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Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting

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World Journal of Gastroenterology 2006年第48期12卷 7779-7785页

作者： Robert A Enns yves m gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group Division of Gastroenterology University of British Columbia Vancouver Canada Occam Research & Consulting Inc. VancouverCanada Department of medicine Division of Gastroenterology McGill University and the McGill UniversityHealth Center Montreal Canada Division of Gastroenterology McMaster University Medical Centre Hamilton Canada Division of Gastroenterology University of Western Ontario London Canada Division of Gastroenterology University of Alberta Edmonton Canada 不详

AIm: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. mETHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures.

关键词： Upper gastrointestinal bleeding Nonvariceal Predictors Rockall Outcomes

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Vortex　Simulation　of　Axisymmetrical　Flows　in　Cylindrical　***：Application　to　Pipes　Incorporating　an　Orifice　Plate

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Journal of Thermal Science 1995年第4期4卷 221-228页

作者： André Giovannini yves gagnon Université Paul Sabatier and Centre d’études et de recherches de Toulouse Toulouse France Université de moncton Campus d’Edmundston Edmundston Canada

The Random Vortex method extended to an azisymmetrical flow is used in the study of the flow field inside pipes incorporating an orifice plate with different contraction ratios and different inlet velocity profiles. Three test-cases, each having experimental measurements available in the literature, are studied. In particular, instantaneous and average velocity fields along with the turbulent statistics for high Reynolds number flows are computed and compared to the corresponding experimental *** comparisons show the ability and the citations of the method. The results of the numerical simulations are used in the physical analysis of the flow fields and thus allow for a better understanding of the dynamics of the flow in pipes incorporating an orifice plate.

关键词： orifice plate axisymmetrical flows vorticity.

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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin yves Rolland Annelise Genoux Guillaume Combes mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.martinez Philipe de Souto Barreto For the mAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine mitochondria

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Structure of Channel Flows with Surface mounted Ribs

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Journal of Thermal Science 2004年第3期13卷 213-219页

作者： Gérard J. POITRAS Laurent-Emmanuel BRIZZI yves gagnon Université de moncton Moncton (NB) CanadaLaboratoire d'études aérodynamiques Université de Poitiers 86960 Futuroscope FranceUniversité de Moncton Edmundston (NB) Canada

The flow inside a channel with surface mounted ribs is studied by numerical simulation and experimental flow visualization. Both the geometry with one rib and the geometry with two ribs, placed perpendicular to the flow, are studied, with particular emphasis on the effect of the variation of the distance between the ribs on the structure of the flow. Results show that, for Reynolds number flows of 400 and 1000 (based on the uniform incoming velocity and the height of the ribs), the flow reattaches between the ribs when they are separated by distances of 12h (h being the height of the ribs) and 6h, respectively. In this respect, however, the numerical results for the Reynolds number flow of 1000 are in contradiction with published results.

关键词： vortex methods flow visualization channel flows ribs.

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Numerical　Simulation　of　the　Flow　over　a　model　of　the　Cavities　on　a　Butterfly　Wing

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Journal of Thermal Science 1995年第3期4卷 185-192页

作者： Rodrigue Savoie yves gagnon (University de moncton, Campus d’Edmundston, Edmundston (NB) Canada) Université de moncton Campus d’Edmundston Edmundston Canada

The objective of this paper is to present results of numerical simulations for the flow over cavities modeling the scale structures on the upper surface of a typical butterfly wing. The numerical results,obtained using a vortex method, show that the dynamics of the flow are strongly dependent on the Reynolds number of the flow. The large coherent structures, formed in the cavity of adjoining scales, exhibit a stationary behaviour for low Reynolds number flows, while they exhibit strong dynamics and instabilities for high Reynolds number flows. The numerical results are in very good agreement with corresponding experimental results available in the literature.

关键词： vortex methods vorticity cavity butterfly.

