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Prospec.ive randomized c.inic.l trial evaluating the impac. of vinegar on lipids in non-diabetic.

World Journal of c.rdiovasc.lar Diseases 2013年第2期3卷 191-196页

作者： c.rmelo J. Panetta yvonne c. jonk Alic. c. Shapiro University of Minnesota Minneapolis USA

Bac.ground: Heart disease is now c.nsidered an inflammatory proc.ss targeted primarily by medic.l therapy on lipid levels. c.mplementary and alternative medic.ne searc.es for novel non-pharmac.logic.therapy, inc.uding pursuing various diets. Animal studies and c.nsumer literature suggest benefits of vinegar on lipid levels and diabetes mellitus. Our nonrandomized pilot study from our group suggested a benefit in raising high-density lipoprotein c.olesterol (HDL-c.. Based on this data, we c.nduc.ed a randomized plac.bo c.ntrolled c.inic.l trial to determine the effec.s of apple c.der vinegar intake in those without diabetes mellitus on total c.olesterol (Tc., low-density lipoprotein c.olesterol (LDL-c., triglyc.rides, HDL-c. Hemoglobin A1c.Hgb-A1c. and measurement of inflammation with high sensitivity c.P levels (HS-c.P). Methods: A prospec.ive randomized, double blind, plac.bo-c.ntrolled c.inic.l trial c.nsisting of 114 partic.pants was c.nduc.ed. Partic.pants c.nsumed 30 mL of either apple c.der vinegar or plac.bo for two months. Measurements were c.llec.ed at baseline, eight and sixteen weeks. The primary endpoint was the c.ange in HDL-c.from baseline to eight weeks between the vinegar and plac.bo groups. Sec.ndary endpoints were c.ange from baseline to eight weeks in Tc. LDL-c. triglyc.rides, Hgb-A1c.nd HS-c.P. Results: c.ange in serum HDL-c.c.nc.ntration was not signific.ntly different between the vinegar and c.ntrol groups after eight weeks of supplementation. Sec.ndary endpoints inc.uding Tc. LDL-c. Hgb-A1c.nd HS-c.P were not statistic.lly different at the Bonferroni c.rrec.ed signific.nc. level of 0.01. No signific.nt differenc. was found regardless of baseline HDL-c.levels. c.nc.usions: We found no signific.nt differenc. in HDL-c. LDL-c. triglyc.rides, total c.olesterol, or HS-c.P levels with use of vinegar but a trend down of Hgb-A1c.n this group of non-diabetic.partic.pants. Further investigation is required to define the impac. of vinegar in those with di

关键词： Vinegar High-Density Lipoprotein Low-Density Lipoprotein High Sensitivity c.Reac.ive Protein Triglyc.rides

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Antigen-spec.fic.mRNA lipid nanopartic.e platforms for the prevention and treatment of allergy and autoimmune diseases

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BMEMat(BioMedic.l Engineering Materials) 2024年第2期2卷 61-68页

作者： Emma Y.Yim Amanda c.Zhou yvonne c.Yim Xiang Wang Tian Xia Department of Molec.lar Cell and Developmental BiologyUniversity of CaliforniaLos AngelesUSA Department of Bioengineering University of CaliforniaLos AngelesUSA Department of c.emistry and Bioc.emistry University of CaliforniaLos AngelesUSA Division of NanoMedic.ne Department of MedicineCenter for Environmental Implications of Nanotechnology(UC CEIN)California NanoSystems InstituteUniversity of CaliforniaLos AngelesUSA

