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钠—葡萄糖协同转运蛋白2抑制剂在糖尿病心肌病中作用机制的研究进展

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齐齐哈尔医学院学报 2024年第15期45卷 1459-1464页

作者：常雨欣王宇航康品方蚌埠医科大学临床医学院安徽蚌埠233000 蚌埠医科大学第一附属医院心血管科

糖尿病心肌病(Diabetic cardiomyopathy,DCM)是排除高血压,冠心病,先天性心脏病等其他心血管疾病后的特异性心肌病,临床上其发病率持续增高,但是DCM的早期筛查手段和治疗方法仍然有限。因此当务之急是寻找一种敏感可靠的治疗药物,降低DC... 详细信息

糖尿病心肌病(Diabetic cardiomyopathy,DCM)是排除高血压,冠心病,先天性心脏病等其他心血管疾病后的特异性心肌病,临床上其发病率持续增高,但是DCM的早期筛查手段和治疗方法仍然有限。因此当务之急是寻找一种敏感可靠的治疗药物,降低DCM的发病率。有大量的临床试验证实,钠—葡萄糖协同转运蛋白2抑制剂(Sodium-Glucose Cotransporter-2 Inhibitor,SGLT2i)治疗有利于糖尿病心肌病的代谢、微循环、线粒体功能、纤维化、氧化应激、内质网应激、程序性细胞死亡、自噬和肠道菌群等。本文就SGLT2i治疗DCM作用机制的最新研究进展进行综述,以期为临床早期治疗DCM提供参考。

关键词：钠—葡萄糖协同转运蛋白2抑制剂糖尿病心肌病线粒体氧化应激

Metal-Organic Frameworks Functionalized Separators for Robust Aqueous Zinc-Ion Batteries

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Nano-Micro Letters 2022年第12期14卷 521-534页

作者： Yang Song Pengchao Ruan Caiwang Mao yuxin chang Ling Wang Lei Dai Peng Zhou Bingan Lu Jiang Zhou Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshan 063009People’s Republic of China School of Materials Science and Engineering Hunan Provincial Key Laboratory of Electronic Packaging and Advanced Functional MaterialsCentral South UniversityChangsha 410083People’s Republic of China Hunan Provincial Key Defense Laboratory of High Temperature Wear-Resisting Materials and Preparation Technology Hunan University of Science and TechnologyXiangtan 411201People’s Republic of China School of Physics and Electronics Hunan UniversityChangsha 410082People’s Republic of China

Aqueous zinc-ion batteries(AZIBs)are one of the promising energy storage systems,which consist of electrode materials,electrolyte,and *** first two have been significantly received ample development,while the prominent role of the separators in manipulating the stability of the electrode has not attracted sufficient *** this work,a separator(UiO-66-GF)modified by Zr-based metal organic framework for robust AZIBs is ***-66-GF effectively enhances the transport ability of charge carriers and demonstrates preferential orientation of(002)crystal plane,which is favorable for corrosion resistance and dendrite-free zinc ***,Zn|UiO-66-GF-2.2|Zn cells exhibit highly reversible plating/stripping behavior with long cycle life over 1650 h at 2.0 mA cm^(−2),and Zn|UiO-66-GF-2.2|MnO_(2) cells show excellent long-term stability with capacity retention of 85%after 1000 *** reasonable design and application of multifunctional metal organic frameworks modified separators provide useful guidance for constructing durable AZIBs.

关键词： Aqueous zinc-ion batteries Separators Metal-organic frameworks Ion transport Dendrite-free

Functional carbon materials for high-performance Zn metal anodes

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Journal of Energy Chemistry 2022年第12期75卷 135-153,I0005页

作者： Caiwang Mao yuxin chang Xuanting Zhao Xiaoyu Dong Yifei Geng Ning Zhang Lei Dai Xianwen Wu Ling Wang Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshan 063009HebeiChina College of Chemistry&Environmental Science Hebei UniversityBaoding 071002HebeiChina School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000HunanChina Hebei Province Key Laboratory of Photocatalytic and Electrocatalytic Materials for Environment North China University of Science and TechnologyTangshan 063009HebeiChina

The realization of“carbon peak”and“carbon neutralization”highly depends on the efficient utilization of renewable energy *** reliable and low-cost electrochemical energy storage systems is an ever-growing demand for renewable energy *** available candidates,aqueous zinc-ion batteries(AZIBs)receive extensive researchers'attention because of their material abundance,high capacity,high safety,and environmental ***,the irreversible issues of Zn anode in terms of notorious dendric Zn growth,Zn corrosion/hydrogen evolution,and passivation significantly impede the commercialization of high-performance *** materials have advantages of large specific surface area,low cost,high electrical conductivity,controllable structure,and good *** application provides remedies for improving the comprehensive performance of Zn *** this review,the fundamentals and issues of Zn anodes,and the research progress with functional carbon materials for Zn anodes in recent years are *** major strategies are described in detail,including the use of carbon materials(carbon nanotubes,graphene,carbon fiber,metal-organic framework(MOF)derived host,etc.)as Zn plating/stripping substrates,as protective coating layers on Zn,and as electrolyte ***,the remaining challenges and perspectives of carbon materials in high-performance AZIBs are outlined.

