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Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors

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Cancer Communications 2024年第7期44卷 739-760页

作者： yuze wu Ming Yi Mengke Niu Binghan Zhou Qi Mei Kongming wu Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Breast Surgery Zhejiang University School of Medicine First Affiliated HospitalHangzhouZhejiangP.R.China Cancer Center Shanxi Bethune HospitalShanxi Academy of Medical ScienceTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxiP.R.China Cancer Center Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Immunotherapy,particularly with immune checkpoint inhibitors,has significantly transformed cancer *** its success,many patients struggle to respond adequately or sustain long-lasting clinical improvement.A growing consensus has emerged that radiotherapy(RT)enhances the response rate and overall efficacy of *** combining RT and immunotherapy has been extensively investigated in preclinical models and has shown promising results,establishing itself as a dynamic and thriving area of research,clinical evidence for this combination strategy over the past five years has shown both positive and disappointing results,suggesting the need for a more nuanced *** review provides a balanced and updated analysis of the combination of immunotherapy and *** summarized the preclinical mechanisms through which RT boosts antitumor immune responses andmainly focused on the outcomes of recently updated clinical trials,including those that may not have met *** investigated the optimization of the therapeutic potential of this combined strategy,including key challenges,such as fractionation and scheduling,lymph node irradiation,and ***,we offered insights into the prospects and challenges associated with the clinical translation of this combination therapy,providing a realistic perspective on the current state of research and potential future directions.

关键词： immunotherapy radiotherapy immune checkpoint inhibitor abscopal effect tumor microenvironment

Targeting cytokine and chemokine signaling pathways for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3381-3428页

作者： Ming Yi Tianye Li Mengke Niu Haoxiang Zhang yuze wu Kongming wu Zhijun Dai Department of Breast Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000People's Republic of China Department of Gynecology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000People's Republic of China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People's Republic of China Department of Hepatopancreatobiliary Surgery Fujian Provincial HospitalFuzhou 350001People's Republic of China

Cytokines are critical in regulating immune responses and cellular behavior,playing dual roles in both normal physiology and the pathology of diseases such as *** molecules,including interleukins,interferons,tumor necrosis factors,chemokines,and growth factors like TGF-β,VEGF,and EGF,can promote or inhibit tumor growth,influence the tumor microenvironment,and impact the efficacy of cancer *** advances in targeting these pathways have shown promising therapeutic potential,offering new strategies to modulate the immune system,inhibit tumor progression,and overcome resistance to conventional *** this review,we summarized the current understanding and therapeutic implications of targeting cytokine and chemokine signaling pathways in *** exploring the roles of these molecules in tumor biology and the immune response,we highlighted the development of novel therapeutic agents aimed at modulating these pathways to combat *** review elaborated on the dual nature of cytokines as both promoters and suppressors of tumorigenesis,depending on the context,and discussed the challenges and opportunities this presents for therapeutic *** also examined the latest advancements in targeted therapies,including monoclonal antibodies,bispecific antibodies,receptor inhibitors,fusion proteins,engineered cytokine variants,and their impact on tumor growth,metastasis,and the tumor ***,we evaluated the potential of combining these targeted therapies with other treatment modalities to overcome resistance and improve patient ***,we also focused on the ongoing research and clinical trials that are pivotal in advancing our understanding and application of cytokine-and chemokine-targeted therapies for cancer patients.

关键词： cytokine chemokine overcome

Fabrication and Characterization of High-Bonding-Strength Al/Ti/Al-Laminated Composites via Cryorolling

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Acta Metallurgica Sinica(English Letters) 2020年第6期33卷 871-880页

作者： Juan Liu yuze wu Lin Wang Hui Wang Charlie Kong Alexander Pesin Alexander PZhilyaev Hailiang Yu State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Light Alloys Research Institute Central South UniversityChangsha 410083China Research Center for Advanced Science and Technology The University of TokyoMeguroTokyo 1530041Japan Mark Wainwright Analytical Centre University of New South WalesSydneyNSW 2052Australia Laboratory of Mechanics of Gradient Nanomaterials Nosov Magnitogorsk State Technical UniversityMagnitogorskRussia 455000

Sandwich-like Al/Ti/Al-laminated composites have many advantages such as low density and high specific strength with value in mechanical manufacturing and aerospace engineering. Here, Al/Ti/Al-laminated composites were fabricated by hot roll bonding and subsequent processes: cryorolling(-190 ℃ and-100 ℃), cold rolling(25 ℃), and hot rolling(300 ℃). Their bonding strength and mechanical properties were then studied by an Autograph AGS-X universal electronic testing machine. The results show that cryorolling can improve the interface bonding strength and tensile strength of Al/Ti/Allaminated composites. For the Al/Ti/Al-laminated composites subjected to cryorolling at-100 ℃, they have the highest strength near 260 MPa—this is 48 MPa and 41 MPa higher than the laminated composites subjected to cold and hot rolling, respectively. These results also show the strongest peeling strength. Finally, the mechanisms of the enhancement of bonding strength and mechanical properties of Al/Ti/Al-laminated composites subjected to cryorolling were mainly discussed.

