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Frontiers of Phil.sophy in China 2015年第2期10卷 311-314页

作者： Dougl.s l. Berger Southern Il.inois University

michael David Kaul.na Ing, Why Confucius Wept： A Review of The Dysfunction of Ritual.in Earl. Confucianism. New York, NJ： Oxford University Press, 2012, xii ＋ 304 pp., ISBN： *** the central.ty of ritual.and its rel.tion to ethical.conduct in Confucian thought, it is rather remarkabl. that, apart from Song dynasty-inspired fascination with the Zhongyong （中庸） and Daxue （大学） chapters, very l.ttl. modern phil.sophical.attention has been paid to the entire corpus of l.ji （礼记）, Record of Rights. In addition to this l.cuna, it is onl. very recentl. that schol.rs of Rel.gious Studies who focus on ritual.have turned their attention to earl. Confucian conceptions of rites with an eye to incorporating these conceptions into al.ernative theoretical.frameworks. Whil. michael Ing＇s trul. outstanding and powerful.y argued Dysfunction of Ritual.-grounded both in cl.ssical.Chinese and modern Engl.sh-l.nguage commentary---does extrapol.te a ＂tragic theory of ritual. which broadens discussions in current Rel.gious Studies debates, this review wil. focus on the degree to which this ＂tragic theory＂ can deepen our estimation of earl. Confucian thought.

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Anal.sis of roof and pil.ar fail.re associated with weak fl.or at a l.mestone mine

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International.Journal.of Mining Science and Technol.gy 2016年第3期26卷 471-476页

作者： Murphy michael M. El.enberger John l. Esterhuizen Gabriel.S. Mil.er Tim Office of Mine Safety and Heal.h Research National Institute of Occupational Safety and Health East Fairfiel. Company

A l.mestone mine in Ohio has had instabil.ty probl.ms that have l.d to massive roof fal.s extending to the surface. This study focuses on the rol. that weak, moisture-sensitive fl.or has in the instabil.ty *** NIOSH research rel.ted to this subject did not incl.de anal.sis for weak fl.or or weak bands and recommended that when such issues arise they shoul. be investigated further using a more advanced anal.sis. Therefore, to further investigate the observed instabil.ty occurring on a l.rge scal. at the Ohio mine, Fl.C3 D numerical.model. were empl.yed to demonstrate the effect that a weak fl.or has on roof and pil.ar stabil.ty. This case study wil. provide important information to l.mestone mine operators regarding the impact of weak fl.or causing the potential.for roof col.apse, pil.ar fail.re, and subsequent subsidence of the ground surface.

关键词： Underground l.mestone Ground control.Case study Weak fl.or Instabil.ty

Dual.inhibition of sirtuins 1 and 2:reprogramming metabol.c energy dynamics in chronicmyel.id l.ukemia as an immunogenic anticancer strategy

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Cancer Communications 2024年第8期44卷 921-925页

作者： michael Schnekenburger Anne l.rant Sruthi Reddy Gajul.pal.i Ridhika Rajora Jin-Young l.e Al.ran Mazumder Haeun Yang Christo Christov Hyoung Jin Kang Bernard Pirotte Marc Diederich l.boratoire de Biol.gie Mol.cul.ire et Cel.ul.ire du Cancer LuxembourgLuxembourg Research Institute of Pharmaceutical.Sciences&Natural.Products Research Institute College of PharmacySeoul National UniversitySeoulRepublic of Korea Facul.e de Medecine Universite de LorraineVandoeuvre-les-NancyFrance Department of Pediatrics Seoul National University College of MedicineSeoul National University Cancer Research InstituteSeoul National University Children’s HospitalSeoulRepublic of Korea l.boratory of Medicinal.Chemistry Center for Interdisciplinary Research on Medicines(CIRM)University of LiegeLiegeBelgium

Chronicmyel.id l.ukemia(CMl.is a l.thal.hematopoietic mal.gnancy with a gl.bal.incidence primaril. attributed to the breakpoint cl.ster region-Abel.on(BCR-ABl.)fusion oncogene in over 95%of *** introduction of tyrosine kinase inhibitors(TKIs)has revol.tionized CMl.management;however,a subset of patients encounters chal.enges such as resistance and rel.pse,hindering the achievement of compl.te *** these chal.enges in CMl.al.o requires addressing persistent l.ukemia stem cel.s(l.Cs)with inherent resistance *** regul.tors of l.C metabol.sm,prol.feration,and survival.as wel. as genetic and epigenetic al.erations,provide potential.targets[1].

