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Zebrafish Foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression

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Journal of Genetics and Genomics 2022年第6期49卷 559-568页

作者： Luqingqing He Qinxin Zhang Dongya Jiang Yunfeng Zhang yuxuan wei Yuxi Yang Nan Li Shuang Wang Yunyun Yue Qingshun Zhao Model Animal Research Center Medical SchoolNanjing UniversityNanjingJiangsu 210061China Department of Prenatal Diagnosis Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjingJiangsu 210009China

Chamber maturation is a significant process in cardiac development. Disorders of this crucial process lead to a range of congenital heart defects. Foxc1a is a critical transcription factor reported to regulate the specification of cardiac progenitor cells. However, little is known about the role of Foxc1a in modulating chamber maturation. Previously, we reported that foxc1a-null zebrafish embryos exhibit disrupted heart structures and functions. In this study, we observe that ventricle structure and cardiomyocyte proliferation are abolished during chamber maturation in foxc1a-null zebrafish embryos. To observe the endogenous localization of Foxc1a in the hearts of living embryos, we insert eyfp at the foxc1a genomic locus using TALEN. Analysis of the knockin zebrafish show that foxc1a is widely expressed in ventricular cardiomyocytes during chamber development. Cardiac RNA sequencing analysis reveals the downregulated expression of the Hippo signaling effector wwtr1. Dual-luciferase and chromatin immunoprecipitation assays reveal that Foxc1a can bind directly to three sites in the wwtr1 promoter region. Furthermore, wwtr1m RNA overexpression is sufficient to reverse the ventricle defects during chamber maturation. Conditional overexpression of nkx2.5 also partially rescues the ventricular defects during chamber development. These findings demonstrate that wwtr1 and nkx2.5 are direct targets of Foxc1a during ventricular chamber maturation.

关键词： Zebrafish Foxc1a Cardiac ventricular development wwtr1 nkx2.5

Hierarchical molybdenum disulfide nanosheet arrays stemmed from nickel-cobalt layered double hydroxide/carbon cloth for highly-efficient hydrogen evolution reaction

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Journal of Energy Chemistry 2021年第6期30卷 587-592,I0014页

作者： yuxuan wei Yanlong Lv Beidou Guo Jianru Gong Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience CAS Key Laboratory for Nanosystem and Hierarchical FabricationNational Center for Nanoscience and TechnologyBeijing 100190China University of CAS Beijing 100049China

The hierarchical structure of molybdenum disulfide(MoS2)nanosheet arrays stemmed from nickelcobalt layered double hydroxide(NiCo-LDH)/carbon cloth was prepared by growing the MoS_(2) nanosheet arrays onto the NiCo-LDH template which was pre-deposited onto the carbon cloth substrate.In this electrode configuration,carbon cloth is the three dimensional and conductive skeleton;NiCo-LDH nanosheets,as the template,ensure the oriented growth of MoS2 nanosheet arrays.Therefore,more MoS_(2) active sites are exposed and the catalyst exhibits good hydrogen evolution reaction activity.

关键词： Hydrogen evolution reaction catalysts Hierarchical structure Molybdenum disulfide Nickel-cobalt layered double hydroxide

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脑源成像技术及其应用研究进展

中国科学：技术科学 2024年第2期54卷 196-224页

作者：魏玉烜王旭江海腾孟建军上海交通大学机械与动力工程学院机器人研究所上海200240 浙江大学医学院附属精神卫生中心(杭州市第七人民医院) 杭州310013

脑电图(EEG)和脑磁图(MEG)为观察和分析人脑活动提供了重要的无创测量工具. EEG/MEG可采集大规模神经集群放电活动引起的体表电势/磁场,采集的信号具备高时间分辨率,因而在神经科学、临床医学与神经工程等领域得到广泛的应用.然而, EEG/... 详细信息

脑电图(EEG)和脑磁图(MEG)为观察和分析人脑活动提供了重要的无创测量工具. EEG/MEG可采集大规模神经集群放电活动引起的体表电势/磁场,采集的信号具备高时间分辨率,因而在神经科学、临床医学与神经工程等领域得到广泛的应用.然而, EEG/MEG测得的是颅内神经集群活动经过脑组织、脑脊液、颅骨和头皮等人体容积导体组织弥散传播后引起的颅外电势/磁场,其空间分辨率低,无法反映神经活动的真实空间分布.源成像是一种结合人体头部组织的数学模型,用EEG/MEG来推导颅内神经活动源的成像技术,是目前公认的提高无创测量空间分辨率的有效技术.典型的源成像问题包括正问题建模和逆问题求解两个方面,其中逆问题求解是源成像的核心,而正问题建模是逆问题求解的基础,两者相辅相成.本文通过文献检索梳理和归纳目前存在的正问题建模和逆问题求解的典型方法和常用软件,介绍影响源成像精度的因素和评价源成像性能的指标和方法.另外,本文还着重介绍了源成像技术在神经科学、临床医学以及神经工程-脑机接口方面的应用和研究进展.最后,讨论了当前源成像技术面临的挑战,以及针对这些挑战该领域内的研究前沿和趋势,展望了源成像在推动神经科学、临床医学等科学研究和技术进步方面的潜力.

