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Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 557-562页

作者： Toshiaki Tsurui yuya Hirasawa Yutaro Kubota Kiyoshi Yoshimura Takuya Tsunoda Department of Medical Oncology Showa UniversityTokyo 1428555Japan Department of Clinical Immuno Oncology Clinical Research Institute of Clinical Pharmacology and TherapeuticsShowa UniversityTokyo 1578577Japan

BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic ***,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently *** SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe *** tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated *** RAS or BRAF mutations were *** Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was *** drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly ***,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse *** Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.

关键词： Colorectal neoplasms Panitumumab Chemotherapy Hyperbilirubinemia Jaundice Case report

Computer-controlled ultra high voltage amplifier for dielectric elastomer actuators

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Biomimetic Intelligence & Robotics 2024年第1期4卷 14-23页

作者： Ardi Wiranata Zebing Mao Yu Kuwajima yuya Yamaguchi Muhammad Akhsin Muflikhun Hiroki Shigemune Naoki Hosoya Shingo Maeda Department of Mechanical and Industrial Engineering University of Gadjah MadaYogyakarta 55281Indonesia Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan Department of Engineering and Science Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Electrical Engineering Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Engineering Science and Mechanics Shibaura Institute of TechnologyTokyo 135-8548Japan Living Systems Materialogy(LiSM)Research Group International Research Frontiers Initiative(IRFI)Tokyo Institute of TechnologyYokohama 226-8501Japan

Soft robotics is a breakthrough technology to support human-robot *** soft structure of a soft robot can increase safety during human and robot *** of the promising soft actuators for soft robotics is dielectric elastomer actuators(DEAs).DEAs can operate silently and have an excellent energy *** simple structure of DEAs leads to the easy fabrication of soft *** simplicity combined with silent operation and high energy density make DEAs interesting for soft robotics *** actuation follows the Maxwell-pressure *** pressure produced in the DEAs actuation depends much on the voltage *** DEAs requires high voltage to gain an *** the power consumption of DEAs is in the milli-Watt range,the current needed to operate the DEAs can be *** commercially available DC-DC converters can convert the volt range to the kV *** order to get a voltage in the 2-3 kV range,the reliable DC-DC converter can be pricy for each *** problem hinders the education of soft actuators,especially for a newcomer laboratory that works in soft electric *** paper introduces an entirely do-it-yourself(DIY)Ultrahigh voltage amplifier(UHV-Amp)for education in soft ***-Amp can amplify 12 V to at a maximum of 4 kV *** a demonstration,we used this UHV-Amp to test a single layer of powdered-based *** strategy to build this educational type UHV-Amp was utilizing a Cockcroft-Walton circuit structure to amplify the voltage range to the kV *** its current state,the UHV-Amp has the potential to achieve approximately 4 *** created a simple platform to control the UHV-Amp from a personal *** near future,we expect this easy control of the UHV-Amp can contribute to the education of soft electric actuators.

关键词： Dielectric elastomer actuators Electric amplifier Soft actuators Soft robotics Soft actuator education

Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato yuya Miyasaka Yasuhito Hagiwara Natsuko Yano Hiroko Akamatsu Mayumi Harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

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西昌的烧烤

人民司法 2024年第6期 20-21页

作者：陈彧雅四川省遂宁市中级人民法院

西昌位于大凉山腹地,背靠安宁河谷,是一座春天栖息的城市,也是我出生的地方。年关将至,在外的游子思念家乡,跃然脑中的除了父亲母亲,便是过年回家团聚时的那一口西昌烧烤。那是这座城市最常见的晚餐,也是民族混居下食材和调料碰撞出的... 详细信息

