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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang yuyu zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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桥本甲状腺炎患者甲状腺功能及生化指标变化情况分析

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中国社区医师 2024年第15期40卷 62-64页

作者：邱远梅周育育嘉峪关市第一人民医院检验科甘肃嘉峪关735100

目的:分析桥本甲状腺炎患者甲状腺功能及生化指标的变化。方法:选取2021年3月—2023年5月嘉峪关市第一人民医院收治的66例桥本甲状腺炎患者作为桥本组,选取同期66例健康体检者作为非桥本组。两组均进行甲状腺功能及生化指标检测,比较桥... 详细信息

目的:分析桥本甲状腺炎患者甲状腺功能及生化指标的变化。方法:选取2021年3月—2023年5月嘉峪关市第一人民医院收治的66例桥本甲状腺炎患者作为桥本组,选取同期66例健康体检者作为非桥本组。两组均进行甲状腺功能及生化指标检测,比较桥本组与非桥本组、桥本组不同疾病分期患者的甲状腺功能、生化指标水平。结果:桥本组游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平低于非桥本组,促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)、微小核糖核酸-454(miR-454)、可诱导共刺激分子(ICOS)、神经轴突导向分子SA(SemaSA)水平高于非桥本组,差异有统计学意义(P0.05)。桥本组不同疾病分期患者FT_(3)、FT_(4)水平比较,甲状腺功能亢进期>甲状腺功能亢进和甲状腺功能减退并存期>甲状腺功能减退期,差异有统计学意义(P0.05)。结论:桥本甲状腺炎患者多存在甲状腺功能异常,外周血miR-454、ICOS、SemaSA等生化指标呈高表达状态,且不同疾病分期桥本甲状腺炎患者甲状腺功能及生化指标水平存在差异,可为桥本甲状腺炎的诊断提供参考。

关键词：桥本甲状腺炎生化指标甲状腺功能

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An improved urban cellular automata model by using the trend-adjusted neighborhood

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Ecological Processes 2020年第1期9卷 314-326页

作者： Xuecao Li yuyu zhou Wei Chen Department of Geological and Atmospheric Sciences Iowa State UniversityAmesIA 50011USA

Background:Cellular automata(CA)-based models have been extensively used in urban sprawl ***,most studies focused on the improvement of spatial representation in the modeling,with limited efforts for considering the temporal context of urban *** this paper,we developed a Logistic-Trend-CA model by proposing a trend-adjusted neighborhood as a weighting factor using the information of historical urban sprawl and integrating this factor in the commonly used Logistic-CA *** applied the developed model in the Beijing-Tianjin-Hebei region of China and analyzed the model performance to the start year,the suitability surface,and the neighborhood ***:Our results indicate the proposed Logistic-Trend-CA model outperforms the traditional Logistic-CA model significantly,resulting in about 18%and 14%improvements in modeling urban sprawl at medium(1 km)and fine(30 m)resolutions,*** proposed Logistic-Trend-CA model is more suitable for urban sprawl modeling over a long temporal interval than the traditional Logistic-CA *** addition,this new model is not sensitive to the suitability surface calibrated from different periods and spaces,and its performance decreases with the increase of the neighborhood ***:The proposed model shows potential for modeling future urban sprawl spanning a long period at regional and global scales.

关键词： Cellular automata(CA)model Temporal context Urban sprawl Logistic regression Neighborhood

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Sustainable urban systems:from landscape to ecological processes

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Ecological Processes 2022年第1期11卷 360-362页

作者： yuyu zhou Gang Chen Weiqi zhou Department of Geological and Atmospheric Sciences Iowa State UniversityAmesIA 50011USA Laboratory for Remote Sensing and Environmental Change(LRSEC) Department of Geography and Earth SciencesUniversity of North Carolina at CharlotteCharlotteNC 28223USA State Key Laboratory of Urban and Regional Ecology Research Center for Eco‑Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Our world is experiencing unprecedented land cover and land use changes(LCLUC)due to population growth,economic development,and global climate ***,one major form of LCLUC,has received growing attention for its significant role in changing ecological processes and functions of urban *** is a growing need,from both the academic and the policy-making communities,for science-based information and evidence to enhance our understanding of the urban ecological processes and societal needs because of the rapid urbanization over the past few decades across the *** information is key to informing the development of best practices for improved landscape and urban planning.

