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A phase separation-fortified bi-specific adaptor for conditional tumor killing

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Science China(Life Sciences) 2024年第7期67卷 1385-1397页

作者： yuyan Liu Yuting Zhu Weifan Xu Pilong Li State Key Laboratory of Membrane Biology Frontier Research Center for Biological StructureTsinghua University-Peking University Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

A common approach in therapeutic protein development involves employing synthetic ligands with multivalency,enabling sophisticated control of signal *** the emerging concept of liquid-liquid phase separation(LLPS)and its ability to organize cell surface receptors into functional compartments,we herein have designed modular ligands with phase-separation modalities to engineer programmable interreceptor communications and precise control of signal pathways,thus inducing the rapid,potent,and specific apoptosis of tumor *** their simplicity,these“triggers”,named phase-separated Tumor Killers(hereafter referred to as psTK),are sufficient to yield interreceptor clustering of death receptors(represented by DR5)and tumor-associated receptors,with notable features:LLPSmediated robust high-order organization,well-choreographed conditional activation,and broad-spectrum capacity to potently induce apoptosis in tumor *** development of novel therapeutic proteins with phase-separation modalities showcases the power of spatially reorganizing signal *** approach facilitates the diversification of cell fate and holds promising potential for targeted therapies against challenging tumors.

关键词： phase separation therapeutic proteins receptor-ligand interactions DR5 tumor apoptosis

Cross-linkedα-amylase aggregates on Fe3O4 magnetic nanoparticles modified with polydopamine/polyethyleneimine for efficient hydrolysis of starch

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Particuology 2024年第7期90卷 98-105页

作者： Jiandong Cui Xiuming tang Qingqing Ma yuyan Chang Qunli Zhang Shiru Jia State Key Laboratory of Food Nutrition and Safety Laboratory of Industrial Fermentation MicrobiologyMinistry of EducationTianjin University of Science and TechnologyTianjin 300457China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China

In this workα-amylase was immobilized on magnetic Fe3O4 nanoparticles with polyethylenimine(PEI)/polydopamine(PDA)coating or 3-aminopropyl triethoxysilane(APTES)for the first time via adsorption–precipitation–*** with the freeα-amylase,the resultant magnetic cross-linkedα-amylase aggregates(PEI/PDA-M-CLEAs and N-M-CLEAs)exhibited excellent thermal and storage stability as well as pH *** storage at 25°C for 60 days,freeα-amylase only retained 60%of its initial activity,while PEI/PDA-M-CLEAs and N-M-CLEAs retained 80%and 78%of their initial activities,***,N-M-CLEAs and PEI/PDA-M-CLEAs showed good *** 6 repeated uses,PEI/PDA-M-CLEAs and N-M-CLEAs still maintained 65%and 62%of their initial activities,***,PEI/PDA-M-CLEAs and N-M-CLEAs exhibited higher starch hydrolysis efficiency than freeα-*** maximum dextrose equivalent(DE)values of starch hydrolysis by PEI/PDA-M-CLEAs and N-M-CLEAs reached 29.24%and 28.79%within 90 min,***,the maximum DE values of starch hydrolysis by the freeα-amylase was only 27.89%even in 150 *** magnetic cross-linkedα-amylase aggregates could be introduced as effective biocatalyst for industrial applications in production of maltose syrups.

关键词： α-amylase Magnetic nanoparticles Functional modification Magnetic cross-linked enzyme aggregates Hydrolysis of starch

“中国科技期刊卓越行动计划”领军期刊2018—2021年发文质量分析

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中国科技期刊研究 2023年第2期34卷 220-230页

作者：姜旭谭玉燕上海交通大学医学院附属瑞金医院《转化神经变性病(英文)》编辑部上海市200025 上海交通大学医学院附属瑞金医院神经内科上海市200025

【目的】分析入选“中国科技期刊卓越行动计划”领军期刊项目的期刊在项目实施前后的发文质量变化,同时与同领域国际知名期刊进行比较,以期从稿源角度为我国建设世界一流期刊提供借鉴和方向。【方法】通过查询Web of Science数据库,分... 详细信息

【目的】分析入选“中国科技期刊卓越行动计划”领军期刊项目的期刊在项目实施前后的发文质量变化,同时与同领域国际知名期刊进行比较,以期从稿源角度为我国建设世界一流期刊提供借鉴和方向。【方法】通过查询Web of Science数据库,分析22种期刊在项目实施前(2018—2019年)和项目实施后(2020—2021年)2个时间段内的发文规模、发文类型、国际论文比、稿源国数量、论文影响力等指标,并与同领域国际知名期刊进行横向比较。【结果】在“中国科技期刊卓越行动计划”的助力下,我国领军期刊在发文规模、论文影响力方面稳步提升,国际论文比相较于“中国科技期刊卓越行动计划”实施前有所下降。半数期刊栏目类型比较单一,在内容延伸方面有进步空间。和同领域国际知名期刊相比,我国期刊在发文的质和量方面仍存在差距。【结论】我国科技期刊的稿源建设既需要科技评价体系、期刊扶持政策的支持,也需要期刊自身的努力。

