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Science China Chemistry 2014年第4期57卷 596-604页

作者： HOU LinXi PECK yvonne WANG XiaoWen WANG DongAn College of Chemistry and Chemical Engineering Fuzhou University Division of Bioengineering School of Chemical and Biomedical Engineering Nanyang Technological University

Polyurethanes(PUs) are well-known for their biocompatibility but their intrinsic inert property hampers cell-matrix interactions. Surface modifications are thus necessary to widen their use for biomedical applications. In this work, surface modifications of PU were achieved first by incorporating polyhedral oligomeric silsesquioxane(POSS), followed by alteration of the surface topography via the breath figures method. Subsequently, surface chemistry was also modified by immobilization of gelatin molecules through grafting, for the enhancement of the surface cytocompatibility. Scanning electron microscopy(SEM) was used to verify the formation of highly ordered microstructures while static contact angle, FTIR and XPS confirmed the successful grafting of gelatin molecules onto the surfaces. In vitro culture of human umbilical vein endothelial cells(HUVECs) revealed that endothelial cell adhesion and proliferation were significantly enhanced on the gelatin-modified surfaces, as shown by live/dead staining and WST-1 proliferation assay. The results indicated that the combination of the strategies yielded an interface that improves cell attachment and subsequent growth. This enhancement is important for the development of higher quality biomedical implants such as vascular grafts.

关键词： biomaterials surface modification pattern polyurethane silsesquioxane gelatin endothelization

MiRNA as potential biomarkers and therapeutic targets for gastric cancer

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World Journal of Gastroenterology 2014年第30期20卷 10432-10439页

作者： Vivian yvonne Shin Kent-Man Chu Department of Surgery The University of Hong KongQueen Mary Hospital

Gastric cancer is one of the leading causes of cancer mortality in the world. Aberrant expression of microRNAs (miRNAs) is the hallmark of this disease. MiRNAs are endogenous non-coding RNAs that are involved in many biological processes (e.g., cell proliferation, differentiation, apoptosis, invasion and development) through gene repression. Deregulation of miRNA expression in gastric tumors and cancer cell lines have been documented to contribute in tumorigenesis, and the expression signature may correlate with different cancer types and clinicopathological features. Here, we summarized the updated gastric cancer-associated miRNAs and the downstream targets in the process of tumorigenesis. Recently, many researchers make use of the miRNA microarray platform to profile miRNA expression in gastric cancer and correlated with different clinical parameters. Its application on cancer diagnosis, prognosis and predicting treatment response rate are still underway and needs further investigation. Emerging roles of miRNAs with oncogenic or tumor suppressive properties in gastric tumorigenesis were discussed. Epigenetic silencing of miRNA by hypermethylation of promoter CpG island was also observed in gastric cancer. However, detailed mechanisms of how miRNAs regulate gene expression in gastric cancer has not been well studied. In this review, we highlight the up-to-date findings on the deregulated miRNAs in gastric cancer, and the potential use of miRNA in the clinical settings, such as diagnostic/prognostic markers and chemotherapeutic tools.

关键词： MicroRNA Gastric cancer Biomarker Diagnosis Prognosis Clinical application

Continuous-Variable Quantum Computation in Circuit QED

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Chinese Physics Letters 2023年第11期40卷 14-17页

作者： Xiaozhou Pan Pengtao Song yvonne Y.Gao Centre for Quantum Technologies National University of SingaporeSingapore Department of Physics National University of SingaporeSingapore

Quantum computation (QC) offers the promise of enhanced computational capabilities and drastic accelerations in solving complex tasks such as quantum chemistry^([1,2])and prime factorization.^([3])Various physical implementations for practical QC are being pursued across the academic and industrial research *** ones include trapped ions,^([4])nuclear spin,^([5]).

关键词： acceleration quantum Quantum

A role for mitogen-activated protein kinase phosphatase 1(MKP1) in neural cell development and survival

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Neural Regeneration Research 2015年第11期10卷 1748-1749页

作者： André Toulouse yvonne M.Nolan Department of Anatomy and Neuroscience University College Cork

The mitogen-activated protein kinase（MAPK）pathways are a group of conserved intracellular signalling pathways present in most cells including neurons and *** pathways respond to a variety of stimuli including growth factors,cytokines and oxidative stress to generate appropriate cellular responses such as modulation of gene expression,cell proliferation,differentiation and survival as well as the stress response（Korhonen and Moilanen,2014）.