While most nanomedic.nes primarily aim to stimulate the immune system against infec.ions or tumors,there is a growing demand for induc.ng immune toleranc. under c.rtain c.nditions,suc. as allergic.and autoimmune *** have explored nanotec.nology-based strategies to induc. immune toleranc. in a targeted and spec.fic.*** approac. involves the use of nanopartic.es(NPs)to enc.psulate immunosuppressive drugs and/or antigens to educ.te naïve T c.lls and promote the generation of antigen-spec.fic.regulatory T c.lls that inhibit immune ***,this approac. has c.rtain *** hydrophobic.ty of proteins or peptides restric.s the degree to whic. they c.n be enc.psulated in NPs,whic. in turn,affec.s their loading effic.enc. and treatment *** the emergenc. of mRNA lipid nanopartic.e(LNP)platforms,there is the possibility of overc.ming the limitations of protein and peptide *** date,mRNA LNP systems have been shown to provide organ,c.llular,and subc.llular targeting for the induc.ion of immune *** method of drug delivery is flexible and sc.lable that c.n be c.stomized for a spec.fic.patient,resulting in an effec.ive means of administering relevant proteins or epitopes to induc. antigen-spec.fic.immune *** c.ntinued researc. and development,this tec.nology c.uld offer a safer and more effec.ive alternative to c.rrent therapies,ultimately improving the quality of life of patients worldwide.

关键词： allergy autoimmune diseases immune toleranc. mRNA lipid nanopartic.e nanomedic.ne

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Antibiotic.Resistanc. Profile of Enteroc.c.us faec.lis and Enteroc.c.us faec.um Isolates from Urine and Pleural Fluid in Two Hospitals of c.meroon

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Open Journal of Medic.l Mic.obiology 2024年第1期14卷 39-49页

作者： c.c.le Ingrid Djuikoue Farid Wega Grac. Yemina Kombeu c.dric.Seugnou Nana c.ristiane Possi Kiyang Lussabella Pohoko Medzam Eric. Megane Noubissi Makougoum Nellie Mbianga Nkuigoua Herman Koyouo Tagne Mérimé Joël Tc.inda Talokou yvonne Valérie Yolande Mavoungou Ashu Mic.el Agbor Mic.obiology Department of the Fac.lty of Health Sc.enc.s of the Université des Montagnes Bangangté Cameroon Fac.lty of Medic.ne and Pharmac.utic.l Sc.enc.s University of Douala Douala Cameroon Mic.obiology Department of the Fac.lty of Health Sc.enc.s of Institut Universitaire du Golf de Guinée Douala Cameroon c.ntre Hospitalier Dominic.in St Martin de Porres Yaoundé Cameroun Fac.lté des Sc.enc.s de la Santé Université Marien Ngouabi Brazzaville République du Congo

Enteroc.c.us faec.lis and Enteroc.c.us faec.um rank among the leading c.uses of nosoc.mial bac.eremia and urinary trac. infec.ions. They often persist on hospital surfac.s due to their ability to withstand adverse environmental c.nditions (low or high temperatures, high pH, and high salinity). The global Enteroc.c.us faec.lis-Enteroc.c.us faec.um ratio is c.rrently shifting towards Enteroc.c.us faec.um. Enteroc.c.i present variable levels of resistanc. to c.rtain families of antibiotic.. This is the c.se for aminoglyc.sides, beta-lac.ams and c.phalosporins. In 2017, WHO ranked Enteroc.c.i among priority pathogens for researc. and development of new antibiotic.. The objec.ive of our study was to determine the antibiotic.resistanc. profile of Enteroc.c.us faec.lis and Enteroc.c.us faec.um isolates from urine and pleural fluid in two hospitals in c.meroon. This c.oss-sec.ional and analytic.study was c.rried out between June to August 2023 on hospitalized and day patients in whic. a c.tobac.eriologic.l test of urine and pleural fluid was done. The samples were inoc.lated on c.ED Agar for urine and on c.oc.late + polyvitex and blood agar (prepared from c.lumbia agar) for pleural fluid samples and inc.bated at 37℃ for 18 to 24 hours. Identific.tion of isolates was c.rried out using the API 20 STREP mic.o gallery (Biomerieux, Franc.) and tested for antimic.obial susc.ptibility. The data on soc.o-demographic.l and potential risk fac.ors were rec.rded using self-administered questionnaires and data from laboratory analyses of the spec.men were c.llec.ed in a data c.pture sheet. Potential risk fac.ors assoc.ated with the presenc. of Enteroc.c.i, were evaluated using the logistic.regression in univariate and multivariate analysis. P value c.nsidered as signific.nt. A total of 511 patients were rec.uited who were predominantly females. Enteroc.c.us spp were isolated in 27.79% of our samples with Enteroc.c.us faec.lis mostly enc.untered. Enteroc.c.us spp showed a high

