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Plasma transthyretin is a nutritional biomarker in human morbidities

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Frontiers of Medicine 2022年第4期16卷 540-550页

作者： yves Ingenbleek Faculty of Pharmacy Laboratory of NutritionUniversity of StrasbourgRoute du RhinIllkirch–Graffenstaden F-67401(Strasbourg)France

Transthyretin(TTR)is a small liver-secreted plasma protein that shows close correlations with changes in lean body mass(LBM)during the entire human lifespan and agglomerates the bulk of nitrogen(N)-containing substrates,hence constituting the cornerstone of body *** acids(AAs)dietary restriction causes inhibition of TTR production and impairs the accretion of LBM *** disorders result in cytokine-induced abrogation of TTR synthesis and urinary leakage of nitrogenous *** together,the data indicate that malnutrition and inflammation may similarly suppress the production of TTR through distinct and unrelated pathophysiological mechanisms while operating in concert to downsize LBM *** hepatic synthesis of TTR integrates both machineries,acting as a marker of reduced LBM resources still available for defense and repair *** operates as a universal surrogate analyte that allows for the grading of residual LBM capacity to reflect disease *** of TTR is a simple,rapid,and inexpensive micromethod that may be reproduced on a daily basis,hence ideally suited for the follow-up of the most intricated clinical situations and as a reliable predictor of any morbidity outcome.

关键词： lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis

Overall Thermodynamic Model of an Ultra Micro Turbine

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Journal of Thermal Science 2004年第4期13卷 297-301页

作者： yves RIBAUD ONERA DEFA 29 Avenue de la Division Leclerc 92 CHATILLON France

The overall thermodynamic model of an ultra micro turbine engine has been established and applied in different situations in this tiny engine where heat transfer is dominant. The aerothermal conditions of the flow were calculated and analyzed. A corresponding calculation software (hot button software) was developed. The first results show that the non-adiabatic operation of the turbomachines leads to a strong penalty in performances. The dramatic influence of the compressor and turbine efficiency is confirmed in a non-adiabatic operation. A better knowledge of heat transfer coefficients at low Reynolds numbers in different components of the micro turbine has to be obtained to refine the results of this study.

关键词： micro energy micro engines micro turbine micro propulsion micro turbine thermodynamic model MEMS

On the Multi-Dimensional Duality Principle of Sawyer Type

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Acta Mathematica Sinica,English Series 2001年第1期17卷 81-88页

作者： yves RAKOTONDRATSIMBA Institut Polytechnique St-Louis EPMI 13 boulevard de l'Hautil 95 092 Cergy-Pontoise cedex France

A multi-dimensional version of the duality principle of Sawyer type [1] is obtained whenever the corresponding weight satisfies some doubling property.

关键词： Multi--dimensional duality principle Doubling weights Weighted inequalities Decreasing functions

Three Problems on Trigonometric Sums

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Acta Mathematica Sinica,English Series 2019年第6期35卷 721-727页

作者： yves MEYER CMLA ENS Paris-Saclay

Let Λ ? R^n be a uniformly discrete set and let C_Λ be the vector space consisting of all mean periodic functions whose spectrum is simple and contained in Λ. If Λ is a gentle set then for every f ∈ C_Λ we have f(x) = O(ω_Λ(x)) as |x| →∞ and ω_Λ(x) can be estimated(Theorem 4.1). This line of research was proposed by Jean-Pierre Kahane in 1957.

关键词： Mean periodic functions almost periodic functions trigonometric sums

Effect of vertical electromagnetic stirring on solute distribution in billet continuous casting process

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Journal of Iron and Steel Research International 2022年第1期29卷 132-143页

作者： Tao Wang En-gang Wang yves Delannoy yves Fautrelle Olga Budenkova Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang 110004LiaoningChina CNRS Grenoble INPSIMAPUniversité Grenoble AlpesGrenoble 38000France School of Metallurgy Northeastern UniversityShenyang 110004LiaoningChina CNRS Grenoble INPLEGIUniversité Grenoble AlpesGrenoble 38000France

A volume averaged columnar solidification model,which couples the flow,temperature and solute concentration fields,is applied to simulate experimental continuous casting cases with and without vertical electromagnetic stirring(V-EMS).The calculated distribution of magnetic induction intensity and final macrosegregation maps are consistent with the experimental *** results reveal that the V-EMS promotes longitudinal melt flow,accelerates heat dissipation and solidification and finally reduces the central segregation of ***,when V-EMS is applied,the solute distribution becomes asymmetric because the melt flow shows opposite directions between the near and far sides from *** obvious positive segregation band is observed at about 1/4 width of the billet near the stirrer in both calculated and experimental *** position and degree of such positive segregation could be affected by installation height of stirrer,as demonstrated by additional simulation cases.

