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CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy

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World Journal of Hepatology 2013年第4期5卷 189-195页

作者： Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura yuzo umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara Department of Gastroenterological Surgery Transplantand Surgical OncologyOkayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan

AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after *** tomography(CT)images were evaluated every 6 mo after PD for *** steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield *** biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo *** compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver ***-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy ***:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after *** patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin *** biopsy was performed in four patients with NAFLD after *** four patients showed moderate-to-severe steatosis and NASH was diagnosed in *** of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy *** number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with meta

关键词： Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells

Investigation of the microbiota associated with traditionally produced fruit vinegars with focus on acetic acid bacteria and lactic acid bacteria

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Food Bioscience 2022年第3期47卷 307-315页

作者： Ilkin Yucel Sengun Gulden Kilic Piyanat Charoenyingcharoen Pattaraporn Yukphan yuzo Yamada Ege University Engineering FacultyFood Engineering Department35100BornovaIzmirTurkey National Center for Genetic Engineering and Biotechnology (BIOTEC) National Science and Technology Development Agency (NSTDA)Khlong LuangPathum Thani12120Thailand Laboratory of Applied Microbiology (Professor Emeritus) Department of Applied Biological ChemistryFaculty of AgricultureShizuoka UniversitySuruga-kuShizuoka422-8529Japan Japan International Cooperation Agency (JICA Senior Overseas Volunteer) Shibuya-kuTokyo151-8558Japan

The microbiological properties of traditionally produced fruit vinegars,i.e.,fig,mulberry,apple and plum vinegars,supplied from different cities in Turkey were *** counts of acetic acid bacteria(AAB),lactic acid bacteria(LAB)and mold-yeast for fruit vinegars were found in the range of 2.54–7.05,1.91–6.81 and 1.32–7.10 log CFU/mL,*** indigenous AAB and LAB isolates were recovered from the vinegars and characterized based on a combination of phenotypic and genotypic approaches including 16S rRNA gene *** AAB three different species,Acetobacter pasteurianus,*** and ***,and in LAB five species,Lacticaseibacillus paracasei,Lactiplantibacillus plantarum,Levilactobacillus brevis,Leuconostoc *** Weisella confusa were identified in the vinegar *** was the first study reporting the identification of *** and Leuconostoc sp.,which were isolated from fig *** results of the study showed that *** and *** were predominant species found in vinegar *** study provides potential strains which may be used as starter cultures in food industry.

关键词： Microbial characterization Acetic acid bacteria Fig Mulberry Plum Fruit vinegar

Delayed immune-related sclerosing cholangitis after discontinuation of pembrolizumab:A case report

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World Journal of Gastroenterology 2022年第28期28卷 3732-3738页

作者： Takeshi Tanaka Arata Sakai Masahiro Tsujimae Yasutaka Yamada Takashi Kobayashi Atsuhiro Masuda yuzo Kodama Division of Gastroenterology Department of Internal MedicineKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Secondary sclerosing cholangitis,characterized by biliary obstruction,can be caused by drugs such as immune checkpoint inhibitors(ICIs).While there a few reports of sclerosing cholangitis after immune checkpoint inhibitor administration,no case has been reported after discontinuation of such *** SUMMARY A 68-year-old man who underwent chemotherapy for lung adenocarcinoma with bone metastasis presented with abdominal pain and fever 4 mo after the final administration of *** tomography revealed thickening of the gallbladder wall and dilatation of the common bile *** retrograde cholangiopancreatography revealed an irregularly narrowed intrahepatic bile *** of the bile duct demonstrated that CD8+T cells were predominant over CD4+T *** biopsy showed dominant infiltration of CD8+T in the portal tract,but onion-skin lesions were not *** patient was diagnosed with immune-related sclerosing cholangitis induced by *** of methylprednisolone and endoscopic nasobiliary drainage were performed,but the cholangiography and laboratory test findings did not *** further treatment was administered due to disease progression,and the patient was referred for palliative *** Immune-related sclerosing cholangitis may have a late onset,and such cases occurring after discontinuation of ICIs should be carefully managed.

