检索结果-南通市图书馆

Primary Considerations for Primary TEFL in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基础教育外语教学研究 2007年第2期 25-31页

作者： yvonne Griffiths

This article will focus on five key areas relating to Primary TEFL in ***,the real TEFL context in Chinese primary schools will be discussed in terms of its special ***,the current methodological approach will be examined from both a theoretical perspective,focusing on government(MOE)policy for primary TEFL,and a practical perspective,based on personal observations of classroom *** third section of the article will highlight some perceived shortcomings of current practice,while the fourth will outline the actual needs of primary learners in the Chinese educational ***,the question of how teachers can meet these needs will be examined in relation to:methodological integration; integration of skills and sub-skills teaching/learning;and the exploitation of materials and activities to provide learners with three different types of language input and output opportunities(extensive,intensive and analysed:Swan,2006).

关键词：英语教育中国环境方法

Home Living in French Styles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design（产品设计） 2008年第3期 10-13页

作者： yvonne

2008年1月24至28日法国巴黎惟的一个专业家具博览会MeubleParis，与家居和装饰领域的Majson＆Objet巴黎家居装饰博览会首次共同合作，向世人呈现了一场活力四射的家居全景盛会、本次博览会涉及家具、壁纸布艺礼品装饰等各大领域，以更... 详细信息

2008年1月24至28日法国巴黎惟的一个专业家具博览会MeubleParis，与家居和装饰领域的Majson＆Objet巴黎家居装饰博览会首次共同合作，向世人呈现了一场活力四射的家居全景盛会、本次博览会涉及家具、壁纸布艺礼品装饰等各大领域，以更加全面、完整。

关键词：家具博览会家居装饰法国巴黎国际化时尚春夏

Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2004年第5期14卷 379-388页

作者： Olesya D. FEDORYAK,yvonne SEARLS,Irina V. SMIRNOVA,Douglas M. BURNS,Lisa STEHNO-BITTEL Departments of Physical Therapy and Rehabilitation Sciences University of Kansas Medical Center Kansas City KS 66160 USA Departments of Physical Therapy and Rehabilitation Sciences University of Kansas Medical Center Kansas City KS 66160 USA Department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS 66160 USA Departments of Physical Therapy and Rehabilitation Sciences University of Kansas Medical Center Kansas City KS 66160 USA VA Medical Center Kansas City MO 64128 USA Departments of Physical Therapy and Rehabilitation Sciences University of Kansas Medical Center Kansas City KS 66160 USA Department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS 66160 USA

Spontaneous Ca2+ oscillations in vascular smooth muscle cells have been modeled using a single Ca2+ pool. This report describes spontaneous Ca2+ oscillations dependent on two separate Ca2+ sources for the nuclear versus cytoplas- mic compartments. Changes in free intracellular Ca2+ were monitored with ratiometric Ca2+- fluorophores using confo- cal microscopy. On average, spontaneous oscillations developed in 79% of rat aortic smooth muscle cells that were synchronous between the cytoplasm and nucleus. Reduction of extracellular Ca2+ (< 1 μM) decreased the frequency and amplitude of the cytoplasmic oscillations with 48% of the oscillations asynchronous between the nuclear and cytoplasmic compartments. Similar results were obtained with the Ca2+ channel blockers, nimodipine and diltiazem. Arg-vasopressin (AVP) induced a rapid release of intracellular Ca2+ stores that was greater in the nuclear compartment (4.20 ± 0.23 ratio units, n = 56) than cytoplasm (2.54 ± 0.28) in cells that had spontaneously developed prior oscillations. Conversely, cells in the same conditions lacking oscillations had a greater AVP-induced Ca2+ transient in the cytoplasm (4.99 ± 0.66, n = 17) than in the nucleus (2.67 ± 0.29). Pre-treatment with Ca2+ channel blockers depressed the AVP responses in both compartments with the cytoplasmic Ca2+ most diminished. Depletion of internal Ca2+ stores prior to AVP exposure blunted the nuclear response, mimicking the response of cells that lacked prior oscillations. Spontaneous oscillating cells had a greater sarcoplasmic reticulum network than cells that did not oscillate. We propose that sponta- neous nuclear oscillations rely on perinuclear sarcoplasmic reticulum stores, while the cytoplasmic oscillations rely on Ca2+ influx.