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On the Improvement of Wind Power Predictions Based on Terrain Characteristics and measurements of the Annual Energy Production

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Journal of Flow Control, measurement & Visualization 2017年第1期5卷 1-20页

作者： Jonathan Dorval Christian masson yves gagnon Department of mechanical Engineering &EACUTE cole de technologie supê rieure Montreal Canada Department of Sciences Universit&ecirc de moncton Edmundston Canada

The assessment of the production capacity of wind farms is a crucial step in wind farm design processes, where a poor assessment can cause significant economic losses. Data from Canadian wind farms benefiting from national production incentive programs show that wind farms are typically characterized by an overestimation of the production capacity. In this context, a study has been done to provide insight on the origin of the discrepancies between the energy production estimates and the measured energy generation, and to develop a method to reduce these discrepancies. To this end, the WAsP and mS-micro models have been studied. Besides the wind speed measurements, topography indices have been developed to identify the influence of the various characteristics of the site on the error in the annual energy production (AEP). In addition, roughness classes have been created, including a reference roughness and a roughness complexity. The indices have also allowed establishing correlations and developing equations to evaluate the error based on the site characteristics and the positions of wind turbines on the measured annual energy production. An average reduction of up to 83% on the AEP errors was obtained when the methodology was applied to five wind farms in Canada.

关键词： Wind Energy Wind Farm Assessment WAsP mS-micro Roughness Classes Roughness Complexity

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Singular perturbation analysis of a two-site model for an epidemic in age-structured population

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International Journal of Biomathematics 2018年第7期11卷 83-107页

作者： Rodrigue yves m'pika massoukou Hermane mambili-mamboundou School of mathematics Statistics and Computer Science University of KwaZulu-Natal145 King Edward Avenue PietermaritzburgKwaZulu-Natal 3209/ScottsvilleSouth Africa School of mathematical and Statistical Sciences North-West University Mafikeng Campus Unit 5 Corner of Albert Luthuli and University Drive Mmabatho2735South Africa

We formulate a model describing the dynamics for the spatial propagation of an SIS epidemic within a population,with age structure,living in an environment divided into two *** analysis of the model is *** prove the existence of a unique disease free equilibrium (DFE)and its (local and global)***,we assume that fast infection processes and fast migration processes take place in the above-mentioned model;*** processes last only a few days (less than a week).In opposition to such processes,demographic processes such as birth,death and maturation last quite a lot of *** a gap between the time scales gives rise to a multiple time scales model,in particular a singularly perturbed *** a singular perturbation analysis,based on Tikhonov theorem,we prove that for certain classes of initial conditions the nonlinear perturbed model can be approximated with very good accuracy by lower-dimensional linear models.

关键词： SIS epidemic model age structured population spatial dynamics multiple time scales slow-fast system dynamical system Tikhonov theorem

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Spatio-temporal Variability of Northern Hemipheric Sea Level Pressure(SLP)and Precipitation over the mid-to-Low Reaches of the Yangtze River

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Advances in Atmospheric Sciences 2008年第3期25卷 458-466页

作者：韩雪魏凤英 yves m.TOURRE 董文杰 Institute of Atmospheric Physics Chinese Academy of Sciences State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081 mEDIAS-France Toulouse State Key Laboratory for Earth Surface Processes and Resource Ecology Beijing Normal University100875

The spatio-temporal variability of Northern Hemisphere Sea Level Pressure （SLP） and precipitation over the mid-to-low reaches of the Yangtze River （PmLY） is analyzed jointly using the multi-taper/singular value decomposition method （mTm-SVD）. Statistically significant narrow frequency bands are obtained from the local fractional variance （LFV） spectrum. Significant interdecadal （i.e., 16-to-18-year periods） and interannual （i.e., 3-to-6-year periods） signals are identified. moreover, a significant quasi-biennial signal is identified but only for PmLY data. The spatial joint evolution of patterns obtained for peaks in the LFV spectrum sheds light on relationships between SLP and PmLY： the Arctic Oscillation （AO） modulates the variability of the PmLY while the interannual variability of PmLY is in phase with the Northern Atlantic Oscillation （NAO） and the Northern Pacific Oscillation （NPO）.

