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The emerging role of snoRNAs in human disease

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Genes & Diseases 2023年第5期10卷 2064-2081页

作者： Xinhai Zhang Chenglong Wang Shujun Xia Fei Xiao Jianping Peng yuxuan gao Fengbin Yu Chuandong Wang Xiaodong Chen Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200092China Ultrasound Department Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200025China Department of Orthopaedic Surgery Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Orthopaedics The 72nd Group Army Hospital of PLAHuzhouZhejiang 313000China

Small nucleolar RNAs(snoRNAs)play critical roles in various biological processes.The aberrant expression or depletion of snoRNAs is related to various diseases.In previous research,most of the snoRNAs were categorized as C/D box snoRNAs and H/ACA box snoRNAs,whose typical functions were thought of as regulation of 2′-O-ribose methylation and pseudouridylation of ribosome RNAs,respectively.However,in the past two decades,studies have revealed an increasing number of snoRNAs without specific targets or determined cell functions.These findings indicated that some potential roles of snoRNAs are still unknown.Numerous studies have indicated the correlation of snoRNAs with human diseases.SnoRNAs play various roles in abundant biological processes,and they have great potential in controlling human diseases.This new and rising field could benefit from investigations of the disease pathogenesis,biomarker identification,and the determination of novel therapeutic targets.This review summarized the reports on snoRNAs and the regulation of different diseases in recent years.

关键词： Cancer Genetic disease Inflammation Metabolism Small nucleolar RNAs

Influence of the intensity and loading time of direct current electric field on the directional migration of rat bone marrow mesenchymal stem cells

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Frontiers of Medicine 2016年第3期10卷 286-296页

作者： Xiaoyu Wang yuxuan gao Haigang Shi Na Liu Wei Zhang Hongbo Li Department of Stomatology Chinese PLA General Hospital Beijing 100853 China Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China

Exogenic electric fields can effectively accelerate bone healing and remodeling through the enhanced migration of bone marrow mesenchymal stem cells （BMSCs） toward the injured area. This study aimed to determine the following：（1） the direction of rat BMSC （rBMSC） migration upon exposure to a direct current electric field （DCEF）, （2） the optimal DCEF intensity and duration, and （3） the possible regulatory role of SDF-1/ CXCR4 axis in rBMSC migration as induced by DCEF. Results showed that rBMSCs migrated to the positive electrode of the DCEF, and that the DCEF of 200 mV/mm for 4 h was found to be optimal in enhancing rBMSC migration. This DCEF strength and duration also upregulated the expression of osteoblastic genes, including ALP and OCN, and upregulated the expression of ALP and Runx2 proteins. Moreover, when CXCR4 was inhibited, rBMSC migration due to DCEF was partially blocked. These findings indicated that DCEF can effectively induce rBMSC migration. A DCEF of 200 mV/mm for 4 h was recommended because of its ability to promote rBMSC migration, proliferation, and osteogenic differentiation. The SDF-1/CXCR4 signaling pathway may play an important role in regulating the DCEF-induced migration of rBMSCs.

关键词： DCEF migration osteogenesis differentiation rBMSCs SDF-1/CXCR-4

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山西黄河流域生态保护与高质量发展路径研究

经济师 2024年第2期 7-9页

作者：高宇轩韩芸山西省社会科学院<山西省人民政府发展研究中心>生态文明研究所山西太原030032

实现山西黄河流域生态保护和高质量发展是山西践行“两山”理论、加快转型发展的有力抓手,也可深化黄河流域生态保护和高质量发展研究。近年来,山西在推动黄河流域生态修复、减污降碳及文旅产业发展方面取得积极成效,但仍存在生态环境... 详细信息

实现山西黄河流域生态保护和高质量发展是山西践行“两山”理论、加快转型发展的有力抓手,也可深化黄河流域生态保护和高质量发展研究。近年来,山西在推动黄河流域生态修复、减污降碳及文旅产业发展方面取得积极成效,但仍存在生态环境改善难度大、文旅资源利用不充分及要素保障能力不强等现实问题,建议山西走好产业转型道路,切实推动污染防治、低碳产业发展及文旅产业发展等工作走深走实,使山西黄河流域成为高质量发展的又一典范。

关键词：山西黄河流域高质量发展

生态文明视域下能源产业生态化发展路径探索——以山西为例

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煤炭经济研究 2024年第2期44卷 98-103页

作者：韩芸高宇轩山西省社会科学院(山西省人民政府发展研究中心)生态文明研究所山西太原030032

促进人与自然和谐共生是生态文明建设的核心要义,是推动中国式现代化的内在要求。产业生态化是推动产业结构转型升级,提升产业竞争力,建设生态文明,实现人与自然和谐共生的有效路径。山西是典型的能源资源省份,近年来,立足能源资源禀赋... 详细信息