西昌位于大凉山腹地,背靠安宁河谷,是一座春天栖息的城市,也是我出生的地方。年关将至,在外的游子思念家乡,跃然脑中的除了父亲母亲,便是过年回家团聚时的那一口西昌烧烤。那是这座城市最常见的晚餐,也是民族混居下食材和调料碰撞出的艺术。西昌烧烤的版图,其实可以拿来和武侠片里江湖各大门派相类比。武林门派依照地域、山头、宗教区分,而西昌的烧烤江湖,也按照各地不同的人口、风俗分化出不同的风格流派。更相似之处在于,烧烤和武功一样,各个门派都保有独特的招式秘籍,一般不轻易外传。烧烤在西昌,主要分为城南、城北、城东三大派系。

关键词：风格流派门派西昌江湖大凉山安宁河谷

虚拟服务器管理技术在机房管理中的应用研究与实现

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福建技术师范学院学报 2024年第2期42卷 32-37页

作者：乔昱亚福建技术师范学院艺术与传媒学院福建福清350300

深入分析传统机房在管理方面所面临的诸多挑战,详细探究虚拟服务器技术在性能、可靠性和成本效益方面相对传统方法的优势.研究表明虚拟化技术可以革新机房管理,优化其操作流程.

关键词：机房管理虚拟服务器技术集中管理平台

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中药蛋白资源提取分离及产业化路径展望

中草药 2024年第8期55卷 2828-2842页

作者：倪雅迪徐羚欣朱钰雅肖平段金廒南京中医药大学药学院江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心国家中医药管理局中药资源循环利用重点研究室江苏南京210023

蛋白在中药中的作用不容小觑,具有多重资源利用价值,包括药用价值、保健价值、饲用价值等,故中药蛋白开发潜力巨大。蛋白的提取分离是其产业化过程中的关键环节,亟需技术突破和集成创新。因此,需要剖析当前中药蛋白不同提取分离技术的... 详细信息

蛋白在中药中的作用不容小觑,具有多重资源利用价值,包括药用价值、保健价值、饲用价值等,故中药蛋白开发潜力巨大。蛋白的提取分离是其产业化过程中的关键环节,亟需技术突破和集成创新。因此,需要剖析当前中药蛋白不同提取分离技术的优劣势,整合各技术的优势为中药蛋白资源产业化服务。鉴于中药材具有来源天然、储量可观、生物活性好等特点,中药蛋白实际应用的前景乐观。如何合理开发利用中药蛋白资源并推动其产业化进程是当下面临的重大考验。通过对中药蛋白的资源分布情况、利用现状、提取分离纯化方法进行概述。此外,还总结了中药蛋白资源产业化所面临的主要问题并提出策略和展望,为中药蛋白资源科学开发和产业健康发展提供思路。

关键词：中药蛋白资源分布蛋白提取分离纯化产业化路径

Impacts of uneven surface heating of an ideal street canyon on airflows and indoor ventilation:Numerical study using OpenFOAM coupled with EnergyPlus

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Building Simulation 2022年第2期15卷 265-280页

作者： yuya Xiong Hong Chen School of Architecture and Urban Planning Huazhong University of Science and TechnologyWuhanHubei430000China

In the daytime,building facades and ground surfaces are heated by solar radiation,and the resulting buoyancy can change the flow field inside street *** this study,the impacts of uneven and time-varying heating of surfaces inside an ideal urban street canyon(aspect ratio=1)on single-sided indoor natural ventilation are *** work introduces a methodology for a numerical approach based on the coupling between a computational fluid dynamics(CFD)model and an energy balance ***,EnergyPlus is employed to calculate the time-varying and uneven surface *** are performed at four typical study times(05:00,09:00,15:00,20:00)during a hot summer day(July 15)in Wuhan,***,the surface temperature results are transferred to OpenFOAM for CFD *** inlet wind velocities(U_(ref))are *** results show that for a relatively strong ambient wind(U_(ref)=3 m/s),the buoyancy caused by surface heating does not significantly change the airflow structures and indoor ventilation compared with those in the isothermal ***,for a weak ambient wind(U_(ref)=0.5 m/s),the airflow structures inside the street canyon vary with the time of ***,the average air exchange rate(ACH)differs by-25.0% to 15.9%compared with that in the isothermal case,and the ACH of a single room increases by up to 2710%.The results indicate that the surface-heating-induced buoyancy is nonnegligible and should be carefully investigated,especially for weak ambient winds.