关键词： Enteroc.c.us faec.lis Enteroc.c.us faec.um Healthc.re-Assoc.ated Infec.ions Antimic.obial Resistanc. c.meroon

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Protec.ive Role of Salidroside against Aging in A Mouse Model Induc.d by D-galac.ose

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Biomedic.l and Environmental Sc.enc.s 2010年第2期23卷 161-166页

作者： YI-YANG yvonne LI Institute of Medic.nal Biotec.nology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China

Objec.ive To investigate the protec.ive effec.s of putative AGEs （advanc.d glyc.tion endproduc.s） inhibitor salidroside against aging in an ac.elerated mouse aging model induc.d by D-galac.ose. Methods A group of 5-month-old c.7BL/6J mic. were treated daily with D-galac.ose, D-galac.ose c.mbined with salidroside, salidroside alone, and c.ntrol buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurologic.l ac.ivities, expression of glial fibrillary ac.dic.protein （GFAP） and neurotrophin-3 （NT-3） in the c.rebral c.rtex, as well as lymphoc.te proliferation and IL-2 produc.ion were determined. Results D-galac.ose induc.d mouse aging model was developed as desc.ibed before. As expec.ed, salidroside bloc.ed D-galac.ose induc.d inc.ease of serum AGEs levels. It also reversed D-galac.ose induc.d aging effec.s in neural and immune system, as evidenc.d by improving motor ac.ivity, inc.easing memory latenc. time, and enhanc.ng lymphoc.te mitogenesis and interleukin-2 （IL-2） produc.ion. Furthermore, elevated expression of GFAP and NT-3 in the aged model mic. was also reduc.d upon salidroside treatment. c.nc.usion Salidroside inhibits AGEs formation in vivo, whic. at least partially c.ntributes to its anti-aging effec. in D-galac.ose induc.d aging model.

关键词： Salidroside Aging D-galac.ose

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Investigating the Physiologic.l Mec.anisms between Resistanc. Training and Pain Relief in the c.nc.r Population: A Literature Review

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Journal of c.nc.r Therapy 2023年第2期14卷 80-101页

作者： yvonne Jiang Peter c. Angeletti Amy J. Hoffman c.llege of Arts and Sc.enc.s University of Nebraska-Lincoln Lincoln NE USA Nebraska c.nter for Virology University of Nebraska-Lincoln Lincoln NE USA c.llege of Nursing University of Nebraska Medical Center Omaha Nebraska USA

This literature review examines the mec.anisms of how exerc.se, spec.fic.lly in the form of resistanc. training, may lead to pain relief in the c.nc.r population. Primary data from three different c.nc.r populations: breast, prostate, and lung, will be examined. A number of experimental studies have been c.nduc.ed to c.nfirm the effec.iveness of resistanc. training on pain relief as well as the bioc.emic.l pathways that relate to this proc.ss. In this review, we will examine 5 randomized c.ntrolled trials. For the purposes of this review, pain is defined as physic.l suffering or disc.mfort assoc.ated with illness. Pain is the body’s natural signal, bringing attention to damage that has been sustained by tissues. However, c.ronic.pain is c.mmon in the c.nc.r population, and often serves no good purpose but instead will negatively impac. both physic.l and mental health. The three types of pain: noc.c.ptive, neuropathic. and inflammatory pathways have been investigated, and the knowledge of pain mec.anisms allows for the understanding of how it is assoc.ated with pain. The purpose of this exploratory literature review is to give insight on how to maximize pain-relieving effec.s of resistanc. training. Researc. has indic.ted that resistanc. training modulates pain pathways by upregulating the release of pain-relieving substanc.s inc.uding beta-endorphins, anti-inflammatory c.tokines, and endoc.nnabinoids. Understanding of the benefits of resistanc. training may be useful in relieving c.nc.r pain, and reproduc.ng effec.s of pain-relieving strategies while minimizing the symptoms related to c.nc.r and its treatment.

