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Modeling Drug Concentration in Blood through Caputo-Fabrizio and Caputo Fractional Derivatives

Computer Modeling in Engineering & Sciences 2023年第6期135卷 2767-2785页

作者： Muath Awadalla Kinda Abuasbeh yves Yannick Yameni Noupoue Mohammed S.Abdo Department of Mathematics and Statistics College of ScienceKing Faisal UniversityHafufAl Ahsa31982Saudi Arabia Institute of Statistics Biostatistics and Actuarial ScienceFaculty of ScienceUniversite Catholique de LouvainLouvain-La-Neuve1348Belgium Department of Mathematics Hodeidah UniversityAl-Hudaydah3114Yemen

This study focuses on the dynamics of drug concentration in the *** general,the concentration level of a drug in the blood is evaluated by themean of an ordinary and first-order differential *** precisely,it is solved through an initial value *** proposed a newmodeling technique for studying drug concentration in blood *** technique is based on two fractional derivatives,namely,Caputo and Caputo-Fabrizio *** first provided comprehensive and detailed proof of the existence of at least one solution to the problem;we later proved the uniqueness of the existing *** proof was written using the Caputo-Fabrizio fractional derivative and some fixed-point *** via theUlam-Hyers(UH)technique was also *** application of the proposedmodel on two real data sets revealed that the Caputo derivative wasmore suitable in this ***,for the first data set,the model based on the Caputo derivative yielded a Mean Squared Error(MSE)of 0.03095 with a corresponding best value of fractional order of derivative of ***-Fabrizio-basedderivative appeared to be the second-best method for the problem,with an MSE of 0.04324 for a corresponding best fractional derivative order of *** the second experiment,Caputo derivative-based model still performed the best as it yielded an MSE of 0.04066,whereas the classical and the Caputo-Fabrizio methods were tied with the same MSE of *** interesting finding was that the MSE yielded by the Caputo-Fabrizio fractional derivative coincided with the MSE obtained from the classical approach.

关键词： Pharmacokinetics caputo fractional derivative stability study Caputo-Fabrizio fractional derivative

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Larval interference competition between the native Neotropical mosquito Limatus durhamii and the invasive Aedes aegypti improves the fitness of both species

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Insect Science 2018年第6期25卷 1102-1107页

作者： Stanislas Talaga Alain Dejean Clémence Mouza yves Dumont Céline Leroy lnsUtut Pasteur de la Guyane Unitéd'Entomologie MédicaleCayenne cedexFrance CNRS UMR EcoFoGAgroParisTechCiradINRAUniversitédes AntillesUniversitéde GuyaneKourouFrance CNRS INPTUPSEcolabUniversitéde ToulouseToulouseFrance AMAP CIRADCNRSINRAIRDUniversit6MontpellierMontpellierFrance

Interspecific competition with native species during biological invasions can sometimes limit alien *** aimed to determine the potential ecological effects of Limatus durhamii Theobald 1901,a native Neotropical mosquito (Diptera:Culicidae) species,on the invasive species Aedes (Stegomyia)aegypti (Linnaeus 1762)that breeds in the same artificial water *** time and adult dry mass were measured in 3 rearing conditions:control (a single larva),intraspecific competition (2 conspecific larvae),and interspecific competition (2 heterospecific larvae).Food was provided ad libitum to eliminate exploitative *** ***,development time was not affected by interspecific interference competition (nonsignificant differences with the control)and the adult dry mass was significantly higher,meaning that individual fitness likely ***,because previous studies showed longer development time and lighter adults during competition with other invasive mosquitoes,it is likely that *** can express a different phenotype depending on the competing *** similar pattern found for *** females and the nonsignificant difference with the control for males explain in part why this species can compete with ***.