关键词： mTm-SVD coupled spatio-temporal characteristics

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Dairy sheep production research at the University of Wisconsin-madison,USA-a review

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Journal of Animal Science and Biotechnology 2014年第2期5卷 127-138页

作者： David L Thomas yves m Berger Brett C mcKusick Claire m mikolayunas University of Wisconsin-madison Department of Animal Sciences Spooner Agricultural Research Station Current address:merial Ltd midwest Organic Services Association ViroquaWisconsinUSA

Commercial milking of sheep is a new agricultural industry in the United States starting approximately 30 yr ago. The industry is still small, but it is growing. The majority of the sheep milk is used in the production of specialty cheeses. The United States is the major importer of sheep milk cheeses with 50 to 60% of annual world exports coming to the United States during the past 20 yr. Therefore, there is considerable growth potential for the industry in the United States. The only dairy sheep research flock in North America is located at the Spooner Agricultural Research Station of the University of Wisconsin-madison. The research program started in 1993 and has been multifaceted; dealing with several areas important to commercial dairy sheep farmers. The East Friesian and Lacaune dairy breeds were compared and introduced to the industry through the research program. Both dairy breeds produced significantly more milk than traditional meat-wool breeds found in the U.S., but the two breeds differed in their production traits. East Friesian-cross ewes produced more lambs and slightly more milk than Lacaune-cross ewes whereas Lacaune-cross ewes produced milk with a higher percentage of fat and protein than East Friesian-cross ewes. Lactation physiology studies have shown that ewes with active corpora lutea have increased milk yields, oxytocin release during milking is required to obtain normal fat percentages in the milk, large udder cisterns of dairy ewes can allow for increased milking intervals, and short daylengths during late pregnancy results in increased milk yield. In the nutrition area, legume-grass pastures and forages with a higher percentage of legume will result in increased milk production. Grazing ewes respond to additional supplementation with increased milk yield, but it is important to match the supplement to the quality of the grazing. Ewes on high quality legume-grass pastures that are high in rumen degradable protein respond with increased milk

关键词： Dairy sheep East Friesian Grazing Lacaune Lactation physiology Nitrogen efficiency RDP RUP Supplementation

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Direct Ni Electroless metallization of Poly(etherimide) without Using Palladium as a Catalyst

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材料热处理学报 2004年第5B期25卷 1106-1111页

作者： marlène Charbonnier maurice Romand yves Goepfert Laboratoire de Sciences et Ingenierie des Surfaces Universite Claude Bernard - Lyon 1 69622 Villeurbanne Cedex FranceLaboratoire de Sciences et Ingenierie des Surfaces Universite Claude Bernard - Lyon 1 69622 Villeurbanne Cedex FranceUMR 5180 des Sciences Analytiques Universite Claude Bernard - Lyon 1 69622 Villeurbanne Cedex France

Nickel or copper electroless metallization of polymers needs the grafting of a catalyst (palladium in the Pd(0) oxidation state) on the substrate surface to be coated. Our previous works on this topic [1-5] have allowed to develop a simple, tin-free method to attach Pd(+2) species from a palladium chloride (PdCl2) solution on any insulating surface and subsequently to reduce them, in the wet way, into the Pd(0) oxidation state. This Pd(0) state of the catalyst allows an instantaneous initiation of the Ni or Cu deposit by immersion in a plating bath. As palladium is an expensive chemical, it appears interesting to replace it by Ni(0) or Cu(0) species which are catalysts of their own ion reduction. Concerning the direct Ni electroless plating, the polymer surface (PI) was made catalytic for the electroless process by deposition (spin- coating or dipping) of an ultra-thin film of an organic nickel salt in an alcoholic solution. The chemical reduction of this salt, checked by XPS, was performed by chemical or photochemical ways and by plasma. Under these conditions, the initiation, by autocatalysis, of the Ni film deposition in an industrial plating bath was immediate i.e. without any initiation time. The film obtained was homogeneous, dense, bright, well-adhering up to thicknesses reaching

关键词：镍非电金属喷镀等离子处理 XPS 聚酰亚胺

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