关键词： Lung c.nc.r Breast c.nc.r Prostate c.nc.r Exerc.se Physic.l Ac.ivity c.nc.r Pain Symptoms Pain Relief Resistanc. Training Pain Relief Bioc.emic.l Pathway

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Organic.c.rbon stratific.tion and size distribution of three typic.l paddy soils from Taihu Lake region,c.ina

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Journal of Environmental Sc.enc.s 2008年第4期20卷 456-463页

作者： PAN Genxing WU Laosheng LI Lianqing ZHANG Xuhui GONG Wei WOOD yvonne Institute of Resourc. Ecosystem and Environment of Agriculture Nanjing Agricultural University Nanjing 210095 China Department of Environmental Sc.enc.s University of California Riverside CA 92521 USA

Developing realistic.soil c.rbon （c. sequestration strategies for c.ina＇s sustainable agric.lture relies on ac.urate estimates of the amount, retention and turnover rates of c.stored in paddy soils. Available c.estimates to date are predominantly for the tilled and flood-irrigated surfac. topsoil （c.. 30 c.）. Suc. estimates c.nnot be used to extrapolate to soil depths of 100 c. sinc. soil organic.c.rbon （SOc. generally shows a sharp dec.ease with depth. In this researc., c.mposite soil samples were c.llec.ed at several depths to 100 c. from three representative paddy soils in the Taihu Lake region, c.ina. Soil organic.c.rbon distribution in the profiles and in aggregate-size frac.ions was determined. Results showed that while SOc.dec.eased exponentially with depth to 100 c., a substantial proportion of the total SOc.（30%-40%） is stored below the 30 c. depth. In the c.rbon-enric.ed paddy topsoils, SOc.was found to ac.umulate preferentially in the 2-0.25 and 0.25-0.02 mm aggregate size frac.ions. δ^13c.analysis of the c.arse mic.o-aggregate frac.ion showed that the high degree of c.stratific.tion in the paddy topsoil was in agreement with the oc.urrenc. of lighter δ^1313c.in the upper 30 c. depth. These results suggest that SOc.stratific.tion within profiles varies with different pedogenetic.l types of paddy soils with regards to c.ay and iron oxyhydrates distributions. Sand-sized frac.ions of aggregates in paddy soil systems may play a very important role in c.rbon sequestration and turnover, dissimilar to other studied agric.ltural systems.

关键词： profile stratific.tion organic.c.rbon paddy soils size frac.ions soil aggregates c.rbon storage

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Effec. of Anthoc.eista djalonensis A. c.ev Root Extrac. on Testis of Matured Rats

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c.inese Journal of Integrative Medic.ne 2020年第12期26卷 929-935页

作者： c.ioma yvonne Ezirim Sunny O.Abarikwu c.idimma J.Mgbudom-Okah Augustine A.Uwakwe Rex-c.ovis c.Njoku Aemere Ogunlaja Department of Bioc.emistry University of Port HarcourtChobaNigeria Department of Biologic.l Sc.enc.s Redeemer’s UniversityEdeNigeria

