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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

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Frontiers of Medicine 2024年第1期18卷 180-191页

作者： Fang Wang yuxing Liu Yi Dong Meifang Zhao Hao Huang Jieyuan jin Liangliang Fan Rong Xiang Department of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China Department of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes,which play crucial roles in lipid metabolism.However,little is known about the function of Lipin3 in triglyceride(TG)metabolism.Here,we identified a novel mutation(NM_001301860:p.1835A>T/p.D612V)of Lipin3 in a large family with hypertriglyceridemia(HTG)and obesity through whole-exome sequencing and Sanger sequencing.Functional studies revealed that the novel variant altered the half-life and stability of the Lipin3 protein.Hence,we generated Lipin3 heterozygous knockout(Lipin3-heKO)mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG metabolism.We found that Lipin3-heKO mice exhibited obvious obesity,HTG,and non-alcoholic fatty liver disorder.Mechanistic study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and nucleoplasm.The increased expression of Lipin1 in cytosol may contribute to TG anabolism,and the decreased Lipin1 in nucleoplasm can reduce PGC1α,further leading to mitochondrial dysfunction and reduced TG catabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

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Size-dependent thermomechanical vibration characteristics of rotating pre-twisted functionally graded shear deformable microbeams

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1015-1032页

作者： Songye jin Bo ZHANG Wuyuan ZHANG yuxing WANG Huoming SHEN jing WANG Juan LIU School of Mechanics and Aerospace Engineering Southwest Jiaotong UniversityChengdu 610031China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China School of Mechanical and Electrical Engineering Southwest Petroleum UniversityChengdu 610500China

A three-dimensional(3D)thermomechanical vibration model is developed for rotating pre-twisted functionally graded(FG)microbeams according to the refined shear deformation theory(RSDT)and the modified couple stress theory(MCST).The material properties are assumed to follow a power-law distribution along the chordwise direction.The model introduces one axial stretching variable and four transverse deflection variables including two pure bending components and two pure shear ones.The complex modal analysis and assumed mode methods are used to solve the governing equations of motion under different boundary conditions(BCs).Several examples are presented to verify the effectiveness of the developed model.By coupling the slenderness ratio,gradient index,rotation speed,and size effect with the pre-twisted angle,the effects of these factors on the thermomechanical vibration of the microbeam with different BCs are investigated.It is found that with the increase in the pre-twisted angle,the critical slenderness ratio and gradient index corresponding to the thermal instability of the microbeam increase,while the critical material length scale parameter(MLSP)and rotation speed decrease.The sensitivity of the fundamental frequency to temperature increases with the increasing slenderness ratio and gradient index,and decreases with the other increasing parameters.Moreover,the size effect can suppress the dynamic stiffening effect and enhance the Coriolis effect.Finally,the mode transition is quantitatively demonstrated by a modal assurance criterion(MAC).

关键词： thermomechanical vibration rotating pre-twisted functionally graded(FG)microbeam refined shear deformation theory(RSDT) modified couple stress theory(MCST) modal assurance criterion(MAC)

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Opportunities and challenges in studies of mammalian hybrid speciation

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Science China(Life Sciences) 2024年第3期67卷 614-617页

作者： Hong Wu yuxing Zhang Li Yu State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan School of Life SciencesYunnan UniversityKunming 650091China

Revealing the mechanisms of speciation remains one of the most attractive and challenging issues in the field of evolutionary biology, and is also key to understanding the biodiversity present in nature.

关键词： biodiversity attractive evolutionary

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Voltage rise rate-related generalised probabilistic lifetime model of turn-to-turn insulation in inverter-fed motors

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High Voltage 2024年第1期9卷 46-55页

作者： Yan Yang Xueyang Bai yuxing Lei Kai Liu Guangning Wu School of Electrical Engineering Southwest Jiaotong UniversityChengduChina

The lifetime model of turn-to-turn insulation in inverter-fed motors is studied.A lifetime model has been built by considering the effect of inverter-generated high voltage rise rate(dv/dt up to 20 V/ns).This model is followed by the generalised probabilistic model,in which the lifetime is proportional to the nth power of the voltage rise rate.Moreover,by investigating the effect of voltage rise rate on the partial discharge characteristics,it is found that the effect of voltage rise rate on the charge transport process in a voltage cycle is similar to that of the voltage amplitude.The enhanced partial discharge activity and induced charges are responsible for accelerated ageing and thus determine the final lifetime of turn-to-turn insulation.In this case,the generalised probabilistic electric lifetime model is applicable to the voltage rise rate as well as the voltage amplitude.

