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儿童肾脓肿2.例临床分析

中华实用儿科临床杂志 2024年第5期39卷 355-359页

作者：王凯歌王筱雯黄霖王道静丁娟娟武汉科技大学医学部医学院武汉430070 华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)肾内科武汉430014

目的:分析儿童肾脓肿的临床特点,为早期诊断、治疗和随访提供参考。方法:本研究为回顾性队列研究,共纳入武汉儿童医院肾内科2.18年1月至2.2.年6月诊断为肾脓肿的患儿2.例。收集患儿的临床表现、实验室及影像学检查、治疗和随访数据。分... 详细信息

目的:分析儿童肾脓肿的临床特点,为早期诊断、治疗和随访提供参考。方法:本研究为回顾性队列研究,共纳入武汉儿童医院肾内科2.18年1月至2.2.年6月诊断为肾脓肿的患儿2.例。收集患儿的临床表现、实验室及影像学检查、治疗和随访数据。分类变量的数据采用Fisher′s精确检验,连续变量分析采用Kruskal-Wallis检验。结果:入组患儿中男女各12.,年龄17.96(8.2.,49.56)个月。起病症状以发热和纳差/呕吐常见。实验室检查以炎症急性期指标升高为主;13例(54.2.)患儿尿白细胞阴性;病原学阳性率低,血培养阳性者1例,为粪肠球菌;尿培养阳性者4例,其中粪肠球菌2.,屎肠球菌1例,黄曲霉菌1例。影像学检查:肾脏超声提示肾脓肿者15例,提示肾脓肿可疑者9例(其中7例经超声增强检查明确,2.经肾脏CT+增强明确);15例患儿行肾静态显像,均提示肾脏皮质功能受损;14例患儿行逆行尿路造影,9例(64.3%)阳性。2.例患儿内科保守治疗成功。肾脓肿3 cm以内的患儿抗生素总疗程2.3周,3 cm以上者为3~4周,3例患儿行外科干预,其中经皮引流2.,1例行患肾及输尿管切除术。肾脓肿≤2.cm者影像学恢复时间为10(7,15)d,2.4 cm者为2.(15,30)d。共2.例患儿规律门诊随访(1~6个月),均未见脓肿复发。结论:肾脓肿的临床表现及实验室检验均无特异性,肾脏超声是肾脓肿最简单经济的诊断方式。建议肾脓肿患儿完善逆行尿路造影及肾静态显像评估有无膀胱输尿管反流和肾脏瘢痕形成。4 cm以内的肾脓肿可首选内科保守治疗。

关键词：肾脓肿儿童肾脏超声检查肾静态显像膀胱输尿管反流

基于Jack的老年电动代步车人机工程设计与优化

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包装工程 2024年第4期45卷 107-114页

作者：朱桐宋端树张善超白道靖刘立江苏师范大学江苏徐州221116

目的满足行动不便的老年用户群体复杂的出行需求,提高电动代步车类工具使用过程中的舒适度。方法在传统老年电动代步车的基础上附加辅助站立结构,创新设计出一款坐、立两用的新型电动代步车,并借助Jack仿真软件,对老年用户坐姿驾驶和辅... 详细信息

目的满足行动不便的老年用户群体复杂的出行需求,提高电动代步车类工具使用过程中的舒适度。方法在传统老年电动代步车的基础上附加辅助站立结构,创新设计出一款坐、立两用的新型电动代步车,并借助Jack仿真软件,对老年用户坐姿驾驶和辅助站立支撑状态下的舒适度、可达域、可视域,以及上车过程中L4/L5下背部的受力情况进行分析,以验证关键人机交互结构、尺寸设计的合理性及舒适性。结论通过验证和调整,对电动代步车的初期设计方案进行改进,优化后的方案为老年电动代步工具的设计提供了参考,可以为满足老年用户复杂的出行需求、提高电动代步车类工具使用过程中的舒适度和安全性提供帮助。

关键词：工业设计人机工程学老年代步车 Jack

维普期刊数据库博看期刊

Urban Spatial Carrying Capacity and Sustainable Urbanization in the Middle-east Section of North Slope of Kunlun Mountains in Xinjiang,China

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Chinese Geographical Science 2023年第3期33卷 426-440页

作者： WANG Tao zHOU daojing WANG Li WU Jianxiong School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China Xinjiang Arts University Urumqi 830049China Institutes of Science and Development Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China