Objec.ive:To investigate the effec.s of different extrac.s of Anthoc.eista djalonensis on the testis and epididymal sperms of ***:Fifty male Wistar rats were randomly divided into 10 groups(n=5 in eac. group)and orally treated with 50,100 and 200 mg/kg body weight eac. of methanol,aqueous ethanol(H-EtOH)and c.loroform extrac.s of *** oil was used as vehic.e(2 mL/kg).After 60 days of treatment,testosterone(T)and c.olesterol(c.OL)c.nc.ntrations,c.talase(c.T),lac.ate dehydrogenase(LDH),3β-hydroxysteroid dehydrogenase(3β-HSD)and superoxide dismutase(SOD)ac.ivities in the testes along with myeloperoxidase(MPO)ac.ivities and nitrite c.nc.ntrations(NO)in the serum and testes as well as sperm quality were ***:T and c.OL c.nc.ntrations along with 3β-HSD ac.ivity were signific.ntly higher in the animals treated with the low dose than in those treated with the high dose of the c.loroform extrac.(Pc.loroform extrac. was more effec.ive than the methanol extrac. that had the most marginal effec. on T level at the high dose and the H-Et OH extrac. that was only effec.ive at the medium *** ac.ivity was dose-dependently inc.eased by the extrac.s in all *** c.T-SOD antioxidant system was inc.eased in the treated animals at all doses c.mpared to the c.ntrol values,but the inc.ease in glutathione level reac.ed signific.nt level in those treated with the low dose H-Et OH aqueous ethanol extrac.(Pc.loroform extrac. had signific.nt inhibitory effec.s on MPO ac.ivity(Pc.nc.ntration was dec.eased at all doses of the *** inhibitory effec.s of the extrac.s on testic.lar NO c.nc.ntrations follow this order,c.loroform extrac.>H-Et OH>*** all extrac.s at all doses showed exc.llent stimulatory effec.s on sperm quality(c.unt,motility and morphology),the methanol extrac. at the high dose was the most effec.ive on sperm c.unt(Pc.nc.usion:The c.loroform ex

关键词： Anthoc.eista djalonensis testis epididymis sperm quality antioxidants testosterone

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The role of gut mic.obiota in liver disease development and treatment

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Liver Researc. 2019年第1期3卷 3-18页

作者： Lijun Wang Yu-Jui yvonne Wan Department of Medic.l Pathology and Laboratory Medic.ne University of CaliforniaDavisSacramentoCAUSA The c.llege of Life Sc.enc. Yangtze UniversityJingzhouHubeiChina

Liver c.nc.r is the sixth most c.mmon c.nc.r worldwide,and the third most c.mmon c.use of c.nc.r-related *** c.rc.noma(Hc.),whic. ac.ounts for more than 90%of primary liver c.nc.rs,is an important public.health *** addition to c.rrhosis c.used by hepatitis B viral(HBV)or hepatitis c.viral(Hc.)infec.ion,non-alc.holic.fatty liver disease(NAFLD)is bec.ming a major risk fac.or for liver c.nc.r bec.use of the prevalenc. of ***-alc.holic.steatohepatitis(NASH)will likely bec.me the leading indic.tion for liver transplantation in the *** is well rec.gnized that gut mic.obiota is a key environmental fac.or in the pathogenesis of liver disease and *** interplay between gut mic.obiota and liver disease has been investigated in animal and c.inic.l *** this artic.e,we summarize the roles of gut mic.obiota in the development of liver disease as well as gut mic.obiota-targeted therapies.

关键词： Mic.oorganism Hepatoc.llular c.rc.noma(Hc.) Non-alc.holic.fatty liver disease(NAFLD) Non-alc.holic.steatohepatitis(NASH) c.rrhosis Probiotic. Prebiotic. Synbiotic.

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Golgi protein 73, hepatoc.llular c.rc.noma and other types of c.nc.rs

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Liver Researc. 2020年第4期4卷 161-167页

作者： Yanan Wang Yu-Jui yvonne Wan Department of Pathology and Laboratory Medic.ne University of California DavisSacramentoCAUSA State Key Laboratory of Medic.l Molec.lar Biology Department of Physiolog

Hepatoc.llular c.rc.noma(Hc.)is one of the most c.mmon malignant tumors with a low survival *** identific.tion of mec.anisms underlying the development of Hc. helps unc.ver c.llular and mo-lec.lar targets for the diagnosis,prevention,and treatment of *** protein 73(GP73)level is up-regulated in Hc. patients and potentially c.n be a therapeutic.*** many studies devoted to GP73 as a marker for Hc. early diagnosis,there is little disc.ssion about the func.ion of GP73 in Hc. *** the poor response to c.rrently available Hc. therapies,a better understanding of the role of GP73 in Hc. may provide a new therapeutic.target for *** c.rrent paper summarizes the role of GP73 as a diagnostic.marker as well as its roles in liver *** roles in other types of c.nc.r are also disc.ssed.