关键词： Immune-related adverse events Sclerosing cholangitis Delayed immunerelated events Case report

Large Eddy Simulation of Swirling Jet in a Bluff-Body Burner

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Journal of Thermal Science 2005年第1期14卷 28-33页

作者： Yohei FUJIMOTO yuzo INOKUCHI Nobuhiko YAMASAKI Department of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581Japan

The large eddy simulation (LES) is applied to an unconfined swirling flow of an air surrounding a bluff-body having a central jet of air, and the complicated flowfield that involves the recirculation and vortex breakdown is investigated. The Smagorinsky model is used as the sub-grid scale model. The results of the present numerical simulation are compared with the experimental data of the mean and stochastic root mean square (RMS) variations of two velocity components. Although the inflow conditions are specified in a simple manner, the obtained numerical results are in reasonable agreement with the experiments, except for a part of RMS variation values near downstream of the bluff body. The present numerical calculations can successfully reproduce the two characteristics of the flow, i.e., an upstream recirculation zone established just downstream of the burner plane and the additional recirculation zone established at the more downstream location.

关键词：旋涡射流非流线体旋转仿真数字模型

Whole-exome sequencing for a more accurate diagnosis of intraductal papillary neoplasms of the bile duct

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Gastroenterology Report 2022年第1期10卷 618-621页

作者： Tomoaki Matsumori Norimitsu Uza Nobuyuki Kakiuchi Toshihiro Morita Yoshihiro Nishikawa Masahiro Shiokawa Kojiro Taura yuzo Kodama Hiroshi Seno Department of Gastroenterology and Hepatology Graduate School of MedicineKyoto UniversityKyotoJapan Department of Phathology and Tumor Biology Kyoto UniversityKyotoJapan Department of Hepato-Biliary-Pancreatic Surgery Graduate school of MedicineKyoto UniversityKyotoJapan Department of Gastroenterology Kobe UniversityKobeJapan

Introduction According to the World Health Organization(WHO,2018),intraductal papillary neoplasms of the bile duct(IPNB)are characterized as polypoid masses in dilated bile ducts;additionally,invasive IPNB occasionally presents with a nodular surface or mass formation[1,2].The IPNB diagnostic criteria are,however,often ambiguous,*** IPNB is considered a type of cancer and whether it must have mucus production are debatable[3].Therefore,establishing new IPNB diagnostic criteria based on an alternative approach,such as whole-exome sequencing,is ***,we present a case of IPNB with atypical features on which we performed a detailed genetic analysis to determine the genetic,morphological,and histological features of IPNB in this case.

关键词： neoplasms bile diagnosis

Overview of Exercise Prescription for Diabetes Patients and Its Application in Japan

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Journal of Science in Sport and Exercise 2020年第3期2卷 226-235页

作者： yuzo Sato Aichi Mizuho College 2-13Shunko-choMizuho-kuNagoyaAichi 467-0867Japan

In recent years,the Westernization of dietary habits and increasingly sedentary lifestyle have contributed to a marked increase in the number of type 2 diabetes *** behavior may play a significant role in the development and aggravation of type 2 *** results of various follow-up studies have demonstrated that proper diet combined with physical exer-cise is useful in the prevention and treatment of type 2 diabetes.A nationwide survey regarding exercise therapy for diabetes patients in Japan revealed that relatively few physicians provide patients with exercise guidance because of time constraints,that the physicians do not receive additional consultation fee,and that there is a lack of specialized physical exercise *** exercise promotes the utilization of glucose and free fatty acids in the muscles,and thus lowers blood glucose(BG)*** restriction and physical exercise are effective in the prevention and treatment of type 2 diabetes by improving the in vivo sensitivity to *** adults with diabetes should engage in 150 min or more of moderate-to-vigorous intensity aerobic activity per week,spread out over at least 3 days/week,with no more than two consecutive days without ***-intensity resistance training such as half squat and calf raise is recommended for elderly individuals who have decreased muscle strength and mass(sarcopenia).Prolonged sitting should be interrupted every 30 min for BG benefits,particularly in adults with type 2 *** with type 2 diabetes are also encouraged to increase their total daily unstructured physical activity(daily movement).