关键词： Laminated composites Cryorolling Bonding strength Peeling strength Mechanical property Bonding mechanism

RViT: Robust Fusion Vision Transformer with Variational Hierarchical Denoising Process for Image Classification

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Guidance,Navigation and Control 2024年第3期4卷 191-217页

作者： Zhenghong Lin yuze wu Jiawei Chen Shiping Wang College of Computer and Data Science Fuzhou University Key Laboratory of Intelligent Metro Fujian Province University

Transformers designed for natural language processing have originally been explored for computer vision in recent research. Various Vision Transformers(Vi Ts) play an increasingly important role in the field of image tasks such as computer vision, multimodal fusion and multimedia analysis. However, to obtain promising performance, most existing ViTs usually rely on artificially filtered high-quality images, which may suffer from inherent noise ***, such well-constructed images are not always available in every situation. To this end,we propose a Robust ViT(RViT) to focus on the relevant and robust representation learning for image classification tasks. Specifically, we first develop a novel Denoising VTUnet module,where we conceptualize the nonrobust noise as the uncertainty under the variational ***, we design a fusion transformer backbone with a tailored fusion attention mechanism to perform image classification based on the extracted robust representations effectively. To demonstrate the superiority of our model, the compared experiments are conducted on several popular datasets. Benefiting from the sequence regularity of the Transformer and captured robust feature,the proposed method exceeds compared Transformer-based models with superior performance in visual tasks.

关键词： Image classification vision transformer robust representation learning variational inference fusion attention

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异种钢焊接结构的开孔补强计算

一重技术 2018年第2期 1-4页

作者：吴学彬吴雨泽一重集团大连工程技术有限公司辽宁大连116600 中南大学湖南长沙410012

以不锈钢S30403接管与低合金钢Q345R筒体焊接结构为例,对D类和A类两种焊接接头的开孔分别进行补强计算。对A类焊接接头进行方案1(不锈钢部分增厚)和方案2(不增厚)的对比,计算结果显示按GB 150等面积补强方法,异种钢的A类焊接接头不锈钢... 详细信息

以不锈钢S30403接管与低合金钢Q345R筒体焊接结构为例,对D类和A类两种焊接接头的开孔分别进行补强计算。对A类焊接接头进行方案1(不锈钢部分增厚)和方案2(不增厚)的对比,计算结果显示按GB 150等面积补强方法,异种钢的A类焊接接头不锈钢部分必须进行增厚设计,以补偿不锈钢材料强度低所引起的强度削弱。同时应用ANSYS软件,建立方案2的结构模型,对接管区域进行应力分析,并按JB 4732对危险截面进行应力分析评定,结果显示方案2可以满足强度要求。

关键词：异种钢开孔补强应力分析

基于CNN-XGBoost的采煤机健康状态评估

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煤炭技术 2022年第11期41卷 173-176页

作者：曹现刚陈瑞昊伍宇泽孟伟西安科技大学机械工程学院西安710054 陕西省矿山机电装备智能监测重点实验室西安710054 中国船舶集团有限公司第705研究所昆明分部昆明650021

针对采煤机数据集类别数据不平衡导致评估准确率不高和单一评估算法局部搜索能力较弱等问题,提出一种基于卷积神经网络(CNN)和极端梯度提升算法(XGBoost)的采煤机健康状态评估方法。根据采煤机结构及工作原理构建健康状态评估指标体系,... 详细信息

针对采煤机数据集类别数据不平衡导致评估准确率不高和单一评估算法局部搜索能力较弱等问题,提出一种基于卷积神经网络(CNN)和极端梯度提升算法(XGBoost)的采煤机健康状态评估方法。根据采煤机结构及工作原理构建健康状态评估指标体系,将预处理后的采煤机状态数据集输入CNN模型提取特征信息,利用XGBoost模型进行状态评估。实验结果表明:基于CNN-XGBoost的采煤机健康状态评估方法平均准确率可达95.4%,能有效解决数据集的不平衡问题和状态评估难题。