关键词： Aedes aegypti increased fitness interference competition Limatus durhamii phenotypic plasticity resistance to invasion

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Dental stem cell-conditioned medium for tissue regeneration: Optimization of production and storage

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World Journal of Stem Cells 2022年第4期14卷 287-302页

作者： Batoul Chouaib Frédéric Cuisinier Pierre-yves Collart-Dutilleul Laboratory Bioengineering and Nanosciences UR_UM104 University of MontpellierMontpellier 34000France

BACKGROUND Mesenchymal stem cells(MSC)effects on tissue regeneration are mainly mediated by their secreted substances(secretome),inducing their paracrine *** Conditioned medium(CM),including soluble factors(proteins,nucleic acids,lipids)and extracellular vesicles is emerging as a potential alternative to cell ***,the manufacturing of CM suffers from variable procedures and protocols leading to varying results between ***,there is no welldefined optimized procedure targeting specific applications in regenerative *** To focus on conditioned medium produced from dental MSC(DMSC-CM),we reviewed the current parameters and manufacturing protocols,in order to propose a standardization and optimization of these manufacturing *** We have selected all publications investigating the effects of dental MSC secretome in in vitro and in vivo models of tissue regeneration,in accordance with the PRISMA *** A total of 351 results were *** based on the inclusion criteria described above,118 unique articles were included in the systematic ***-CM production was considered at three stages:before CM recovery(cell sources for CM),during CM production(culture conditions)and after production(CM treatment).CONCLUSION No clear consensus could be recovered as evidence-based methods,but we were able to describe the most commonly used protocols:donors under 30 years of age,dental pulp stem cells and exfoliated deciduous tooth stem cells with cell passage between 1 and 5,at a confluence of 70%to 80%.CM were often collected during 48 h,and stored at-80°*** is important to point out that the preconditioning environment had a significant impact on DMSCCM content and efficiency.

关键词： Tissue engineering Mesenchymal stem cells Dental Conditioned medium Secretome Regeneration

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Have some landscapes in the eastern Canadian boreal forest moved beyond their natural range of variability?

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Forest Ecosystems 2018年第4期5卷 412-428页

作者： Pierre Grondin Sylvie Gauthier Veronique Poirier Patrice Tardif Yan Boucher yves Bergeron Direction de la Recherche Forestiere Ministere des Foretsde la Faune et des Pares (MFFP)2700rue EinsteinQuebecQC GIP 3W8Canada Ressources Naturelles Canada/Natural Resources Canada Service Canadien des forets/Canadian Forest ServiceCentre de foresterie des Laurentides/Laurentian Forestry Center1055 rue du P.E.P.SQuebecQC G1V 4C7 Canada Institut de Recherche sur les Forets Universite du Quebec en Abitibi-Temiscamingue445boul.de I'UniversiteRouyn-NorandaQC J9X 5E4Canada Centre d'etude de la Foret Universite du QuebecMontreal CP 8888succ AMontrealQC H3C 3P8Canada

Background: In the contxt of ecosystem management, the present study aims to compare the natural and the present-day forested landscapes of a large territory in Quebec(Canada). Using contemporary and long-term fire cycles, each natural forst landscape is defined according to the variability of its structure and composition, and compared to the present-day landscape. This analysis was conducted to address the question of whether human activities have moved these ecosystems outside the range of natural landscape ***: The study encompassed a forested area of 175 000 km2 divided into 14 landscapes. Using a framework that integrates fire cycles, age structure and forest dynamics, we characterized the forest composition and age structures that resulted from three historical fire cycles(110,140, and 180 years) representative of the boreal forest of eastern Canada. The modeled natural landscapes were compared with present-day landscapes in regard to the proportion of old-growth forests(landscape level) and the proportion of late-successional forest stands(landscape level and potential vegetation type).Results: Four landscapes(39%) remain within their natural range of variability. In contrast, nine landscapes(54%)show a large gap between natural and present-day landscapes. These nine are located in the southern portion of the study area, and are mainly associated with Abies-Betula vegetation where human activities have contributed to a strong increase in the proportion of Populus tremuloides stands(early-successional stages) and a decrease of oldgrowth forest stands(more than 100 years old). A single landscape(7%), substantially changed from its potential natural state, is a candidate for adaptive-based ***: Comparison of corresponding natural(reference conditions) and present-day landscapes showed that ten landscapes reflecting an important shift in forest composition and age structure could be considered beyond the range of their natural v

关键词： Ecosystem management Reference conditions Natural variability Resilience Fire cycle Age structure Forest dynamics Potential vegetation type Landscape ecology Theoretical natural landscape Present-day landscape

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Review on modelling of corrosion under droplet electrolyte for predicting atmospheric corrosion rate

