检索结果-南通市图书馆

WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第10期17卷 2126-2130页

作者： Alexandre Vallée yves Lecarpentier Jean-Noël Vallée Department of Clinical Research and Innovation(DRCI) Foch HospitalSuresnesFrance Centre de Recherche Clinique Grand Hôpital de l’Est Francilien(GHEF)MeauxFrance Laboratoire de Mathématiques et Applications(LMA) Universitéde PoitiersPoitiersFrance Centre Hospitalier Universitaire(CHU)Amiens Picardie UniversitéPicardie Jules Verne(UPJV)AmiensFrance

The neuropsychiatric disease named obsessive-compulsive disorder is composed by obsessions and/or ***-compulsive disorder etiologies are ***,numerous mechanisms in several localizations are *** studies showed that both glutamate,inflammatory factors and oxidative stress could have main functions in obsessive-compulsive *** synthase kinase-3β,the major negative controller of the WNT/β-catenin pathway is upregulated in obsessive-compulsive *** obsessive-compulsive disorder,some studies presented the actions of the different circadian clock ***/β-catenin pathway and circadian clock genes appear to be ***,this review focuses on the interaction between circadian clock genes and the WNT/β-catenin pathway in obsessive-compulsive disorder.

关键词： circadian rhythms glutamatergic pathway inflammation obsessive-compulsive disorder oxidative stress WNT/β-catenin pathway

Recent advances in the management of autoimmune pancreatitis in the era of artificial intelligence

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第48期28卷 6867-6874页

作者： Sahar Mack yves Flattet Philippe Bichard Jean Louis Frossard Division of Gastroenterology Department of Medical SpecialtiesUniversity Hospital of GenevaGeneva 1205Switzerland

Autoimmune pancreatitis(AIP)is a type of immune-mediated pancreatitis subdivided into two subtypes,type 1 and type 2 ***,type 1 AIP is considered to be the pancreatic manifestation of the immunoglobulin G4(IgG4)-related ***,AIP is increasingly researched and recognized,although its diagnosis represents a challenge for several reasons:False positive ultrasound-guided cytological samples for a neoplastic process,difficult to interpret levels of IgG4,the absence of biological markers to diagnose type 2 AIP,and the challenging clinical identification of atypical ***,60%and 78%of type 1 and type 2 AIP,respectively,are retrospectively diagnosed on surgical specimens of resected pancreas for suspected *** distinguishing AIP from pancreatic ductal adenocarcinoma can be challenging,obtaining a definitive diagnosis can therefore prove difficult,since endoscopic ultrasound fine-needle aspiration or biopsy of the pancreas are *** paper focuses on recent innovations in the management of AIP with regard to the use of artificial intelligence,new serum markers,and new therapeutic approaches,while it also outlines the current management recommendations.A better knowledge of AIP can reduce the recourse to surgery and avoid its overuse,although such an approach requires close collaboration between gastroenterologists,surgeons and *** knowledge on AIP and IgG4-related disease remains necessary to diagnose and manage patients.

关键词： Autoimmune pancreatitis Pancreatic ductal adenocarcinoma Immunoglobulin G4-related disease Prednisone Rituximab Artificial intelligence Plasmablasts

Modeling Drug Concentration in Blood through Caputo-Fabrizio and Caputo Fractional Derivatives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第6期135卷 2767-2785页

作者： Muath Awadalla Kinda Abuasbeh yves Yannick Yameni Noupoue Mohammed S.Abdo Department of Mathematics and Statistics College of ScienceKing Faisal UniversityHafufAl Ahsa31982Saudi Arabia Institute of Statistics Biostatistics and Actuarial ScienceFaculty of ScienceUniversite Catholique de LouvainLouvain-La-Neuve1348Belgium Department of Mathematics Hodeidah UniversityAl-Hudaydah3114Yemen