Urban spatial carrying capacity is the comprehensive support capacity of natural resources for urban development,which is of great significance in guaranteeing the sustainable *** middle-east section of North Slope of Kunlun Mountains in Xinjiang,China,is characterized by harsh climate and sparse population,whereas it is important for the initiative of the new Silk Road Belt because of its important *** in this area have begun to take shape,and the implementation of the Silk Road Belt Initiative will inevitably stimulate the urbanization in this *** extent to which the cities in this area will be supported by natural resources and how to fulfill the requirements of sustainable socioeconomic development needs to be *** view of this,the present study evaluated the urban spatial carrying capacity and discussed feasible approaches that could support the sustainable urbanization in this *** results show that 97.59%of the study area belongs to the low and relatively low levels of spatial carrying capacity for urban construction,and the area of medium,relatively high and high levels is 1.12.104 km2.accounting for 2.41%of the total study area,mainly distributed in small clusters in the central alluvial fan oasis *** and environmental factors highly constrain urban construction,and low spatial matching of land and water resources,harsh climatic conditions and high risk of geological disasters are three major *** addition,lagging transportation infrastructure construction and the resulting weak internal and external spatial connections also affect urban *** this basis,the scientific arrangement of urban distribution,steady promotion of regional economic development based on local characteristics,further improvement of transportation infrastructure construction and strengthening the cooperation between the Xinjiang Production and Construction Corps and local governments are suitable approaches fo

关键词： Sustainable Xinjiang Middle

利妥昔单抗治疗儿童激素依赖/频复发型肾病综合征后低丙种球蛋白血症发生情况及与严重感染的关系

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中华医学杂志 2024年第6期104卷 433-439页

作者：智元昭曹璐应道静窦文杰谷睿张建江郑州大学第一附属医院儿科河南省儿童肾脏病临床诊疗中心，郑州450052

目的探讨激素依赖/频复发型肾病综合征(SDNS/FRNS)患儿接受利妥昔单抗(RTX)治疗后低丙种球蛋白血症(HGG)的发生率、影响因素及其与严重感染的关系。方法回顾性分析2.2.年12.至2.2.年1月于郑州大学第一附属医院儿科接受RTX治疗的SDNS/F... 详细信息

目的探讨激素依赖/频复发型肾病综合征(SDNS/FRNS)患儿接受利妥昔单抗(RTX)治疗后低丙种球蛋白血症(HGG)的发生率、影响因素及其与严重感染的关系。方法回顾性分析2.2.年12.至2.2.年1月于郑州大学第一附属医院儿科接受RTX治疗的SDNS/FRNS患儿的临床资料。RTX治疗采用B细胞指导方案(单次剂量375 mg/m 2.最大500 mg/剂,复查外周血CD19+B细胞≥1%时追加1剂)。根据随访期间是否出现HGG分为HGG组与非HGG组。采用多因素logistic回归模型分析HGG的影响因素,绘制受试者工作特征(ROC)曲线评估各影响因素对HGG的预测价值。结果共纳入59例SDNS/FRNS患儿,男48例,女11例,首次RTX治疗时年龄[M(Q_(1),Q_(3))]9.4(6.5,12.2.岁,应用3(2.4)剂RTX。随访15.5(9.9,2..8)个月,16例(2..1%)出现HGG,其中7例持续存在1年以上。与非HGG组相比,HGG组病程较短[3.3(2.1,3.6)比4.6(2.4,8.0)年,P=0.030],首次RTX治疗时年龄较小[6.2.5.6,7.4)比11.3(8.8,13.3)岁,P2.g/L,P2.95%CI:0.35~0.78,P=0.002.是HGG的影响因素。首次RTX治疗时年龄预测HGG的AUC为0.887(95%CI:0.778~0.955,P2.)患儿发生严重感染,HGG组与非HGG组严重感染的发生率差异无统计学意义[12.5%(2.16)比9.3%(4/43),P=1.000]。结论SDNS/FRNS患儿接受RTX治疗后的HGG并不少见,其中近半数HGG持续存在1年以上,首次RTX治疗时年龄≤8.3岁者发生HGG的可能性大,但HGG并未增加患儿的严重感染风险。

关键词：肾病综合征儿童利妥昔单抗低丙种球蛋白血症严重感染

IMAGING AND MTI PROCESSING BASED ON DUAL-FREQUENCIES DUAL-APERTURES SPACEBORNE SAR

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Journal of Electronics(China) 2009年第1期26卷 38-44页

作者： Yin Jianfeng Li daojing Wu Yirong National Key Laboratory of Microwave Imaging Technology Institute of Electronics Chinese Academy of Sciences Beijing 100190 China Graduate University of Chinese Academy of Sciences Beijing 100190 China

Based on dual-frequencies dual-apertures spaceborne SAR （Synthetic Aperture Radar）, a new SAR system with four receiving channels and two operation modes is presented in this paper, SAR imaging and Moving Target Indication （MTI） are studied in this system. High resolution imaging with wide swath is implemented by the Mode Ⅰ, and MTI is completed by the Mode Ⅱ. High azimuth resolution is achieved by the Displaced Phase Center （DPC） multibeam technique. And the Coherent Accumulation （CA） method, which combines dual channels data of different carrier frequency, is used to enhance the range resolution. For the data of different carrier frequency, the two aperture interferometric processing is executed to implement clutter cancellation, respectively. And the couple of clutter suppressed data are employed to implement Dual Carrier Frequency Conjugate Processing （DCFCP）, then both slow and fast moving targets detection can be completed, followed by moving target imaging. The simulation results show the validity of the signal processing method of this new SAR system.

