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Serum 25-hydroxyvitamin D,genetic susceptibility,and the risk of incident type 2 diabetes:A prospective cohort in East China

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Chinese Medical Journal 2024年第8期137卷 972-979页

作者： Ying Sun Haojie Zhang Bin wang yuying wang Chi Chen Yi Chen Yingli Lu Ningjian wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China Department of Endocrinology and Metabolism and Department of Guideline and Rapid Recommendation Cochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

Background:The serum vitamin D level varies widely by population,and studies have linked vitamin D levels with the risk of type 2 diabetes mellitus(T2DM).However,the relationship is inconsistent and the impact of vitamin D on T2DM among East Chinese adults is *** study aimed to investigate the association between serum 25-hydroxyvitamin D(25[OH]D)levels and the risk of T2DM and evaluated whether the association is modified by genetic ***:In the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)cohort,1862 participants free of T2DM at baseline were included.A weighted genetic risk score was calculated with 28 variants associated with *** logistic models were used to examine the association of serum 25(OH)D and genetic risk with ***:After a 5-year follow-up,132 cases of T2DM were *** observed no significant association between quartiles of serum 25(OH)D and T2DM risk after multivariable adjustment(χ^(2)=0.571,P_(for trend)=0.426).Compared to those in the lowest quartile of 25(OH)D,the odds ratios(ORs)(95%confidence interval[CI])for participants with increased quartiles were 1.29(0.74-2.25),1.35(0.77-2.36),and 1.27(0.72-2.24),*** observed a positive association of glycated hemoglobin(HbA1c)with 25(OH)D at baseline(β=1.752,P=0.001)and after follow-up(β=1.385,P=0.003),and a negative association of ln conversion homeostasis model assessment(HOMA)-βwith 25(OH)D at baseline(β=-0.982,P=0.021).There was no significant interaction between 25(OH)D and diabetes genetic predisposition on the risk of T2DM(χ^(2)=2.710,P_(for interaction)=0.100).The lowest OR(95%CI)of T2DM was among participants with low genetic risk and the highest quartile of 25(OH)D(0.17[0.05-0.62]).Conclusion:Serum 25(OH)D may be irrelevant to the risk of incident T2DM among East Chinese adults regardless of genetic predisposition.

关键词： Vitamin D Diabetes mellitus,Type 2 Genetic predisposition to disease Prospective cohort Glycated hemoglobin SPECT-China

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HOPF Bifurcation in Regulatory Biological Networks

HOPF Bifurcation in Regulatory Biological Networks

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第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Liping Zhang yuying wang Faculty of Science Nanjing University of Aeronautics and Astronautics Faculty of Science xi'an Jiaotong University

Recent experiment have shown that the oscillatory behavors for the activities p53 and Mdm2 proteins in respect to DNA damage,we propose a new nonlinear dynamics with three delays to describe the p53-mdm2 *** choosing the delay as a bifurcation parameter,The stability and the existence of bifurcation are researched in this *** particular,the formulae determining the direction of the bifurcations and the stability of the bifurcating periodic solutions are derived by using the normal form theory and center manifold *** proposed mathematical method have the significance in the problems,as well as the time delays have the characteristic biological ***,numerical simulations supporting the theoretical analysis are also given.

关键词： p53-Mdm2 Interaction Negative Feedback Loop Hopf bifurcation,delay

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地震前电磁辐射日变异常观测数据的分析

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高技术通讯 2008年第12期18卷 1291-1296页

作者：佟晓辉王玉莹辽宁省地震局沈阳110034

利用苏家屯地震台的电磁辐射数字化分钟值资料研究了地震前电磁辐射前兆异常现象。发现地震前观测到的电磁辐射超低频电场与磁场出现明显的短期日变异常;超低频电场幅度从120mV 逐渐上升为700mV,超低频磁场则由100nT 逐渐上升为1100nT... 详细信息

利用苏家屯地震台的电磁辐射数字化分钟值资料研究了地震前电磁辐射前兆异常现象。发现地震前观测到的电磁辐射超低频电场与磁场出现明显的短期日变异常;超低频电场幅度从120mV 逐渐上升为700mV,超低频磁场则由100nT 逐渐上升为1100nT。在此异常期间,电磁辐射显示出每天一个准周期的近似方波形态,方波上升和下降时间的规律变化符合'晨昏电势'的概念;信息发展过程明显地周期变化,周期为13.5天,表明晨昏电场是地震孕育过程中的重要现象。发现了以往没有注意到的电离层'异常'现象,拓展了数字地磁观测资料异常提取的应用范围。