关键词： MKP1 A role for mitogen-activated protein kinase phosphatase 1 in neural cell development and survival cell

Quantification of coarse aggregate shape in concrete

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Frontiers of Structural and Civil Engineering 2014年第3期8卷 308-321页

作者： Xianglin GU yvonne TRAN Li HONG Department of Structural Engineering Tongii University Shanghai 200092 China

The objective of this study is to choose indices for the characterization of aggregate form and angularity for large scale application. For this purpose, several parameters for aggregate form and angularity featured in previous research are presented. Then, based on these established parameters, 200 coarse quartzite aggregates are analyzed herein by using image processing technology. This paper also analyzes the statistical distributions of parameters for aggregate form and angularity as well as the correlation between form and angularity parameters. It was determined that the parameters for form or angularity of coarse aggregates could be fitted by either normal distribution or log-normal distribution at a 95% confidence level, Some of the form parameters were influenced by changes in angularity characteristics, while aspect ratio and angularity using outline slope, area ratio and radius angularity index, and aspect ratio and angularity index were independent of each other, respectively; and consequently, the independent parameters could be used to quantify the aggregate form and angularity for the purpose to study the influence of aggregate shape on the mechanical behavior of concrete. Furthermore, results from this study＇s in-depth investigations showed that the aspect ratio and the angularity index can further understanding of the effects of coarse aggregates form and angularity on concrete mechanical properties, respectively. Finally, coarse aggregates with the same content, type and surfaces texture, but different aspect ratios and angularity indices were used to study the influence of coarse aggregate form and angularity on the behavior of concrete. It was revealed that the splitting tensile strength of concrete increased with increases in the aspect ratio or angularity index of coarse aggregates.

关键词： coarse aggregate form angularity digital image analysis statistical distribution splitting tensile strength

Organic carbon stratification and size distribution of three typical paddy soils from Taihu Lake region,China

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Journal of Environmental Sciences 2008年第4期20卷 456-463页

作者： PAN Genxing WU Laosheng LI Lianqing ZHANG Xuhui GONG Wei WOOD yvonne Institute of Resource Ecosystem and Environment of Agriculture Nanjing Agricultural University Nanjing 210095 China Department of Environmental Sciences University of California Riverside CA 92521 USA

Developing realistic soil carbon （C） sequestration strategies for China＇s sustainable agriculture relies on accurate estimates of the amount, retention and turnover rates of C stored in paddy soils. Available C estimates to date are predominantly for the tilled and flood-irrigated surface topsoil （ca. 30 cm）. Such estimates cannot be used to extrapolate to soil depths of 100 cm since soil organic carbon （SOC） generally shows a sharp decrease with depth. In this research, composite soil samples were collected at several depths to 100 cm from three representative paddy soils in the Taihu Lake region, China. Soil organic carbon distribution in the profiles and in aggregate-size fractions was determined. Results showed that while SOC decreased exponentially with depth to 100 cm, a substantial proportion of the total SOC （30%-40%） is stored below the 30 cm depth. In the carbon-enriched paddy topsoils, SOC was found to accumulate preferentially in the 2-0.25 and 0.25-0.02 mm aggregate size fractions. δ^13C analysis of the coarse micro-aggregate fraction showed that the high degree of C stratification in the paddy topsoil was in agreement with the occurrence of lighter δ^1313C in the upper 30 cm depth. These results suggest that SOC stratification within profiles varies with different pedogenetical types of paddy soils with regards to clay and iron oxyhydrates distributions. Sand-sized fractions of aggregates in paddy soil systems may play a very important role in carbon sequestration and turnover, dissimilar to other studied agricultural systems.

关键词： profile stratification organic carbon paddy soils size fractions soil aggregates carbon storage

Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling

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Genes & Diseases 2023年第2期10卷 373-376页

作者： Birte Kespohl Roland Hartig yvonne Garbers Juliane Lokau Christoph Garbers Department of Pathology Otto-von-Guericke-UniversityMedical Faculty39120 MagdeburgGermany Health Campus Immunology Infectiology and InflammationOtto-von-Guericke-University39120 MagdeburgGermany Center for Health and Medical Prevention (ChaMP) Otto-von-Guericke-University39120 MagdeburgGermany Institute for Molecular and Clinical Immunology and Service Unit Multiparametric Bioimaging and Cytometry Medical FacultyUniversity of Magdeburg39120 MagdeburgGermany Institute of Communication Management Faculty of ManagementCulture and Technology (Lingen Campus)Osnabrück University of Applied Sciences49809 LingenGermany

Interleukin-11(IL-11)is a member of the IL-6 family of cytokines.1 IL-11 activates its target cells via binding to the IL-11 receptor(IL-11R),which also exists in soluble forms generated by proteolytic cleavage(sIL-11R,required for trans-signaling).2 Formation of the IL-11/IL-11R complex leads to the recruitment and homodimerization of two molecules of the signal-transducingβ-receptor gp130,which then activates intracellular signaling cascades,including the Jak/STAT,PI3K and ERK pathways.

关键词： STAT3 PI3K gp130

Electrospun Poly(Vinylidene Fluoride)/Poly(Methyl Methacrylate)/Cellulose Acetate Nanofiber Membrane Separators for Re-Chargeable Liquid Electrolyte Li-ion Batteries

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Electrospun Poly(Vinylidene Fluoride)/Poly(Methyl Methacryla...

