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Histological study of the structural layers around the esophagus in the lower mediastinum

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1331-1339页

作者： Toshifumi Saito Satoru Muro Hisashi Fujiwara yuya Umebayashi yuya Sato Masanori Tokunaga Keiichi Akita Yusuke Kinugasa Department of Gastrointestinal Surgery Tokyo Medical and Dental UniversityBunkyo-ku 113-8519TokyoJapan Department of Clinical Anatomy Tokyo Medical and Dental UniversityBunkyo-ku 113-8519TokyoJapan

BACKGROUND In Japan,the transhiatal approach,including lower mediastinal lymph node dissection,is widely performed for Siewert type II esophagogastric junction *** procedure is generally performed in a magnified view using laparoscopy or a robotic system,therefore,the microanatomy of the lower mediastinum is ***,mediastinal microanatomy is still unclear and classification of lower mediastinal lymph nodes is not currently based on fascia or other microanatomical *** To clarify the fascia and layer structures of the lower mediastinum and classify the lower mediastinal *** We dissected the esophagus and surrounding organs en-bloc from seven cadavers fixed in 10%*** and tissues were then cut at the level of the lower thoracic esophagus,embedded in paraffin,and serially *** sections were stained with Hematoxylin-Eosin(all cadavers)and immunostained for the lymphatic endothelial marker D2-40(three cadavers).We observed the periesophageal fasciae and layers,and defined lymph node boundaries based on the *** vessels around the esophagus were observed on immunostained tissue *** We identified two fasciae,A and *** then classified lower mediastinal tissue into three areas,paraesophageal,paraaortic,and intermediate,using these fasciae as *** nodes were found to be present and were counted in each *** dorsal part of the intermediate area was thicker on the caudal side than on the cranial side in all *** the dorsal side,no blood vessels penetrated the fasciae in six of the seven cadavers,whereas the proper esophageal artery penetrated fascia B in one cadaver.D2-40 immunostaining showed lymphatic vessel connections between the paraesophageal and intermediate areas on the lateral and ventral sides of the esophagus,but no lymphatic connection between areas on the dorsal side of the *** Histological studies identified two fasciae surroun

关键词： Esophagogastric junction Histology Mediastinum Adenocarcinoma Esophageal cancer Gastric cancer

肝豆灵片通过调控PKCβⅡ/ACSL4/ALOX5信号通路改善肝豆状核变性铁死亡的机制

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山东科学 2024年第4期37卷 34-44页

作者：吴博进董婷闻雨雅田丽伟赵晨玲安徽中医药大学第一附属医院安徽合肥230031 新安医学教育部重点实验室安徽合肥230038

基于PKCβⅡ/ACSL4/ALOX5信号通路,探讨肝豆灵片对TX小鼠肝豆状核变性铁死亡的影响以及对CuCl 2诱导的HT22细胞铁死亡的作用机制。将TX小鼠分为对照组、模型组、肝豆灵片组、Fer-1组、谷胱甘肽组,HT22细胞分为对照组、模型组、肝豆灵片... 详细信息

基于PKCβⅡ/ACSL4/ALOX5信号通路,探讨肝豆灵片对TX小鼠肝豆状核变性铁死亡的影响以及对CuCl 2诱导的HT22细胞铁死亡的作用机制。将TX小鼠分为对照组、模型组、肝豆灵片组、Fer-1组、谷胱甘肽组,HT22细胞分为对照组、模型组、肝豆灵片组、Fer-1组、肝豆灵片+Fer-1组,采用HE染色检测各组小鼠海马组织病理学改变,蛋白质免疫印迹检测各组小鼠海马组织与HT22细胞中PKCβⅡ、ACSL4、ALOX5蛋白的表达,以及HT22细胞中SLC7A11、GPX4蛋白的表达,微量法检测各组TX小鼠海马组织中Fe 2+的浓度,微板法检测各组HT22细胞中SOD(超氧化物歧化酶)、MDA(丙二醛)、GSH-Px水平,实时荧光定量聚合链式反应检测各组HT22细胞中PKCβⅡ、ACSL4、ALOX5 mRNA的表达。结果表明:与对照组相比,模型组海马组织出现明显损伤,PKCβⅡ、ACSL4、ALOX5蛋白表达均明显增高,SLC7A11、GPX4蛋白表达明显下降,Fe 2+的浓度明显升高(P<0.05);与模型组相比,肝豆灵片组、Fer-1组和谷胱甘肽组海马组织的病理损伤均得到改善,且肝豆灵片组效果明显;肝豆灵片组和Fer-1组能抑制HT22细胞铁死亡,PKCβⅡ、ACSL4、ALOX5蛋白与mRNA表达较模型组均明显减少,MDA的浓度明显降低(P<0.05),SOD活力及GSH-Px浓度明显增加(P<0.05)。肝豆灵片能减轻TX小鼠海马组织铁死亡,抑制CuCl 2诱导的HT22细胞铁死亡,其机制可能与下调PKCβⅡ/ACSL4/ALOX5信号通路,减轻细胞内脂质过氧化有关。