关键词：数字化分钟值电磁辐射晨昏电势异常特征

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Life’s Essential 8 and risk of non-communicable chronic diseases:Outcome-wide analyses

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Chinese Medical Journal 2024年第13期137卷 1553-1562页

作者： Yuetian Yu Ying Sun Yuefeng Yu yuying wang Chi Chen Xiao Tan Yingli Lu Ningjian wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China School of Public Health Zhejiang UniversityHangzhou 310058ZhejiangChina Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden

Background:Life’s Simple 7,the former construct of cardiovascular health(CVH)has been used to evaluate adverse non-communicable chronic diseases(NCDs).However,some flaws have been recognized in recent years and Life’s Essential 8 has been *** this study,we aimed to analyze the association between CVH defined by Life’s Essential 8 and risk of 44 common NCDs and further estimate the population attributable fractions(PAFs)of low-moderate CVH scores in the 44 ***:In the UK Biobank,170,726 participants free of 44 common NCDs at baseline were *** Life’s Essential 8 composite measure consists of four health behaviours(diet,physical activity,nicotine exposure,and sleep)and four health factors(body mass index,non-high density lipoprotein cholesterol,blood glucose,and blood pressure),and the maximum CVH score was 100 *** score was categorized into low,moderate,and high *** were followed up for 44 NCDs diagnosis across 10 human system disorders according to the International Classification of Diseases 10th edition(ICD-10)code using linkage to national health records until *** proportional hazard models were used in this *** hazard ratios(HRs)and PAFs of 44 NCDs associated with CVH score were ***:During the median follow-up of 10.85 years,58,889 incident NCD cases were *** linear dose-response associations were found between higher CVH score and lower risk of 25(56.8%)of 44 ***-moderate CVH(<80 points)score accounted for the largest proportion of incident cases in diabetes(PAF:80.3%),followed by gout(59.6%),sleep disorder(55.6%),chronic liver disease(45.9%),chronic kidney disease(40.9%),ischemic heart disease(40.8%),chronic obstructive pulmonary disease(40.0%),endometrium cancer(35.8%),lung cancer(34.0%),and heart failure(34.0%)as the top *** the eight modifiable factors,overweight/obesity explained the largest number of cases of incident NCDs in endocrine,nutritional,and me

关键词： Life’s Essential 8 Cardiovascular risk score Non-communicable chronic disease Population health management Cohort analysis Healthy lifestyle UK Biobank

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Precise mode control of laser-written waveguides for broadband,low-dispersion 3D integrated optics

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Light(Science & Applications) 2024年第6期13卷 1186-1195页

作者： yuying wang Lijing Zhong Kuen Yao Lau Xuhu Han Yi Yang Jiacheng Hu Sergei Firstov Zhi Chen Zhijun Ma Limin Tong Kin Seng Chiang Dezhi Tan Jianrong Qiu College of Optical Science and Engineering Zhejiang University310027HangzhouChina Institute of Light+X Science and Technology College of Information Science and EngineeringNingbo University315211NingboChina School of Optoelectronic Science and Engineering&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University215006SuzhouChina Prokhorov General Physics Institute of the Russian Academy of Sciences Dianov Fiber Optics Research Center38 Vavilov str.Moscow119333Russia Zhejiang Lab 311121HangzhouChina College of Materials Science and Engineering Key Laboratory of Advanced Materials of Yunnan ProvinceKunming University of Science and Technology650093KunmingYunnanChina Department of Electrical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina School of Materials Science and Engineering Zhejiang University310027HangzhouChina

Three-dimensional(3D)glass chips are promising waveguide platforms for building hybrid 3D photonic circuits due to their 3D topological capabilities,large transparent windows,and low coupling *** present,the key challenge in scaling down a benchtop optical system to a glass chip is the lack of precise methods for controlling the mode field and optical coupling of 3D waveguide ***,we propose an overlap-controlled multi-scan(OCMS)method based on laser-direct lithography that allows customizing the refractive index profile of 3D waveguides with high spatial precision in a variety of *** the basis of this method,we achieve variable mode-field distribution,robust and broadband coupling,and thereby demonstrate dispersionless LP21-mode conversion of supercontinuum pulses with the largest deviation of<0.1 dB in coupling ratios on 210 nm *** approach provides a route to achieve ultra-broadband and low-dispersion coupling in 3D photonic circuits,with overwhelming advantages over conventional planar waveguide-optic platforms for on-chip transmission and manipulation of ultrashort laser pulses and broadband supercontinuum.