关键词： Spaceborne Synthetic Aperture Radar (SAR) Dual-frequencies dual-apertures Enhancing range resolution Slow and fast moving target detection Moving target imaging

伴右向左分流隐源性卒中患者发病风险预测模型研究

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中华行为医学与脑科学杂志 2024年第6期33卷 505-512页

作者：唐素娟吴庆文李玲儿李道静赵洪芹青岛大学附属医院神经内科青岛266035 济宁医学院附属医院重症医学科济宁272030 济宁医学院附属医院数据中心济宁272030 济宁医学院附属医院神经内科济宁272030

目的利用机器学习预测右向左分流(right-to-left shunt,RLS)人群隐源性卒中(cryptogenic stroke,CS)发病风险,为CS的准确和高效预测提供解决方案。方法回顾分析2.18年1月至2.2.年9月在青岛大学附属医院崂山院区神经内科治疗的经颅多普... 详细信息

目的利用机器学习预测右向左分流(right-to-left shunt,RLS)人群隐源性卒中(cryptogenic stroke,CS)发病风险,为CS的准确和高效预测提供解决方案。方法回顾分析2.18年1月至2.2.年9月在青岛大学附属医院崂山院区神经内科治疗的经颅多普勒超声发泡试验(c-TCD)阳性的2.9例RLS人群的临床数据,包括人口统计学信息、疾病史、实验室检查指标、诊断和治疗等。使用机器学习train_test_split()函数将数据集随机分为训练集和测试集,比例为8∶2.采用Logistic回归、决策树、随机森林、极端梯度提升、人工神经网络、梯度提升、极限树和自适应增强等算法构建RLS人群CS风险预测模型,使用受试者工作特征曲线(receiver operating characteristic,ROC)及曲线下面积(area under curve,AUC)、混淆矩阵、精确率、召回率、准确率、F1值、校准曲线、决策曲线等综合评估模型性能。性能最优的模型使用特征重要性和SHAP值进行可解释性分析。使用SPSS 2..0进行t检验、Mann-Whitney U检验和χ^(2.检验。采用Delong检验比较两模型间AUC的差异。结果2.9例RLS人群发生CS 166例(57.5%),非CS 12.例(42.5%)。统计分析结果显示,CS患者D-二聚体、平均血小板体积、纤维蛋白原等血液生化指标高于非CS患者(均P0.05)。对测试集进行CS风险预测,随机森林模型取得了最高的AUC(0.885)、精确率(0.806)、召回率(0.879)、准确率(0.810)以及F1得分(0.841)。校准曲线显示随机森林模型最接近参考线,决策曲线表明随机森林模型具有更大的净受益。可解释性分析显示高风险因素包括平均血小板体积、D-二聚体、国际标准化比值、体质量指数以及年龄。结论基于随机森林的预测工具表现出色,在预测RLS人群CS风险方面准确性较高。

关键词：隐源性卒中右向左分流机器学习预测模型随机森林模型

Dynamic Assessment and Sustainability Strategies of Ecological Security in the Irtysh River Basin of Xinjiang, China

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Chinese Geographical Science 2023年第3期33卷 393-409页

作者： FAN Jie ABUDUMANAN Ahemaitihali WANG Li zHOU daojing WANG zhao LIU Hanchu Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100190China Institutes of Science and Development Chinese Academy of SciencesBeijing 100190China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The drylands of China are extensive,and they are home to more than one-third of the country’s ***,the watershed territories of the drylands,where the majority of human activities are concentrated have long experienced strained human-land relationships,culminating in ecological security ***,it is essential to carry out a comprehensive assessment of the ecological security of dryland watersheds and to identify the key factors influencing ecological security in order to formulate strategies that ensure the sustainability of *** on the Driving-Pressure-State-Impact-Response(DPSIR)model,this study developed an ecological security index and applied it to the Irtysh River Basin of Xinjiang,China,from 2.00 to *** obstacle degree model was applied to reveal the obstacles in two dimensions:criterion level and indicator *** findings suggested that the ecological security comprehensive index in the Irtysh River Basin has increased significantly from 2.00 to 2.2.,irrespective of the fact that it decreased during the study period and then *** ecological security level changed from‘critically safe’in 2.00 to‘general safety’in 2.2.,with the state subsystem and pressure subsystem becoming ecological security *** primary factors influencing the ecological security of the study area were water consumption,the area of high-efficiency water-saving irrigation,the proportion of wetland area,vegetation coverage,and livestock *** ecological security of different counties in the basin varies greatly,whereas the factors that influence ecological security showed both similarities and differences among the *** light of on the findings,we proposed that future strategies for ecological security enhancement should concentrate on enacting the policy of localizing spatial differentiation,optimizing industrial structure,strengthening scientific and technological support in the field of water conservat