关键词：采煤机卷积神经网络极端梯度提升状态评估

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高压复合管线法兰连接设计及疲劳寿命分析

石油机械 2022年第8期50卷 140-148页

作者：吴雨泽龙连春吴奇徐加军王锦程北京工业大学材料与制造学部中国石油化工股份有限公司胜利油田分公司胜利采油厂

针对油田高压注水地面管线腐蚀严重问题,以干线大口径复合管线为研究对象,设计了法兰连接复合管线连接处的6种内衬结构。依据抗凹陷强度准则,确定了管线内衬厚度。基于流固耦合理论,建立了复合管线不同连接结构的流固耦合有限元仿真分... 详细信息

针对油田高压注水地面管线腐蚀严重问题,以干线大口径复合管线为研究对象,设计了法兰连接复合管线连接处的6种内衬结构。依据抗凹陷强度准则,确定了管线内衬厚度。基于流固耦合理论,建立了复合管线不同连接结构的流固耦合有限元仿真分析模型,研究了高压注水条件下复合管线的应力分布。利用中间计算点插值拟合的方法,结合脉动频率与假设函数形态,得到了停机水锤下内衬最大应力的变化规律,基于Walker疲劳寿命模型,对复合管线启停机安全性进行了评估。研究结果表明:超高分子量聚乙烯具有较高的抗内压强度和耐疲劳性,更适合作为高压注水管道内衬材料;168 mm复合管线内衬的优选厚度为5 mm,245 mm复合管线内衬的优选厚度为7 mm,且所得复合管线径厚比S计算式通用;内衬翻边处理、限位环定位锁紧是大口径复合管线的合理连接方式;设计了水锤频繁冲击下具有较长疲劳寿命的连接方案。研究结果可为干线大口径高压复合管线的连接设计及工程应用提供参考。

关键词：高压注水管线内衬设计法兰连接流固耦合疲劳寿命

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闽南压白尺法的民俗文化探析

闽江学院学报 2023年第6期44卷 1-9页

作者：汪晓东吴雨泽集美大学美术与设计学院福建厦门361021

压白尺法是我国闽南民间的传统营造技法之一。文章以传统时代下人们的民俗文化心理为基础,结合相关文献及田野调查资料,探讨压白尺法在闽南兴起的原因及其民俗文化的动态发展过程。研究发现,民间对建筑尺度和建筑方位的重视,以及关于数... 详细信息

压白尺法是我国闽南民间的传统营造技法之一。文章以传统时代下人们的民俗文化心理为基础,结合相关文献及田野调查资料,探讨压白尺法在闽南兴起的原因及其民俗文化的动态发展过程。研究发现,民间对建筑尺度和建筑方位的重视,以及关于数值与空间的择吉信仰,都根源于底层民众趋福避祸的心理需求,体现了人们对美好生活的向往。在压白尺法的推算流程中,可以窥见其作为营造范式体现出的公共意识形态,虽然其中不乏封建迷信的内容,但只要辩证看待风水术与营造术之间的交融关系,深入理解二者同根同源、互动发展的模式,对中国当代建筑学和民俗文化建构具有重要意义。

关键词：闽南压白尺法民俗文化

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古浪县生态移民政策效益评价指标体系构建

管理科学与研究（中英文版） 2023年第4期12卷 80-88页

作者：吴玉泽王文棣甘肃农业大学管理学院甘肃兰州730070

“十四五”时期是国家推进乡村振兴战略的重要时期,巩固拓展脱贫攻坚成果同乡村振兴有效衔接、高质量推进乡村振兴战略意义重大。古浪县生态移民工程较大的搬迁规模和人口数量决定了移民社区的发展一定程度上影响着全县的经济社会发展,... 详细信息

“十四五”时期是国家推进乡村振兴战略的重要时期,巩固拓展脱贫攻坚成果同乡村振兴有效衔接、高质量推进乡村振兴战略意义重大。古浪县生态移民工程较大的搬迁规模和人口数量决定了移民社区的发展一定程度上影响着全县的经济社会发展,对古浪县生态移民政策实施效益进行客观、科学的评价显得尤为必要。基于理论与现实依据,构建了古浪县生态移民政策实施效益评价指标体系,并计算了对应的权重,为政策效益评价提供了有效遵循。

关键词：生态移民评价指标体系指标权重