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Comprehensive experimental database and analysis of circular concrete-filled double-skin tube stub columns:A review

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Frontiers of Structural and Civil Engineering 2023年第12期17卷 1830-1848页

作者： Hongyuan TANG Hongfei TAN Sisi GE Jieyu QIN yuzhuo wang Institute of Structural Engineering Xihua UniversityChengdu 610039China School of Civil Engineering Shandong Jianzhu UniversityJinan 250101China

A concrete-filled double-skin tube(CFDST)is a new type of composite *** studies have been conducted to investigate the axial compression behavior of CFDST members for approximately 30 *** paper provides a review of the status of axial compression bearing capacity tests conducted on circular CFDST stub columns as well as a summary of test data for 165 circular CFDST stub columns reported in 22 papers.A relatively complete high-quality test database is *** on this database,the main factors affecting the axial compression bearing capacity of the CFDST stub columns are *** prediction accuracy and robustness of an existing theoretical prediction model,which is a data-driven model,are evaluated,and a numerical simulation of the axial compression bearing capacity of the CFDST stub columns is *** addition,the differences between the basic theory and experimental results of various models are compared,and the possible sources of prediction errors are *** current model for predicting the axial compression capacity of CFDST stub columns cannot simultaneously satisfy the requirements of high accuracy and confidence,and the stress independency assumption introduced in the test is not *** main error source in the theoretical prediction model is the non-simultaneous consideration of the effects of the void ratio and inner steel tube.

关键词： CFDST bearing capacity model confined concrete model test database

Chromoplexy： a new paradigm in genome remodeling and evolution

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Asian Journal of Andrology 2013年第6期15卷 711-712页

作者： Kendric wang yuzhuo wang Colin C Collins Vancouver Prostate Centre & Department of Urologic Sciences University of British Columbia Vancouver BC V6H 3Z6 Canada Department of Experimental Therapeutics BC Cancer Agency Vancouver BC V5Z 1L3 Canada

Early massively-parallel sequencing stu-dies have revealed the mutational land-scape of protein-coding genes in prostate cancer. However, most of these studies have not explored the extensive influence of geno- mic rearrangement in prostate cancer. In a recent Cell article, Baca and colleagues used whole-genome sequencing to tackle this issue, comprehensively surveying the abun-dance of genomic rearrangements present in a large cohort of 57 prostate cancers. They characterized a wide-spread phenomenon termed ＇chromoplexy＇, which may drive can-cer evolution through the phenomena of punctuated equilibrium by concurrently dys-regulating numerous cancer genes across multiple chromosomes. While the causes of this event still require elucidation, this defin-ing discovery undoubtedly offers an impor- tant glimpse into the evolutionary process of prostate cancer.

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Copper-based nanodots as efficient biomimetic antibiotics for the treatment of oral bacterial infections Author links open overlay panel

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Particuology 2024年第8期91卷 190-201页

作者： Ying Li Nan Tang Lingling Zhao Xingfu Bao yuzhuo wang Zhanxin wang Min Hu Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of StomatologyJilin UniversityChangchunChina Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijingChina

Oral infectious diseases caused by a variety of pathogenic bacteria seriously affect the quality of ***,these diseases remain a clinical challenge because of the lack of simple,safe,and universal *** address these limitations,we synthesize CuO_(x)nanodots(CuO_(x)NDs)with excellent Fenton-like reaction activity and utilize them in the treatment of oral bacterial *** from other complicated approaches,CuO_(x)NDs are rationally prepared using a facile one-pot aqueous *** the presence of H_(2)O_(2),these well-developed CuO_(x)NDs can efficiently catalyze the generation of hydroxyl radicals(·OH)around oral pathogens,leading to the death of various ***,results of biosafety indicate the high biocompatibility and extremely low toxicity of these CuO_(x)*** understanding the admirable in vitro antibacterial effect of CuO_(x)NDs in the presence of H_(2)O_(2),we further explore their in vivo antibacterial performance on several classical animal models including oral mucosal wound model,intragingival bacteria-infected model,and the periodontal infection *** expected,these CuO_(x)NDs with wide-spectrum antibacterial activity can serve as high-performance antibacterial reagents for the treatment of various oral bacterial infections with the help of H_(2)O_(2).In brief,current nanoplatform can act as efficient antibiotics against oral pathogens with broadening the biomedical applications of copper-based nanomaterials.