关键词： landscape Sustainable urban

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以患者获益为核心,促进医联体可持续发展

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协和医学杂志 2024年第5期15卷 1006-1010页

作者：郑文婷周俞余金启明袁一刘雁斌马小军周炯中国医学科学院北京协和医院医务处北京100730 北京市第六医院门诊部北京100007 北京市第六医院医务科北京100007

医联体作为推进分级诊疗制度的实践载体,对于平衡医疗资源、提升医疗服务效率具有重大意义。本文基于以北京协和医院为核心的“1+5+1”医联体合作模式,借助疾病诊断相关分组(diagnosis related group,DRG)指标,分析了医联体建设历程中... 详细信息

医联体作为推进分级诊疗制度的实践载体,对于平衡医疗资源、提升医疗服务效率具有重大意义。本文基于以北京协和医院为核心的“1+5+1”医联体合作模式,借助疾病诊断相关分组(diagnosis related group,DRG)指标,分析了医联体建设历程中患者、成员医院、牵头医院的获益情况,以期为构建医联体评价体系提供参考。医联体建设不仅提高了患者对优质医疗资源的可及性,同时提升了成员医院的诊疗水平,并为牵头医院调整病种结构、提升学科建设水平提供了空间。DRG作为医保支付方式改革的核心,通过病例组合指数和DRG组数等指标,为病例管理和病种结构优化提供了客观、可量化的数据支撑,有效引导医疗资源合理分配和医联体内病种/术种调整。综合利用DRG评价指标,可构建一套多维度的医联体建设评价体系,为医联体深度合作提供明确的指导方向,从而整体推动医联体良性可持续发展,实现多方共赢。

关键词：医联体 DRG 分级诊疗医疗资源可持续发展

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中国≥45岁人群健康体检服务利用情况:一项基于CHARLS2018的全国横断面调查

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中国全科医学 2024年第10期27卷 1179-1185页

作者：高川李庆印柯丹丹周俞余张宇扬何仲中国医学科学院阜外医院护理研究室北京市100037 北京协和医学院人文和社会科学学院北京市100005 中国医学科学院北京协和医院北京市100005

背景居民门诊和住院的医疗卫生服务利用情况及影响因素的研究已经十分成熟,然而分析我国居民预防性就医及健康体检服务利用情况的相关研究却较少。目的了解我国≥45岁人群健康体检服务利用情况,并分析其影响因素。方法利用2018年《中国... 详细信息

背景居民门诊和住院的医疗卫生服务利用情况及影响因素的研究已经十分成熟,然而分析我国居民预防性就医及健康体检服务利用情况的相关研究却较少。目的了解我国≥45岁人群健康体检服务利用情况,并分析其影响因素。方法利用2018年《中国健康与养老追踪调查》(CHARLS)的数据,选取≥45岁人群,统计其2015—2018年参加体检率和体检项目数。采用零膨胀负二项回归(Zinb)模型,分析居民参加体检项目数的影响因素。结果本研究共纳入17203例居民,平均年龄(62.4±10.0)岁,参加体检率为47.73%(8211/17203)。体检参加率排名前三位的分别是新疆维吾尔自治区(96.47%)、上海市(83.67%)和北京市(82.05%),排名后三位的分别为辽宁省(35.41%)、青海省(36.55%)和福建省(36.94%)。8211例参加过常规体检的人群平均年龄(64.1±9.9)岁,人均参加体检项目中位数为9(5,12)项。体检项目数排名前三位的分别为北京市(14项)、上海市(14项)和新疆维吾尔自治区(13项),排名后三位的分别为甘肃省(7项)、安徽省(7项)和辽宁省(7.5项)。非参数检验显示,城镇居民体检项目数高于农村(10项与8项),东部高于中部(10项与8项)、西部(10项与9项)及东北部(10项与8项),西部高于中部(9项与8项)(P<0.001)。Zinb模型显示,经济区域(中部、西部、东北部)、居住地类型(城镇地区)、性别(女性)、年龄(60岁及以上)、文化程度(初中及以上)、健康状况(共患病)和基本医疗保险类型(职工医疗保险)是居民参加体检项目数的影响因素(P<0.001)。按照城镇和农村进行亚组分析,结果显示经济区域(中部、西部、东北部)、年龄(60岁及以上)、文化程度(初中及以上)是城镇和农村居民参加体检项目数的共同影响因素(P<0.05)。除此之外,对于城镇地区居民而言,已婚是其参加体检项目数的影响因素(P<0.001);对于农村地区居民而言,男性、共病、具有职工医疗保险是其参加体检项目数的影响因素(P<0.001)。结论我国≥45岁人群健康体检服务利用率较低,城镇地区、东部地区健康体检服务更多,年龄和文化程度是居民利用健康体检服务的影响因素,婚姻状况是城镇地区居民利用健康体检服务的影响因素,性别、健康状态和基本医疗保险类型是农村地区居民利用健康体检服务的影响因素。未来应进一步提高居民健康体检服务的利用率,并分城乡和地域制定不同的政策措施。