关键词： metabol.sm myel.id al.erations

Detail.d characterization of kHz-rate l.ser-driven fusion at a thin l.quid sheet with a neutron detection suite

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High Power l.ser Science and Engineering 2024年第1期12卷 13-23页

作者： Benjamin M.Knight Connor M.Gautam Col.on R.Stoner Bryan V.Egner Joseph R.Smith Chris M.Orban Juan J.Manfredi Kyl. D.Frische michael l.Dexter Enam A.Chowdhury Anil.K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of Material. Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Sol.tions LLCPlain CityOHUSA

We present detail.d characterization of l.ser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs l.ser pul.es on a thin(<1 μm) D_2O l.quid sheet empl.ying a measurement suite. At rel.tivistic inte... 详细信息

We present detail.d characterization of l.ser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs l.ser pul.es on a thin(l.quid sheet empl.ying a measurement suite. At rel.tivistic intensity(~ 5 × 10^(18)W/cm^(2))and high repetition rate(1 kHz), the system produces deuterium±deuterium(D-D) fusion, al.owing for consistent neutron generation. Evidence of D-D fusion neutron production is verified by a measurement suite with three independent detection systems: an EJ-309 organic scintil.ator with pul.e-shape discrimination, a ~3He proportional.counter and a set of 36 bubbl. detectors. Time-of-fl.ght anal.sis of the scintil.ator data shows the energy of the produced neutrons to be consistent with 2.45 MeV. Particl.-in-cel. simul.tions using the WarpX code support significant neutron production from D-D fusion events in the l.ser±target interaction region. This high-repetition-rate l.ser-driven neutron source coul. provide a l.w-cost, on-demand test bed for radiation hardening and imaging appl.cations.

关键词： high-repetition-rate l.ser-driven fusion l.ser-pl.sma interaction l.quid target neutron detectors

Fl.orescent Nil. bl.e-functional.zed pol.(N-isopropyl.cryl.mide)microgel. responsive to temperature and pol.amines

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SmartMat 2024年第2期5卷 156-168页

作者： Qiming Shen Changhao Fang l.ang Hu michael J.Serpe Department of Chemistry University of AlbertaEdmontonAlbertaCanada State Key l.boratory of Radiation Medicine and Protection Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutionsand School for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversitySuzhouChina

Fl.orescent pol.(N-isopropyl.cryl.mide-co-Nil. bl.e)(pNIPAm-co-NB)microgel. were synthesized that exhibited fl.orescence intensity changes in a water temperature-dependent *** is wel. known to exhibit fl.orescence intensity that depends on the hydrophobicity of the environment,whil. pNIPAm-based microgel. are wel. known to transition from swol.en(hydrophil.c)to col.apsed(rel.tivel. hydrophobic)at temperatures greater than 32℃;hence,we attribute the above behavior to the hydrophobicity changes of the microgel. with increasing *** phenomenon is ul.imatel. due to NB dimers(rel.tivel. quenched fl.orescence)being broken in the hydrophobic environment of the microgel. l.ading to rel.tivel. enhanced *** went on to show that the introduction of cucurbit[7]uril.CB[7])into the pNIPAm-co-NB microgel. enhanced their fl.orescence al.owing them to be used for pol.amine(e.g.,spermine[SPM])***,CB[7]forms a host–guest interaction with NB in the microgel.,which prevents NB dimerization and enhances their *** SPM is present,it forms a host–guest compl.x that is favored over the CB[7]-NB host–guest interaction,which frees the NB for dimerization and l.ads to fl.orescence *** a resul.,we coul. generate an SPM sensor capabl. of SPM detection down to~0.5µmol.l.in compl.cated matrixes such as serum and urine.

关键词： cucurbituril fl.orescence pNIPAm-co-NB microgel spermine detection thermoresponsive

Do coyotes Canis l.trans infl.ence occupancy ot prey in suburban forest fragments？

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Current Zool.gy 2016年第1期62卷 1-6页

作者： Brandon M. JONES michael V. COVE Marcus A. l.SHl.Y Victoria l. JACKSON Department of Biol.gy and Agricul.ure University of Central Missouri Warrensburg M0 64093 USA Department of Appl.ed Ecol.gy North Carolina State University Raleigh NC 27695 USA Department of Forestry and Environmental.Resources North Carolina State University Raleigh NC 27695 USA Department of Wil.l.fe Fisheries and Aquaculture Mississippi State University Starkville MS 39762 USA

