by brain stem peptidergic neurons

Relationship Between Interpersonal Violence Victimization and Suicide Risk in Indian College Students:Does Prior Exposure to Interpersonal Violence Also Matter?

在线全文

cnki会议

学校读者我要写书评

暂无评论

Relationship Between Interpersonal Violence Victimization an...

第二十一届全国心理学学术会议

作者： Edward C.Chang Shanmukh V.Kamble Mingqi Li zihao zhou Jeff z.yang Tianbi Duan Casey N.-H.Batterbee Olivia D.Chang Qiwei Li Weiyi Tian Department of Psychology University of Michigan Department of Psychology Karnatak University Department of Psychology Skidmore College Faculty of Psychology Beijing Normal University Department of Psychology University of Pennsylvania

We examined interpersonal violence victimization and prior interpersonal violence exposure as predictors of suicide risk, namely, suicide ideation and suicide attempt, in a sample of 207 Indian college students. Results of regression analyses indicated that interpersonal violence victimization, but not prior interpersonal violence exposure, was a unique predictor of suicide risk, independent of age and sex. Finally, we found support for a significant Interpersonal Violence Victimization × Past Interpersonal Violence Exposure interaction effect consistent with the notion that the association between interpersonal violence victimization and suicide risk is potentiated by the presence of prior interpersonal violence exposure among Indian students.

关键词： Interpersonal Violence Suicide Risk College Students Asian Indian

Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15

在线全文

cnki会议

学校读者我要写书评

暂无评论

Protein & Cell 2024年第7期15卷 547-552页

作者： Fumiaki Ito Hanjing yang z.Hong zhou Xiaojiang S.Chen Molecular and Computational Biology Department of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90089United States Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095United States California NanoSystems Institute University of CaliforniaLos AngelesCA90095United States Genetic Molecular and Cellular Biology ProgramKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States Norris Comprehensive Cancer Center University of Southern CaliforniaLos AngelesCA 90089United States Center of Excellence in NanoBiophysics University of Southern CaliforniaLos AngelesCA 90089United States

Dear Editor,Coronaviruses have evolved a wide array of tactics to evade host antiviral *** host cells detect invading foreign nucleic acids including viral genome and viral replication intermediates,they activate interferon(IFN)signaling via cytoplasmic pattern recognition receptors(Kang et al.,2002;Kato et al.,2006).Remarkable stealth activities exhibited by coronaviruses are facilitated by a series of non-structural proteins(Nsps),such as Nsp15(Deng and Baker,2018;Deng et al.,2019;Hackbart et al.,2020),which is a uridine-specific endoribonuclease that mediates evasion of host detection of viral double-stranded RNA(dsRNA)(Bhardwaj et al.,2004;Deng et al.,2017;Frazier et al.,2021;Ivanov et al.,2004).Nsp15 targets a polyuridine[poly(U)]tract on the coronavirus negative strand RNA(Hackbart et al.,2020).Nsp15 limits the abundance and length of poly(U)within the negative strand RNA 5ʹ-extension by trimming down the initially synthesized poly(U)lead sequence to the optimal length that can suppress dsRNA formation but still serves as a template for poly(A)tail of the positive strand genome of the coronaviruses(Hofmann and Brian,1991).

关键词： p15 interferon template

Stability Investigation and Improvement for DC Cascade Systems with Simplified Impedance-based Stability Criterion

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第3期10卷 1044-1052页

作者： Junbin Fang zhikang Shuai yang Li zhibing Wang Xiangyang Wu Xia Shen z.John Shen College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Renewable Energy Department of China Electric Power Research Institute Beijing 100192China Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616USA IEEE

In DC distributed power systems(DPSs),the complex impedance interactions possibly lead to DC bus voltage oscillation or *** previous research,the stability analysis of DPSs is implemented based on mathematical analysis in control *** specific mechanisms of the instability of the cascade system have not been intuitively *** this paper,the stability analysis of DPSs based on the traditional Nyquist criterion is simplified to the resonance analysis of the seriesconnected port impedance(z=R+jX)of source and load *** reveals that the essential reason for impedance instability of a DC cascade system is that the negative damping characteristic(Rzero-crossing *** simplified stability criterion for DC cascade systems can be concluded as:in the negative damping frequency ranges(Rzero-crossing point of the reactance component(i.e.,X=0).According to the proposed stability criterion,the oscillation modes of cascade systems are classified.A typical one is the internal impedance instability excited by the negative damping,and the other one is that the external disturbance amplified by negativity in a low stability ***,the impedance reshaping method for stability improvement of the system can be further *** validity of the simplified criterion is verified theoretically and experimentally by a positive damping reshaping method.

关键词： DC cascaded system,impedance model impedance reconstruction stability criterion

Transient Characteristics and Accommodative Current Limiting Strategy for Bidirectional Interlinking Converters in Hybrid AC/DC Microgrids

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第4期10卷 1575-1588页

作者： Xia Shen zhikang Shuai Wen Huang Chao Shen yang Shen z.John Shen College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616 USA

Bidirectional interlinking converter(BIC)is the core equipment in a hybrid AC/DC microgrid connected between AC and DC ***,the variety of control modes and flexible bidirectional power flow complicate the influence of AC faults on BIC itself and on DC sub-grid,which potentially threaten both converter safety and system *** study first investigates AC fault influence on the BIC and DC bus voltage under different BIC control modes and different pre-fault operation states,by developing a mathematical model and equivalent sequence ***,based on the analysis results,a general accommodative current limiting strategy is proposed for BIC without limitations to specific mode or operation *** amplitude is predicted and constrained according to the critical requirements to protect the BIC and relieving the AC fault influence on the DC bus *** with conventional methods,potential current limit failure and distortions under asymmetric faults can also be ***,experiments verify feasibility of the proposed method.

关键词： Bidirectional interlinking converter current limiting fault characteristic hybrid AC/DC microgrid variation/oscillation of DC bus voltage