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The effects of coloring therapy on patients with generalized anxiety disorder

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Animal Models and Experimental Medicine 2022年第6期5卷 502-512页

作者： Bosomtwe Samuel Hongmei Wang Chengdong Shi Yongliang Pan yuzi Yu Weiyu Zhu zhou Jing School of Medicine Huzhou UniversityZhejiangChina Department of Nursing Gregory Catholic HospitalBuduburamCentral RegionGhana Department of Nursing West China Hospital of Sichuan UniversitySichuanChina Department of Nursing Shenzhen Baoan Maternal and Child Health HospitalGuangdongChina Department of Psychosomatic Diseases Huzhou Third People's HospitalZhejiangChina School of Teacher Education Huzhou UniversityZhejiangChina

Generalized anxiety disorder(GAD)has harmful effects on physical and mental health and quality of *** therapy has been reported to have a positive effect on improving patient anxiety and *** there are no reported clinical trials examining their effectiveness as a treatment for *** study was planned to evaluate the effectiveness of coloring therapy combined with conventional therapy in improving anxiety,depression,and positive and negative emotions with *** randomized controlled study comprising 88 GAD patients was selected for intervention in different *** control group(n=45)was given conventional antianxiety medication and physical therapy,and the experimental group(n=43)received coloring therapy combined with conventional *** Self-Rating Depression Scale,Self-Rating Anxiety Scale(SAS),Hamilton Depression Scale,Hamilton Anxiety Scale(HAMA),and Positive and Negative Affect Scale were assessed in both groups before and 3 weeks after the *** the intervention,there were statistical differences in intra-and inter-group comparisons of anxiety,depression,and positive and negative mood scales in the experimental and control groups(p.05).For GAD patients,adding coloring therapy based on conventional drug therapy and physical therapy can not only reduce depression and negative emotions but also have better effects on reducing anxiety and improving po

关键词： anxiety coloring therapy depression generalized anxiety disorder

Microwave synthesis of single-phase nanoparticles made of multiprincipal element alloys

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Nano Research 2022年第6期15卷 4886-4892页

作者： Siyu Wu yuzi Liu Yang Ren Qilin Wei Yugang Sun Department of Chemistry Temple University1901 North 13th StreetPhiladelphiaPennsylvania 19122USA Center for Nanoscale Materials Argonne National Laboratory9700 South Cass AvenueLemontIllinois 60439USA X-ray Science Division Advanced Photon SourceArgonne National Laboratory9700 South Cass AvenueLemontIllinois 60439USA

Metal nanoparticles of multi-principal element alloys(MPEA)with a single crystalline phase have been synthesized by flash heating/cooling of nanosized metals encapsulated in micelle vesicles dispersed in an oil phase(e.g.,cyclohexane).Flash heating is realized by selective absorption of a microwave pulse in metals to rapidly heat metals into uniform *** oil phase barely absorbs microwave and maintains the low temperature,which can rapidly quench the high-temperature metal melts to enable the flash cooling *** precursor ions of four metals,including Au,Pt,Pd,and Cu,can be simultaneously reduced by hydrazine in the aqueous solution encapsulated in the micelle *** resulting metals efficiently absorb microwave energy to locally reach a temperature high enough to melt themselves into a uniform *** duration of microwave pulse is crucial to ensure the reduced metals mix uniformly,while the temperature of oil phase is still low to rapidly quench the metals and freeze the single-phase crystalline lattices in alloy *** microwave-enabled flash heating/cooling provides a new method to synthesize single-phase MPEA nanoparticles of many metal combinations when the appropriate water-in-oil micelle systems and the appropriate reduction reactions of metal precursors are available.