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Journal of Materials Science & Technology 2021年第3期62卷 254-267页

作者： Bangalore Gangadharacharya Koushik Nils Van den Steen Mesﬁn Haile Mamme yves Van Ingelgem Herman Terryn Vrije Universiteit Brussel Research Group Electrochemical and Surface Engineering(SURF)Pleinlaan 21050 BrusselsBelgium Vrije Universiteit Brussel Eenheid Algemene Chemie(ALGC)Pleinlaan 21050 BrusselsBelgium

Atmospheric corrosion of metals is the most common type of corrosion which has a significant impact on the environment and operational safety in various situations of everyday *** of the common examples can be observed in land,water and air transportation systems,electronic circuit boards,urban and offshore *** dew drops formed on metal surface due to condensation of atmospheric moisture facilitates corrosion as an *** corrosion mechanisms under these droplets are different from classically known bulk electrolyte *** to thin and non-uniform geometric thickness of the droplet electrolyte,the atmospheric oxygen requires a shorter diffusion path to reach the metal *** corrosion under a droplet is driven by the depletion of oxygen in the center of the droplet compared to the edge,known as differential *** case of a larger droplet,differential aeration leads to preferential cathodic activity at the edge and is controlled by the droplet ***,for a smaller droplet,the oxygen concentration remains uniform and hence cathodic activity is not controlled by droplet *** geometry of condensed droplets varies dynamically with changing environmental parameters,influencing corrosion mechanisms as the droplets evolve in *** this review,various modelling approaches used to simulate the corrosion under droplet electrolytes are *** the efforts of developing a comprehensive model to estimate corrosion rates,it has been noted from this review that the influence of geometric evolution of the droplet due to condensation/evaporation processes on corrosion mechanisms are yet to be *** varying external factors like environmental temperature,relative humidity,presence of hygroscopic salts and pollutants influence the evolution of droplet electrolyte,making it a complex phenomenon to ***,an overview of available dropwise condensation and evaporation models which descri

关键词： Atmospheric corrosion Water droplets Mathematical modelling Condensation Evaporation

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China and Peacemaking in the DRC:Prospects for Tangible Military Cooperation

China and Peacemaking in the DRC:Prospects for Tangible Mili...

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作者： Birhonga Ndemba yves Israel 华中师范大学

学位级别：硕士

自1972年以来,中国和刚果民主共和国一直保持着良好的外交关系。表现为刚果民主共和国支持中国成为联合国常任理事国的候选国,坚持“一个中国原则”等。近二十年来,刚果民主共和国一直处于政治不稳定状态,特别是在军事上,侵略战争和各... 详细信息

