检索结果-南通市图书馆

Signal Transduction and Targeted Th.rapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yih.o Tian Quazi T.h.Sh.bh.a Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Department of h.man Anatomy and h.stology and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Institute of Ch.mistry University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent study publish.d in Nature Nanotech.ology,Li et *** th. synth.sis of a novel ph.tosensitizer with.unique aggregation-induced emission(AIE)ch.racteristics.1 Th.y microencapsulated th.s ph.tosensitizer inside engineered nanoparticles(NPs)coated with.pre-activated macroph.ge cell membranes(CMs),an innovative approach.marking a significant leap in nanomedicine by offering a path.ay to potent tuberculosis(TB)treatments th.t bypass antibiotic resistance with.unparalleled precision.

关键词： tuberculosis macroph.ge aggregation

Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mech.nisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.T.Jeong S.W.Lee W.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

Th. superplastic beh.vior and associated deformation mech.nisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with.a grain size of 3.2μm,primarily composed of th. BCCβph.se and a small amount of th. h.Pαph.se,were examined in a temperature range of 473 K to 623 *** microstructural refinement of th.s alloy was ach.eved by employing h.gh.ratio differential speed *** best superplasticity was ach.eved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),wh.re tensile elongations of 550±600%were *** th. h.ating and h.lding stage of th. tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider th.s effect wh.n analyzing and understanding th. superplastic deformation beh.vior and *** th. investigated strain rate range,th. superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,wh.le at h.gh.strain rates,lattice diffusion-controlled dislocation climb creep was th. rate-controlling deformation *** was concluded th.t solute drag creep is unlikely to *** th. late stages of deformation at 523 K,it was observed th.t grain boundary sliding led to th. agglomeration of th.αph.se,resulting in significant strain *** mech.nism maps were constructed forβ-Mg-Li alloys in th. form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using th. constitutive equations for various deformation mech.nisms derived based on th. data of th. current tests.

关键词： Magnesium-lith.um alloy Superplasticity Severe plastic deformation Grain size Grain growth

Connections Between Induction Generator Effect and Open-loop Modal Proximity to Cause Sub-synch.onous Oscillations in Series-compensated Power System

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第3期10卷 963-973页

作者： Wenjuan Du Yang Wang h.F.Wang Tao Zh.o Tim Littler College of Electrical Engineering Sichuan UniversityChengduChina Sch.ol of Electrical Engineering the Queen’s University of BelfastBelfastUK IEEE

Th. induction generator effect(IGE)and th. openloop modal proximity(OLMP)are two different reasons wh. subsynch.onous oscillations(SSOs)in a series-compensated power system(SCPS)may *** IGE attributes th. growing SSOs to negative resistance,wh.le th. OLMP explains th. SSO mech.nism from th. standpoint of modal *** th.s paper,we investigate th. connections between th. IGE and th. OLMP th.ough.equivalent RLC circuit and open-loop modal *** investigation is conducted for two types of seriescompensated power systems wh.re eith.r a synch.onous generator or a DFIG is connected at th. sending *** investigation reveals th. conditions,in wh.ch.th. IGE and th. OLMP may jointly cause th. growing SSOs,i.e.,both.th. IGE and th. OLMP can explain wh. th. growing SSOs ***,th. investigation indicates th.t th. IGE and th. OLMP may be totally irrelevant and lead to growing SSOs *** implies th.t it is possible th.t in a SCPS,th. growing SSOs are only due to th. IGE,and th. OLMP is non-existent,and vice ***,wh.n th. growing SSOs occurs in a SCPS,examination based on both.th. IGE and th. OLMP sh.uld be carefully conducted in order to find if th. oscillatory instability is due to th. IGE,or th. OLMP,or both.of th.m.

关键词： Induction generator effect open-loop modal proximity series compensation sub-synch.onous oscillations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

威尔是如何逃出矿井的

快乐语文 2024年第1期 66-67页

作者： []威廉.h.麦加菲不详

威尔的姨妈给他一个小本子作为生日礼物,在本子中间有一支铅笔,威尔非常喜欢这个小本子,所以他总是把它带在身上。一天,妈妈非常忙,没空搭理威尔。于是威尔叫上他的狗:“来吧,卡珀,我们出去玩。”当妈妈发现威尔不见了时,她便到屋里去找... 详细信息

威尔的姨妈给他一个小本子作为生日礼物,在本子中间有一支铅笔,威尔非常喜欢这个小本子,所以他总是把它带在身上。一天,妈妈非常忙,没空搭理威尔。于是威尔叫上他的狗:“来吧,卡珀,我们出去玩。”当妈妈发现威尔不见了时,她便到屋里去找,但是怎么也找不到。但她知道卡珀跟他在一起,所以稍稍放了点心,想威尔可能一会儿玩够了就会回来。

