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磁光效应下PT对称结构独特的非互易传输模式

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中国激光 2018年第12期45卷 306-311页

作者：王誉雅夏景方云团江苏大学计算机科学与通信工程学院江苏镇江212013

设计了一种嵌入磁性材料微腔的可调制的PT对称结构。通过传输矩阵法计算结构的传输谱,研究了磁微腔共振对PT对称结构的调制效应,得到一种可被入射角度方向和大小双重调制的增强的非互易带边模式,调制结果是带边模式在左右带边的转换。... 详细信息

设计了一种嵌入磁性材料微腔的可调制的PT对称结构。通过传输矩阵法计算结构的传输谱,研究了磁微腔共振对PT对称结构的调制效应,得到一种可被入射角度方向和大小双重调制的增强的非互易带边模式,调制结果是带边模式在左右带边的转换。磁场大小的增加会导致带边模式向高频移动,磁场方向的变化也会引起带边模式在左右带边的转换。

关键词：微纳光学 PT对称结构磁光调制非互易性传输带边模式

Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma:A case report

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 186-194页

作者： Yuki Murakami Hiroki Tanabe Yusuke Ono yuya Sugiyama Yu Kobayashi Takehito Kunogi Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Nobuhiro Ueno Shin Kashima Sayaka Yuzawa Kentaro Moriichi Yusuke Mizukami Mikihiro Fujiya Toshikatsu Okumura Division of Metabolism and Biosystemic Science Department of Gastroenterology and Hematology/OncologyDepartment of MedicineAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Institute of Biomedical Research Sapporo-Higashi Tokushukai HospitaSapporo 065-0033HokkaidoJapan Department of Diagnostic Pathology Asahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan

BACKGROUND Mucinous adenocarcinoma of the colorectum is a rare histological subtype characterized by an abundant mucinous *** tumors are frequently diagnosed at an advanced stage,which indicates an aggressive ***,few case reports have been published,and little information is available concerning genetic alterations in mucinous *** SUMMARY A 76-year-old man underwent en bloc endoscopic submucosal dissection(ESD)for the management of a type 0-Is+IIa *** examination revealed an intramucosal mucinous adenocarcinoma with signet-ring cell carcinoma and well-to-moderately differentiated tubular *** years after the ESD,local recurrence was detected by an endoscopic examination,revealing a new 0-Is+IIa lesion with a phenotype similar to the previously resected ***-ESD was chosen for the management of the recurrent tumor,and the histological examination showed positive tumor infiltration at the vertical *** surgical resection was performed for the curative *** analysis showed pathogenic alterations in RNF43 and TP53 in the adenoma and an additional SMAD4 alteration in the *** This mucinous mucosal adenocarcinoma case was suggested to have an aggressive phenotype and a careful and close follow-up are required.

关键词： Rectal cancer Mucinous adenocarcinoma Endoscopic submucosal dissectio TP53 Colitic cancer pathway Case report

Clinical significance of MET in gastric cancer

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 317-327页

作者： Mikito Inokuchi Sho Otsuki Yoshitaka Fujimori yuya Sato Masatoshi Nakagawa Kazuyuki Kojima Department of Gastrointestinal Surgery Tokyo Medical and Dental University Department of Minimally Invasive Surgery Tokyo Medical and Dental University

Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer(GC),although outcomes remain *** molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed,and monoclonal antibodies targeting human epidermal growth factor receptor 2 or vascular endothelial growth factor receptor 2 have become standard therapy for *** growth factor and its receptor,c-MET(MET),play key roles in tumor growth through activated signaling pathways from receptor in GC *** amplification of MET leads to the aberrant activation found in GC tumors and is related to survival in patients with *** review discusses the clinical significance of MET in GC and examines MET as a potential therapeutic target in patients with *** studies in animal models have shown that MET antibodies or smallmolecule MET inhibitors suppress tumor-cell proliferation and tumor progression in MET-amplified GC *** drugs are now being evaluated in clinical trials as treatments for metastatic or unresectable GC.