关键词： oscillations vascular smooth muscle cells nuclear Ca2+ vasopressin thapsigargin diltiazem nimodipine.

Adapting Teaching to Match Learning Styles

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基础教育外语教学研究 2005年第12期 27-32页

作者： yvonne Griffiths University of Wales

Introduction The teaching of English as a foreign language (TEFL) experienced a major methodological shift in the 1970s and 80s, with a move away from the Grammar-Translation (G-T) and Audio -lingua] Approaches, which had been so popular throughout the 1950s and 60s, towards Communicative Language Teaching (CLT) and other humanistic approaches. This new direction reduired significant changes in tradi-

关键词：中小学英语教学竞赛教学风格 CLT

Outcomes of curative esophageal cancer surgery in elderly:A metaanalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第2期13卷 131-146页

作者： Nikolaj S Baranov Cettela Slootmans Frans van Workum Bastiaan R Klarenbeek yvonne Schoon Camiel Rosman Department of Surgery Radboud University Medical CenterNijmegen 6525GAthe Netherlands Department of Geriatrics Radboud University Medical CenterNijmegen 6525GAthe Netherlands

BACKGROUND An increasing number of older patients is undergoing curative,surgical treatment of esophageal *** meta-analyses have shown that older patients suffered from more postoperative morbidity and mortality compared to younger patients,which may lead to patient selection based on ***,only studies including patients that underwent open esophagectomy were ***,it remains unknown whether there is an association between age and outcome in patients undergoing minimally invasive *** To perform a systematic review on age and postoperative outcome in esophageal cancer patients undergoing *** Studies comparing older with younger patients with primary esophageal cancer undergoing curative esophagectomy were ***-analysis of studies using a 75-year age threshold are presented in the manuscript,studies using other age thresholds in the Supplementary ***,Embase and the Cochrane Library were searched for articles published between 1995 and *** of bias was assessed with the Newcastle-Ottawa *** outcomes were anastomotic leak,pulmonary and cardiac complications,delirium,30-and 90-d,and in-hospital *** outcomes included pneumonia and 5-year overall *** Seven studies(4847 patients)using an age threshold of 75 years were included for meta-analysis with 755 older and 4092 younger *** patients(9.05%)had higher rates of 90-d mortality compared with younger patients(3.92%),(confidence interval=1.10-5.56).In addition,older patients(9.45%)had higher rates of in-hospital mortality compared with younger patients(3.68%),(confidence interval=1.01-5.91).In the subgroup of 2 studies with minimally invasive esophagectomy,older and younger patients had comparable 30-d,90-d and in-hospital mortality *** Older patients undergoing curative esophagectomy for esophageal cancer have a higher postoperative mortality *** invasive esopha

关键词： Elderly Minimally invasive esophagectomy Open esophagectomy Esophageal cancer Clinical outcome Perioperative mortality

Ustekinumab: “Real-world” outcomes and potential predictors of nonresponse in treatment-refractory Crohn’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第31期25卷 4481-4492页

作者： Peter Hoffmann Johannes Krisam Cyrill Wehling Petra Kloeters-Plachky yvonne Leopold Nina Belling Annika Gauss Department of Gastroenterology and Hepatology University Hospital HeidelbergHeidelberg 69120Germany Department of Medical Biometry University Hospital HeidelbergHeidelberg 69120Germany

