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Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1441-1456页

作者： Xin Zhuo Yue Wu Xiujuan Fu Jianbin Li yuxin xiang Xiaoyu Liang Canquan Mao Yuhong Jiang Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases,immune cell infiltration and protease-driven tissue *** is an urgent need to explore potential drug strategies for mitigating lung ***-activated receptor 2(PAR2)as a vital molecular target principally participates in various inflammatory diseases via intracellular signal ***,it has been rarely reported about the role of PAR2 in lung *** study applied CRISPR-Cas9 system encoding Cas9 and sg RNA(p Cas9-PAR2)for PAR2 knockout and fabricated an anionic human serum albuminbased nanoparticles to deliver p Cas9-PAR2 with superior inflammation-targeting efficiency and stability(TAP/p Cas9-PAR2).TAP/p Cas9-PAR2 robustly facilitated p Cas9-PAR2 to enter and transfect inflammatory cells,eliciting precise gene editing of PAR2 in vitro and in ***,PAR2 deficiency by TAP/p Cas9-PAR2 effectively and safely promoted macrophage polarization,suppressed proinflammatory cytokine releases and alleviated acute lung inflammation,uncovering a novel value of *** also revealed that PAR2-mediated pulmonary inflammation prevented by TAP/p Cas9-PAR2was mainly dependent on ERK-mediated NLRP3/IL-1β and NO/i NOS ***,this work indicated PAR2 as a novel target for lung inflammation and provided a potential nanodrug strategy for PAR2 deficiency in treating inflammatory diseases.

关键词： Protease-activated receptor 2(PAR2) CRISPR-Cas9 Gene editing Inflammation Acute lung inflammation NLRP3 Nanoparticles Drug delivery

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《关于慢性抽动障碍治疗失败定义的专家共识》解读

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中华实用儿科临床杂志 2024年第9期39卷 650-654页

作者：向雨欣孙丹刘智胜华中科技大学同济医学院附属武汉儿童医院神经内科武汉430016

正确判断慢性抽动障碍治疗失败能防止持续使用不必要的治疗方法,有利于适时升级为试验性甚至侵入性治疗,但目前仍缺乏关于慢性抽动障碍治疗失败的标准定义。由加拿大卡尔加里大学Davide Martino教授牵头,通过网络平台开展了多轮德尔菲... 详细信息

正确判断慢性抽动障碍治疗失败能防止持续使用不必要的治疗方法,有利于适时升级为试验性甚至侵入性治疗,但目前仍缺乏关于慢性抽动障碍治疗失败的标准定义。由加拿大卡尔加里大学Davide Martino教授牵头,通过网络平台开展了多轮德尔菲调查法,制定了《关于慢性抽动障碍治疗失败定义的专家共识》。该共识基于行为干预和药物治疗,从治疗无效、依从性、耐受性和共患病影响4个方面形成抽动障碍治疗失败,并且进一步确定了行为干预整体治疗失败以及药物治疗整体治疗失败的定义。现就该共识的制订流程及关键内容进行解读,并补充探讨近年来关注的难治性抽动障碍定义,以帮助临床医师提高对慢性抽动障碍治疗失败的认知水平。

关键词：慢性抽动障碍治疗失败行为干预药物治疗难治性抽动障碍

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A High-Contrast Autolysosome Probe for Detecting Interaction between Autophagosomes and Autolysosomes in Mitophagy

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Chinese Journal of Chemistry 2024年第8期42卷 858-866页

作者： Weihua Wang Chu Han Shengjie Xie Zisong Cong Zixuan Yang yuxin Feng Limin xiang Heng Song College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,Autophagy is a multi-step cell metabolism process in which cells remove damaged and unwanted *** autophagy,autophagosomes fuse with lysosomes to form *** membrane components are recycled from autolysosomes through the autophagosomal components recycling(ACR),while lysosomal components circulate on the autolysosomal surface through the autophagic lysosome reformation(ALR)*** contain components from autophagosomes and ***,whether there is a fusion between autolysosome and autophagosome or lysosome at the organelle level remains *** this study,a pH and viscosity dual-controlled mitochondria-targeting fluorescent probe Mito-Q was designed based on an asymmetric norcyanine to achieve the high-contrast imaging of mitochondria-containing ***-Q not only effectively detected mitochondrial viscosity changes and mitophagy with high sensitivity,but more importantly,the fusion of mitochondria-containing autolysosomes and autophagosomes(FMAA)was observed during autophagy by the real-time confocal imaging of HeLa cells.