促进人与自然和谐共生是生态文明建设的核心要义,是推动中国式现代化的内在要求。产业生态化是推动产业结构转型升级,提升产业竞争力,建设生态文明,实现人与自然和谐共生的有效路径。山西是典型的能源资源省份,近年来,立足能源资源禀赋和比较优势,在深化能源革命中不断推动能源产业生态化效率和质量双提升。但是,能源产业生态化仍存在相关配套体系不完善、生态遗留问题较多、新技术赋能不足等问题,在此基础上,提出能源产业生态化发展路径。

关键词：能源产业生态化双碳目标能源革命生态文明

基于深度强化学习的公共安全领域文本关键词抽取方法

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工业建筑 2024年第2期54卷 155-160页

作者：高誉轩孙丽娟丁洪鑫熊子奇成都市河湖保护和智慧水务中心成都610072 中电科大数据研究院有限公司贵阳550022 提升政府治理能力大数据应用技术国家工程研究中心贵阳550022

在国内政务大数据高速发展的背景下,充分利用大量无标注的公共安全领域政策公文文本数据,有效提取文本的关键信息,对提升城市安全治理能力有重要意义。因此,提出一种基于深度强化学习的公共安全领域文本关键词提取模型,通过无监督的方... 详细信息

在国内政务大数据高速发展的背景下,充分利用大量无标注的公共安全领域政策公文文本数据,有效提取文本的关键信息,对提升城市安全治理能力有重要意义。因此,提出一种基于深度强化学习的公共安全领域文本关键词提取模型,通过无监督的方式快速实现文本内容的标签化,以提升用户对公共安全领域文件或事件的检索能力。文章以log-sum范数正则项作为该模型损失函数的稀疏约束,以引导策略网络学习到保留重要词汇、舍弃非重要词汇的策略。同时设计了一种mini-batch大小可变的模型训练方法,通过设置不同的mini-batch大小控制策略网络学习的难度,从而提高策略网络的泛化能力。性能对比结果显示,该模型在测试集的关键词提取任务上优于传统无监督关键词提取方法。

关键词：深度强化学习关键词提取 log-sum范数公共安全大数据

Linear-fitting-based recursive filtering for nonlinear systems under encoding-decoding mechanism

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Science China(Information Sciences) 2024年第5期67卷 183-196页

作者： Bo JIANG Hongli DONG Zhiwei gao yuxuan SHEN Fan YANG Artificial Intelligence Energy Research Institute Northeast Petroleum University Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Sanya Offshore Oil & Gas Research Institute Northeast Petroleum University School of Electrical & Information Engineering Northeast Petroleum University

This paper deals with a recursive filtering problem for a class of discrete time-varying nonlinear networked systems with the encoding-decoding mechanism. The linear fitting method is introduced to handle the nonlinearity. An encoding-decoding mechanism is constructed to describe the data transmission process in wireless communication networks(WCNs). To be specific, the measurement outputs are mapped by a quantizer to unique codewords for transmission in WCNs. Then, the codewords are decoded by the decoder to recover the measurement outputs which are sent to the filter. The processing/encoding delay and network delay have been considered. Firstly, on the premise that the upper bound of the filtering error covariance is minimum, the appropriate filtering gain is calculated. Then, the mean square exponential boundedness of the filtering error is analyzed. Finally, two simulation examples are presented to verify the effectiveness of the proposed algorithm.

关键词： encoding-decoding mechanism uniform quantizer linear fitting networked systems recursive filtering

DNA framework signal amplification platform-based highthroughput systemic immune monitoring

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1115-1131页

作者： Ye Chen Xingyu Chen Bowen Zhang Yuxin Zhang Songhang Li Zhiqiang Liu Yang gao yuxuan Zhao Lin Yan Yi Li Taoran Tian Yunfeng Lin State Key Laboratory of Oral Diseases National Center for StomatologyNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041 SichuanPR China Department of Prosthodontics Tianjin Stomatological HospitalSchool of MedicineNankai UniversityTianjin 300041PR China Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041 SichuanPR China Sichuan Provincial Engineering Research Center of Oral Biomaterials Chengdu 610041 SichuanChina