关键词： MET Gastric cancer Genomic amplification Immunohis

Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu

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Astrodynamics 2020年第2期4卷 89-103页

作者： Naoko Ogawa Fuyuto Terui yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda Japan Aerospace Exploration Agency Sagamihara252-5210Japan NEC Corporation Fuchu183-8501Japan NEC Space Technologies Ltd.Fuchu183-8551Japan Systems Engineering Consultants Co. Ltd.Tokyo158-0097Japan Planetary Exploration Research Center Chiba Institute of TechnologyNarashino275-0016Japan

Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration *** spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,*** the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully *** were based on autonomous image-based descent and landing *** paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown.

关键词： Hayabusa2 Ryugu image-based navigation target marker tracking

Systematic review of anastomotic complications of esophagojejunostomy after laparoscopic total gastrectomy

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World Journal of Gastroenterology 2015年第32期21卷 9656-9665页

作者： Mikito Inokuchi Sho Otsuki Yoshitaka Fujimori yuya Sato Masatoshi Nakagawa Kazuyuki Kojima Department of Surgical Oncology Tokyo Medical and Dental University Department of Minimally Invasive Surgery Tokyo Medical and Dental University

AIM: To investigate the anastomotic complications ofesophagojejunostomy(EJS) after laparoscopic total gastrectomy(LTG), we reviewed retrospective ***: A literature search was conducted in Pub Med for studies published from January 1, 1994 through January 31, 2015. The search terms included "laparoscopic," "total gastrectomy," and "gastric cancer." First, we selected 16 non-randomized controlled trials(RCTs) comparing LTG with open total gastrectomy(OTG) and conducted an updated meta-analysis of anastomotic complications after total gastrectomy. The Newcastle-Ottawa scoring system(NOS) was used to assess the quality of the non-RCTs included in this study. Next, we reviewed anastomotic complications in 46 case studies of LTG to compare the various procedures for EJS. RESULTS: The overall incidence of anastomotic leakage associated with EJS was 3.0%(30 of 984 patients) among LTG procedures and 2.1%(31 of 1500 patients) among OTG procedures in the 16 non-RCTs. The incidence of anastomotic leakage did not differ significantly between LTG and OTG(odds OR = 1.42, 95%CI: 0.86-2.33, P = 0.17, I2 = 0%). Anastomotic stenosis related to EJS was reported in 72(2.9%) of 2484 patients, and the incidence was 3.2% among LTG procedures and 2.7% among OTG procedures. The incidence of anastomotic stenosis related to EJS was slightly, but not significantly, higher in LTG than in OTG(OR = 1.55, 95%CI: 0.94-2.54, P = 0.08, I2 = 0%). The various procedures for LTG were classified into six categories in the review of case studies of LTG. The incidence of EJS leakage was similar(1.1% to 3.2%), although the incidence of EJS stenosis was relatively high when the Or VilTM device was used(8.8%) compared with other procedures(1.0% to 3.6%).CONCLUSION:The incidence of anastomotic complications associated with EJS was not different between LTG and OTG. Anastomotic stenosis was relatively common when the Or VilTM device was used.

关键词： Gastric cancer Laparoscopic Gastrectomy Anastomosi

The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations

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Astrodynamics 2020年第4期4卷 377-392页

作者： Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda Institute of Space and A stronautical Science Japan A erospace Exploration AgencySagamihara 252-5210Japan The Graduate University for Aduanced Studies Hayama 240-0193Japan Research and Development Directorate Japan Aerospace Exploration AgencySagamihara 252-5210Japan University of Liverpool Liverpool L693BXUK Chiba Institute of Technology Narashino 275-0016Japan National Institute of Aduanced Industrial Science and Technology Koto-ku 135-0064Japan Rikkyo University Toshima-ku 171-8501Japan

The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are *** was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary *** weighted least-squares batch filter is used for the orbit estimator of *** orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small *** system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking *** the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the *** example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar *** large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of *** the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by *** type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before.