关键词： subsystem watershed dimensions

Discriminative fine-grained network for vehicle re-identification using two-stage re-ranking

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Science China(Information Sciences) 2020年第11期63卷 147-158页

作者： Qi WANG Weidong MIN daojing HE Song zOU Tiemei HUANG Yu zHANG Ruikang LIU School of Information Engineering Nanchang University School of Software Nanchang University Jiangxi Key Laboratory of Smart City Nanchang University School of Computer Science and Software Engineering East China Normal University

Research on the application of vehicle re-identification to video surveillance has attracted increasingly growing attention. Existing methods are associated with the difficulties of distinguishing different instances of the same car model owing to the incapability of recognizing subtle differences among these instances and the possibility that a subtle difference may lead to incorrect results of ranking. In this paper, a discriminative fine-grained network for vehicle re-identification based on a two-stage re-ranking framework is proposed to address these issues. This discriminative fine-grained network(DFN) is composed of fine-grained and Siamese networks. The proposed hybrid network can extract discriminative features of the vehicle instances with subtle differences. The Siamese network is rather suitable for general object re-identification using two streams of the network, while the fine-grained network is capable of detecting subtle *** proposed two-stage re-ranking method allows obtaining a more reliable ranking list by using the Jaccard metric and merging the first and second re-ranking lists, where the latter list is formed using the sample mean feature. Experimental results on the VeR i-776 and VehicleID datasets show that the proposed method achieves the superior performance compared to the state-of-the-art methods used in vehicle re-identification.

关键词： vehicle re-identification DFN two-stage re-ranking fine-grained Jaccard metric

利妥昔单抗治疗儿童频复发/激素依赖型肾病综合征的疗效及影响因素

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中华实用儿科临床杂志 2024年第2期39卷 114-117页

作者：窦文杰应道静曾慧勤智元昭史佩佩张建江郑州大学第一附属医院儿科河南省儿童肾脏病临床诊疗中心郑州450052

目的探讨利妥昔单抗(RTX)治疗儿童频复发/激素依赖型肾病综合征(FRNS/SDNS)的疗效和安全性,以及影响疗效的因素。方法回顾性病例系列研究。收集2.19年9月至2.2.年3月在郑州大学第一附属医院接受B细胞指导下RTX治疗(单次剂量375 mg/m2.最... 详细信息

目的探讨利妥昔单抗(RTX)治疗儿童频复发/激素依赖型肾病综合征(FRNS/SDNS)的疗效和安全性,以及影响疗效的因素。方法回顾性病例系列研究。收集2.19年9月至2.2.年3月在郑州大学第一附属医院接受B细胞指导下RTX治疗(单次剂量375 mg/m2.最大500 mg,当外周血CD19+B细胞≥0.01时追加1剂)的FRNS/SDNS患儿的临床资料,比较RTX治疗前后复发次数及激素累积剂量;Kaplan-Meier方法分析RTX治疗后无复发生存率和无FRNS/SDNS生存率。Cox比例风险回归模型分析复发的影响因素。结果纳入47例患儿,男35例,女12.;首次应用RTX年龄10.2.6.9,13.0)岁;既往使用1种免疫抑制剂33例,2.及以上14例;RTX治疗剂次3.0(2.0,3.0)次。RTX治疗后复发次数[0(0,0.55)次/年比1.62.1.09,2.40)次/年]和激素累积剂量[0.12.0.05,0.2.)mg/(kg·d)比0.40(0.2.,0.56)mg/(kg·d)]均较既往免疫抑制剂治疗时明显下降,差异均有统计学意义(z=-5.56、-5.54,均P2.18、2.个月无复发生存率分别为80.9%、72.3%、68.1%、68.1%,无FRNS/SDNS生存率分别为93.6%、89.4%、89.4%、89.4%。单因素Cox回归分析显示,既往免疫抑制剂治疗时的复发次数多是RTX治疗后复发的危险因素(Pz=-2.84,P=0.005)。RTX治疗及随访期间无严重不良反应发生。结论B细胞指导下RTX治疗儿童FRNS/SDNS有效且安全,既往免疫抑制剂治疗时的复发次数多是RTX治疗后复发的危险因素,B细胞耗竭状态时复发预示RTX治疗结局不良。

关键词：利妥昔单抗肾病综合征儿童影响因素