关键词： lifetime inverter insulation

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The significance of resource recycling for coking wastewater treatment:based on environmental and economic life cycle assessment

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Green Chemical Engineering 2024年第1期5卷 50-59页

作者： Di Zhang He Zhao Wenfang Gao yuxing Sheng Hongbin Cao Institute of Process Engineering Innovation Academy for Green ManufactureChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Chemistry&Chemical Engineering Data Center Chinese Academy of SciencesBeijing100190China Tianjin Key Laboratory of Clean Energy and Pollutant Control School of Energy and Environmental EngineeringHebei University of TechnologyTianjin300401China

The sustainability of the coking industry is supported by reasonable production profit and environmental quality requirements.The traditional measures substantially increased the related costs for enterprises to reach standards.This paper aims to develop a comprehensive cost combined environmental impact assessment method that is necessary for the analysis of wastewater treatment systems.Typical three coking wastewater treatment processes in China were evaluated.Results showed that eutrophication dominantly contributed to the overall environmental effect.Improving effluent quality could significantly reduce the total environmental impact.In terms of an economic perspective,the price of raw materials was the main factor that affected the operating cost of comprehensive treatment.Based on subsystem analysis,the pretreatment stage accounted for the majority of environmental and cost burdens,respectively reaching 64%-78%and 64%-86%.Optimizing the pretreatment process by enhancing the efficiency of high concentration raw material recovery and substituting toxic raw materials for extractant could reduce the environmental impact and economic cost by 43.8%and 57%,respectively,which was an effective way to improve the potential performance of coking wastewater treatment plants(WWTPs).

关键词： Life cycle assessment Environmental impact Economic evaluation Coking wastewater treatment Resource recycling Comprehensive benefits

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Arc Grounding Fault Identification Using Integrated Characteristics in the Power Grid

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Energy Engineering 2024年第7期121卷 1883-1901页

作者： Penghui Liu Yaning Zhang yuxing Dai Yanzhou Sun School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo454003China Research and Development Center Guangdong Zhicheng Champion Group Co.Ltd.Dongguan523000China Henan Key Laboratory of Intelligent Detection and Control of Coal Mine Equipment Henan Polytechnic UniversityJiaozuo454003China

Arc grounding faults occur frequently in the power grid with small resistance grounding neutral points.The existing arc fault identification technology only uses the fault line signal characteristics to set the identification index,which leads to detection failure when the arc zero-off characteristic is short.To solve this problem,this paper presents an arc fault identification method by utilizing integrated signal characteristics of both the fault line and sound lines.Firstly,the waveform characteristics of the fault line and sound lines under an arc grounding fault are studied.After that,the convex hull,gradient product,and correlation coefficient index are used as the basic characteristic parameters to establish fault identification criteria.Then,the logistic regression algorithm is employed to deal with the reference samples,establish the machine discrimination model,and realize the discrimination of fault types.Finally,simulation test results and experimental results verify the accuracy of the proposed method.The comparison analysis shows that the proposed method has higher recognition accuracy,especially when the arc dissipation power is smaller than 2×103 W,the zero-off period is not obvious.In conclusion,the proposed method expands the arc fault identification theory.

关键词： Arc fault convex hull algorithm correlation coefficient fault identification gradient logistic regression

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Multi-process production occurs in the iron and steel industry,supporting‘dual carbon'target:An in-depth study of CO_(2)emissions from different processes

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Journal of Environmental Sciences 2024年第6期140卷 46-58页

作者： Hongming Na yuxing Yuan Tao Du Tianbao Zhang Xi Zhao jingchao Sun Ziyang Qiu Lei Zhang SEP Key Laboratory of Eco-Industry Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

Reducing CO_(2)emissions of the iron and steel industry,a typical heavy CO_(2)-emitting sector is the only way that must be passed to achieve the‘dual-carbon’goal,especially in China.In previous studies,however,it is still unknown what is the difference between blast furnace basic oxygen furnace(BF-BOF),scrap-electric furnace(scrap-EF)and hydrogen metallurgy process.The quantitative research on the key factors affecting CO_(2)emissions is insufficient There is also a lack of research on the prediction of CO_(2)emissions by adjusting industria structure.Based on material flow analysis,this study establishes carbon flow diagrams o three processes,and then analyze the key factors affecting CO_(2)emissions.CO_(2)emissions of the iron and steel industry in the future is predicted by adjusting industrial structure The results show that:(1)The CO_(2)emissions of BF-BOF,scrap-EF and hydrogen metallurgy process in a site are 1417.26,542.93 and 1166.52 kg,respectively.(2)By increasing pellet ratio in blast furnace,scrap ratio in electric furnace,etc.,can effectively reduce CO_(2)emissions(3)Reducing the crude steel output is the most effective CO_(2)reduction measure.There is still 5.15×10^(8)-6.17×10^(8) tons of CO_(2)that needs to be reduced by additional measures.