关键词： Diabetes mellitus Exercise prescription Sedentary behavior Aerobic exercise Resistance exercise Nationwide survey

Measurement and Numerical Simulation of a Small Centrifugal Compressor Characteristics at Small or Negative Flow Rate

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Journal of Thermal Science 2017年第2期26卷 107-112页

作者： Kaname Tsukamoto Mizuki Okada yuzo Inokuchi Nobuhiko Yamasaki Akihiro Yamagata Kyushu University Motooka 744819-0395FukuokaJapan IHI Corporation Shin-Nakahara 1235-8501YokohamaJapan

For centrifugal compressors used in automotive turbochargers, the extension of the surge margin is demanded because of lower engine speed. In order to estimate the surge line exactly, it is required to acquire the compressor characteristics at small or negative flow rate. In this paper, measurement and numerical simulation of the characteristics at small or negative flow rate are carried out. In the measurement, an experimental facility with a valve immediately downstream of the compressor is used to suppress the surge. In the numerical work, a new boundary condition that specifies mass flow rate at the outlet boundary is used to simulate the characteristics around the zero flow rate region. Furthermore, flow field analyses at small or negative flow rate are performed with the numerical results. The separated and re-circulated flow fields are investigated by visualization to identify the origin of losses.

关键词：流量特性数值模拟小流量离心压气机测量离心压缩机质量流率边界条件

Characteristics of obese or overweight dogs visiting private Japanese veterinary clinics

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 338-343页

作者： Shiho Usui Hidemi Yasuda yuzo Koketsu School of Agriculture Meiji University Department of Veterinary Research and Development Spectrum Lab Japan

Objective:To characterize obese or overweight dogs that visited private Japanese veterinary clinics located in humid subtropical climate ***:Dogs were categorized into four body condition score groups and five body size groups based on their *** logistic regression models were applied to the data.A Chi-squared test was used to examine whether the percentage of obese or overweight dogs differed between ***:There were 15.1% obese dogs and 39.8% overweight *** dogs were characterized by increased age and female sex,whereas overweight dogs were characterized by increased age and neuter status(P < 0.05).Peak probabilities of dogs being either obese or overweight were between 7 and 9 years of age,with the probabilities then declining as the dogs got *** example,in toy sized dogs,the probability of dogs being overweight increased from 33.4% to a peak of 55.1% as dog age rose from 1 to 8years ***,in medium,small and toy sized dogs,neutered dogs were more likely to be overweight than intact dogs,whereas neutered small sized dogs were more likely to be obese than intact small sized dogs(P < 0.05).Additionally,the percentages of obese or overweight dogs differed between the 10 selected breeds with the highest percentage of obese or overweight ***:By taking age,body size,sex and neuter status into account,veterinarians can advise owners about maintaining their dogs in ideal body condition.

关键词： Age Canine Factors Obesity Overweight

Impact of penile rehabilitation with low-dose vardenafil on recovery of erectile function in Japanese men following nerve-sparing radical prostatectomy

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Asian Journal of Andrology 2014年第6期16卷 892-896页

作者： yuzo Nakano Hideaki Miyake Koji Chiba Masato Fujisawa Division of Urology Kobe University Graduate School of Medicine Kusunoki-cho Chuo-ku Kobe Japan.

Erectile dysfunction （ED） is a major complication after radical prostatectomy （RP）; however, debatecontinues regarding the efficacy of penile rehabilitation in the recovery of the postoperative erectile function （EF）. This study includeda total of 103 consecutive sexually active Japanese men with localized prostate cancer undergoing nerve-sparing RP, and analyzed the postoperative EF, focusing on the significance of penile rehabilitation. In this series, 24 and 79 patients underwent bilateral and unilateral nerve-sparing RPs, respectively, and 10 or 20 mg of vardenafil was administered to 35 patients at least once weekly, who agreed to undergo penile rehabilitation. Twelve months after RP, 48 （46.6%） of the 103 patients were judged to have recovered EF sufficient for sexual intercourse without any assistance. The proportion of patients who recovered EF in those undergoing penile rehabilitation （60.0%） was significantly greater than that in those without penile rehabilitation （38.2%）. Of several parameters examined, the preoperative International Index of Erectile Function-5 （IIEF-5） score and nerve-sparing procedure were significantly associated with the postoperative EF recovery rates in patients with and without management by penile rehabilitation, respectively. Furthermore, univariate analysis identified the preoperative IIEF-5 score, nerve-sparing procedure and penile rehabilitation as significant predictors of EF recovery, among which the preoperative IIEF-5 score and nerve-sparing procedure appeared to be independently associated with EF recovery. Considering these findings, despite the lack of independent significance, penile rehabilitation with low-dose vardenafil could exert a beneficial effect on EF recovery in Japanese men following nerve-sparing RP.

关键词： erectile function nerve-sparing radical prostatectomy penile rehabilitation vardenafil