关键词： waveguide mode dispersion

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<i>In Vitro</i>Mass Scale Propagation of Wild <i>Cymbidium lowianum</i>with a Rare and Endangered Plant

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American Journal of Plant Sciences 2013年第7期4卷 1500-1507页

作者： yuying wang Zhilin Li Liping Huang Jun Su Foreign Languages Institute Yunnan Agricultural University Kunming China Institute of Horticulture Yunnan Academy of Agricultural Sciences Kunming China. Institute of Landscape Plants Yunnan Agricultural University Kunming China

The wild Cymbidium lowianum, a national-level rare and endangered species of Orchid, is an excellent garden plant with ornamental flowers with striking, deep red lips in a V-shaped formation. The objective of this study was to establish a micropropagation protocol system via immature seeds of wild Cymbidium lowianum, evaluate the Murashige and Skoog (MS), half-strength Murashige and Skoog (1/2 MS) medium, 6-benzylaminopurine (BA), a-napthaleneacetic acid (NAA), organic additions activated charcoal (AC) and banana pulp (BP) effects on the different morphogenesis (seed germination, multiple shoot and rooting) in vitro. The optimal combination for the germination of seed was 1.0 mg·L-1 BA with 0.5 mg·L-1 NAA in 1/2 MS, and addition 0.3%AC, which resulted in 95% seed germination in 90 days. The best formulation for multiple shoot was 1/2 MS medium containing 2.5 mg·L-1 BA, 0.5 mg·L-1 NAA and addition 8% BP in which produced 19.8 shoots per protocorm in 60 days. Multiple shoots were cut and rooted in 1/2 MS supplemented with 1.5 mg·L-1 NAA,0.1 mg·L-1 BA and 0.3% AC, roots initiated 20 days after culture, the rooting percentages reached to 100%, in which 4.7 per shoot produced roots in 60 days. The survival rate of plantlet was up to 92% in moss after 30 days. This finding reveals that it is possible to obtain in vitro culture of Cymbidium lowianum using immature seeds in asymbiotic culture.

关键词： Wild Cymbidium lowianum Seed Germination Propagation Protocorm Multiple Shoots

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Birth weight,ideal cardiovascular health metrics in adulthood,and incident cardiovascular disease

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Chinese Medical Journal 2024年第10期137卷 1160-1168页

作者： Ying Sun Bin wang Yuefeng Yu yuying wang Xiao Tan Jihui Zhang Lu Qi Yingli Lu Ningjian wang Department of Endocrinology and Metabolism Institute of Endocrinology and MetabolismShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China School of Public Health Zhejiang UniversityHangzhouZhejiang 310058China Department of Medical Sciences Uppsala UniversityUppsala 75105Sweden Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510370China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLA 70118USA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02138USA Channing Division of Network Medicine Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02138USA

Background:Prenatal and postnatal factors may have joint effects on cardiovascular health,and we aimed to assess the joint association of birth weight and ideal cardiovascular health metrics(ICVHMs)prospectively in adulthood with incident cardiovascular disease(CVD).Methods:In the UK Biobank,227,833 participants with data on ICVHM components and birth weight and without CVD at baseline were *** ICVHMs included smoking,body mass index,physical activity,diet information,total cholesterol,blood pressure,and hemoglobin *** Cox proportional hazards model was used to estimate the hazard ratios(HRs)and 95%confidence intervals(CIs)in men and ***:Over a median follow-up period of 13.0 years(2,831,236 person-years),we documented 17,477 patients with incident *** with participants with birth weights of 2.5-4.0 kg,the HRs(95%CIs)of CVD among those with low birth weights was 1.08(1.00-1.16)in men and 1.23(1.16-1.31)in *** association between having a birth weight<2.5 kg and CVD risk in men was more prominent for those aged<50 years than for those of older age(P for interaction=0.026).Lower birth weight and non-ideal cardiovascular health metrics were jointly related to an increased risk of *** with birth weights<2.5 kg and ICVHMs score 0-1 had the highest risk of incident CVD(HR[95%CI]:3.93[3.01-5.13]in men;4.24[3.33-5.40]in women).The joint effect(HR[95%CI]:1.36[1.17-1.58])could be decomposed into 24.7%(95%CI:15.0%-34.4%)for a lower birth weight,64.7%(95%CI:56.7%-72.6%)for a lower ICVHM score,and 10.6%(95%CI:2.7%-18.6%)for their additive interaction in ***:Birth weight and ICVHMs were jointly related to CVD *** a normal birth weight and ideal ICVHMs may reduce the risk of CVD,and a simultaneous improvement of both prenatal and postnatal factors could further prevent additional cases in women.

