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Epidemiology of hepatocellular carcinoma in nonalcoholic fatty liver disease

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Hepatoma Research 2019年第12期5卷 12-25页

作者： Michihisa Moriguchi yuya Seko Aya Takahashi Yoshito Itoh Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyoto 602-8566Japan

Along with the changes in our food culture and lifestyle,conditions such as obesity,diabetes mellitus,and metabolicsyndrome have been on the rise,and the incidence of nonalcoholic fatty liver disease(NAFLD),which is closelyrelated to these diseases,has also increased *** being a risk factor for the development of hepatocellularcarcinoma(HCC),NAFLD has no established screening method,and HCC originating from NAFLD often tends to be discovered in its advanced and symptomatic stages,which has become an important clinical *** though the carcinogenicity rate among the entire population of NAFLD patients is not high compared to that of patients with viral hepatitis,since HCC also often develops from non-cirrhotic livers,it is difficult to narrow down the cases that need to be under *** forward,it will be important to clarify the clinical characteristics and genetic background of NAFLD-related HCC and establish not only a useful surveillance method but also preventive methods.

关键词： Hepatocellular carcinoma nonalcoholic fatty liver disease epidemiology

A Combined Computational and Experimental Study on the Structure-Regulation Relationships of Putative Mammalian DNA Replication Initiator GINS

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Genomics, Proteomics & Bioinformatics 2006年第3期4卷 156-164页

作者： Reiko Hayashi Takako Arauchi Moe Tategu yuya Goto Kenichi Yoshida Department of Life Sciences Meiji University School of Agriculture Kawasaki Kanagawa 214-8571 Japan.

GINS, a heterotetramer of SLD5, PSF1, PSF2, and PSF3 proteins, is an emerging chromatin factor recognized to be involved in the initiation and elongation step of DNA replication. Although the yeast and Xenopus GINS genes are well documented, their orthologous genes in higher eukaryotes are not fully characterized. In this study, we report the genomic structure and transcriptional regulation of mammalian GINS genes. Serum stimulation increased the GINS mRNA levels in human cells. Reporter gene assay using putative GINS promoter sequences revealed that the expression of mammalian GINS is regulated by 17β-Estradiolstimulated estrogen receptor a, and human PSF3 acts as a gene responsive to transcription factor E2F1. The goal of this study is to present the current data so as to encourage further work in the field of GINS gene regulation and functions in mammalian cells.

关键词： DNA replication initiation bioinformatics gene structure gene regulation 17β-Estradiol transcription factor E2F1

Enhancement of Magneto-Optic Effect in Optical Isolator with Semiconductor Guiding Layer by Selective Oxidation of AlInAs

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光学学报 2003年第S1期23卷 179-180页

作者： Takashi Sakai yuya Shoji Hideki Yokoi Tetsuya Mizumoto Department of Electrical and Electronic Engineering Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 JapanDepartment of Electrical and Electronic Engineering Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 JapanDepartment of Electrical and Electronic Engineering Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 JapanDepartment of Electrical and Electronic Engineering Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 Japan

Selective oxidation of an AlInAs layer was investigated for enhancement of magneto-optic effect in an optical isolator. Twelve times nonreciprocal phase shift enhancement was estimated from a measured AlInAs-oxide ref... 详细信息

关键词： of by with in YIG Figure

肝豆灵片通过调控PKCβⅡ/ACSL4/ALOX5信号通路改善肝豆状核变性铁死亡的机制

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山东科学 2024年第4期37卷 34-44页

作者：吴博进董婷闻雨雅田丽伟赵晨玲安徽中医药大学第一附属医院安徽合肥230031 新安医学教育部重点实验室安徽合肥230038

基于PKCβⅡ/ACSL4/ALOX5信号通路,探讨肝豆灵片对TX小鼠肝豆状核变性铁死亡的影响以及对CuCl 2诱导的HT22细胞铁死亡的作用机制。将TX小鼠分为对照组、模型组、肝豆灵片组、Fer-1组、谷胱甘肽组,HT22细胞分为对照组、模型组、肝豆灵片... 详细信息