BACKGROUND Ustekinumab was approved in Europe for the treatment of adults with moderate to severe Crohn's disease(CD)in 2016,and there is an urgent need for data on its everyday *** To obtain data on the daily use of *** This is a retrospective monocentric *** with moderate to severe CD who began ustekinumab therapy at the inflammatory bowel diseases outpatient clinic of the Heidelberg University Hospital between December 2016 and March 2018 were selected based on electronic patient *** primary study endpoint was combined steroid-free clinical remission or steroid-free clinical response at 24±6 wk of ustekinumab *** study endpoints were:achievement of mucosal healing,sonographic and magnetic resonance imaging response,biochemical response,the need for intestinal surgery within 24±6 wk after treatment initiation,the occurrence of adverse events,treatment discontinuation due to nonresponse or adverse events,improvement of extraintestinal manifestations,clinical response at 48±6 wk of therapy,and association of response with nucleotid oligodimerisation domain 2 *** Fifty-seven patients with CD(5.3%anti-tumour necrosis factorαnaive,63.2%having undergone at least one intestinal surgery)were included in the *** patients(35.1%)achieved steroid-free clinical remission,6(10.5%)steroid-free clinical response and 31(54.4%)were *** discontinuation due to adverse events occurred in two patients(3.5%).Male sex,the presence of extraintestinal manifestations and the use of steroids at baseline were predictors of nonresponse to ustekinumab *** In a“real-world”treatment-refractory cohort of patients with CD,ustekinumab appeared efficacious and safe.

关键词： Eeal-world Ustekinumab Crohn’s disease

MicroRNA sequences modulating inflammation and lipid accumulation in macrophage “foam” cells: Implications for atherosclerosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2020年第7期12卷 303-333页

作者： Richard James Lightbody Janice Marie Walsh Taylor yvonne Dempsie Annette Graham Department of Biological and Biomedical Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgow G40BAUnited Kingdom

Accumulation of macrophage"foam"cells,laden with cholesterol and cholesteryl ester,within the intima of large arteries,is a hallmark of early"fatty streak"lesions which can progress to complex,multicellular atheromatous plaques,involving lipoproteins from the bloodstream and cells of the innate and adaptive immune *** accumulation triggers induction of genes encoding proteins mediating the atheroprotective cholesterol efflux *** the arterial intima,however,this mechanism is overwhelmed,leading to distinct changes in macrophage phenotype and inflammatory *** the last decade marked gains have been made in understanding of the epigenetic landscape which influence macrophage function,and in particular the importance of small non-coding micro-RNA(miRNA)sequences in this *** review identifies some of the miRNA sequences which play a key role in regulating"foam"cell formation and atherogenesis,highlighting sequences involved in cholesterol accumulation,those influencing inflammation in sterol-loaded cells,and novel sequences and pathways which may offer new strategies to influence macrophage function within atherosclerotic lesions.

关键词： Coronary heart disease Atherosclerosis Macrophage“foam”cell Cholesterol Inflammation MicroRNA

Early Childhood Education for Sustainability Through Contradicting and Overlapping Dimensions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ECNU Review of Education 2019年第4期2卷 374-395页

作者： Liv Torunn Grindheim yvonne Bakken Kjellrun Hiis Hauge Marianne Presthus Heggen KINDknow–Kindergarten Knowledge Centre for Systemic Research on Diversity and Sustainable Futures Western Norway University of Applied Sciences5063 BergenNorway Western Norway University of Applied Sciences

Purpose:The article investigates how to make a broader understanding of sustainability relevant for early childhood education(ECE)guided by the four dimensions suggested by United Nations Educational,Scientific and Cultural Organization:ecological,economic and social/cultural sustainability,and good ***/Approach/Methods:Previous research on ECE on sustainability is discussed in relation to the four dimensions and to Biesta’s concepts of socialization,qualification,and ***:The investigation finds that all four dimensions are necessary in ECE for sustainability,and it suggests how the dimensions can be understood,how they may overlap,and how they can be ***/Value:The article depicts how children’s opportunities to engage and to disturb established ways of thinking can be facilitated through all dimensions.

关键词： Conflicts dimensions of sustainability early childhood education overlaps

Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第39期18卷 5489-5494页

作者： yvonne LB Klaver Valery EPP Lemmens Simon W Nienhuijs Misha DP Luyer Ignace HJT de Hingh Department of Surgical Oncology Catharina Hospital EindhovenMichelangelolaan 25623 EJ EindhovenThe Netherlands Department of Public Health Erasmus Medical Centre RotterdamDr Molewaterplein 503015 CE RotterdamThe Netherlands

Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC.

关键词： Colorectal cancer Peritoneal carcinomato-sis Hyperthermic intraperitoneal chemotherapy Che-motherapy Prognosis