关键词： Mitophagy Autolysosomes Bioimaging Biosensors Fluorescence imaging

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Experimental demonstration of a photonic spiking neuron based on a DFB laser subject to side-mode optical pulse injection

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Science China(Information Sciences) 2024年第3期67卷 271-280页

作者： Shuiying xiang Shuang GAO Yuechun SHI Yuna ZHANG Ziwei SONG Xingxing GUO Yahui ZHANG yuxin MA xiangfei CHEN State Key Laboratory of Integrated Service Networks Xidian University Yongjiang Laboratory 3. College of Engineering and Applied Sciences Nanjing University

We proposed and experimentally demonstrated a simple and novel photonic spiking neuron based on a distributed feedback(DFB) laser subject to side-mode optical pulse injection(SMOPI). The DFB laser chip is designed and fabricated based on asymmetric equivalent π phase shift(π-EPS) with the reconstruction-equivalent-chirp(REC) technique. Under side-mode continuous-wave(CW) optical injection,excitability pulse was experimentally observed during the dominant mode switching process due to the injection-locked effect. Based on the transition between the excitability regime and the side-mode injection locking effect, the controllable and repeatable neuron-like spiking response can be realized when external stimulus pulses are electro-optically modulated on the CW optical carrier. The experimental results show that the spike threshold, temporal integration, and refractory period, which are important spike processing mechanisms in biological neurons, can all be achieved in the optically-injected DFB laser. The experimental findings are also verified numerically with a rate equation model that considers the SMOPI. To the best of our knowledge, this is the first experimental demonstration of a photonic spiking neuron based on a DFB laser subject to SMOPI, which holds promise for realizing large-scale photonic spiking neuron arrays for hardware photonic spiking neural network chips.

关键词： neuromorphic photonics photonic spiking neuron DFB laser side-mode optical pulse injections

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Enhancing alkyne semi-hydrogenation through engineering metal-support interactions of Pd on oxides

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Nano Research 2024年第5期17卷 3707-3713页

作者： Yuefeng Wu Xiaotong Lu Pengfei Cui Wenyu Jia Jun Zhou Yuan Wang Hussain Zahid yuxin Wu Muhammad Umer Rafique Xiong Yin Baoshan Li Leyu Wang Guolei xiang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Supported Pd catalysts show superior activities for olefin productions from alkynes through semi-hydrogenation reactions,but over-hydrogenation into alkanes highly decreases olefin *** phenylacetylene semi-hydrogenation as a model reaction,here we explore the optimization approaches toward better Pd catalysts for alkyne semi-hydrogenation through investigating support effect and metal-support *** results show that the states of Pd with supports can be tuned by varying oxide reducibility,loading ratios,and *** our system,0.06 wt.%Pd on rutile-TiO_(2) nanorods shows the highest activity owing to the synergistic effects of single-atoms and *** reducibility can change the filling degrees of Pd 4d orbitals through varying interfacial bonding strengths,which further affect catalytic activity and selectivity.

关键词： alkyne semi-hydrogenation support effect metal-support interaction Pd catalyst single-atom catalyst

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Hybrid-integrated 200 Gb/s REC-DML array transmitter based on photonic wire bonding technology

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Chinese Optics Letters 2024年第8期22卷 64-69页

作者： yuxin Ma Jie Zhao Tongtong Yang Yipeng Mei Zhenxing Sun Jun Lu Shaobo Li xiang Ma xiangfei Chen Key Laboratory of Intelligent Optical Sensing and Manipulation of the Ministry of Education&National Laboratory of Solid State Microstructures&College of Engineering and Applied Sciences&Institute of Optical Communication Engineering&Nanjing University-Tongding Joint Lab for Large-Scale Photonic Integrated Circuits Nanjing UniversityNanjing 210023China Optical Communication Research and Development Center 54th Research Institute of China Electronics Technology Group CorporationShijiazhuang 050081China

An 8-channel hybrid-integrated chip for 200 Gb/s(8×25 Gb/s)signal transmission has been *** channels are all within the O-band,and with a spacing of 800 *** core of this chip is a monolithic integrated multi-wavelength laser array of 8 directly-modulated distributed feedback(DFB)*** using the reconstruction equivalent chirp technique,multi-wavelength integration and asymmetric phase shift structures are achieved in the laser *** output laser beams of the array are combined by a planar light-wave circuit,which is hybrid-integrated with the laser array by photonic wire *** results of this transmitter chip show good single-mode working of each unit laser,with a sidemode suppression ratio above 50 dB,and the modulation bandwidth is above 20 *** eye diagrams are obtained in the lasers for 25 Gb/s non-return-to-zero modulation,which implies a total 200 Gb/s transmission rate for the whole chip.