基于PKCβⅡ/ACSL4/ALOX5信号通路,探讨肝豆灵片对TX小鼠肝豆状核变性铁死亡的影响以及对CuCl 2诱导的HT22细胞铁死亡的作用机制。将TX小鼠分为对照组、模型组、肝豆灵片组、Fer-1组、谷胱甘肽组,HT22细胞分为对照组、模型组、肝豆灵片组、Fer-1组、肝豆灵片+Fer-1组,采用HE染色检测各组小鼠海马组织病理学改变,蛋白质免疫印迹检测各组小鼠海马组织与HT22细胞中PKCβⅡ、ACSL4、ALOX5蛋白的表达,以及HT22细胞中SLC7A11、GPX4蛋白的表达,微量法检测各组TX小鼠海马组织中Fe 2+的浓度,微板法检测各组HT22细胞中SOD(超氧化物歧化酶)、MDA(丙二醛)、GSH-Px水平,实时荧光定量聚合链式反应检测各组HT22细胞中PKCβⅡ、ACSL4、ALOX5 mRNA的表达。结果表明:与对照组相比,模型组海马组织出现明显损伤,PKCβⅡ、ACSL4、ALOX5蛋白表达均明显增高,SLC7A11、GPX4蛋白表达明显下降,Fe 2+的浓度明显升高(P<0.05);与模型组相比,肝豆灵片组、Fer-1组和谷胱甘肽组海马组织的病理损伤均得到改善,且肝豆灵片组效果明显;肝豆灵片组和Fer-1组能抑制HT22细胞铁死亡,PKCβⅡ、ACSL4、ALOX5蛋白与mRNA表达较模型组均明显减少,MDA的浓度明显降低(P<0.05),SOD活力及GSH-Px浓度明显增加(P<0.05)。肝豆灵片能减轻TX小鼠海马组织铁死亡,抑制CuCl 2诱导的HT22细胞铁死亡,其机制可能与下调PKCβⅡ/ACSL4/ALOX5信号通路,减轻细胞内脂质过氧化有关。

关键词：肝豆灵片肝豆状核变性 PKCβⅡ/ACSL4/ALOX5信号通路铁死亡机制

Surface Properties of Cement Paste Evaluated by Scanning Probe Microscopy

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Open Journal of Civil Engineering 2016年第4期6卷 643-652页

作者： yuya Sakai Institute of Industrial Science The University of Tokyo Tokyo Japan

The microscopic physical properties of Hardened Cement Paste (HCP) surfaces were evaluated by using Scanning Probe Microscopy (SPM). The cement pastes were cured under a hydrostatic pressure of 400 MPa and the contacting surfaces with a slide glass during the curing were studied. Scanning Electron Microscope (SEM) observation at a magnification of 7000 revealed smooth surfaces with no holes. The surface roughness calculated from the SPM measurement was 4 nm. The surface potential and the frictional force measured by SPM were uniform throughout the measured area 24 h after the curing. However, spots of low surface potential and stains of low frictional force and low viscoelasticity were observed one month after curing. This change was attributed to the carbonation of hydrates.

关键词： Cement Paste Scanning Probe Microscopy Surface Potential Frictional Resistance Viscoelasticity

Empirical correlations for predicting the self-leveling behavior of debris bed

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Nuclear Science and Techniques 2013年第1期24卷 43-52页

作者： CHENG Songbai YAMANO Hidemasa SUZUKI Tohru TOBITA Yoshiharu NAKAMURA yuya ZHANG Bin MATSUMOTO Tatsuya MORITA Koji Advanced Nuclear System R&D Directorate Japan Atomic Energy Agency (JAEA) Department of Applied Quantum Physics and Nuclear Engineering Kyushu University

Studies on the self-leveling behavior of debris bed are crucial for the assessment of core-disruptive accident (CDA) occurred in sodium-cooled fast reactors (SFR). To clarify this behavior over a comparatively wider range of gas velocities, a series of experiments were performed by injecting nitrogen gas uniformly from a pool bottom. Current experiments were conducted in a cylindrical tank, in which water, nitrogen gas and different kinds of solid particles, simulate the coolant, vapor (generated by coolant boiling) and fuel debris, respectively. Based on the quantitative data obtained (mainly the time variation of bed inclination angle), with the help of dimensional analysis technique, a set of empirical correlations to predict the self-leveling development depending on particle size, particle density and gas injection velocity was proposed and discussed. It was seen that good agreement could be obtained between the calculated and experimental values. Rationality of the correlations was further confirmed through detailed analyses of the effects of experimental parameters such as particle size, particle density, gas flow rate and boiling mode. In order to facilitate future analyses and simulations of CDAs in SFRs, the obtained results in this work will be utilized for the validations of an advanced fast reactor safety analysis code.