关键词： Vertical electromagnetic stirring Macrosegregation Volume averaged method Continuous casting

Optical gravitational wave detectors on the ground and in space:theory and technology

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Research in Astronomy and Astrophysics 2010年第10期10卷 956-1004页

作者： Jean-yves Vinet ARTEMIS Observatoire de la Cte d'Azur Université de Nice-Sophia Antipolis 06304 NICE France

Major predictions of General Relativity, unforeseen at the beginning of the preceding century, are now under investigation. The existence of black holes of any mass from tens to billions of solar masses is now established, and the physics around these objects begins to be studied through direct observations in a wide electromagnetic spectrum from visible light to X-rays. General relativity, however, provides an extra medium which carries more information on the regions of intense gravitational field, namely gravitational waves （GWs）. Due to their extremely weak coupling to matter, GWs are precisely generated in those regions of spacetime undergoing strong curvature, which is very exciting for modern astrophysics. On the other hand, this weak coupling makes it difficult for GWs to cause appreciable effects in human made instruments. This is why technology of GW detectors took such a long time to reach a sensitivity level consistent with GW amplitudes predicted by theoretical models of sources. In the present status, apart from resonant solid detectors, two large interferometric antennas （LIGO in the USA and the French-Italian Virgo） are beginning to produce data, and a joint ESA-NASA space mission, resulting from a wide effort of European and American groups, is reaching a crucial approval phase. The aim of the present review is to give the theoretical bases of GW detectors using light.

关键词： gravitation -- gravitational waves -- interferometry

Post-translational Regulation of SPX Proteins for Coordinated Nutrient Signaling

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Molecular Plant 2019年第8期12卷 1041-1043页

作者： yves Poirier Department of Plant Molecular Biology University of Lausanne1015 LausanneSwitzerland

Proteins containing an SPX domain are involved in numerous aspects of phosphate homeostasis and the response to phosphate ***4 is known to bind to the transcription factor PHR2 in the presenee of inositol polyphosphate,affecting its ability to activate the expression of phosphate-starvation-induced (PSI) *** have evolved mechanisms to coordinate the uptake and utilization of phosphate and *** recent works (Hu et al.,2019;Ruan et al.,2019) have identified different E3 ubiquitin ligases that mediate the degradation of SPX4 under either phosphate-deficient conditions or nitrate-replete *** studies highlight the potential of SPX proteins,E3 ubiquitin ligases,and inositol polyphosphate to regulate distinet nutrient signaling pathways in a coordinated fashion.

关键词： Post-translational Regulation SPX Proteins Coordinated Nutrient Signaling phosphate-starvation-induced(PSI)

Surface movement above old coal longwalls after mine closure

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International Journal of Mining Science and Technology 2017年第3期27卷 481-490页

作者： André Vervoort Pierre-yves Declercq Department of Civil Engineering KU Leuven Leuven 3001 Belgium Geological Survey of Belgium Royal Belgian Institute of Natural Sciences Brussels 1000 Belgium

Although most subsidence occurs in the months and years after mining by the longwall method, surface movement is still occurring many decades after the mining. The aim of the study is to quantify the long term behavior. Satellite data(radar-interferometry) were analyzed to study an area of about 2 km^2 during the 18 years following the closure of the underground infrastructure and the flooding of the underground workings and rock mass. It was observed that, on average, a residual downward movement took place till 7–12 years after the closure, followed by a clear uplift. However, the first signs of an uplift occurred in certain sub-areas 3–4 years after the closure. Zones within the area studied were identified with either larger or smaller movements. However, the spatial variation of the surface subsidence or uplift could not be directly explained by the characteristics of mining.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry

Upward surface movement above deep coal mines after closure and flooding of underground workings

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International Journal of Mining Science and Technology 2018年第1期28卷 53-59页

作者： André Vervoort Pierre-yves Declercq Department of Civil Engineering KU Leuven Geological Survey of Belgium Royal Belgian Institute of Natural Sciences

After the mass closures of entire coal mine districts in Europe at the end of the last century, a new phenomenon of surface movement was observed—an upward *** most surface movement(i.e., subsidence) occurs in the months and years after mining by the longwall method, surface movement still occurs many decades after mining is *** the closure and flooding of underground excavations and surrounding rock, this movement was *** paper focuses on quantifying the upward movement in two neighboring coal mines(Winterslag and Zwartberg, Belgium).The study is based on data from a remote sensing technique: interferometry with synthetic aperture radar(INSAR).The results of the study show that the rate of upward movement in the decade after closure is about 10 mm/year on *** upward movements are not linked directly to the past exploitation directly underneath a *** amounts of subsidence at specific locations are linked mainly to their positions relative to an inverse trough shape situated over the entire mined-out areas and their immediate *** features, such as geological faults, can have a secondary effect on the local variation of the *** processes of subsidence and uplift are based on completely different *** is initiated by a caving process, while the process of uplift is clearly linked to flooding.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry