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Decatungstate as a direct hydrogen atom transfer photocatalyst for synthesis of trifluromethylthioesters from aldehydes

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Chinese Chemical Letters 2021年第10期32卷 3027-3030页

作者： Xiaochen Wang Jianyang Dong Yuxiu Liu Hongjian Song Qingmin Wang State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300071China

We have developed a versatile,mild protocol for trifluoromethylthiolation reactions of aldehydes with catalysis by a decatungstate hydrogen atom transfer photocatalyst under redox-neutral conditions.The protocol is highly selective,operationally simple,and compatible with a wide array of sensitive functional groups.It can be used for late-stage functionalization of bioactive molecules,which makes it convenient for drug discovery.

关键词： Aldehydes Decatungstate photocatalyst Redox-neutral Hydrogen atom transfer Trifluoromethylthiolation

Rh(Ⅲ)-catalyzed C8 arylation of quinoline N-oxides with arylboronic acids

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Chinese Chemical Letters 2020年第6期31卷 1572-1575页

作者： Yuanqiong Huang Xueli Lv Hongjian Song Yuxiu Liu Qingmin Wang State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300071China

Herein,we report the first Rh~Ⅲ-catalyzed regioselective C8 arylation of quinoline N-oxides with commercially available arylboronic acids as coupling partners.This procedure is simple,and the reaction shows perfect regioselectivity,a broad substrate scope,and isolated yields of up to 92%.We demonstrate the utility of the reaction by using it for late-stage functionalization of a fungicide.

关键词： Rh^Ⅲ-catalyzed C8 arylation Quinoline N-oxides Arylboronic acids Regioselectivity

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT NK0238

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Frontiers of Agricultural Science and Engineering 2022年第1期9卷 110-119页

作者： Wentao XU Hao TIAN Hongjian SONG Yuxiu Liu Yongqiang LI Qingmin WANG State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300071China

It has previously been shown that tryptophan, the biosynthesis precursor ofPeganum harmala alkaloids, and its derivatives have anti-TMV activity bothin vitro and in vivo. Further exploration of this led to the identification of NK0238as a highly effective agent for the prevention and control of diseases caused byplant viruses, but the existing routes are unsuitable for its large-scale synthesis.This study optimized a route for two-step synthesis of this virucide candidate viareaction of L-tryptophan with triphosgene to produce L-tryptophan-N-carboxylicanhydride, which then reacts with n-octylamine to give NK0238 at up to 94%yield and nearly 97% HPLC purity. In addition, the route was used for thepreparation of NK0238 on a > 40 g scale permitting further assessment of itsantivirus activity in the greenhouse and field experiments, and toxicity tests.NK0238 exhibited useful antiviral activities against a variety of viruses both ingreenhouse and field experiments. The toxicity tests showed that NK0238 wasnot acutely toxic to birds, fish, honey bees and silkworms. The optimized routeprovides a solid foundation for its large-scale synthesis and subsequent efficacyand toxicity studies, its excellent activity and safety make NK0238 a promisingdrug candidate for further development.

关键词： antiviral plant protectant antiviral in the greenhouse field evaluation L-trp-NCA synthesis optimization toxicity tests

SARS-CoV-2 Serological Survey of Cats in China before and after the Pandemic

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Virologica Sinica 2020年第6期35卷 846-848页

作者： Junhua Deng Yuxiu Liu Chunyan Sun Jingjing Bai Jie Sun Liying Hao Xiangdong Li Kegong Tian Luoyang Putai Biotechnology Co. LtdLuoyang 471003China National Research Center for Veterinary Medicine Luoyang 471003China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China

Dear Editor,SARS-Co V-2 or COVID-19 has become pandemic and spread to more than 200 countries with over 24 million human infected cases(WHO 2020).The origin of SARSCo V-2 remains unknown,though bat,pangolin,and snake ... 详细信息

关键词： reservoirs origin snake

Phosphorylation of ATF2 promotes odontoblastic differentiation via intrinsic HAT activity

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Journal of Genetics and Genomics 2023年第7期50卷 497-510页

作者： Huanyan Zuo Yao Xiao Jiahao Han yuxiu Lin Cheng Tian Shu Zhang Guohua Yuan Huan liu Zhi Chen State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Department of Cariology and Endodontics School of StomatologyWuhan UniversityWuhanHubei 430079China Department of Periodontology School of StomatologyWuhan UniversityWuhanHubei 430079China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhanHubei 430079China

Mouse dental papilla cells(mDPCs)are cranial neural crest-derived dental mesenchymal cells that give rise to dentin-secreting odontoblasts after the bell stage during odontogenesis.The odontoblastic differentiation of mDPCs is spatiotemporally regulated by transcription factors(TFs).Our previous work reveals that chromatin accessibility was correlated with the occupation of the basic leucine zipper TF family during odontoblastic differentiation.However,the detailed mechanism by which TFs regulate the initiation of odontoblastic differentiation remains elusive.Here,we report that phosphorylation of ATF2(p-ATF2)is particularly increased during odontoblastic differentiation in vivo and in vitro.ATAC-seq and p-ATF2 CUT&Tag experiments further demonstrate a high correlation between p-ATF2 localization and increased chromatin accessibility of regions near mineralization-related genes.Knockdown of Atf2 inhibits the odontoblastic differentiation of mDPCs,while overexpression of p-ATF2 promotes odontoblastic differentiation.ATAC-seq after overexpression of p-ATF2 reveals that p-ATF2 increases the chromatin accessibility of regions adjacent to genes associated with matrix mineralization.Furthermore,we find that p-ATF2 physically interacts with and promotes H2BK12 acetylation.Taken together,our findings reveal a mechanism that p-ATF2 promotes odontoblastic differentiation at initiation via remodeling chromatin accessibility and emphasize the role of the phosphoswitch model of TFs in cell fate transitions.