关键词：中年人老年人体格检查预防卫生服务健康体检影响因素分析

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Quantifying the response of surface urban heat island to urbanization using the annual temperature cycle model

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Geoscience Frontiers 2022年第1期13卷 478-487页

作者： Huidong Li yuyu zhou Gensuo Jia Kaiguang Zhao Jinwei Dong Department of Geological and Atmospheric Sciences Iowa State UniversityAmes 50011USA Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Ohio Agricultural Research and Development Center School of Environment and Natural ResourcesThe Ohio State UniversityWoosterOH 44691USA Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101

Urban heat island(UHI),driving by urbanization,plays an important role in urban sustainability under climate ***,the quantification of UHI’s response to urbanization is still challenging due to the lack of robust and continuous temperature and urbanization datasets and reliable quantification *** study proposed a framework to quantify the response of surface UHI(SUHI)to urban expansion using the annual temperate cycle *** built a continuous annual SUHI series at the buffer level from 2003 to 2018 in the Jing-Jin-Ji region of China using MODIS land surface temperature and imperviousness derived from *** then investigated the spatiotemporal dynamic of SUHI under urban expansion and examined the underlying ***,the largest SUHI interannual variations occurred in suburban areas compared to the urban center and rural ***,the increase in SUHI under urban expansion was more significant in daytime compare to *** found that the seasonal variation of SUHI was largely affected by the seasonal variations of vegetation in rural areas and the interannual variation was mainly attributed to urban expansion in urban ***,urban greening led to the decrease in summer daytime SHUI in central urban *** findings deepen the understanding of the long-term spatiotemporal dynamic of UHI and the quantitative relationship between UHI and urban expansion,providing a scientific basis for prediction and mitigation of UHI.

关键词： Urban heat island Urbanization Spatiotemporal dynamics Annual temperature cycle model Diurnal temperature range

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Re-understanding of land surface albedo and related terms in satellite-based retrievals

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Big Earth Data 2020年第1期4卷 45-67页

作者： Yanmin Shuai Latipa Tuerhanjiang Congying Shao Feng Gao yuyu zhou Donghui Xie Tao Liu Ji Liang Nan Chu School of Geomatics and Geography Liaoning Technical UniversityFuxinLiaoningChina State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geographyand Research Center for Ecology and Environment of Central AsiaCASUrumqiChina School for the Environment University of MassachusettsBostonMAUSA College of Resource and Environment Sciences Xinjiang UniversityXinjiangChina USDA-ARS Hydrology and Remote Sensing Laboratory BeltsvilleMDUSA Department of Geological and Atmospheric Sciences Iowa State UniversityAmesIAUSA School of Geography and Remote Sensing Science Beijing Normal UniversityBeijingChina National-Local Joint Engineering Laboratory of Geo-Spatial Information Technology Hunan University of Science and TechnologyXiangtanHunanChina