关键词： Blast furnace-basic oxygen furnace process Scrap-electric furnace process Hydrogen metallurgy process Carbon flow diagram Influencing factors CO_(2)emission prediction

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Immune states:integrated views of immunity by combining traditional Chinese medicine and modern medicine

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Science China Life Sciences 2024年

作者： Anlong Xu yuxing Zhi School of Life Sciences and Qi-Huang School of Chinese Medicine Beijing University of Chinese Medicine School of Life Sciences Sun Yat-sen University

Human immune system is an extraordinarily complex physiological system composed of multiple anatomical systems,diverse tissues and molecules from macroscopic to microscopic level. Numerous cells and molecules collectively participate in immune defense and immune surveillance to maintain homeostasis. More than two thousand years ago, the traditional Chinese medicine(TCM) practitioner has recognized that there are factors in the human body responsible for resisting various exogenous and endogenous pathogens, and referred these factors as“Zheng Qi”(healthy Qi), but referred various pathogenic factors as “Xie Qi”(un-healthy Qi).

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Large-scale interplant exchange of macromolecules between soybean and dodder under nutrient stresses

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Plant Diversity 2024年第1期46卷 116-125页

作者： jingxiong Zhang Shalan Li Wenxing Li Zerui Feng Shuhan Zhang Xijie Zheng yuxing Xu Guojing Shen Man Zhao Guoyan Cao Xuna Wu Jianqiang Wu Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan and Center for Life Science School of Life SciencesYunnan UniversityKunming 650500China

Parasitic plants and their hosts communicate through haustorial connections.Nutrient deficiency is a common stress for plants,yet little is known about whether and how host plants and parasites communicate during adaptation to such nutrient stresses.In this study,we used transcriptomics and proteomics to analyze how soybean(Glycine max)and its parasitizing dodder(Cuscuta australis)respond to nitrate and phosphate deficiency(-N and-P).After-N and-P treatment,the soybean and dodder plants exhibited substantial changes of transcriptome and proteome,although soybean plants showed very few transcriptional responses to-P and dodder did not show any transcriptional changes to either-N or-P.Importantly,large-scale interplant transport of mRNAs and proteins was detected.Although the mobile mRNAs only comprised at most 0.2%of the transcriptomes,the foreign mobile proteins could reach 6.8%of the total proteins,suggesting that proteins may be the major forms of interplant communications.Furthermore,the interplant mobility of macromolecules was specifically affected by the nutrient regimes and the transport of these macromolecules was very likely independently regulated.This study provides new insight into the communication between host plants and parasites under stress conditions.

关键词： Cuscuta Mobile molecules Nutrient deficiency Host plant-parasitic plant interaction Interplant transport Systemic signaling

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Surface air temperature change in the Wuyi Mountains,southeast China

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Journal of Mountain Science 2024年第6期21卷 1992-2004页

作者： QIN Yihui WEI yuxing LU Jiayi MAO Jiahui CHEN Xingwei GAO Lu CHEN Ying LIU Meibing DENG Haijun Institute of Geography Fujian Normal UniversityFuzhou 350117China National Demonstration Center for Experimental Geography Education Fujian Normal UniversityFuzhou 350117China School of Geographical Science Fujian Normal UniversityFuzhou 350117China Fujian Provincial Engineering Research Center for Monitoring and Assessing Terrestrial Disasters Fujian Normal UniversityFuzhou 350117China Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China

Detecting changes in surface air temperature in mid-and low-altitude mountainous regions is essential for a comprehensive understanding of warming trend with altitude.We use daily surface air temperature data from 64 meteorological stations in Wuyi Mountains and its adjacent regions to analyze the spatio-temporal patterns of temperature change.The results show that Wuyi Mountains have experienced significant warming from 1961 to 2018.The warming trend of the mean temperature is 0.20℃/decade,the maximum temperature is 0.17℃/decade,and the minimum temperature is 0.26℃/decade.In 1961-1990,more than 63%of the stations showed a decreasing trend in annual mean temperature,mainly because the maximum temperature decreased during this period.However,in 1971-2000,1981-2010 and 1991-2018,the maximum,minimum and mean temperatures increased.The fastest increasing trend of mean temperature occurred in the southeastern coastal plains,the quickest increasing trend of maximum temperature occurred in the northwestern mountainous region,and the increase of minimum temperature occurred faster in the southeastern coastal and northwestern mountainous regions than that in the central area.Meanwhile,this study suggests that elevation does not affect warming in the Wuyi Mountains.These results are beneficial for understanding climate change in humid subtropical middle and low mountains.

关键词： Climate change Surface air temperature Temporal and spatial changes Mann-Kendall nonparametric test Wuyi Mountains

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