关键词： Antibacterial treatment Oral diseases Fenton-likecatalytic reaction Reactive oxygen species

The role of mRNA splicing in prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 515-521页

作者： Anna V Lapuk Stanislav V Volik yuzhuo wang Colin C Collins Vancouver Prostate CentreUniversity of British Columbia Vancouver BC Canada. Department of Experimental Therapeutics BC Cancer AgencyUniversity of British Columbia Vancouver BC Canada. Department of Urologic Sciences University of British Columbia Vancouver BC Canada.

Alternative splicing （AS） is a crucial step in gene expression. It is subject to intricate regulation, and its deregulation in cancer can lead to a wide array of neoplastic phenotypes. A large body of evidence implicates splice isoforms in most if not all hallmarks of cancer, including growth, apoptosis, invasion and metastasis, angiogenesis, and metabolism. AS has important clinical implications since it can be manipulated therapeutically to treat cancer and represents a mechanism of resistance to therapy. In prostate cancer （PCa） AS also plays a prominent role and this review will summarize the current knowledge of alternatively spliced genes with important functional consequences. We will highlight accumulating evidence on AS of the components of the two critical pathways in PCa： androgen receptor （AR） and phosphoinositide 3-kinase （PI3K）. These observations together with data on dysregulation of splice factors in PCa suggest that AR and PI3K pathways may be interconnected with previously unappreciated splicing regulatory networks. In addition, we will discuss several lines of evidence implicating splicing regulation in the development of the castration resistance.

关键词： alternative splicing prostate cancer androgen receptor PI3K pathway CRPC neuroendocrine transdifferentiation REST repressor complex

Climate change threats to protected plants of China: an evaluation based on species distribution modeling

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Chinese Science Bulletin 2014年第34期59卷 4652-4659页

作者： Yinbo Zhang yuzhuo wang Minggang Zhang Keping Ma College of Environmental and Resource Sciences Shanxi University Institute of Loess Plateau Shanxi University State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences

Climate change poses major new challenges to biodiversity conservation. Distribution ranges of species have been proven to be affected by climate *** the extent of protected species response to climate change can help formulate flexible conservation strategies to overcome the changing climate. Using species distribution modeling and high resolution climate data, we simulated current distribution patterns of 233 protected plants in China. Those patterns were then projected into future suitable habitats for each species under nine climate change scenarios, with no migration or full migration hypotheses. Under the most extreme climate change scenario(CGCM-B2a), we evaluated species extinction *** percent of protected plants are expected to lose more than 30 % of their current ranges. By calculating areal shifts, hotspots for emigrants, immigrants, and persistent species were identified under climate *** conservation strategies were addressed for thoseregions. Those strategies strongly depend on the migration types of species and sensitivity of the hotspots to changing climate. In hotspots for emigrants, the main conservation strategy is ex situ protection; protected species from these regions should be stored in seed banks or botanical gardens. For hotspots of immigrants, enough space should be maintained for new species, and some measures are necessary to assist dispersal. For hotspots of persistent species,more natural reserves are needed. We highlight related fields that can help conserve protected species in the future,such as conserving the soil seed bank and understanding of the effects of migration ability and interactions between protected species.

关键词：气候变化物种分布保护植物建模评估中国生物多样性保护土壤种子库

The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing

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Asian Journal of Andrology 2013年第3期15卷 301-308页

作者： Alexander W Wyatt Fan Mo yuzhuo wang Colin C Collins Vancouver Prostate Centre & Department of Urologic Sciences University of British Columbia Vancouver BC V6H 3Z6 Canada Department of Experimental Therapeutics BC Cancer Agency Vancouver BC VSZ 1L3 Canada

Prostate cancer is a leading cause of global cancer-related death but attempts to improve diagnoses and develop novel therapies have been confounded by significant patient heterogeneity. In recent years, the application of next-generation sequencing to hundreds of prostate tumours has defined novel molecular subtypes and characterized extensive genomic aberration underlying disease initiation and progression. It is now clear that the heterogeneity observed in the clinic is underpinned by a molecular landscape rife with complexity, where genomic rearrangements and rare mutations combine to amplify transcriptomic diversity. This review dissects our current understanding of prostate cancer ＇omics＇, including the sentinel role of copy number variation, the growing spectrum of oncogenic fusion genes, the potential influence of chromothripsis, and breakthroughs in defining mutation-associated subtypes. Increasing evidence suggests that genomic lesions frequently converge on specific cellular functions and signalling pathways, yet recurrent gene aberration appears rare. Therefore, it is critical that we continue to define individual tumour genomes, especially in the context of their expressed transcriptome. Only through improved characterisation of tumour to tumour variability can we advance to an age of precision therapy and personalized oncology.