关键词： microwave synthesis flash heating and cooling high-entropy alloys quaternary alloys metal nanoparticles

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白簕多糖颗粒剂的制备工艺研究

广东药科大学学报 2024年第1期40卷 14-21页

作者：伍国羽林榆子潘育方广东药科大学药学院广东广州510006 广东药科大学新药研发中心广东广州510006 广东省局部精准药物递药制剂工程技术研究中心广东广州510006

目的研究白簕多糖颗粒的制备工艺。方法采用湿法制粒工艺制备颗粒,以成型率、休止角、溶化性作为颗粒剂制备工艺的考察指标。应用单因素法考察多糖与稀释剂配比、润湿剂浓度与用量、干燥温度、干燥时间对颗粒剂质量的影响;在此基础上... 详细信息

目的研究白簕多糖颗粒的制备工艺。方法采用湿法制粒工艺制备颗粒,以成型率、休止角、溶化性作为颗粒剂制备工艺的考察指标。应用单因素法考察多糖与稀释剂配比、润湿剂浓度与用量、干燥温度、干燥时间对颗粒剂质量的影响;在此基础上,以多糖与稀释剂配比、润湿剂浓度、润湿剂用量为考察因素,采用星点设计-响应面法优化处方,并进行工艺验证,计算综合评分评估制备工艺的可行性。结果最优制备工艺为:赤藓糖醇与白簕多糖配比为3.22:1、润湿剂乙醇浓度为73.68%、乙醇用量为17.51%,在该条件下制备的白簕多糖颗粒剂的成型率达93.60%,休止角为28.20°,溶化率达98.12%,平均综合评分为97.24。制得的白簕多糖颗粒剂在外观、粒度、水分、总糖含量等方面均符合2020年版《中国药典》颗粒剂项下要求。结论该制备工艺稳定可行,质量可靠。

关键词：白簕多糖颗粒制剂工艺星点设计-响应面法质量评价

Probabilistic Optimal Power Flow Considering the Dependence of Multiple Wind Farms Using Pair Diffusive Kernel Copula

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CSEE Journal of Power and Energy Systems 2023年第5期9卷 1641-1654页

作者： Tianyao Ji Yantai Lin yuzi Jiang Mengshi Li Qing-Hua Wu the School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

As wind farms are commonly installed in areas with abundant wind resources,spatial dependence of wind speed among nearby wind farms should be considered when modeling a power system with large-scale wind *** this paper,a novel bivariate non-parametric copula,and a bivariate diffusive kernel(BDK)copula are proposed to formulate the dependence between random *** copula is then applied to higher dimension using the pair-copula method and is named as pair diffusive kernel(PDK)copula,offering flexibility to formulate the complicated dependent structure of multiple random ***,a quasi-Monte Carlo method is elaborated in the sampling procedure based on the combination of the Sobol sequence and the Rosen-blatt transformation of the PDK copula,to generate correlated wind speed *** proposed method is applied to solve probabilistic optimal power flow(POPF)*** effectiveness of the BDK copula is validated in copula ***,three different data sets are used in various goodness-of-fit tests to verify the superior performance of the PDK copula,which facilitates in formulating the dependence structure of wind speeds at different wind ***,samples obtained from the PDK copula are used to solve POPF problems,which are modeled on three modified IEEE 57-bus power *** to the Gaussian,T,and parametric-pair copulas,the results obtained from the PDK copula are superior in formulating the complicated dependence,thus solving POPF problems.

关键词： Bivariate diffusive kernel copula correlated wind speeds pair diffusive kernel copula probabilistic optimal power flow quasi-Monte Carlo Rosenblatt transformation

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铁稳态失衡在脓毒症中的研究进展

中国小儿急救医学 2024年第9期31卷 700-703页

作者：张靖枭金玉子敬小青承德医学院附属医院小儿内科

脓毒症是宿主对感染的反应失调导致的危及生命的器官功能障碍, 是全世界健康威胁的重要原因。近年研究发现, 铁稳态的代谢失衡与脓毒症关系密切, 机体拥有高度精密的铁代谢和调节系统, 以防止铁缺乏或铁过载。目前认为细胞内铁稳态失衡... 详细信息

脓毒症是宿主对感染的反应失调导致的危及生命的器官功能障碍, 是全世界健康威胁的重要原因。近年研究发现, 铁稳态的代谢失衡与脓毒症关系密切, 机体拥有高度精密的铁代谢和调节系统, 以防止铁缺乏或铁过载。目前认为细胞内铁稳态失衡是脓毒症的重要机制之一, 可能是临床干预的新靶点。