作者： TUSIIMIRE yvonne 东华大学

学位级别：硕士

Optimum electrospinning conditions for PVDF membranes was first *** was carried out by verifying the solution concentrations 10wr%,12wt%,14wt%and 16wt%while varying the electrospinning voltage between 14kV,16kV and 18kV and the spinning distance varied between 16cm,20cm and *** electrospinning rate of 0.8ml/h,solvent mixture acetone:DMAc ratio at 3:7 and atmospheric conditions were kept *** surface morphology was analyzed using the SEM to determine the nanofiber diameter distribution and *** was deduced that uniform fiber production and distribution was at a solution concentration of 12wt%,electrospinning voltage of 16kV at a spinning distance of *** spinning conditions were then used for this *** the optimized conditions,blended polymer membranes were then electrospun at PVDF:PMMA ratios of 100:0,90:10,85:15 and 80:*** tests were analyzed and *** was found out that addition of PMMA led to increase of absorption properties,pore size,mechanical properties and average nanofiber *** was also observed that addition of PMMA led to a decrease in the contact angle to 100°,melting temperature to 159.7℃(80/20 PVDF/PMMA)and crystallinity%to 30.93%(80/20 PVDF/PMMA).These observations were due to the amorphous nature of PMMA and also due to its big side group CH3OCO-.To electrospin CA based membrane,optimizing the mixing solvent was *** was because there were literature proving that with certain ratios of acetone:DMAc,CA was not possible to *** acetone:DMAc ratios were varied as 7:3 and 3:*** two ratios were used to mix and electrospin PVDF:PMMA:CA ratios of 90:0:10 and 90:5:5 *** tests were analyzed and *** was observed that to electrospin relatively uniform nanofiber diameters with better distribution,acetone:DMAc at a ratio of 3:7 was to be *** the verified optimum conditions,blended polymer membranes were electrospun at PVDF:PM

关键词： Electrospinning Poly(vinylidene fluoride)(PVDF) Poly(methyl methacrylate)(PMMA) Cellulose acetate(CA) Li-ion battery separator

Regulation of bile acid receptor activity

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Liver Research 2018年第4期2卷 180-185页

作者： Yu-Jui yvonne Wan Lili Sheng Department of Medical Pathology and Laboratory Medicine University of CaliforniaDavisSacramentoCAUSA

Many receptors can be activated by bile acids(BAs)and their *** include nuclear receptors farnesoid X receptor(FXR),pregnane X receptor(PXR),and vitamin D receptor(VDR),as well as membrane receptors Takeda G protein receptor 5(TGR5),sphingosine-1-phosphate receptor 2(S1PR2),and cholinergic receptor muscarinic 2(CHRM2).All of them are implicated in the development of metabolic and immunological diseases in response to endobiotic and xenobiotic *** epigenetic regulation is critical for organisms to adapt to constant environmental changes,this review article summarizes epigenetic regulation as well as post-transcriptional modification of bile acid *** addition,the focus of this review is on the liver and digestive tract although these receptors may have effects on other *** regulatory mechanisms are implicated in the disease process and critically important in uncovering innovative strategy for prevention and treatment of metabolic and immunological diseases.

关键词： Bile acid receptor Farnesoid X receptor(FXR) G protein-coupled bile acid receptor Takeda G protein receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Acetylation Methylation Glycosylation

Demographic Processes Linked to Genetic Diversity and Positive Selection across a Species’ Range

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Plant Communications 2020年第6期1卷 72-84页

作者： yvonne Willi Marco Fracassetti Olivier Bachmann Josh Van Buskirk Department of Environmental Sciences University of BaselSch€onbeinstrasse 6CH-4056 BaselSwitzerland Department of Evolutionary Biology and Environmental Studies University of Z€urichCH-8057 Z€urichSwitzerland Department of Ecology Environment and Plant SciencesScience for Life LaboratoryStockholm UniversitySE-10691 StockholmSweden

Demography determines the strength of genetic drift,which generally reduces genetic variation and the efficacy of ***,we disentangled the importance of demographic processes at a local scale(census size and mating system)and at a species-range scale(old split between population clusters,recolonization after the last glaciation cycle,and admixture)in determining within-population genomic diversity and genomic signatures of positive *** were based on re-sequence data from 52 populations of North American Arabidopsis lyrata collected across its entire *** mating system and range dynamics since the last glaciation cycle explained around 60%of the variation in genomic diversity among populations and 52%of the variation in the signature of positive *** was lowest in selfing compared with outcrossing populations and in areas further away from glacial *** parallel,reduced positive selectionwas found in selfing populations and in populations with a longer route of postglacial range *** signature of positive selection was also reduced in populations without *** conclude that recent range expansion can have a profound influence on diversity in coding and non-coding DNA,similar in magnitude to the shift toward *** limits may in fact be caused by reduced effective population size and compromised positive selection in recently colonized parts of the range.

关键词： admixture-dependent selection directional selection genetic drift range expansion selfing small population size