自1972年以来,中国和刚果民主共和国一直保持着良好的外交关系。表现为刚果民主共和国支持中国成为联合国常任理事国的候选国,坚持“一个中国原则”等。近二十年来,刚果民主共和国一直处于政治不稳定状态,特别是在军事上,侵略战争和各种叛乱频发。尽管政府和联合国对此做了多方努力,但在面对各种黑暗势力时,政府军仍常常被现实压得喘不过气来。中国对刚果民主共和国来说,是一个特殊的伙伴,尤其是在军事问题上,中国为刚果民主共和国培训军官,提供军事装备。因此,鉴于中国军队的经验、财力和专业水平,与中国建立更高级别的关系是值得欢迎的。中国军队能够有效的帮助刚果民主共和国推进和平进程,实现和维持其国内的和平与发展。和平的刚果民主共和国不仅将促进两国之间在包括基础设施和矿产贸易在内的各个领域的经济伙伴关系,而且还将推动刚果民主共和国的发展。此外,鉴于刚果民主共和国位于非洲腹地的位置优势,它还将促进整个非洲的发展。中国是联合国维和部队的重要力量,是联合国安理会所有常任理事国中派遣维和人数最多的国家,目前,在刚果民主共和国的中国维和人员多达200余人。然而,尽管如此,刚果民主共和国东部仍不稳定,面临着安全的威胁。尤其是在应对紧急情况时,联合国维和部队的运作本身也十分繁琐。因此,如果我们想要迅速的实现和平,深化中国和刚果民主共和国之间的军事合作就势在必行。为了加强现有的军事合作,除了在联合国框架内的不断努力之外,中国还需要与刚果民主共和国政府军队一道部署军事力量。这种为维护和平而存在的军事合作,将对可能的威胁起到震慑作用,能够更好的帮助刚果民主共和国恢复和平、保持稳定。安全与发展同韵。安全是自变量,发展是因变量。这就是为什么我们不能在没有安全的情况下谈论发展。安全与发展存在于同一个体系之中,两者相互关联。中国和刚果民主共和国之间的军事合作必须扩展到军事行动领域,因为中国装备充足,拥有足够的后勤和技术手段能够帮助其他国家的军队,而这是在联合国承认的合法干涉权的范围内。尽管中国在刚果民主共和国部署了联合国部队,但这支队伍的兵力范围有限,因为在当地发生紧急情况时,联合国所有部队和纽约联合国总部的官僚机构都需要执行任务。中国人民解放军与刚果民主共和国武装力量并肩作战,是刚果民主共和国展示其军事实力的重要资产。在战胜这次的新冠肺炎后,中国的大国地位不再有争议。中国一贯倡导普遍和平,因此可以与刚果民主共和国一道,帮助实现联合国20多年前无法实现的和平与稳定。对于设想中国人民解放军与刚果民主共和国武装部队之间的合作乃至并肩作战,是存在先例的,并非前所未有。自2017年以来,中国在另一个非洲国家吉布提部署了一个大型军事基地,吉布提军事基地是近年来中国首个海外军事基地,该基地将使中国军队能够“更好地履行起在亚丁湾、索马里海域护航以及开展人道主义救援等国际义务”。由于中国军事基地的存在,使得该地区的海盗活动已大大减少。自此,吉布提发展成为一个更加安全和经济稳定的国家。对于中国与吉布提两国而言,也恢复了人民之间的密切往来和友好交流。因此,中国军队通过军事外交,与非洲和世界各地的一些军队合作是存在前景的,由此可以看出对于中国和刚果在军队和军事上的合作并不存在阻碍。面对非洲国家,尤其是刚果民主共和国面临的诸多挑战,中国相比欧美等国而言更倾向于与其伙伴共同前进,从而更好地化解困难。笔者认为,刚果民主共和国需要对两国之间的军事合作做好相应的准备,从而更好地实现国家和平、安宁和稳定。刚果享有充分的独立性,除了在不进行任何地缘政治考量或地缘战略争议的情况下,要求中国帮助其实现和平是存在很大可能的,并且刚果亦能拥有与中国达成任何军事协议的独立、完整权力。显而易见的是,中国虽然拥有多个合作伙伴,但刚果民主共和国也有权选择其政策偏好。在联合国框架之外,中国毫无疑问是一个可靠的伙伴,能够帮助刚果民主共和国努力恢复该国的和平与稳定。

关键词：中国外交刚果民主共和国军事合作维和

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Topological Modeling of a One Stage Spur Gear Transmission

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Chinese Journal of Mechanical Engineering 2014年第5期27卷 900-908页

作者： MILADI CHAABANE Mariem PLATEAUX Régis CHOLEY Jean-yves KARRA Chafik RIVIERE Alain HADDAR Mohamed Mechanical Modeling and Manufacturing Unit National Engineering School of Sfax(ENIS) BP 1173 – 3038 – Sfax – Tunisia Laboratory of Engineering of the Mechanical Structures and Materials High Institute of Mechanic of Paris(SUPMECA)3 rue Fernand HainautNational 93407 Saint-Ouen Cedex Mechanical Modeling and Manufacturing Unit National Engineering School of Sfax(ENIS) BP 1173–3038–Sfax–Tunisia

Finding a basis of unification for the modeling of mechatronic systems is the search subject of several *** paper is a part of a general research designed to the application of topology as a new approach for the modeling of mechatronic ***,the modeling of a one stage spur gear transmission using a topological approach is *** approach is based on the concepts of topological collections and transformations and implemented using the MGS（modeling of general systems）*** topological collections are used to specify the interconnection laws of the one stage spur gear transmission and the transformations are used to specify the local behavior laws of its different *** order to validate this approach,simulation results are presented and compared with those obtained with MODELICA language using Dymola *** good results are achieved,this approach might be used as a basis of unification for the modeling of mechatronic systems.