关键词： direct modulation laser array reconstruction equivalent chirp photonic wire bonding hybrid integration

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Controllability Gramian-based measures of graph product networks

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Science China(Information Sciences) 2024年第10期67卷 315-331页

作者： Yuequan xiang Linying xiang School of Information Science and Engineering Northeastern University School of Artificial Intelligence Tiangong University

This paper addresses the controllability measures of composite networks based on graph products, in which the graph product networks are either Kronecker product networks or Kronecker sum *** primary objective pursued here is to reveal the controllability Gramian-based measure links between the graph product composite network and its subnetworks. First, the analytical expression of the average controllability for the Kronecker product network is derived by using the corresponding controllability measures of its subnetworks. An upper bound of volumetric control energy is further obtained for the Kronecker product network. Then, the upper bounds are derived for the controllability measures of the Kronecker sum network,which provide a valuable reference for designing controllable networks in practical applications. Finally, the controllability of the Kronecker product network is compared with that of the Kronecker sum network, and it is found that when the subnetworks satisfy certain conditions, the Kronecker product network has better average controllability than the Kronecker sum network.

关键词： composite network graph product controllability Gramian-based measure average controllability control energy

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Modeling and Analysis of Flexible Manufacturing Systems Based on Linear Temporal Logic

Modeling and Analysis of Flexible Manufacturing Systems Base...

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第35届中国过程控制会议

作者： yuxin Cen Shaoyuan Li xiang Ying Department of Automation Shanghai Jiao Tong University

In this paper, we investigate the modeling and analysis problems of flexible manufacturing systems based on *** work on this topic primarily focuses on supervisory control theory and discrete event systems. In our approach, we propose to use LTS to model the system and LTL to describe system properties. We present utilizing model checking methods to verify system properties and generate deterministic system control sequences. To address non-deterministic system control problems, we propose a game-based formal control synthesis method that transforms the system control problem into a game problem. We provide the algorithms for model checking and three games. Finally, we illustrate the feasibility of our proposed method through a case study.

关键词： Lable transtion system linear temporal logic model checking formal control synthesis

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Dual-ion carrier storage through Mg^(2+) addition for high-energy and long-life zinc-ion hybrid capacitor

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 179-185页

作者： Junjie Zhang xiang Wu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

Cation additives can efficiently enhance the total electrochemical capabilities of zinc-ion hybrid capacitors (ZHCs).However their energy storage mechanisms in zinc-based systems are still under ***,we modulate the electrolyte and achieve dual-ion storage by adding magnesium *** we assemble several Zn//activated carbon devices with different electrolyte concentrations and investigate their electrochemical reaction dynamic *** zinc-ion capacitor with Mg^(2+)mixed solution delivers 82 mAh·g^(-1)capacity at 1 A·g^(-1) and maintains 91%of the original capacitance after 10000 *** is superior to the other assembled zinc-ion devices in single-component *** finding demonstrates that the double-ion storage mechanism enables the superior rate performance and long cycle lifetime of ZHCs.

关键词： zinc-ion hybrid capacitor MgSO_(4) electrolyte rate performance storage mechanism

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Microstructure and mechanical properties of a cast TRIP-assisted multiphase stainless steel

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China Foundry 2024年第3期21卷 221-228页

作者： Meng-xin Wang Zi-xiang Wu Jing-yu He xiang Chen School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Stainless steels are used in a wide range of complex environments due to their excellent corrosion *** stainless steels can offer an excellent combination of strength,toughness and corrosion resistance due to the coexistence of different *** microstructure and mechanical properties of a novel cast multiphase stainless steel,composed of martensite,ferrite,and austenite,were investigated following appropriate heat treatment processes:solution treatment at 1,050℃ for 0.5 h followed by water quenching to room temperature,and aging treatment at 500℃ for 4 h followed by water quenching to room *** show reversed austenite is formed by diffusion of Ni element during aging process,and the enrichment of Ni atoms directly determines the mechanical stability of *** austenite with a lower Ni content undergoes a martensitic transformation during plastic *** tensile strength of the specimen exceeds 1,100 MPa and the elongation exceeds 24%after solid solution,and further increases to 1,247 MPa and 25%after aging *** enhancement is due to the TRIP effect of austenite and the precipitation of the nanoscale G-phase pinning dislocations in ferrite and martensite.

关键词： multiphase stainless steel mechanical properties TRIP effect reversed austenite G-phase

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