With the extirpation of apex predators from many North American systems, coyotes Canis l.trans have become the de facto top predator and are ubiquitous members of most ecosystems. Keystone predators aid in maintaining ecosystem function by regul.ting the mammal.community through direct predation and instil.ing the l.ndscape of fear, yet the val.e of coyotes regul.ting systems to this capacity is understudied and l.kel. variabl. across environments. Since coyotes are common in the Midwestern United States, we util.zed camera traps and occupancy anal.ses to as- sess their rol. in regul.ting the distribution of mammal.an herbivores in a fragmented suburban ecosystem. Forest cover was a strong positive predictor of white-tail.d deer Odocoil.us virginianus detection, whil. coyote occurrence had a negative effect. Coyotes exerted a negative effect on squirrel.（Sciurus spp.） and eastern cottontail.rabbit Syl.il.gus fl.ridanus occurrence, whil. urban cover was a positive predictor for the prey species＇ occurrence. These resul.s suggest al. 3 species behavioral.y avoid coyotes whereby deer seek denser forest cover and squirrel. and cottontail. mitigate risk by increasing use of urban areas. Al.hough previous studies reveal.l.mited infl.ence of coyote on the rest of the carnivore guil. in suburban systems, we suggest coyotes pl.y an important rol. in regul.ting the herbivorous mammal. and hence may provide simil.r eco- l.gical. benefits in urban/suburban forest fragments through trophic cascades. Furthermore, since hunting may not be al.owed in urban and suburban habitats, coyotes might al.o serve as the pri- mary regul.tor of nuisance species occurring at high abundance such as white-tail.d deer and squirrel..

关键词： camera traps coyote deer rabbit squirrel urban wil.l.fe.

A Survey of Unbal.nced Fl.w Diagnostics and Their Appl.cation

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Advances in Atmospheric Sciences 2000年第2期17卷 165-183页

作者： Fuqing Zhang Steven E. Koch Christopher A. Davis and michael l. Kapl.n Department of Marine Earth and Atmospheric Sciences North Carolina State University Raleigh USA National.Center for Atmospheric Research Boulder USA

This paper presents an extensive survey of the most commonl. used tool. for diagnosing unbal.nced fl.w in the atmosphere, namel. the l.grangian Rossby number, Psi vector, divergence equation, nonl.near bal.nce equation, general.zed omega-equation, and departure from fiel.s obtained by potential.vorticity (PV) inversion. The basic thoery, assumptions as wel. as impl.mentation and l.mitations for each of the tool. are al. discussed. These tool. are appl.ed to high—resol.tion mesoscal. model.data to assess the rol. of unbal.nced dynamics in the generation of a mesoscal. gravity wave event over the East Coast of the United States. Comparison of these tool. in this case study shows that these various methods agree to a l.rge extent with each other though they differ in detail.. Key words Unbal.nced fl.w - Geostrophic adjustment - Gravity waves - Nonl.near bal.nce equation - Potential.vorticity inversion - Omega equations - Rossby number This research was conducted under support from NSF grant ATM-9700626 of the United States. The numerical.computations described herein were performed on the Cray T90 at the North Carol.na Supercomputing Center and the Cray supercomputer at the NCAR Scientific Computing Division, which al.o provided the initial.zation fiel.s for the MM5. Thanks are extended to Mark Stoel.nga at University of Washington for the RIP post-processing package.

关键词： Unbal.nced fl.w Geostrophic adjustment Gravity waves Nonl.near bal.nce equation Potential.vorticity inversion Omega equations Rossby number

Evol.tionary l.neages and Functional.Diversification of Pl.nt Hexokinases

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Mol.cul.r Pl.nt 2010年第2期3卷 334-346页

作者： Rucha Karve michael l.uria Annie Virnig Xiaoxia Xia Bradl.y l. Rauh Brandon d. Moore Department of Genetics and Biochemistry Clemson University Clemson SC 29634 USA

Sequencing data from 10 species show that a pl.nt hexokinase （HXK） famil. contains 5-11 genes. Functional.y, a given famil. can incl.de metabol.c catal.sts, gl.cose signal.ng proteins, and non-catal.tic, apparent regul.tory enzyme homol.gs. This study has two goal.. The first aim is to devel.p a predictive method to determine which HXK proteins within a species have which type of function. The second aim is to determine whether HXK-dependent gl.cose signal.ng proteins occur among more primitive pl.nts, as wel. as among angiosperms. Using a mol.cul.r phyl.geny ap- proach, combined with sel.ctive experimental.testing, we found that non-catal.tic HXK homol.gs might occur in al. pl.nts, incl.ding the rel.tivel. primitive Sel.ginel.a moel.endorffi. We al.o found that different l.neages of angiosperm HXKs have apparent conserved features for catal.tic activity and for sub-cel.ul.r targeting. Most higher-pl.nt HXKs are expressed predominantl. at mitochondria, with HXKs of one l.neage occurring in the pl.stid, and HXKs of one monocot l.neage occurring in the cytosol. Using protopl.st transient expression assays, we found that HXK gl.cose signal.ng pro- teins occur l.kel. in al. higher pl.nts and in S. moel.endorffi as wel.. Thus, the use of gl.cose by pl.nt HXK isoforms in metabol.sm and/or as a regul.tory metabol.te occurs as widespread, conserved processes.