关键词： Odontoblast Dental papilla Mesenchymal stem cells ATF Transcription factors Cell differentiation Chromatin accessibility

Predictors and dynamic online nomogram for postoperative delayed hyponatremia after endoscopic transsphenoidal surgery for pituitary adenomas:a single-center,retrospective,observational cohort study with external validation

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Chinese Neurosurgical Journal 2023年第4期9卷 241-250页

作者： Xiangming Cai An Zhang Peng Zhao Zhiyuan liu Yiliyaer Aili Xinrui Zeng Yuanming Geng Chaonan Du Feng Yuan Junhao Zhu Jin Yang Chao Tang Zixiang Cong Yuxiu Liu Chiyuan Ma Department of Neurosurgery Jinling HospitalNanjingChina School of Medicine Southeast UniversityNanjingChina Department of Molecular Cell Biology and Immunology Amsterdam UMCVrije Universiteit AmsterdamAmsterdamNetherlands Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Neurosurgery The Affiliated Jinling Hospital of Nanjing Medical UniversityNanjingChina Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Critical Care Medicine Jinling HospitalNanjing Medical UniversityNanjingChina Department of Biostatistics School of Public HealthSouthern Medical UniversityGuangzhouChina Department of Neurosurgery Jinling Hospitalthe First School of Clinical MedicineSouthern Medical UniversityNanjingChina

Background Postoperative delayed hyponatremia(PDH)is a major cause of readmission after endoscopic transsphenoidal surgery(eTSS)for pituitary adenomas(PAs).However,the risk factors associated with PDH have not been well established,and the development of a dynamic online nomogram for predicting PDH is yet to be realized.We aimed to investigate the predictive factors for PDH and construct a dynamic online nomogram to aid in its prediction.Methods We analyzed the data of 226 consecutive patients who underwent eTSS for PAs at the Department of Neurosurgery in Jinling Hospital between January 2018 and October 2020.An additional 97 external patients were included for external validation.PDH was defined as a serum sodium level below 137 mmol/L,occurring on the third postoperative day(POD)or later.Results Hyponatremia on POD 1-2(OR=2.64,P=0.033),prothrombin time(PT)(OR=1.78,P=0.008),and percentage of monocytes(OR=1.22,P=0.047)were identified as predictive factors for PDH via multivariable logistic regression analysis.Based on these predictors,a nomogram was constructed with great discrimination in internal validation(adjusted AUC:0.613-0.688)and external validation(AUC:0.594-0.617).Furthermore,the nomogram demonstrated good performance in calibration plot,Brier Score,and decision curve analysis.Subgroup analysis revealed robust predictive performance in patients with various clinical subtypes and mild to moderate PDH.Conclusions Preoperative PT and the percentage of monocytes were,for the first time,identified as predictive factors for PDH.The dynamic nomogram proved to be a valuable tool for predicting PDH after eTSS for PAs and demonstrated good generalizability.Patients could benefit from early identification of PDH and optimized treatment decisions.

关键词： Endoscopic transsphenoidal surgery Nomogram Pituitary adenomas Postoperative delayed hyponatremia Predictors

Mild and Highly Efficient Metal-Free Oxidative α-Cyanation of N-Acyl/Sulfonyl Tetrahydroisoquinolines

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Mild and Highly Efficient Metal-Free Oxidative α-Cyanation ...

Copper-Catalyzed Aryltrifluoromethylation of N-Phenylcinnamamides: Access to Trifluoromethylated 3,4-Dihydroquinolin-2（1H）-ones And 1?Azaspiro[4.5]decanes

中国化学会第九届全国有机化学学术会议

作者： Changcun Yan Yuxiu Liu Qingmin Wang State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic Chemistry Nankai University

＜正＞Direct cyanation at theα-position of nitrogen-containing heterocycles such as tetrahydroisoquinolines is an attractive method for the formation ofα-amino nitriles which are highly versatile because the nitrile...

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Copper-Catalyzed Aryltrifluoromethylation of N-Phenylcinnama...

Design, Synthesis, Antiviral, Fungicidal, and Insecticidal Activity Evaluation of β-carboline Derivatives Based on Virus Inhibitors of Plant Sources

中国化学会第九届全国有机化学学术会议

作者： Qiang Wang Guifang Han Yuxiu Liu Qingmin Wang State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering （Tianjin） Nankai University

＜正＞The trifluoromethyl group plays a privileged role in pharmaceuticals,agrochemicals and materials science because of its unique properties,and great efforts have been made to develop reactions for its introductio...

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Design, Synthesis, Antiviral, Fungicidal, and Insecticidal A...