This study focuses on the dynamics of drug concentration in the *** general,the concentration level of a drug in the blood is evaluated by themean of an ordinary and first-order differential *** precisely,it is solved through an initial value *** proposed a newmodeling technique for studying drug concentration in blood *** technique is based on two fractional derivatives,namely,Caputo and Caputo-Fabrizio *** first provided comprehensive and detailed proof of the existence of at least one solution to the problem;we later proved the uniqueness of the existing *** proof was written using the Caputo-Fabrizio fractional derivative and some fixed-point *** via theUlam-Hyers(UH)technique was also *** application of the proposedmodel on two real data sets revealed that the Caputo derivative wasmore suitable in this ***,for the first data set,the model based on the Caputo derivative yielded a Mean Squared Error(MSE)of 0.03095 with a corresponding best value of fractional order of derivative of ***-Fabrizio-basedderivative appeared to be the second-best method for the problem,with an MSE of 0.04324 for a corresponding best fractional derivative order of *** the second experiment,Caputo derivative-based model still performed the best as it yielded an MSE of 0.04066,whereas the classical and the Caputo-Fabrizio methods were tied with the same MSE of *** interesting finding was that the MSE yielded by the Caputo-Fabrizio fractional derivative coincided with the MSE obtained from the classical approach.

关键词： Pharmacokinetics caputo fractional derivative stability study Caputo-Fabrizio fractional derivative

Dental stem cell-conditioned medium for tissue regeneration: Optimization of production and storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2022年第4期14卷 287-302页

作者： Batoul Chouaib Frédéric Cuisinier Pierre-yves Collart-Dutilleul Laboratory Bioengineering and Nanosciences UR_UM104 University of MontpellierMontpellier 34000France

BACKGROUND Mesenchymal stem cells(MSC)effects on tissue regeneration are mainly mediated by their secreted substances(secretome),inducing their paracrine *** Conditioned medium(CM),including soluble factors(proteins,nucleic acids,lipids)and extracellular vesicles is emerging as a potential alternative to cell ***,the manufacturing of CM suffers from variable procedures and protocols leading to varying results between ***,there is no welldefined optimized procedure targeting specific applications in regenerative *** To focus on conditioned medium produced from dental MSC(DMSC-CM),we reviewed the current parameters and manufacturing protocols,in order to propose a standardization and optimization of these manufacturing *** We have selected all publications investigating the effects of dental MSC secretome in in vitro and in vivo models of tissue regeneration,in accordance with the PRISMA *** A total of 351 results were *** based on the inclusion criteria described above,118 unique articles were included in the systematic ***-CM production was considered at three stages:before CM recovery(cell sources for CM),during CM production(culture conditions)and after production(CM treatment).CONCLUSION No clear consensus could be recovered as evidence-based methods,but we were able to describe the most commonly used protocols:donors under 30 years of age,dental pulp stem cells and exfoliated deciduous tooth stem cells with cell passage between 1 and 5,at a confluence of 70%to 80%.CM were often collected during 48 h,and stored at-80°*** is important to point out that the preconditioning environment had a significant impact on DMSCCM content and efficiency.

关键词： Tissue engineering Mesenchymal stem cells Dental Conditioned medium Secretome Regeneration

Lattice Boltzmann Modeling of Miscible Multicomponent Gas Mixtures in the Rarefied Regime

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational Physics 2022年第9期32卷 1179-1216页

作者： Michel Ho Sami Ammar Sebastien Leclaire Marcelo Reggio Jean-yves Trepanier Departement of Mechanical Engineering Polytechnique Montreal2500 Chemin de PolytechniqueMontreal H3T 1J4Canada

An extension to rarefied flow regimes of the lattice Boltzmann methodbased model for miscible mixtures developed by Vienne et al.(Physical Review E 100.2(2019):023309)is *** model is applied to study the gas phase separation phenomenon in mixture flows that traditional macroscopic approaches fail to *** extension includes a wall function approach with an empirical coefficient to define an effectivemean free path in solid geometries,which locally defines the kinematic viscosity and binary diffusion *** algorithm is also modified by a local multi-relaxation time collision operator and slip boundary conditions at solid *** mixture flow simulations are conducted through a 2D plane microchannel within the slip and early transition flow *** a miscible gaseous phase,the mixture loses its homogeneity and independent velocity profiles for each component are observed in the rarefied regime and captured with the current *** addition,the gas separation phenomenon increases with the rarefaction rate and the molecular mass *** individual treatment of the species within mixture flows in the developed lattice Boltzmann model helps understanding the increasing independent behavior of the individual specieswithin themixture as the regime becomesmore rarefied.