关键词：自流平行为模拟冷却水预测气体速度注入氮气粒子密度实验值

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“四责协同”机制构建医院行政科室权责清单

现代医院 2024年第4期24卷 504-507页

作者：徐隽嬿金宇雅姜皓婧顾平赵明珠上海市浦东新区浦南医院上海200125

目的深化细化全面从严治党“四责协同”机制向科室延伸,构建医院行政职能科室监管事项权责一体化清单、压实责任。方法以行政职能科室岗位权力风险防控为基础,加强制度建设为抓手,监督权力运行为核心,对照法律法规、规章制度、岗位职责... 详细信息

目的深化细化全面从严治党“四责协同”机制向科室延伸,构建医院行政职能科室监管事项权责一体化清单、压实责任。方法以行政职能科室岗位权力风险防控为基础,加强制度建设为抓手,监督权力运行为核心,对照法律法规、规章制度、岗位职责,对重点领域、重要事项、关键岗位,查摆权力运行的关键节点、内部管理的薄弱环节、问题易发的风险点,采取自下而上与自上而下相结合的方式,形成行政科室权责一体化清单。结果医院17个行政科室以“一科室一清单”形式,共梳理出209项职权项目、涉及公权力947条。结论通过清单构建工作的开展,进一步完善了廉洁风险防控的制度建设,提升全院依法依纪依规工作的觉悟和能力和精细化管理水平,使党组织管党治党的责任得到有效落实,为医院高质量发展保驾护航。

关键词： “四责协同”机制医院行政权责清单

Preparation of hemicellulolic oligosaccharides from Chamaecyparis obtuse （Hinoki） slurry using commercial enzymes

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 224-231页

作者： yuya KUMAGAI Hirokazu USUKI Yukihiro YAMAMOTO Akihiro YAMASATO Takafumi MUKAIHARA Tadashi HATANAKA Okayama Prefectural Technology Center for Agriculture Forestry and FisheriesResearch Institute for Biological Sciences(RIBS)Okayama 716-1241Japan Research Fellow of the Japan Society for the Promotion of Science(JSPS) Japan Nagoya University Nagoya 464-8601Japan

Wood biomass is anticipated to serve as a substitute for carbon source, which has no feedstock competition with foods. Biomass is commonly used for the production of bio-ethanol by a series of processes such as pretreatment, enzymatic degradation, and fermentation. Hemicellulose, constituting 20 wt-% - 40 wt-% ofbiomass materials, contains various kinds of saccharides known to be bioactive substrates. Practical usage of hemicellulose is generally limited to its conversion to bio-ethanol. Here, we aimed to prepare hemicellulolic oligosaccharides, more valuable products other than ethanol. Therefore, the Hinoki slurry was treated with lime at room temperature for 3 h, and then neutralized with HCI. The resulting sample was treated with 13 types of commercial enzymes, and the saccharides produced in the supernatant were evaluated. The result showed that the commercial enzyme Cellulase SS （Nagase ＆ Co., LTD.） effectively degraded the slurry to produce disaccharides and trisaccharides. Analysis of sugar components by liquid chromatography/mass spectrography （LC/MS） after the derivation with ethyl 4- aminobenzoate （ABEE） showed that mannobiose, manno- Nose, and cellobiose were the major oligosaccharides. These results indicate valuable oligosaccharides can be successfully produced from Hinoki softwood slurry.

关键词： hemicellulolic oligosaccharides Chamaecyparis obtuse (Hinoki) commercial enzyme manno-oligosaccharide cello-oligosaccharide

Preparation of Cu nanoparticles with NaBH_4 by aqueous reduction method

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Transactions of Nonferrous Metals Society of China 2012年第1期22卷 117-123页

作者： LIU Qing-ming ZHOU De-bi yuya YAMAMOTO Ryoichi ICHINO Masazumi OKIDO School of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Department of Materials Science Graduate School of EngineeringNagoya UniversityNagoya 4648603Japan

Cu nanoparticles were prepared by reducing Cu2＋ ions with NaBH4 in alkaline solution. The effects of NaBH4 concentration and dripping rate on the formation of Cu nanoparticles were studied. The optimum conditions are found to be 0.2 mol/L Cu2＋, solution with pH=12, temperature of 313 K and 1% gelatin as dispersant, to which 0.4 mol/L NaBH4 is added at a dripping rate of 50 mL/min. NH3-H2O is found to be the optimal complexant to form the Cu precursor. A series experiments were conducted to study the reaction process at different time points.

关键词： Cu nanoparticles aqueous reduction method precursor reaction process