关键词： topological modeling topological collections transformations MGS language one stage spur gear

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Modelling the Segregation of Impurities During Solidification With Turbulent Electromagnetic Stirring

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Journal of Iron and Steel Research International 2012年第S1期19卷 217-221页

作者： DELANNOY yves ZAIDAT Kader SIMaP laboratory EPM GroupGrenoble INPBP 7538402 St Martin d'HeresFrance

This paper proposes an estimate of the stirring intensity needed to maintain an efficient segregation of impurities towards the liquid when crystallizing semiconductors such as silicon,with rapid solidification rates(several cm/h).The method,valid far from stagnation points or detachments,is based on the properties of turbulent boundary layers,with a normal velocity of the liquid towards the solid/liquid interface due to solidification,that has the same effect as boundary layer suction in *** transition between the diffusive regime(no segregation),and the convective regime(efficient segregation)occurs if the friction at the wall is greater than a threshold depending on the solidification rate.A chart is given to estimate the convecto-diffusive parameter from the ratio between stirring and solidification velocity,and the Reynolds number.

关键词： solidification electromagnetic stirring segregation

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An agent-supported approach for the collaborative design of complex systems

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第2期7卷 1-19页

作者： Moncef Hammadi Amir Guizani Jean-yves Choley Andreas Kellner Peter Hehenberger Laboratoire Quartz EA 7393 Supmeca 3 Rue Fernand Hainaut 93400 Saint-OuenFrance Institute of Mechatronic Design and Production Johannes Kepler Universit¨at Altenberger Straße 694040 LinzAustria

A novel approach for partitioning and coordinating the collaborative design optimization of complex systems is described.A partitioning metric has been formulated to select the best partitioning solutions among the total possibilities of dividing the complex design optimization ***,an agent-supported approach is used for the coordination of the collaborative design *** approach has been applied to the case of a preliminary design of an electric vehicle,to demonstrate how various agents can effectively communicate with each other to provide support to the collaborative design optimization of complex systems.

关键词： Complex design optimization collaborative design agent-supported approach

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Accuracy comparison of dry matter intake prediction models evaluated by a feeding trial of lactating dairy cows fed two total mixed rations with different forage source

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Journal of Integrative Agriculture 2017年第4期16卷 921-929页

作者： PAN Xiao-hua YANG Liang yves Beckers XIONG Ben-hai JIANG Lin-shu State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193P.R.China University of Liege Gembloux Agro-Bio TechPrecision Livestock and NutritionB-5030 GemblouxBelgium Beijing Key Laboratory for Dairy Cow Nutrition Beijing University of AgricultureBeijing 102206P.R.China

Dry matter intake （DMI） prediction models of NRC （2001）, Fox et aL （2004） and Fuentes-Pila et aL （2003） were targeted in the present study, and the objective was to evaluate their prediction accuracy with feeding trial data of 32 lactating Holstein cows fed two total mixed rations with different forage source. Thirty-two cows were randomly assigned to one of two total mixed ration groups： a ration containing a mixed forage （MF） of 3.7% Chinese wildrye, 28.4% alfalfa hay and 26.5% corn silage diet and another ration containing 33.8% corn stover （CS） as unique forage source. The actual DMI was greater in MF group than in CS group （P=0.064）. The NRC model to predict DMI resulted in the lowest root mean square prediction error for both MF and CS groups （1.09 kg d-1 vs. 1.28 kg d-1） and the highest accuracy and precision based on concordance correlation coefficient for both MF and CS diet （0.89 vs. 0.87）. Except the NRC model, the other two models presented mean and linear biases in both MF and CS diets when prediction residuals were plotted against predicted DMI values （P〈0.001）. The DMI variation in MF was caused by week of lactation （55.6%）, milk yield （13.9%）, milk fat percentage （7.1%） and dietary neutral detergent fiber （13.3%）, while the variation in CS was caused by week of lactation （50.9%）, live body weight （28.2%）, milk yield （8.4%）, milk fat percentage （5.2%） and dietary neutral detergent fibre （3.8%）. In a brief, the NRC model to predict DMI is comparatively acceptable for lactating dairy cows fed two total mixed rations with different forage source.

关键词： dairy cows dry matter intake model comparison mixed forage corn stover

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