关键词：铁稳态铁过载铁缺乏脓毒症

Investigation towards scalable processing of silicon/graphite nanocomposite anodes with good cycle stability and specific capacity

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Nano Materials Science 2020年第4期2卷 297-308页

作者： Maziar Ashuri Qianran He yuzi Liu Leon LShaw Department of Mechanical Materials and Aerospace EngineeringIllinois Institute of TechnologyChicagoIL60616USA Center for Nanoscale Materials(CNM) Argonne National LaboratoryLemontIL60439USA

Silicon/graphite(Si/Gr)nanocomposites with controlled void spaces and encapsulated by a carbon shell(Si/Gr@void@C)are synthesized by utilizing high-energy ball milling to reduce micron-sized particles to nanoscale,followed by carbonization of polydopamine(PODA)to form a carbon shell,and finally partial etching of the nanostructured Si core by NaOH solution at elevated *** particular,the effects of ball milling time and NaOH etching temperature on the electrochemical properties of Si/Gr@void@C are *** the ball milling time results in the improved specific capacity of Si-based *** coating further enhances the specific capacity and capacity retention over charge/discharge *** best cycle stability is achieved after partial etching of the Si core inside Si/Gr@void@C particles at either 70 or 80C,leading to little or no capacity decay over 130 ***,it is found that both carbon coating and NaOH etching processes cause some surface oxidation of the nanostructured Si particles derived from high-energy ball *** surface oxidation of the nanostructured Si results in decreases in specific capacity and should be minimized in future *** mechanistic understanding developed in this study paves the way to further improve the electrochemical performance of Si/Gr@void@C nanocomposites in future.

关键词： Li-ion Battery Silicon Anode Polydopamine Nanocomposite Graphite Carbon Coating

基于负荷跟踪和客户低感知的电动汽车群调个控充电管理方法

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电力信息与通信技术 2024年第3期22卷 43-51页

作者：文爱军姜雨滋孟洪民刘泽三国网信息通信产业集团有限公司北京市昌平区100052

针对电动汽车充电站对电网负荷调控指令跟踪精度低、充电客户对站内负荷分配不满意的问题,文章提出了基于负荷跟踪和客户低感知的电动汽车群调个控充电管理方法。首先,基于改进的条件生成对抗网络建立电动汽车单体可调度潜力的预测模型... 详细信息

针对电动汽车充电站对电网负荷调控指令跟踪精度低、充电客户对站内负荷分配不满意的问题,文章提出了基于负荷跟踪和客户低感知的电动汽车群调个控充电管理方法。首先,基于改进的条件生成对抗网络建立电动汽车单体可调度潜力的预测模型,可根据客户车辆电池管理系统历史上报的充电数据,生成车辆调度潜力时序曲线。然后,根据电动汽车充电集群的调度潜力总曲线和来自电网的负荷调控信号,提出计及能量损失和客户低感知的负荷分解优化模型,使用改进的多目标麻雀搜索算法进行求解,并在四川成都的电动汽车充电站验证了所提模型的合理性,证实其能有效地降低对客户车辆的控制功率损失,提高对调度负荷控制信号的跟踪精度,同时提高单个充电客户的感知满意度。

关键词：电动汽车可调度能力负荷跟踪条件生成对抗网络多目标麻雀搜索算法低感知函数

肝细胞癌中环氧合酶-2表达抑制常规1型树突状细胞的瘤内富集及免疫应答的研究

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中华普通外科杂志 2024年第5期39卷 372-378页