关键词：源成像源定位源重建脑电图脑磁图逆问题

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面向大规模数据的高效超图神经网络

中国科学：信息科学 2024年第4期54卷 853-871页

作者：吉书仪魏宇轩戴琼海高跃清华大学软件学院北京100084 清华大学自动化系北京100084 脑与认知智能北京实验室北京100084 北京信息科学与技术国家研究中心北京100084 清华大学脑与认知科学研究院北京100084

高阶关联广泛存在于现实世界中,如社交网络、生物网络、交通网络等,建模及优化高阶关联对于网络属性研究和演化趋势预测具有重要意义.超图是一种灵活的数据结构,能够自然地建模高阶关联.近年来,随着深度学习的发展,基于超图建模的超图... 详细信息

高阶关联广泛存在于现实世界中,如社交网络、生物网络、交通网络等,建模及优化高阶关联对于网络属性研究和演化趋势预测具有重要意义.超图是一种灵活的数据结构,能够自然地建模高阶关联.近年来,随着深度学习的发展,基于超图建模的超图神经网络被广泛应用于面向高阶关联的表示学习.然而,现有的超图神经网络均基于直推学习范式,虽然在小规模超图数据集上取得了不错的效果,但难以应用到大规模数据上,限制了其应用范围.本文首先分析了现有超图神经网络方法在大规模数据上应用的挑战,然后针对该问题提出了面向大规模数据的高效超图神经网络方法(efficient hypergraph neural network,EHGNN).针对现有方法空间、时间复杂度过高的问题,EHGNN分别设计了超图采样模块和基于单阶段超图卷积的计算加速模块,同时降低了超图神经网络的空间开销和时间开销,使得超图神经网络适用于大规模超图数据,显著增强了可扩展性.在4个真实超图数据集上的实验结果验证了EHGNN的有效性和高效性.

关键词：超图计算超图神经网络高阶关联大规模数据节点分类

Multiband camouflage design with thermal management

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Photonics Research 2023年第5期11卷 839-851页

作者： LEHONG HUANG HAOCHUAN LI ZHIGUO LI WENBO ZHANG CAIWEN MA CHUNMIN ZHANG yuxuan wei LIANG ZHOU XUN LI ZHIYUAN CHENG XIAOHUI GUO SHIPING GUO Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China School of Physics Xi’an Jiaotong UniversityXi’an 710049China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Space Precision Measurement Technology Chinese Academy of SciencesXi’an 710119China

Although the effective“stealth”of space vehicles is important,current camouflage designs are inadequate in meeting all application requirements.Here,a multilayer wavelength-selective emitter is demonstrated.It can realize visible light and dual-band mid-infrared camouflage with thermal control management in two application scenarios,with better effect and stronger radiation cooling capability,which can significantly improve the stealth and survivability of space vehicles in different environments.The selective emitter demonstrated in this paper has the advantages of simple structure,scalability,and ease of large-area fabrication,and has made a major breakthrough in driving multiband stealth technology from simulation research to physical verification and even practical application.

关键词： breakthrough driving management

A strategy to synthesize phosphorus-containing nickel phyllosilicate whiskers to enhance the flame retardancy of epoxy composites with excellent mechanical and dry-friction properties

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 39-50页

作者： Shibin Nie Zongquan Zhao yuxuan Xu wei He Wenli Zhai Jinian Yang School of Public Security and Emergency Management Anhui University of Science and TechnologyHefei231131China School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan232001China School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Institute of Energy Hefei Comprehensive National Science CenterHefei230000China

To enhance the fire safety and wear resistance of epoxy,phosphorus-containing nickel phyllosilicate whiskers(FP-NiPS)were synthesized using a facile hydrothermal technology,with 9,10-dihydro-9-oxa-10-phosphaphenanthrene as the organic modifier.The impacts of FP-NiPS on the thermal stability,flame retardancy,and mechanical and tribological properties of EP composites were explored.The findings demonstrated that 5 wt%FP-NiPS elevated the limiting oxygen index of the EP composite from 23.8%to 28.4%,achieving a V-0 rating during vertical burning tests.FP-NiPS could enhance the thermal stability of epoxy resin(EP)and facilitate the development of a dense and continuous carbon layer,thereby significantly improving the fire safety of the EP composites.The FP-NiPS led to an 8.2%increase in the tensile strength and a 38.8%increase in the elastic modulus of the EP composite,showing outstanding mechanical properties.Furthermore,FP-NiPS showed remarkable potential in enhancing the wear resistance of EP.The wear rate of 1 wt%FP-NiPS is 2.34×10^(−5) mm^(3)·N^(−1)·m^(−1),a decrease of 66.7%compared to EP.This work provides a novel promising modification method to enhance the fire safety,mechanical and wear resistance properties of EP.