关键词： Lattice Boltzmann gaseous mixtures rarefied regimes

Overall Thermodynamic Model of an Ultra Micro Turbine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2004年第4期13卷 297-301页

作者： yves RIBAUD ONERA DEFA 29 Avenue de la Division Leclerc 92 CHATILLON France

The overall thermodynamic model of an ultra micro turbine engine has been established and applied in different situations in this tiny engine where heat transfer is dominant. The aerothermal conditions of the flow were calculated and analyzed. A corresponding calculation software (hot button software) was developed. The first results show that the non-adiabatic operation of the turbomachines leads to a strong penalty in performances. The dramatic influence of the compressor and turbine efficiency is confirmed in a non-adiabatic operation. A better knowledge of heat transfer coefficients at low Reynolds numbers in different components of the micro turbine has to be obtained to refine the results of this study.

关键词： micro energy micro engines micro turbine micro propulsion micro turbine thermodynamic model MEMS

Controlled moderative sulfidation-fabricated hierarchical heterogeneous nickel sulfides-based electrocatalyst with tripartite Mo doping for efficient oxygen evolution

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第5期31卷 780-788页

作者： Xing Yu Qingyun Lv Lulu She Long Hou yves Fautrelle Zhongming Ren Guanghui Cao Xionggang Lu Xi Li State Key Laboratory of Advanced Special Steels School of Materials Science and EngineeringShanghai UniversityShanghai 200072China Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming Shanghai Jiao Tong UniversityShanghai 200240China SIMAP-EPM-Madylam/G-INP/CNRS PHELMABP 7538402 St Martin d’HeresCedexFrance

An electrocatalyst with heterogeneous nanostructure, especially the hierarchical one, generally shows a more competitive activity than that of its single-component counterparts for oxygen evolution reaction(OER), due to the synergistically enhanced kinetics on enriched active sites and reconfigured electronic band structure. Here this work introduces hierarchical heterostructures into a NiMo@NiS/MoS_(2)@Ni_(2)S_(2)/MoO_(x)(NiMoS) composite by one-pot controlled moderative sulfidation. The optimal solvent composition and addition of NaOH enable NiMoS to own loose and porous structures, smaller nanoparticle sizes, optimal phase composition and chemical states of elements, improving the OER activity of NiMoS. To achieve current densities of 50 and 100 mA cm^(-1), small overpotentials of 275 and 306 mV are required respectively, together with a minor Tafel slope of 58 mV dec^(-1), which outperforms most reported sulfide catalysts and IrO_(2). The synergistic effects in the hierarchical heterostructures expose more active sites,adjust the electronic band structure, and enable the fast charge transfer kinetics, which construct an optimized local coordination environment for high OER electrocatalytic activity. Furthermore, the hierarchical heterostructures suppress the distinct lowering of electrical conductivity and collapse of pristine structures resulted from the metal oxidation and synchronous S leaching during OER, yielding competitive catalytic stability.