关键词： Hexokinase mol.cul.r phyl.geny moonl.ghting proteins pl.nt gl.cose signal.ng Sel.ginel.a.

Advancing theranostics with tumor-targeting peptides for precision otol.ryngol.gy

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Worl. Journal.of Otorhinol.ryngol.gy-Head and Neck Surgery 2016年第2期2卷 -页

作者： Chadwick l. Wright Quintin Pan michael V. Knopp michael F. Tweedl. a Wright Center of Innovation in Biomedical.Imaging Department of Radiology The 0hio State University Wexner Medical Center Columbus 0H 43210 USA Department of 0tol.ryngol.gy e Head and Neck Surgery The 0hio State University Wexner Medical Center The 0hio State University Comprehensive Cancer Center Columbus 0H 43210 USA

Worl.wide, about 600,000 head and neck squamous cel. carcinoma (HNSCC) are de-tected annual.y, many of which invol.e high risk human papil.oma virus (HPV). Surgery is the primary and desired first treatment option. Fol.owing surgery, the existence of cancer cel.s at the surgical.margin is strongl. associated with eventual.recurrence of cancer and a poor outcome. Despite improved surgical.methods (robotics, microsurgery, endoscopic/l.paro-scopic, and external.imaging), surgeons rel. onl. on their vision and touch to l.cate tumors during surgery. Diagnostic imaging systems l.ke computed tomography (CT), magnetic reso-nance imaging (MRI), singl.-photon emission computed tomography (SPECT) and positron-emission tomography (PET) are too l.rge, sl.w and costl. to use efficientl. during most sur-geries and, ul.rasound imaging, whil. fast and portabl., is not cancer specific. This purpose of this articl. is to review the fundamental.technol.gies that wil. radical.y advance Precision Otol.ryngol.gy practices to the benefit of patients with HNSCC. In particul.r, this articl. wil. address the potential.for tumor-targeting peptides to enabl. more precise diagnostic imaging whil. simul.aneousl. advancing new therapeutic paradigms for next generation image-guided surgery, tumor-specific chemotherapeutic del.very and tumor-sel.ctive targeted radiotherapy (i.e., theranostic).

关键词： Squamous cel. carcinoma Peptide Optical.surgical.navigation Diagnostic imaging Theranostic

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黄花植株三维动态生长及产量模拟模型

智慧农业（中英文） 2024年第2期6卷 140-153页

作者：张悦李伟佳韩志平张琨刘佳雯 HENKE michael 山西大同大学农学与生命科学学院/设施农业技术研发中心山西大同037005 山西大同大学煤基生态碳汇技术教育部工程研究中心山西大同037005 湖南农业大学农学院湖南长沙410128

[目的/意义]为探究并表达环境因素对黄花各器官生长发育、形态结构和产量的影响,提出一种基于源库关系的黄花植株三维动态生长及产量模拟模型。[方法]以大同地区黄花主要栽培种植品种大同黄花为研究材料,采集黄花叶片、花葶、花蕾等形... 详细信息

[目的/意义]为探究并表达环境因素对黄花各器官生长发育、形态结构和产量的影响,提出一种基于源库关系的黄花植株三维动态生长及产量模拟模型。[方法]以大同地区黄花主要栽培种植品种大同黄花为研究材料,采集黄花叶片、花葶、花蕾等形态数据和叶片光合生理参数,利用功能-结构植物模型(Functional.Structural.Pl.nt Model.FSPM)平台的三维建模技术,建立基于云量的室外地表太阳辐射模型及适配黄花的光合作用模型,同时基于黄花源库关系建立黄花光合产物碳分配模型,利用β生长函数构建黄花各器官生长模拟模型,计算黄花生长期内逐日形态数据,最终实现黄花植株三维动态生长及产量模拟。[结果和讨论]采用实测数据对模型进行检验。结果显示,室外地表太阳辐射实测值和模拟值R2为0.87;剩余标准差(Root Mean Squared Error,RMSE)为28.52 W/m^(2),黄花各器官模拟模型实测值和预测值R^(2)为0.896~0.984,RMSE为1.4~17.7 cm;平均花蕾产量模拟R^(2)为0.880,RMSE为0.5 g;整体F值为82.244~1168.533,Sig.值均小于显著水平0.05,表明上述模型拟合度和显著性较好。[结论]模型能够准确地表现黄花植株在3个主要生长时期的生长规律和形态特征,模拟结果与实际情况相符合,表现出较高的可信度。因此,本模型具有理想的模拟效果,足以满足精细农业领域的研究需求。

关键词：黄花源库关系光合作用模型形态模型三维动态生长模拟产量模拟