关键词： Birth weight Health metrics Cardiovascular disease Adult Stroke Coronary heart disease

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基于烯基叠氮合成含氮杂环化合物的研究进展

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有机化学 2018年第5期38卷 1009-1028页

作者：王钰莹刘莉王也铭长春中医药大学药学院长春130117 吉林师范大学化学学院四平136000

自1910年首次被报道以来,烯基叠氮类化合物受到了化学工作者们广泛的关注.作为一类重要的有机合成中间体,尤其是在过渡金属催化下合成氮杂环类化合物方面,烯基叠氮类化合物有着广泛的应用.主要综述了烯基叠氮类化合物在构建含氮杂环化... 详细信息

自1910年首次被报道以来,烯基叠氮类化合物受到了化学工作者们广泛的关注.作为一类重要的有机合成中间体,尤其是在过渡金属催化下合成氮杂环类化合物方面,烯基叠氮类化合物有着广泛的应用.主要综述了烯基叠氮类化合物在构建含氮杂环化合物领域的研究进展.

关键词：烯基叠氮合成含氮杂环

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产学研融合促进中小制造企业高质量发展了吗?———中介效应与调节效应分析

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管理工程学报 2023年第6期37卷 94-107页

作者：王钰莹原长弘西安交通大学管理学院陕西西安710049

构建产学研深度融合的技术创新体系成为当前推动我国中小制造企业转型升级迈向高质量发展的重要路径,引发了商业实践和理论层面的广泛关注。然而,中小制造企业如何有效发挥产学研融合价值进而实现企业高质量发展这一过程机制的“黑箱”... 详细信息

构建产学研深度融合的技术创新体系成为当前推动我国中小制造企业转型升级迈向高质量发展的重要路径,引发了商业实践和理论层面的广泛关注。然而,中小制造企业如何有效发挥产学研融合价值进而实现企业高质量发展这一过程机制的“黑箱”目前仍未揭开。本文整合资源基础理论、资源管理理论和高阶梯队理论等,在明晰产学研融合内涵和特征基础上,构建了中小制造企业产学研融合推动高质量发展的过程机制模型,引入企业探索性创新行为作为中介变量来解释产学研融合对企业高质量发展的具体作用路径,并剖析高管团队异质性对这一作用路径的调节作用机理。通过选取中国中小板制造业上市公司作为研究对象,本文实证检验发现:产学研融合有利于促进中小制造企业开展探索性创新行为;中小制造企业的探索性创新行为促进了企业的高质量发展,并在产学研融合与企业高质量发展关系之间发挥显著的中介效应。而高管团队异质性不仅正向调节了产学研融合与企业探索性创新行为之间的关系,还进一步调节了企业探索性创新行为在产学研融合与企业高质量发展关系间的中介效应,即高管团队异质性较高时,产学研融合能够通过中小制造企业的探索性创新行为实现对资源更为有效的整合和利用,从而推动企业高质量发展。本文的研究发现有助于深入认识产学研融合影响中小制造企业高质量发展的作用路径和边界条件,同时对中小制造企业高质量发展实践有重要的现实指导意义。

关键词：产学研融合高质量发展探索性创新行为中小制造企业

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异常高压、特低渗透油藏油井合理产能研究

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油气井测试 2005年第4期14卷 10-13页

作者：王玉英王江大庆石油学院石油工程学院黑龙江大庆163318 中国石油天然气勘探开发公司海外研究中心北京100083

利用试井资料、啄油PVT资料等,对异常高压、特低渗透油藏储层渗透率伤害、产能变化规律等方面进行了研究,最终给出了油井合理工作制度的确定方法,确定了油井的合理产能,为油田开发方案设计及采油工艺设计提供了依据。

关键词：异常高压低渗透油藏产能指标曲线采油指数特低渗透油藏产能油井油田开发方案工艺设计渗透率伤害

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