关键词：肝豆灵片肝豆状核变性 PKCβⅡ/ACSL4/ALOX5信号通路铁死亡机制

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“四责协同”机制构建医院行政科室权责清单

现代医院 2024年第4期24卷 504-507页

作者：徐隽嬿金宇雅姜皓婧顾平赵明珠上海市浦东新区浦南医院上海200125

目的深化细化全面从严治党“四责协同”机制向科室延伸,构建医院行政职能科室监管事项权责一体化清单、压实责任。方法以行政职能科室岗位权力风险防控为基础,加强制度建设为抓手,监督权力运行为核心,对照法律法规、规章制度、岗位职责... 详细信息

目的深化细化全面从严治党“四责协同”机制向科室延伸,构建医院行政职能科室监管事项权责一体化清单、压实责任。方法以行政职能科室岗位权力风险防控为基础,加强制度建设为抓手,监督权力运行为核心,对照法律法规、规章制度、岗位职责,对重点领域、重要事项、关键岗位,查摆权力运行的关键节点、内部管理的薄弱环节、问题易发的风险点,采取自下而上与自上而下相结合的方式,形成行政科室权责一体化清单。结果医院17个行政科室以“一科室一清单”形式,共梳理出209项职权项目、涉及公权力947条。结论通过清单构建工作的开展,进一步完善了廉洁风险防控的制度建设,提升全院依法依纪依规工作的觉悟和能力和精细化管理水平,使党组织管党治党的责任得到有效落实,为医院高质量发展保驾护航。

关键词： “四责协同”机制医院行政权责清单

Fatigue Property of Additively Manufactured Ti-6Al-4V under Nonproportional Multiaxial Loading

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 76-84页

作者： yuya Kimura Fumio Ogawa Takamoto Itoh Graduate School of Science&Engineering Ritsumeikan UniversityShiga 5258577Japan Fracture and Reliability Research Institute Graduate School of Tohoku UniversityMiyagi 9808579Japan Department of Mechani-cal Engineering Ritsumeikan UniversityShiga 5258577Japan

The low cycle fatigue strength properties of the additively manufactured Ti-6Al-4V alloy are experimentally investi-gated under proportional and nonproportional multiaxial *** fatigue tests were conducted using hollow cylinder specimens with and without heat treatments,at room temperature in *** fatigue tests were conducted:one for proportional loading and one for nonproportional *** proportional loading was represented by a push-pull strain path(PP)and the nonproportional loading by a circle strain path(Cl).The failure lives of the additively manufactured specimens were clearly reduced drastically by internal voids and ***,the sizes of the defects were measured,and the defects were found not to cause a reduction in fatigue strength above a critical *** fracture surface was observed using scanning electron microscopy to investigate the fracture mechanisms of the additively manufactured specimens under the two types of strain *** fracture patterns were recognized for each strain paths;however,both showed retention of the crack propagation,despite the presence of numerous defects,probably because of the interaction of the *** crack propagation properties of the materials with numerous defects under nonproportional multiaxial loading were clarified to increase the reliability of the additively manufactured components.

关键词： Additive manufacturing Ti-6Al-4V Low cycle fatigue Multiaxial stress Nonproportional loading Internal defect

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纤维肌痛综合征发病诱因与加重诱因调查研究

中华风湿病学杂志 2024年第3期28卷 189-194页

作者：李阳贾园肖语雅王辉赵亚云张永锋焦娟中国医科学院广安门医院风湿病科北京100053 北京大学人民医院风湿免疫科北京100044 深圳市中医院风湿病科深圳518033 哈尔滨医科大学附属第一医院风湿免疫科哈尔滨150007 河北省中医院风湿病科石家庄050000 首都医科大学附属北京朝阳医院风湿免疫科北京100020