关键词： cancer sequencing copy number fusion gene genome genome rearrangement personalized oncology prostate cancer transcriptome

Prostate cancer metastasis-driving genes： hurdles and potential approaches in their identification

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Asian Journal of Andrology 2014年第4期16卷 545-548页

作者： Yan Ting Chiang Peter W Gout Colin C Collins yuzhuo wang The Vancouver Prostate Centre Vancouver General Hospital and Department of Urologic Sciences the University of British Columbia Department of Experimental Therapeutics British Columbia Cancer Agency Vancouver British Columbia Canada.

Metastatic prostate cancer is currently incurable. Metastasis is thoughtto result from changes in the expression of specific metastasis-driving genes in nonmetastatic prostate cancer tissue, leading to a cascade of activated downstream genes that set the metastatic process in motion. Such genes could potentially serve as effective therapeutic targets for improved management of the disease. They could be identified by comparative analysis of gene expression profiles of patient-derived metastatic and nonmetastatic prostate cancer tissues to pinpoint genes showing altered expression,

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Polygenic risk scores:the future of cancer risk prediction,screening,and precision prevention

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Medical Review 2021年第2期1卷 129-149页

作者： yuzhuo wang Meng Zhu Hongxia Ma Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 211166JiangsuChina Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijing 100010 Department of Medical Informatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsuChina

Genome-wide association studies(GWASs)have shown that the genetic architecture of cancers are highly polygenic and enabled researchers to identify genetic risk loci for *** genetic variants associated with a cancer can be combined into a polygenic risk score(PRS),which captures part of an individual’s genetic susceptibility to ***,PRSs have been widely used in cancer risk prediction and are shown to be capable of identifying groups of individuals who could benefit from the knowledge of their probabilistic susceptibility to cancer,which leads to an increased interest in understanding the potential utility of PRSs that might further refine the assessment and management of cancer *** this context,we provide an overview of the major discoveries from cancer *** then review the methodologies used for PRS construction,and describe steps for the development and evaluation of risk prediction models that include PRS and/or conventional risk *** utility of PRSs in cancer risk prediction,screening,and precision prevention are *** and practical considerations relevant to the implementation of PRSs in health care settings are discussed.

关键词： cancer screening genome-wide association study(GWAS) polygenic risk score(PRS) precision prevention risk prediction model.

Immune phenotypes of prostate cancer cells: Evidence of epithelial immune cell-like transition?

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Asian Journal of Urology 2016年第4期3卷 195-202页

作者： Dong Lin Xinya wang Stephen Yiu Chuen Choi Xinpei Ci Xin Dong yuzhuo wang Vancouver Prostate Centre&Department of Urologic Sciences University of British ColumbiaVancouverBCCanada Department of Experimental Therapeutics BC Cancer AgencyVancouverBCCanada

Prostate cancers(PCa)have been reported to actively suppress antitumor immune responses by creating an immune-suppressive *** is mounting evidence that PCas may undergo an‘‘Epithelial Immune Cell-like Transition’’(EIT)by expressing molecules conventionally associated with immune cells(e.g.,a variety of cytokines/receptors,immune transcription factors,Ig motifs,and immune checkpoint molecules),which subsequently results in the suppression of anti-cancer immune activity within the tumor *** progress within the field of immune therapy has underscored the importance of immune checkpoint molecules in cancer development,thus leading to the development of novel immunotherapeutic ***,we review the expression of select immune checkpoint molecules in PCa epithelial and associated immune cells,with particular emphasis on clinical data supporting the concept of an EIT-mediated phenotype in ***,we summarize current advances in anti-immune checkpoint therapies,and provide perspectives on their potential applicability.

关键词： Prostate cancer Immune checkpoint Epithelial immune cell-like transition Immune suppression Immune therapy