关键词： uneven surface temperature indoor ventilation urban canyon OpenFOAM EnergyPlus

聚苯硫醚纤维/聚四氟乙烯纤维滤料的定量分析方法探讨

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中国纤检 2024年第3期 71-73页

作者：徐毓亚陈旗盐城市纤维检验所江苏盐城224051

聚苯硫醚纤维和聚四氟乙烯纤维都具有耐热性和耐腐蚀性,是耐高温滤料最常用的两种纤维材料,聚苯硫醚纤维是由聚苯硫醚经熔融纺丝制得,聚四氟乙烯纤维是由聚四氟乙烯为原料,经纺丝或制成薄膜后切割或原纤化而制得的纤维。由于这两种纤维... 详细信息

聚苯硫醚纤维和聚四氟乙烯纤维都具有耐热性和耐腐蚀性,是耐高温滤料最常用的两种纤维材料,聚苯硫醚纤维是由聚苯硫醚经熔融纺丝制得,聚四氟乙烯纤维是由聚四氟乙烯为原料,经纺丝或制成薄膜后切割或原纤化而制得的纤维。由于这两种纤维化学性能稳定,现行有效标准只有加热浓硫酸方法可以准确定量,但该方法操作有一定的难度和危险性。本着环保和节约资源的原则,本文探讨采用马弗炉热重法对这两种纤维进行定量分析,并将该方法与热浓硫酸法进行比较。试验表明,马弗炉热重法可以作为定量检测聚苯硫醚纤维/聚四氟乙烯纤维滤料的参考方法之一。

关键词：聚苯硫醚纤维聚四氟乙烯纤维浓硫酸

基层治理与准行政区划调整的理论与实践——以海南省农场改“居”为例

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地理科学进展 2024年第2期43卷 262-275页

作者：王丰龙李婧瑜刘云刚张吉星郑渝亚华南师范大学地理科学学院/行政区划与空间治理研究中心广州510631 华东师范大学中国行政区划研究中心/中国现代城市研究中心上海200062 华南师范大学北斗研究院广东佛山528225

乡镇等基层政权和村居等自治组织是国家治理单元,对于理顺中央—地方关系、提升基层服务水平等具有重要意义。乡镇属于正式的基层行政区划,村和社区等则可以被视作准行政区划。然而,现有研究很少意识到诸多基层治理单元的准行政区划属性... 详细信息

乡镇等基层政权和村居等自治组织是国家治理单元,对于理顺中央—地方关系、提升基层服务水平等具有重要意义。乡镇属于正式的基层行政区划,村和社区等则可以被视作准行政区划。然而,现有研究很少意识到诸多基层治理单元的准行政区划属性,忽略了基层准行政区划的形成过程及其与正式行政区划之间的冲突。为此,论文以海南省国营农场改制中新设立的“居”为例,从层级、幅员、边界3个维度分析基层准政区设置的逻辑和面临的挑战。研究发现,“居”是海南省农垦集团化、农场公司化和农场社会职能属地化过程中形成的一类典型的基层准行政区划,其行政级别介于社区和镇之间,主要通过政府授权和购买服务等方式行使基层的社会管理和公共服务职能。“居”的准行政区划性质导致其与正式的行政区划(尤其是镇)之间存在层级、幅员和边界上错综复杂的关系,容易导致管理人员晋升通道不畅和社会管理与公共服务的主体缺位等问题,“居”与所属镇和所服务农场公司之间也容易围绕行政管理功能和公共服务供给的属地边界产生争端。研究结果对增进理解单位和国有企业转制、探索基层(准)行政区划的设置和优化路径、深化对准政区问题的研究具有重要意义。

关键词：准行政区划基层治理 “居” 农场层级幅员边界