Systemic immune monitoring is a crucial clinical tool for disease early diagnosis,prognosis and treatment planning by quantitative analysis of immune cells.However,conventional immune monitoring using flow cytometry faces huge challenges in large-scale sample testing,especially in mass health screenings,because of time-consuming,technical-sensitive and high-cost features.However,the lack of high-performance detection platforms hinders the development of high-throughput immune monitoring technology.To address this bottleneck,we constructed a generally applicable DNA framework signal amplification platform(DSAP)based on post-systematic evolution of ligands by exponential enrichment and DNA tetrahedral framework-structured probe design to achieve high-sensitive detection for diverse immune cells,including CD4+,CD8+T-lymphocytes,and monocytes(down to 1/100μl).Based on this advanced detection platform,we present a novel high-throughput immune-cell phenotyping system,DSAP,achieving 30-min one-step immune-cell phenotyping without cell washing and subset analysis and showing comparable accuracy with flow cytometry while significantly reducing detection time and cost.As a proof-of-concept,DSAP demonstrates excellent diagnostic accuracy in immunodeficiency staging for 107 HIV patients(AUC>0.97)within 30 min,which can be applied in HIV infection monitoring and screening.Therefore,we initially introduced promising DSAP to achieve high-throughput immune monitoring and open robust routes for point-of-care device development.

关键词： diagnosis monitoring initially

腹泻型肠易激综合征中医证型与血清Endocan的相关性研究

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现代中西医结合杂志 2024年第7期33卷 895-899,905页

作者：张洪薇王再见谢春娥雷雪李彤高玉璇邹茂琳王悦卿李会霞北京中医药大学北京100020 北京中医药大学第三附属医院北京100029 北京中医药大学东方医院北京100078 北京市怀柔区中医医院北京101499

目的探讨腹泻型肠易激综合征(IBS-D)患者的中医辨证分型特点及其与血清内皮细胞特异性分子-1(Endocan)水平的相关性。方法选取2022年3月—2023年4月在北京中医药大学第三附属医院脾胃病科门诊就诊的127例IBS-D患者作为IBS-D组,另以同期2... 详细信息

目的探讨腹泻型肠易激综合征(IBS-D)患者的中医辨证分型特点及其与血清内皮细胞特异性分子-1(Endocan)水平的相关性。方法选取2022年3月—2023年4月在北京中医药大学第三附属医院脾胃病科门诊就诊的127例IBS-D患者作为IBS-D组,另以同期27例健康体检者作为健康组,收集受检者的年龄、性别、中医四诊辨证资料及实验室检查、影像学检查结果,统计IBS-D患者中医证型分布情况,比较不同中医证型IBS-D患者的血清Endocan水平,Pearson相关性分析中医证型与血清Endocan水平的相关性。结果127例IBS-D患者中,以大肠湿热证[29.9%(38/127)]、肝郁脾虚证[28.3%(36/127)]多见,其次为寒热错杂、脾虚湿盛证和脾肾阳虚证。IBS-D组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、Endocan水平均明显高于健康组(P均0.05)。Pearson相关性分析显示,大肠湿热证、肝郁脾虚证与血清Endocan水平均呈正相关(P均<0.05)。结论IBS-D患者机体存在轻度炎症反应,血清Endocan水平可作为IBS-D的中医辨证分型参考指标。

关键词：腹泻型肠易激综合征内皮细胞特异性分子-1 大肠湿热证肝郁脾虚证

机载光电跟踪系统的自抗扰与快速非奇异终端滑模组合控制方法

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兵工学报 2023年第4期44卷 1071-1085页

作者：高雨轩侯远龙高强侯润民南京理工大学机械工程学院江苏南京210094

机载目标跟踪系统由于受到外部干扰、内部参数摄动和未建模动态等扰动的影响,使跟踪控制分系统设计面临巨大的挑战。以两轴四框架的光电稳定平台为对象研究抗扰动控制方法,针对自抗扰控制的扰动补偿一般留有扰动残差和滑模控制会引入较... 详细信息

机载目标跟踪系统由于受到外部干扰、内部参数摄动和未建模动态等扰动的影响,使跟踪控制分系统设计面临巨大的挑战。以两轴四框架的光电稳定平台为对象研究抗扰动控制方法,针对自抗扰控制的扰动补偿一般留有扰动残差和滑模控制会引入较大抖振的问题,设计一种自抗扰与快速非奇异终端滑模组合控制的方法。利用线性扩张状态观测器来估计总扰动量并在控制端进行补偿,从而允许设计滑模控制的控制率时采用较小的滑模切换增益,并通过设计快速非奇异终端滑模面得到控制率,加快系统收敛的同时避免非奇异现象。数值仿真结果表明,该组合控制方法在外部扰动和模型不确定性的影响下,可以实现快速收敛与高跟踪精度的同时引入较小的抖振,并且实现了机载目标跟踪系统需求的快速响应性能,验证了这个组合控制方法的有效性。

关键词：两轴四框架光电跟踪系统自抗扰控制滑模控制组合控制线性扩张状态观测器