关键词：期刊政策科技评价体系论文影响力发文质量

Space debris environment engineering model 2019:Algorithms improvement and comparison with ORDEM 3.1 and MASTER-8

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Chinese Journal of Aeronautics 2024年第5期37卷 392-409页

作者： yuyan LIU Runqiang CHI Baojun PANG HU Diqi Wuxiong CAO Dongfang WANG School of Astronautics Harbin Institute of TechnologyHarbin 150001China College of Safety Science&Engineering Civil Aviation University of ChinaTianjin 300300China

As an essential tool for realistic description of the current or future debris environment,the Space Debris Environment Engineering Model(SDEEM)has been developed to provide support for risk assessment of *** contrast with SDEEM2015,SDEEM2019,the latest version,extends the orbital range from the Low Earth Orbit(LEO)to Geosynchronous Orbit(GEO)for the years *** this paper,improved modeling algorithms used by SDEEM2019 in propagating simulation,spatial density distribution,and spacecraft flux evaluation are *** debris fluxes of SDEEM2019 are compared with those of three typical models,i.e.,SDEEM2015,Orbital Debris Engineering Model 3.1(ORDEM 3.1),and Meteoroid and Space Debris Terrestrial Environment Reference(MASTER-8),in terms of two assessment *** orbital cases,including the Geostationary Transfer Orbit(GTO),Sun-Synchronous Orbit(SSO)and International Space Station(ISS)orbit,are selected for the spacecraft assessment mode,and the LEO region is selected for the spatial density assessment *** analysis indicates that compared with previous algorithms,the variable step-size orbital propagating algorithm based on semi-major axis control is more precise,the spatial density algorithm based on the second zonal harmonic of the non-spherical Earth gravity(J_(2))is more applicable,and the result of the position-centered spacecraft flux algorithm is more *** comparison shows that SDEEM2019 and MASTER-8 have consistent trends due to similar modeling processes,while the differences between SDEEM2019 and ORDEM 3.1 are mainly caused by different modeling approaches for uncatalogued debris.

关键词： SDEEM2019 Space debris propagating algorithm Spatial density algorithm ORDEM 3.1 MASTER-8

Optimization on magnetic properties of Nd-doped Fe_(3)O_(4) nanoparticles for magnetic shielding fabrics

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Journal of Rare Earths 2024年第4期42卷 683-689页

作者： Xiaolei Song Congzhu Xu yuyan Wang Huizhen Ke Yonggui Li Qufu Wei Xinqun Feng Faculty of Clothing and Design Minjiang UniversityFuzhou350108China Fujian Key Laboratory of Novel Functional Textile Fibers and Materials Minjiang UniversityFuzhou350108China College of Textile and Clothing Jiangnan UniversityWuxi214122China College of Fashion and Design Donghua UniversityShanghai201620China

High magnetic protective fabrics with rare earth Nd doped Fe_(3)O_(4) nanoparticles were fabricated via a grafting *** structure,crystal form,and elemental composition of nanoparticles were investigated by transmission electron microscopy,energy dispersive X-ray,X-ray powder diffraction,and X-ray photoelectron *** obtained NdFe_(2)O_(4) nanoparticles show spherical shape with fine dispersion and reasonable element ***,they demonstrate fine superparamagnetic properties with a magnetic saturation value of 29.25 A·m^(2)/g and low coercivity of 1.902 mT through the vibrating sample magnetometry technique,which can be well developed in magnetic shielding protective ***,the cotton fabrics with plain weave were finished by a proofing rapier loom as a *** NdFe_(2)O_(4) nanoparticles underwent some appropriate surface modification and then were grafted onto the cotton fabrics by a bridge agent of N,N’-dissuccinimidyl *** morphology,structure,dispersion effect,and electromagnetic protective properties of the fabrics were observed through scanning electron microscopy,Fourier infrared spectroscopy,thermogravimetric analysisdifferential scanning calorimetry(TG-DSC),and a vector network *** reliable fabrics with grafting reaction on the interface are expected to have potential applications in the field of electromagnetic protection and biomedicine fields.

关键词： Magnetic property Nd Fe_(3)O_(4)nanoparticles Magnetic shielding Fabrics Rare earths

Photonic neuromorphic architecture for tens-of-task lifelong learning

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Light(Science & Applications) 2024年第3期13卷 519-530页

作者： Yuan Cheng Jianing Zhang Tiankuang Zhou yuyan Wang Zhihao Xu Xiaoyun Yuan Lu Fang Sigma Laboratory Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing 100084China Institute for Brain and Cognitive Science Tsinghua University(THUIBCS)Beijing 100084China