关键词： nickel phyllosilicate epoxy resin flame retardant wear resistance mechanical property

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爬岩红提取物对化学性肝损伤小鼠的保护作用

龙岩学院学报 2024年第2期42卷 44-52页

作者：谭烨敏李嘉嘉余雯琦王雪魏雨萱陈彤龙岩学院福建省家畜疫病防治与生物技术重点实验室福建龙岩364000

分别用体积分数0.5%CCl_(4)、50%乙醇溶液建立小鼠急性肝损伤模型,研究爬岩红水提物、醇提物对CCl_(4)和酒精所致的肝损伤小鼠的保护作用。结果显示,爬岩红水提物、醇提物均能降低CCl_(4)肝损伤小鼠血清ALT活性、肝组织MDA水平,升高肝组... 详细信息

分别用体积分数0.5%CCl_(4)、50%乙醇溶液建立小鼠急性肝损伤模型,研究爬岩红水提物、醇提物对CCl_(4)和酒精所致的肝损伤小鼠的保护作用。结果显示,爬岩红水提物、醇提物均能降低CCl_(4)肝损伤小鼠血清ALT活性、肝组织MDA水平,升高肝组织GSH-PX、T-SOD、CAT、白蛋白水平,减轻CCl4肝损伤小鼠肝组织的病理变化程度,且二者的保肝作用无显著差异(P>0.05);爬岩红水提物、醇提物均能降低酒精性肝损伤小鼠血清ALT活性、肝组织MDA和TG水平,升高肝组织GSH、T-SOD水平,减轻酒精性肝损伤小鼠肝组织的病理变化程度,且水提物的效果更为显著(P<0.05)。爬岩红水提取物、醇提取物对CCl_(4)和酒精所致的肝损伤小鼠均有保护作用,水提物对酒精性肝损伤的保护作用更好。

关键词：爬岩红提取物小鼠肝损伤保护作用

Stochastic programming based coordinated expansion planning of generation,transmission,demand side resources,and energy storage considering the DC transmission system

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Global Energy Interconnection 2024年第1期7卷 25-37页

作者： Liang Lu Mingkui wei yuxuan Tao Qing Wang Yuxiao Yang Chuan He Haonan Zhang Southwest Branch of State Grid Corporation of China Chengdu 610065P.R.China College of Electrical Engineering Sichuan UniversityChengdu 610065P.R.China

With the increasing penetration of wind and solar energies,the accompanying uncertainty that propagates in the system places higher requirements on the expansion planning of power systems.A source-grid-load-storage coordinated expansion planning model based on stochastic programming was proposed to suppress the impact of wind and solar energy fluctuations.Multiple types of system components,including demand response service entities,converter stations,DC transmission systems,cascade hydropower stations,and other traditional components,have been extensively modeled.Moreover,energy storage systems are considered to improve the accommodation level of renewable energy and alleviate the influence of intermittence.Demand-response service entities from the load side are used to reduce and move the demand during peak load periods.The uncertainties in wind,solar energy,and loads were simulated using stochastic programming.Finally,the effectiveness of the proposed model is verified through numerical simulations.

关键词： Hydro-wind-solar complementary Expansion planning Demand response Energy storage system Source-network-demand-storage coordination

Arbuscular mycorrhizal fungi inoculation and exogenous indole-3-acetic acid application induce antioxidant defense response to alleviate cadmium toxicity in Broussonetia papyrifera

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Pedosphere 2024年第2期34卷 447-459页

作者： Xue LI Jingwei LIANG Hongjian wei yuxuan KUANG Hui CHEN Ming TANG Wentao HU State Key Laboratory of Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern AgricultureGuangdong Key Laboratory for Innovative Development and Utilization of Forest Plant GermplasmCollege of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou 510642China

Cadmium(Cd)contamination in soil poses a huge threat to plants even at low concentrations;Broussonetia papyrifera has great potential in remediation of soil heavy metal contamination.However,whether exogenous indole-3-acetic acid(IAA)application and arbuscular mycorrhizal fungi(AMF)have synergistic effects on Cd tolerance of B.papyrifera remains unclear.To investigate the effects of AMF inoculation and IAA application on the tolerance of B.papyrifera to Cd stress,two experiments were conducted:the first to investigate the effect of AMF(Rhizophagus irregularis)inoculation on the tolerance of B.papyrifera to Cd stress and the second to investigate the combined effects of AMF inoculation and IAA application on the tolerance of B.papyrifera to Cd stress.Parameters including endogenous hormone concentration,antioxidant defense response,malondialdehyde(MDA)content,and gene expression related to antioxidant enzyme system and hormone were measured.The results indicated that AMF alleviated Cd toxicity of B.papyrifera by reducing MDA content and improving antioxidant enzyme activities and Cd absorption capacity.Furthermore,the combination of AMF inoculation and IAA application had a synergetic effect on the tolerance of B.papyrifera to Cd stress through upregulating BpAUX1 and BpAUX2,which might contribute to root growth and root xylem synthesis,and by upregulating BpSOD2 and BpPOD34 to enhance the antioxidant enzyme system.This work provides a new insight into the application of IAA in the remediation of soil Cd pollution by mycorrhizal plants.

关键词： enzyme activity geneexpression heavy metal phytoremediation remediation Rhizophagus irregularis soil cadmium pollution stress tolerance