作者：李煜子汪洋程倩李祖寅李照朱继业高杰北京大学人民医院肝胆外科北京100044

目的探讨肝细胞癌(hepatocellular carcinoma,HCC)中环氧合酶-2(cyclooxygenase-2,COX-2)表达对常规1型树突状细胞(conventional type 1 dendritic cell,cDC1)的瘤内富集及免疫应答功能的影响。方法采用免疫荧光染色检测2016年1月至2017年6月北京大学人民医院行肝切除术的111例HCC患者肿瘤组织中cDC1瘤内富集及COX-2表达水平,将HCC患者分为cDC1浸润型与cDC1缺失型,分析HCC细胞表达COX-2与cDC1瘤内浸润的相关性。利用HCC单细胞转录组测序数据检验COX-2编码基因PTGS2与cDC1亚群比例的相关性。回顾性分析HCC肿瘤组织中cDC1浸润情况与患者临床特征及预后的相关性。通过体外造血干细胞(HSC)向cDC1诱导分化及流式分选,获得HSC来源cDC1,与HCC细胞系共培养后进行转录组测序,并用COX-2选择性抑制剂塞来昔布抑制HCC细胞系的COX-2表达,通过FITC-葡聚糖摄取实验、流式检测、Luminex多因子检测探索HCC中COX-2表达对cDC1的抗原摄取、共刺激分子表达和细胞因子分泌功能的影响。结果免疫荧光染色提示cDC1缺失型(n=73)的HCC肿瘤组织中COX-2表达水平显著高于cDC1浸润型(n=38)(P=0.0042)。单细胞转录组测序数据分析提示PTGS2高表达的HCC肿瘤组织中cDC1亚群比例显著降低。cDC1浸润型的HCC患者总体生存率(P=0.037)、无瘤生存率(P=0.048)优于cDC1缺失型。cDC1与HCC共培养后抗原摄取功能、共刺激分子表达、细胞因子分泌的免疫应答功能受到抑制,塞来昔布可改善cDC1的免疫应答功能。结论HCC中cDC1瘤内富集与患者预后良好相关。HCC中表达COX-2可能抑制cDC1向瘤内浸润,抑制cDC1抗原摄取、共刺激分子表达及细胞因子分泌的免疫应答功能。靶向COX-2的抑制剂可逆转HCC对cDC1的功能抑制。

关键词：癌,肝细胞树突细胞环氧合酶-2 免疫应答

未来北极夏季陆面气温变化区域特征及其与北大西洋海面温度的关系

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海洋气象学报 2024年第1期44卷 65-75页

作者：吴雨子胡舒涵赵传湖黄菲中国海洋大学物理海洋教育部重点实验室山东青岛266100 中国海洋大学深海圈层与地球系统前沿科学中心山东青岛266100

未来变暖背景下北极气候变化特征研究具有重要意义,基于国际耦合模式比较计划第六阶段(Coupled Model Intercomparison Project Phase 6,CMIP6)中对北极气候变化模拟能力较好的模式模拟结果,研究SSP2-4.5情景下21世纪北极2 m气温的时空... 详细信息

未来变暖背景下北极气候变化特征研究具有重要意义,基于国际耦合模式比较计划第六阶段(Coupled Model Intercomparison Project Phase 6,CMIP6)中对北极气候变化模拟能力较好的模式模拟结果,研究SSP2-4.5情景下21世纪北极2 m气温的时空变化特征及其影响因素。结果表明:(1)极地陆地的欧亚大陆(Eurasia, EA)和北美-格陵兰(Greenland, GL)对全球变暖具有不同的响应。EA在21世纪中叶前变暖趋势显著,之后主要表现为年代际尺度的冷暖振荡;GL则始终保持增暖趋势。EA、GL分区气温均存在年际、年代际(10~20 a)尺度上的波动,GL分区还存在20~40 a的准周期变化。(2)前冬北大西洋涛动正位相会引起次年夏季北大西洋呈南北向“-、+、-”三极型海面温度异常,并通过影响大气环流导致EA分区气温正异常,这种影响主要体现在年代际尺度上。(3)北大西洋多年代际振荡为正异常时,北美至格陵兰位势高度偏高,GL分区增暖,并且这种影响在21世纪70年代后更重要;北太平洋北部的海面温度正异常对GL分区增温也有贡献。

关键词：北极 2 m气温国际耦合模式比较计划第六阶段(CMIP6) 北大西洋海面温度