Land surface albedo is a critical variable in determining surface energy balance,and regulating climate and ecosystem processes through feedback ***,climatic modelers and radiative monitoring require accurate estimates of land surface *** the instrument development,algorithm upgrade,spectral-band-adjustment in wavelength center or band width,and the increasing distinct requirement from diversified communities,various albedo terms have been generated in related satellite-based *** lack of understanding on the divergence of these terminologies can introduce potential considerable errors in the subsequent applications,or an elevated probability to invert the deduced *** surveyed the basic concepts of reflectance quantities,retrieval strategies,and models developed since the 1970s,and discuss both strength and opportunity for improvements on land surface albedo extraction,and product *** addition,we exemplified the difference of albedo terms using the daily MODIS product(MCD43A)to emphasize the potential risk of the ambiguous usage,over typical IGBP land covers in Northern *** investigation shows that relative differences among various albedo terms can reach up to 181%and 50%,while 0.266 and 0.118 of absolute variance respectively in the narrow and broad-band surface albedo,which illuminated cautions against the ambiguous understanding of albedo terminologies or erroneous usage of albedo products.

关键词： Surface albedo BRDF satellite-based albedo product hemispheric reflectance

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An efficient approach for the equivalent linearization of frame structures with plastic hinges under nonstationary seismic excitations

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 677-690页

作者： Huang Huan Li Yingxiong Li yuyu College of Water Conservancy and Civil Engineering South China Agricultural UniversityGuangzhou 510642China Institute of Smart City and Intelligent Transportation Southwest Jiaotong UniversityChengdu 611756China

An efficient approach is proposed for the equivalent linearization of frame structures with plastic hinges under nonstationary seismic *** concentrated plastic hinges,described by the Bouc-Wen model,are assumed to occur at the two ends of a linear-elastic beam *** auxiliary differential equations governing the plastic rotational displacements and their corresponding hysteretic displacements are replaced with linearized differential ***,the two sets of equations of motion for the original nonlinear system can be reduced to an expanded-order equivalent linearized equation of motion for equivalent linear *** solve the equation of motion for equivalent linear systems,the nonstationary random vibration analysis is carried out based on the explicit time-domain method with high ***,the proposed treatment method for initial values of equivalent parameters is investigated in conjunction with parallel computing technology,which provides a new way of obtaining the equivalent linear systems at different time *** on the explicit time-domain method,the key responses of interest of the converged equivalent linear system can be calculated through dimension reduction analysis with high *** examples indicate that the proposed approach has high computational efficiency,and shows good applicability to weak nonlinear and medium-intensity nonlinear systems.

关键词： nonstationary random vibration plastic hinge equivalent linearization method explicit time-domain method parallel computation

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1.42-fold enhancement of formate selectivity by linker conversion on the Zn-based metal organic framework catalyst

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Journal of Energy Chemistry 2024年第3期90卷 183-190,I0006页

作者： Yayu Guan yuyu Liu Fanghua Ning Jin Yi Jiujun Zhang Institute for Sustainable Energy College of SciencesShanghai UniversityShanghai 200444China

Electro-reduction of carbon dioxide(ERCO_(2)) is considered an effective method to alleviate the greenhouse effect and produce value-added *** the dominant selectivity of Zn-based catalysts for formate remains a *** this article,the ZnIn-E_(12) catalyst is successfully prepared by solvent assisted ligand exchange(SALE) method to convert organic ligands,achieving a Faradaic efficiency of 72.28% for formate at-1.26 V ***(V_(RHE)),which is 1.42 times higher than the original *** shows that the successful conversion of organic ligands can transform the catalyst from the original large size polyhedron to cross-linked network of particles with a diameter of about 30 *** increased specific surface area can expose more active sites and facilitate the electrocatalytic conversion of CO_(2) to *** work is expected to provide inspiration for the regulation of formate selectivity and catalyst size in Zn-based catalysts.

关键词： Electrocatalyst Carbon dioxide Formate Linker conversion

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