目的以类风湿关节炎(RA)为参照,探讨纤维肌痛综合征(FMS)发病与加重诱因的情况与特点。方法本研究调查时间为2015年1月至2021年11月,采用横断面调查研究方法,基于参考文献制定患者报告的"发病诱因与加重诱因调查表",同时调查FMS和RA患者... 详细信息

目的以类风湿关节炎(RA)为参照,探讨纤维肌痛综合征(FMS)发病与加重诱因的情况与特点。方法本研究调查时间为2015年1月至2021年11月,采用横断面调查研究方法,基于参考文献制定患者报告的"发病诱因与加重诱因调查表",同时调查FMS和RA患者,统计2组患者发病诱因和加重诱因的种类和所占比例,并采用χ^(2)检验进行组间比较。结果共415例FMS患者和200例RA患者参与调查。146例FMS患者(35.2%)报告了发病诱因,身体伤害(71例,17.1%)、感受风寒/寒湿(30例,7.2%)、精神压力(26例,6.2%)、运动性疲劳(10例,2.4%)是FMS的常见发病诱因;38例RA(19.0%)患者报告了发病诱因。相较于RA患者,更多的FMS患者报告了发病前经历身体伤害和精神压力[6.2%(26/415)和1.5%(3/200),χ^(2)=6.82,P=0.009]。319例FMS患者(76.9%)报告了病情加重诱因,依次为天气变化(219例,52.7%)、体力劳动(192例,46.2%)、情绪波动(147例,35.4%)、睡眠不足(145例,34.9%)、精神压力(130例,31.3%)等;137例RA患者(68.5%)报告了病情加重诱因。FMS患者因体力劳动[46.2%(192/415)]、情绪波动[35.4%(147/415)]、睡眠不足[34.9%(145/415)]、精神压力[31.3%(130/415)]、感染[9.3%(39/415)]因素导致病情加重者明显高于RA患者[35.0%(70/200),χ^(2)=7.00,P=0.008;19.5%(39/200),χ^(2)=16.22,P<0.001;13.5%(27/200),χ^(2)=30.79,P<0.001;17.5%(35/200),χ^(2)=13.14,P<0.001;3.0%(6/200),χ^(2)=8.15,P=0.004]。结论超过1/3的FMS患者报告了发病诱因,近4/5的FMS患者报告了病情加重诱因。相较于RA患者,FMS患者对环境的变化,以及压力的感知更为敏感。这一现象值得深入研究,或可为本病的发生、发展、治疗和预防提供帮助。

关键词：纤维肌痛二级预防影响因素分析

Wide and Fast Wavelength-Swept Fiber Lasers Based on Dispersion Tuning and Their Application to Optical Coherence Tomography

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Photonic Sensors 2013年第4期3卷 320-331页

作者： Shinji YAMASHITA yuya TAKUBO Research Center for Advanced Science and Technology (RCAST) The University of Tokyo 4-6-1 Komaba Meguro-kuTokyo 153-8904 Japan

We recently proposed a new class of wavelength-swept lasers for swept-source optical coherence tomography (SS-OCT). It uses the same gain medium with the conventional swept lasers, but does not require any tunable filters. It is based on a principle called “dispersion tuning”, in which a highly dispersive medium is inserted in the laser cavity, and loss/gain modulation is applied to mode-lock the laser. Since the cavity contains no mechanical components, such as tunable filters, we could achieve the very high sweep rate. In this review paper, we describe the principle of the dispersion-tuned swept lasers in detail and present our recent work on the application to the SS-OCT system.

关键词：光学相干断层成像可调谐滤波器光纤激光器断层扫描分散介质应用波长激光谐振腔

Numerical Analysis of Turbulent Sonic Jets from Two-Dimensional Convergent Nozzles

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Journal of Thermal Science 2011年第2期20卷 133-138页

作者： Hideo KASHIMURA yuya MASUDA Yoshiaki MIYAZATO Kazuyasu MATSUO Department of Control and Information Systems Engineering Kitakyushu National College of Technology 5-20-1ShiiKokuraminami-kuKitakyushuFukuoka802-0985JAPAN Department of Mechanical Systems Engineering The University of Kitakyushu1-1HibikinoWakamatsu-kuKitakyushuFukuoka808-0135JAPAN

The numerical analysis of a turbulent sonic jet from a two-dimensional convergent nozzle has been carried out using the compressible k-? turbulence model and TVD finite difference scheme. Numerical conditions have been varied over a range of operating pressure ratios from 1.893 to 6.0 which cover the jet flow conditions from correctly expanded to underexpanded. Numerical flow visualization of sonic jet structure using the computer schlieren, a relation between shock cell length in the jet with the operating pressure ratio and the pressure distribution along jet centerline are obtained. Also, a transition process of a two-dimensional sonic jet from correctly expanded to underexpanded conditions is shown in detail and a flow model of jet structure is proposed.