Scalable,high-capacity,and low-power computing architecture is the primary assurance for increasingly manifold and large-scale machine learning *** electronic artificial agents by conventional power-hungry processors have faced the issues of energy and scaling walls,hindering them from the sustainable performance improvement and iterative multi-task *** to another modality of light,photonic computing has been progressively applied in high-efficient neuromorphic ***,we innovate a reconfigurable lifelong-learning optical neural network(L2 ONN),for highly-integrated tens-of-task machine intelligence with elaborated algorithm-hardware *** from the inherent sparsity and parallelism in massive photonic connections,L2 ONN learns each single task by adaptively activating sparse photonic neuron connections in the coherent light field,while incrementally acquiring expertise on various tasks by gradually enlarging the *** multi-task optical features are parallelly processed by multi-spectrum representations allocated with different *** evaluations on freespace and on-chip architectures confirm that for the first time,L2 ONN avoided the catastrophic forgetting issue of photonic computing,owning versatile skills on challenging tens-of-tasks(vision classification,voice recognition,medical diagnosis,etc.)with a single ***,L2 ONN achieves more than an order of magnitude higher efficiency than the representative electronic artificial neural networks,and 14×larger capacity than existing optical neural networks while maintaining competitive performance on each individual *** proposed photonic neuromorphic architecture points out a new form of lifelong learning scheme,permitting terminal/edge AI systems with light-speed efficiency and unprecedented scalability.

关键词： life neural versatile

Research on Scheduling Strategy of Flexible Interconnection Distribution Network Considering Distributed Photovoltaic and Hydrogen Energy Storage

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Energy Engineering 2024年第5期121卷 1263-1289页

作者： Yang Li Jianjun Zhao Xiaolong Yang He Wang yuyan Wang College of Electrical Engineering Northeast Electric Power UniversityJilin132011China Smart Distribution Network Center State Grid Jibei Electric Power Co.Ltd.Qinhuangdao066000China

Distributed photovoltaic(PV)is one of the important power sources for building a new power system with new energy as the main *** rapid development of distributed PV has brought new challenges to the operation of distribution *** order to improve the absorption ability of large-scale distributed PV access to the distribution network,the AC/DC hybrid distribution network is constructed based on flexible interconnection technology,and a coordinated scheduling strategy model of hydrogen energy storage(HS)and distributed PV is ***,the mathematical model of distributed PV and HS system is established,and a comprehensive energy storage system combining seasonal hydrogen energy storage(SHS)and battery(BT)is ***,a flexible interconnected distribution network scheduling optimization model is established to minimize the total active power loss,voltage deviation and system operating ***,simulation analysis is carried out on the improved IEEE33 node,the NSGA-II algorithm is used to solve specific examples,and the optimal scheduling results of the comprehensive economy and power quality of the distribution network are *** with the method that does not consider HS and flexible interconnection technology,the network loss and voltage deviation of this method are lower,and the total system cost can be reduced by 3.55%,which verifies the effectiveness of the proposed method.

关键词： Seasonal hydrogen storage flexible interconnection AC/DC distribution network photovoltaic absorption scheduling strategy

Contactless evaluation of rigidity in Parkinson’s disease by machine vision and machine learning

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Chinese Medical Journal 2023年第18期136卷 2254-2256页

作者： Xue Zhu Weikun Shi Yun Ling Ningdi Luo Qianyi Yin Yichi Zhang Aonan Zhao Guanyu Ye Haiyan Zhou Jing Pan Liche Zhou Linghao Cao Pei Huang Pingchen Zhang Zhonglue Chen Cheng Chen Shinuan Lin Jin Zhao Kang Ren yuyan tan Jun Liu Department of Neurology and Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China GYENNO SCIENCE CO. LTD.ShenzhenGuangdong 518000China HUST-GYENNO CNS Intelligent Digital Medicine Technology Center WuhanHubei 430074China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhanHubei 430074China Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu 226019China

To the Editor:Parkinson’s disease(PD)is one of the most common neurodegenerative movement disorders.[1]Its cardinal symptoms include bradykinesia,tremor,and rigidity.[2]The severity of PD-related motor symptoms is usually semiquantitatively evaluated by the Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)[3]part three(MDS-UPDRS III).A series of machine perception and machine learning technologies have been applied to assist the manual rating of motor symptoms.[4,5]Machine vision,which does not require physical contact between the examiner and the patient.

关键词： rigidity severity tremor

The Ribbon Elements of Drinfeld Double of Radford Hopf Algebra

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Acta Mathematica Sinica,English Series 2024年

作者： Hua SUN yuyan ZHANG Libin LI College of Mathematical Science Yangzhou University

Abstract Let m, n be two positive integers, k be an algebraically closed field with char（k）*** constructed an mn2-dimensional Hopf algebra Rmn（q） such that its Jacobson radical is not a Hopf ideal. We show that the Drinfeld double D(Rmn（q）) of Radford Hopf algebra Rmn（q） has ribbon elements if and only if n is odd. Moreover, if m is even and n is odd, then D(Rmn（q）) has two ribbon elements, if both m and n are odd, then D(Rmn（q）) has only one ribbon element. Moreover,we compute explicitly all ribbon elements of D(Rmn（q）).

关键词： Drinfeld double ribbon Hopf algebra quasi-triangular Hopf algebra