关键词： orbit determination optical navigation gravity measurements superior solar conjunction delta differential one-way ranging(delta-DOR)

Electrochemical Tuning by Polarized UV Light Induced Molecular Orientation of Chiral Salen-type Mn（II） and Co（II） Complexes in an Albumin Matrix

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Journal of Chemistry and Chemical Engineering 2016年第2期10卷 53-59页

作者： Eirika Tsuda yuya Mitsumoto Kazuya Takakura Nobumitsu Sunaga Takashiro Akitsu Taro Konomi Masahiro Katoh Department of Chemistry Faculty of Science Tokyo University of Science 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan UVSOR Institute for Molecular Science 38 Nishigonaka Myodaiji OkazakL Aichi 444-8585 Japan

The authors have prepared supramolecular systems as artificial metalloproteins composed of several chiral salen-type Mn（II） and Co（II） complexes in a HSA （human serum albumin） matrix. The docking was discussed by UV-vis spectral changes and a ligand-protein docking simulation program. After linearly polarized UV light irradiation, that anisotropy of molecular orientation of the complexes increased was confirmed by polarized IR spectra. The authors have observed that the electrochemical behavior of the aligned complexes incorporating diphenyl groups in HSA can be tuned without UV radiation damage of HSA higher structures.

关键词： Redox potential Schiff base Mn(II) complex Co(II) complex albumin.

Development of the Triode-type MCP-based Compact Ion Detector for High Pressure Operation in Miniature Mass Spectrometer

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Development of the Triode-type MCP-based Compact Ion Detecto...

Determination of Heavy Metals at Sub-ppb Levels in Water by Graphite Furnace Atomic Absorption Spectrometry Using a Direct Introduction Technique after Preconcentration with an Iminodiacetate Extraction Disk

2018年中国质谱学术大会（CMSC2018）

作者： Masahiro Hayashi yuya Washiyama Joji Sakakiyama Hayato Inoue Toshiyuki Uchiyama Hamamatsu Photonics K.K.

Recent interest in fieldable mass spectrometric applications has spurred a great deal of research into the development of a miniature mass spectrometer(MS). Since the advantage of the miniature MS is its portability, size reduction is required for composed parts. Vacuum pumps have to be small, therefore the miniature MS used in the system have to be operated under high pressure(up to 0.1 Pa). The conventional MCP-based ion detectors cannot be adapted to high pressure condition, because of ion feedback which causes discharges and decreases in signal-tonoise ratio. The new method is introduced which enables to operate an MCP-based ion detector stably in high pressure condition. Novel Aspect: The MCP-based compact ion detector for high pressure operation was developed by combining the triode structure with a novel potential mode.

关键词： miniature MS Vacuum high pressur ion feedback triode structure

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American Journal of Analytical Chemistry 2012年第10期3卷 683-692页

作者： Tetsuo Inui Atsuko Kosuge Atsushi Ohbuchi Kazuhiro Fujita yuya Koike Masaru Kitano Toshihiro Nakamura Department of Applied Chemistry Meiji University Kawasaki Japan

A direct analysis method combining an iminodiacetate extraction disk (IED) with graphite furnace atomic absorption spectrometry was developed for the determination of Co, Ni, Cu, Cd, Sn, Pb, and Bi at sub-ppb levels in water. A 100 mL water sample was adjusted to pH 5.6 with nitric acid and a 1 mol?L–1 ammonium acetate solution, and then passed through an IED (diameter, 47 mm;effective filtering diameter, 35 mm) at a flow rate of 80 - 100 mL?min–1 to preconcentrate seven analytes. The IED was dried at 100?C for 20 min in an electric oven, and 110 - 145 small disks, each 2 mm in diameter, were punched out from the IED. A small disk was introduced into the graphite furnace and atomized according to a heating program. For Cd, Sn, Pb, and Bi measurements, Pd was used as a chemical modifier to enhance the absorbances. Calibration was performed using aqueous standard solutions. The detection limits, corresponding to three times the standard deviation (n = 5) of the blank values, were 0.092 μg·L–1 for Co, 0.12 μg·L–1 for Ni, 0.40 μg·L–1 for Cu, 0.077 μg·L–1 for Cd, 0.92 μg·L–1 for Sn, 0.61 μg·L–1 for Pb, and 0.80 μg·L–1 for Bi with an enrichment factor of 140 using a 100-mL water sample. A spike test for the seven analytes in tap water, rainwater, river water, and mineral drinking water showed quantitative recoveries (93% - 108%).

关键词： Water Sample Heavy Metal Preconcentration Iminodiacetate Extraction Disk Direct Introduction Technique Graphite Furnace Atomic Absorption Spectrometry