关键词：生日礼物威尔本子妈妈

Astrocytic calcium waves:unveiling th.ir roles in sleep and arousal modulation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason h.h.ang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University Sch.ol of Medicine TempleTXUSA Texas A&M University Sch.ol of Ph.rmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for th. brain’s *** astrocyte activities is crucial for compreh.nding th. complex neural network,particularly th. population-level functions of neurons in different cortical states and associated beh.viors in *** on animal sleep and wakefulness h.ve revealed distinct cortical synch.ony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research.on astrocyte activation during cortical state transitions h.s emph.sized th. influence of norepineph.ine as a neurotransmitter and calcium waves as key components of ion ch.nnel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring th. involvement of noradrenaline signaling,ion ch.nnels,and glutamatergic signaling in different cortical *** findings h.gh.igh. th. significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling path.ays sh.ws promise for treating sleep disorders and arousal *** research.is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future h.man studies to compreh.nsively investigate neuron-astrocyte interactions and pave th. way for th.rapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepineph.ine sleep wakefulness

Bioph.toelectroch.mistry:An emerging frontier for ch.nneling ph.toelectric effect into darkness zone of soils and sediments

在线全文

学校读者我要写书评

暂无评论

Pedosph.re 2024年第1期34卷 5-8页

作者： Jie YE Sh.ngui Zh.U Kenneth.h.NEALSON Ch.istoph.r RENSING Fujian Provincial Key Laboratory of Soil Environmental h.alth.and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China Department of Earth.Science University of Southern CaliforniaLos Angeles CA 90007USA

Solar energy captured by ph.tosynth.tic plants in th. ph.tic zone is recognized as th. main driver for th. formation of organic matter utilized by soil communities. h.wever, th. contribution of organic transformation to th. linkage of solar energy and microbial metabolism of soils is reduced wh.n th. vadose zone is saturated. In contrast to th. conventional bioph.toelectroch.mistry via ph.tosynth.sis with.ph.toplankton during th. periodic saturation of soils, recent studies suggest th.t non-ph.totroph.c microorganisms in soils and sediments are able to conduct ligh.-dependent metabolism to sustain th.ir functionality with.ph.tosensitizers under illumination. Th.se interactions and processes utilize long-distance electron transfer networks to interconnect diverse electron transfer ch.ins th.t ch.nnel ph.toexcited electrons into th. opaque zone for soil communities. Such.an emerging process not only allows for a better understanding of biogeoch.mical processes such.as soil carbon sequestration and mitigation, but also sh.ws great potential for environmental treatment such.as th. bioremediation of contaminated soils. Th.refore, we suggest th.t bioph.toelectroch.mistry via ph.toelectric effect can h.ve significant, h.retofore unappreciated, th.oretical and practical values.

关键词： soils soil metabolism

Cancer cell cycle h.terogeneity as a critical determinant of th.rapeutic resistance

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrah.m h.Maleki Ah.ad Reza Bah.ami Maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Th.rapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral Sch.ol of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotech.ology Research.Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Th.rapeutics Research.Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research.Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor h.terogeneity is now arguably one of th. most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are h.gh.y diverse at genetic,epigenetic,and ph.notypic levels,intra-tumor h.terogeneity can be assumed as an important contributing factor to th. nullification of ch.moth.rapeutic effects,and recurrence of th. *** on th. role of h.terogeneous subpopulations of cancer cells with.varying cell-cycle dynamics and beh.vior during cancer progression and treatment;h.rein,we aim to establish.a compreh.nsive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells th.t play pivotal roles in reducing th. effects of ch.moth.rapy:"resistant"and"tolerant"***,th.s review also h.gh.igh.s th. impact of th. quiescent ph.se of th. cell cycle as a survival mech.nism for cancer *** understanding th. mech.nisms under-lying th. quiescence,it provides an insigh.ful perspective on cancer stem cells(CsCs)and th.ir dual and intertwined functions based on th.ir cell cycle state in response to ***-over,CSCs,epith.lial-mesench.mal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),wh.ch.are mostly in a quiescent state of th. cell cycle are proved to h.ve multiple biological links and can be implicated in our viewpoint of cell cycle h.terogeneity in ***,increasing our knowledge of cell cycle h.terogeneity is a key to identifying new th.rapeutic solutions,and th.s emerging concept may provide us with.new opportunities to prevent th. dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle h.terogeneity Quiescence Th.rapy resistance Th.rapy tolerance Tumor dormancy

Exploring Variability in Sea Level at a Tide Gauge Station th.ough.Control Ch.rts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental & Earth.Sciences 2024年第1期6卷 11-18页

作者： h.Bâkiİz Independent Sch.lar Boca Raton Florida33496USA

Monitoring temporal ch.nges in sea level is important in assessing coastal *** level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such.as trend,acceleration,periodic oscillations,and random *** th.m,th. non-stationary nature of th. random sea level variations of known or unknown origin at coastal regions h.s been long recognized by th. sea level *** study proposes th. analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control *** approach.is demonstrated using Key West,Florida tide gauge *** mean and standard errors of 5-year-long subgroups of th. residuals revealed th.t sea level ch.nges at th.s location h.ve been progressively intensifying from 1913 to th. *** oscillations in sea level at th.s locality may be attributed partly to th. th.rmal expansion of seawater with.increasing temperatures causing larger buoyancy-related sea level fluctuations as well as th. intensification of atmosph.ric events including wind patterns and th. impact of ch.nges in inverted barometer effects th.t will alter coastal risk assessments for th. future.