关键词： Sonic nozzle Underexpanded jet Shock cell length κ-ε turbulence model Numerical analysis

A New One-dimensional Chain Compound Constructed by {Mo_8O_(28)} units via Corner-sharing

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Chinese Journal of Structural Chemistry 2005年第2期24卷 214-218页

作者： yuya-Qin YANGWen-Bin WUChuan-De LUCan-Zhong StateKeyLaboratoryofStructuralChemistry FujianInstituteofResearchontheStructureofMatterTheChineseAcademyofSciencesFuzhouFujian350002China

The title compound, {(H3O)4(NH4)4[Mo8O28]?2H2O}n 1, has been synthesized from the reaction of Zn(OAc)2 and (NH4)6Mo7O24?4H2O in aqueous solution at ambient tempe- rature, and its crystal structure was determined by X-ray single-crystal analysis with the following crystallographic data: monoclinic system, space group P21/n, a = 9.5234(6), b = 11.3235(8), c = 14.8812(10) ?, β = 107.467(2)o, V = 1530.77(18) ?3, Z = 4, F(000) = 1336, μ = 3.293 mm-1 and Dc = 3.037 g/cm3. The final R = 0.0619 for 2691 observed reflections (I > 2σ(I)). X-ray crys- tal structure analysis showed that the novel one-dimensional chain compound is built up by basic {Mo8O28} units via single μ2-O, and such chains are further linked into a three-dimensional net- work by hydrogen bonds.

关键词： polyoxomolybdate octamolybdate one-dimensional chain

IL2rg^(-/-)大鼠支持人RSV在体内的长期感染

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中国实验动物学报 2024年第1期32卷 17-24页

作者：熊芮吴勇杨艳伟屈哲刘甦苏王誉雅马丽颖付瑞彭宜红梁春南范昌发中国食品药品检定研究院实验动物资源研究所(国家啮齿类实验动物资源库) 北京102629 北京大学医学部基础医学院病原生物学系北京100083 中国食品药品检定研究院安全评价研究所(国家药物安全评价监测中心) 北京100176

目的为了克服已有人呼吸道合胞病毒(human respiratory syncytial virus,hRSV)动物模型的局限性,如半受纳性和感染持续时间短,本文利用TALEN基因编辑技术建立了IL2rg基因敲除(IL2rg^(-/-))的大鼠模型。方法用hRSV滴鼻感染该动物模型,观... 详细信息

目的为了克服已有人呼吸道合胞病毒(human respiratory syncytial virus,hRSV)动物模型的局限性,如半受纳性和感染持续时间短,本文利用TALEN基因编辑技术建立了IL2rg基因敲除(IL2rg^(-/-))的大鼠模型。方法用hRSV滴鼻感染该动物模型,观察感染期(0~35 d)的临床表征、体重及体温变化;记录不同时间点(滴鼻感染后第4、11、20、35天)鼻腔、气管、肺等呼吸道脏器的病毒总拷贝数;在观察终点(滴鼻感染后第35天)对感染动物的靶器官进行病理分析;观察不同时间点(滴鼻感染后第4、20、35天)外周血T、B、NK、NKT细胞的变化及不同时间点多种细胞因子的变化。结果(1)通过鼻内接种hRSV后,纯合的IL2rg基因敲除大鼠的呼吸道内能保持较高的病毒载量,鼻腔中病毒的平均峰值滴度能快速升至1×10^(10 )copies/g,至第5周时,病毒依然能维持复制,病毒载量亦可达到1×10^(7)copies/g。(2)但其鼻、气管和肺组织,无明显病变。(3)感染hRSV的IL2rg^(-/-)大鼠外周血B细胞含量有上升。(4)IL-6和MCP-1两种细胞因子都在感染前期上升,在观察终点回落。结论本研究基于TALEN技术建立了IL2rg^(-/-)大鼠模型,并发现该模型能很好地支持hRSV高水平复制和并长期感染,为抗病毒药物筛选、抗hRSV抗体体内效力评价,提供了良好的动物模型。

关键词： IL2rg-/-大鼠 TALEN基因编辑技术 NK细胞缺陷人呼吸道合胞病毒感染动物模型