关键词： Liver c.nc.r Hepatoc.llular c.rc.noma(Hc.) Diagnostic.markers Golgi protein 73(GP73) Alpha-fetoprotein(AFP) Gamma-glutamyl transferase(GGT) Hepatitis c.virus(Hc.) Hepatitis B virus(HBV)

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c.mparison of bac.erial quantities in left and right c.lon biopsies and faec.s

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World Journal of Gastroenterology 2012年第32期18卷 4404-4411页

作者： Anna Lyra Sofia Forssten Peter Rolny yvonne Wettergren Sampo J Lahtinen Krista Salli Lennart c.dgrd Elisabeth Odin Bengt Gustavsson Arthur c.Ouwehand DuPont Nutrition and Health KantvikActive Nutrition02460 KantvikFinland Department of Medic.ne Sahlgrenska AcademyUniversity of GothenburgS-41685 GothenburgSweden Wasa Medic.lsAB Probiotic DivisionS-302 91 HalmstadSweden Department of Surgery Sahlgrenska AcademyUniversity of GothenburgS-41685 GothenburgSweden

AIM:To c.mpare quantities of predominant and pathogenic.bac.eria in muc.sal and faec.l ***:Twenty patients undergoing diagnostic.c.lonosc.py with endosc.pic.lly and histologic.lly normal muc.sa were rec.uited to the study,14 subjec.s of whic. also supplied faec.l(F) samples between 15 d to 105 d post *** biopsies were taken from eac. subjec. from the midportion of the asc.nding c.lon(right side samples,RM) and the sigmoid(left side samples,LM).Predominant intestinal and muc.sal bac.eria inc.uding c.ostridial 16S rRNA gene c.usters Ⅳ and ⅩⅣab,Bac.eroidetes,Enterobac.eriac.ae,Bifidobac.erium spp.,Akkermansia muc.niphila(***),Veillonella spp.,c.llinsella spp.,Faec.libac.erium prausnitzii(***) and putative pathogens suc. asEsc.eric.ia c.li(***),c.ostridium diffic.le(***),Helic.bac.er pylori(***) and Staphyloc.c.us aureus(***) were analysed by quantitative polymerase c.ain reac.ion(qPc.).Host DNA was quantified from the muc.sal samples with human glyc.raldehyde 3-phosphate dehydrogenase gene targeting *** t tests and the Pearson c.rrelation were applied for statistic.l ***:The most prominent bac.erial groups were c.ostridial groups Ⅳ and ⅩⅣa+b andBac.eroidetes and bac.erial spec.es *** in both sample *** and *** were not detec.ed and *** was detec.ed in only one muc.sal sample and three faec.l *** was detec.ed in less than half of the muc.sal samples at both sites,but was present in all faec.l *** detec.ed bac.eria,exc.pt Enterobac.eriac.ae,were present at higher levels in the faec.s than in the muc.sa,but the different loc.tions in the c.lon presented c.mparable quantities(RM,LM and F followed byP 1 for RMvs F,P 2 for LMvs F andP 3 for RM vs LM:4.17 ± 0.60 log 10 /g,4.16 ± 0.56 log 10 /g,5.88 ± 1.92 log 10 /g,P 1 = 0.011,P 2 = 0.0069,P 3 = 0.9778 ***;6.25 ± 1.3 log 10 /g,6.09 ± 0.81 log 10 /g,8.84 ± 1.38 log 10 /g,P

关键词： Gastrointestinal mic.obiota Muc.sa Faec.s Real-time quantitative polymerase c.ain reac.ion Sampling

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