关键词： OER electrocatalysts Controlled moderative sulfidation Hierarchical heterostructures Nickel sulfides Tripartite Mo doping

Associations between Bodyweight and Clinical Outcome in Patients Post-Fontan Procedure: A Systematic Review

在线全文

学校读者我要写书评

暂无评论

Congenital Heart Disease 2022年第6期17卷 617-639页

作者： Emma Payne Thomas Wilson Marjan Haghighi Zoe McCallum yves d’Udekem Julian Ayer The University of Sydney SydneyAustralia The University of Melbourne MelbourneAustralia The Royal Children’s Hospital MelbourneAustralia The Royal Prince Alfred Hospital SydneyAustralia The Children’s National Hospital WashingtonUSA

Background: Patients born with a single ventricle circulation commonly experience growth failure in early life,which is associated with adverse outcomes in infancy. However, associations between bodyweight or weight trajectoryand clinical outcome post-Fontan procedure are yet to be determined. Methods: On the 1st of July 2021, asystematic review was performed in MEDLINE, EMBASE, the Cochrane Library, and Scopus of studies of patientswith clinical outcome data post-Fontan procedure and association with bodyweight. Quality of studies was evaluatedby Newcastle–Ottawa scale for cohort studies and Joanna Briggs Institute tool for cross-sectional ***: Of 527 studies that underwent title and abstract screening, 15 were selected for final review. An increasedrisk of adverse post-Fontan outcomes was found for low weight patients, consistent with findings in *** there is some evidence to suggest increased mortality in overweight adult patients, studies are conflictingas to whether overweight status is associated with increased heart failure. Increased BMI is associated with diminishedexercise capacity and deceased physiological functioning. Negative weight trajectory is associated withadverse outcomes in the peri-Fontan period, whereas a positive weight trajectory is associated with increased Fontanfailure in adulthood. Abnormal BMI (high or low) is associated with increased heart failure and poorer performancein quality-of-life scores. Conclusions: Bodyweight is a modifiable risk factor for poor clinical outcomein patients with a single ventricle circulation. Recognizing associations between bodyweight and Fontan pathophysiologymay help to define patient-centered exercise and diet interventions that minimize patient morbidityand mortality.

关键词： Fontan bodyweight congenital heart disease single ventricle

Dietary methionine sources and levels modulate the intestinal health status of broiler chickens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2023年第4期15卷 242-255页

作者： Lu Gong Tahir Mahmood yves Mercier Huiping Xu Xiaodan Zhang Yizhu Zhao Yimeng Luo Yuming Guo State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Adisseo France S.A.S 03600CommentryFrance

Given the key role of methionine in biological processes,adequate methionine should be provided to meet the nutritional ***-2-hydroxy-4-(methylthio)-butanoic acid(DL-HMTBA)has been considered as an important source of ***,the effects of different sources and levels of methionine on the intestinal health status have not been clarified *** experiment was carried out to investigate the effects of different dietary sources and levels of methionine on the intestinal epithelial barrier,inflammatory cytokines expression,ileal morphology,microbiota composition,and cecal short chain fatty acids(SCFA)*** this purpose,720 male Arbor Acre broiler chicks at 1 d old were randomly assigned to a 2×3 factorial arrangement with 2 methionine sources(DL-methionine and DLHMTBA)and 3 total sulfur amino acids(TSAA)levels(80%,100%,and 120%of Arbor Acre recommendation).The results showed that DL-HMTBA supplementation promoted intestinal physical barrier at both gene expression level of claudin-1 and serum diamine oxidase level(P<0.05),and the inflammatory cytokine IL-6 m RNA expression was down-regulated by dietary DL-HMTBA supplementation compared with the DL-methionine group(P<0.05).Meanwhile,an upregulated gene expression of claudin-1 and zonula occluden-1(ZO-1)were observed in the low-TSAA treatment on d 14(P<0.05),whereas this treatment increased the expression of IL-1βand IL-6(P<0.05).Villus height to crypt depth ratio was high(P<0.05)in the middle-level TSAA ***,DL-HMTBA supplementation optimized the microbiota of the ileum especially the relative abundance of Lactobacillus,where the digestion and absorption were completed,and elevated the concentrations of SCFA(acetate,propionate,and butyrate)in the cecal content on d 21(P<0.01).In conclusion,dietary DL-HMTBA supplementation improved the intestinal barrier function,immune homeostasis and optimized the microbiota to promote intestinal health status in broiler chickens.

关键词： Chicken Methionine 2-Hydroxy-4-(methylthio)-butanoic acid Intestinal health Intestinal barrier