关键词： Climate ch.nge Sea level variance X-bar S control ch.rts

Correlation of work function and stacking fault energy th.ough.Kelvin probe force microscopy and nanoh.rdness in diluteα-magnesium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit Türe Ali Arslan Kaya h.seyin Aydin Jiang Peng Servet Turan Eskiseh.r Tech.ical University Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman University Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey h.seying Aydın TUBITAK MRCTurkey Jiang Peng Chongqing UniversityChina Eskiseh.r Tech.ical University Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of th. Group 2A elements with.magnesium h.ve been studied th.ough.th. dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** investigation incorporated th. difference in th.‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in th. *** was sh.wn th.t th. nano-h.rdness of th. solid-solutionα-Mg ph.se ch.nged in th. order of Mg-Ca>Mg-Sr>***,it was sh.wn,by also considering th. nano-h.rdness levels,th.t SFE of a solid-solution is closely correlated with.its‘Work Function'***-h.rdness measurements on th. eutectics andΔWF difference between eutectic ph.ses enabled an assessment of th. relative bond strength.and th. pertinent electronic structures of th. eutectics in th. th.ee *** with.WF and at least qualitative verification of th.se computed SFE values with.some experimental measurement tech.iques were considered important as th.se computational meth.ds are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by th.s investigation,if th. results of measurement tech.iques can be qualitatively correlated with.th.se of th. computational meth.ds,it can be possible to evaluate th. electronic structures in alloys,starting from binary systems,going to ternary and th.n multi-elemental *** investigation h.s sh.wn th.t such.a qualitative correlation is *** all,th. SFE values are not treated as absolute values but rath.r become essential in comparative investigations wh.n assessing th. influences of alloying elements at a fundamental level,th.t is,free electron density *** study indicated th.t th. principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental meth.ds,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Sh.rt range order Miedema Nanoindentation Eutectics

Primary Total h.p Arth.oplasty on Complex h.ps Conditions in a Low-Resource Setting

在线全文

学校读者我要写书评

暂无评论

Open Journal of Orth.pedics 2024年第7期14卷 325-333页

作者： Souleymane Ouédraogo Malick Diallo Sékou Sidibé Massadiami Soulama Adama Sidibé Ousmane Ouermi Patrick W. h. Dakouré Orth.pedics and Traumatology Department University Hospital Sour SANOU Bobo-Dioulasso Burkina Faso Superior Institute of Medical Sciences University Nazi BONI Bobo-Dioulasso Burkina Faso

Introduction: Total h.p arth.oplasty of complex morph.logy is a ch.llenge for th. orth.paedic surgeon. Careful analysis of th. h.p’s anatomy h.lps to unravel th. difficulties and anticipate th. procedures to be performed and th. implants to be planned. Th. aim was to identify th. types of h.p th.t make first-line Th. difficult, specify th. tech.ical procedures to be used on th.se sites, and assess th. functional results of th. series. Material and Meth.ds: Th.s was a retrospective study th.t concerned patients operated on for total h.p arth.oplasty between January 2015 and December 2022 at th. medical center “La Grâce” in Bobo-Dioulasso, Burkina Faso. Patients with.coxarth.osis (on h.p dysplasia, acetabular protrusio, acetabular malunion or neurological h.p) and th.se with.ankylosis of th. h.p, osteonecrosis secondary to neglected dislocation of th. h.p or h.moglobinopath. were included. Results: A total of 31 total h.p replacements were performed in 30 patients. Th. mean age of patients at th. surgery time was 36.2 years with.extremes of 17 and 61 years. Th. male-to-female sex ratio was 1. Th. main indications for Th. were th. dysplasic h.p osteoarth.itis (11 cases) and th. neglected h.p dislocations (7 cases). In situ femoral neck osteotomy before h.p dislocation was performed in seven cases. Th. acetabulum reconstruction tech.iques varied from th. structural iliac bone graft (n = 3) and cancellous bone graft (n = 4) to th. Kerboull plate (n = 1). After 45 month. of mean follow-up, all h.ps were evaluated. Th. mean PMA score increased from 7.1 [4 - 8] before th. surgery to 13.2 [13 - 17]. Conclusion: Th. large spectrum of ch.llenges in complex h.p management requires effective preoperative planning. Preoperative planning minimizes complications and ensures a better outcome.

关键词： Primary Total h.p Arth.oplasty h.p Dysplasia Complex h.p