关键词： Aqueous zinc-ion battery Carbon material Zn anodes Substrate Coating Additive

Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK

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International Journal of Oral Science 2024年第3期16卷 471-485页

作者： Dexuan Zhuang Shuangshuang Wang Huiting Deng yuxin Shi chang Liu Xue Leng Qun Zhang Fuxiang Bai Bin Zheng Jing Guo Xunwei Wu School and Hospital of Stomatology Cheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral DiseasesJinanChina Engineering Laboratory for Biomaterials and Tissue Regeneration Ningbo Stomatology HospitalSavaid Stomatology SchoolHangzhou Medical CollegeNingboChina Cedars-Sinai Cancer Institute Department of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCAUSA

The efficient clinical treatment of oral squamous cell carcinoma(OSCC)is still a challenge that demands the development of effective new *** has been shown to produce more potent anti-tumor activities than metformin on different tumors,however,not much is known about the influence of phenformin on OSCC *** found that phenformin suppresses OSCC cell proliferation,and promotes OSCC cell autophagy and apoptosis to significantly inhibit OSCC cell growth both in vivo and in ***-seq analysis revealed that autophagy pathways were the main targets of phenformin and identified two new targets DDIT4(DNA damage inducible transcript 4)and NIBAN1(niban apoptosis regulator 1).We found that phenformin significantly induces the expression of both DDIT4 and NIBAN1 to promote OSCC ***,the enhanced expression of DDIT4 and NIBAN1 elicited by phenformin was not blocked by the knockdown of AMPK but was suppressed by the knockdown of transcription factor ATF4(activation transcription factor 4),which was induced by phenformin treatment in OSCC ***,these results revealed that phenformin triggers endoplasmic reticulum(ER)stress to activate PERK(protein kinase R-like ER kinase),which phosphorylates the transitional initial factor eIF2,and the increased phosphorylation of eIF2 leads to the increased translation of *** summary,we discovered that phenformin induces its new targets DDIT4 and especially NIBAN1 to promote autophagic and apoptotic cell death to suppress OSCC cell *** study supports the potential clinical utility of phenformin for OSCC treatment in the future.

关键词： drugs treatment AMPK DDI

An aqueous rechargeable Fe//LiMn_(2)O_()hybrid battery with superior electrochemical performance beyond mainstream Fe-based batteries

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Nano Research 2024年第6期17卷 5168-5178页

作者： Yu Liu Dehui Xie yuxin Shi Rongguan Lv Yingna chang Yuzhen Sun Zhiyuan Zhao Jindi Wang Kefan Song Huayu Wu Tuan K.A.Hoang Rong Xing Huan Pang Institute of New Energy on Chemical Storage and Power Sources School of Chemical and Environmental EngineeringYancheng Teachers UniversityYancheng 224000China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Department of Chemical Engineering University of Waterloo200 University Avenue WestWaterlooOntario N2L 3G1Canada

Aqueous rechargeable batteries(ARBs)are generally safer than non-aqueous analogues,they are also less-expensive,and more friendly to the ***,the inherent disadvantage of the narrow electrochemical window of H2O seriously restricts the energy density and output voltage of ARBs,especially aqueous rechargeable Fe-based ***,we introduce a new battery system:the anode contains C@Fe/Fe_(2)O_(3)composite,which is interfaced with an alkaline electrolyte;the cathode contains LiMn_(2)O_()in contact with a neutral electrolyte.A Li^(+)-conducting membrane is carefully selected to decouple the electrode-electrolyte,which effectively widens the electrochemical window to above 2.65 V,thereby enables an aqueous rechargeable iron *** average output voltage is 1.83 V and its energy density is 235.3 Wh/kg at 549 W/*** this work,we propose the energy storage mechanism with the aid of density functional theory(DFT).The calculated reduction potential of the anode agrees with the experimental ***,this battery system demonstrates long cycle lifespan of approximately 2500 cycles at 2 A/g,corresponding to a capacity retention of 82.1%.These results are very far superior than those of mainstream aqueous rechargeable Fe-based batteries,which guarantee future investigation for storing electricity energy.

关键词： aqueous battery high voltage high energy iron oxide theoretical calculation

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热反射颜填料对建筑节能涂料的影响

北京化工大学学报（自然科学版） 2009年第1期36卷 50-54页

作者：程明吉静常雨鑫北京化工大学材料科学与工程学院北京100029

首先研究了颜填料的折光指数、含量和粒径等因素对涂层反射率的影响,通过正交分析实验,获得了浅色系涂料的优化配方;进一步分析了颜填料的光谱属性与反射率之间的关系,并利用现有颜填料数据库,开发出五种深色系的具有近红外高反射的颜... 详细信息

首先研究了颜填料的折光指数、含量和粒径等因素对涂层反射率的影响,通过正交分析实验,获得了浅色系涂料的优化配方;进一步分析了颜填料的光谱属性与反射率之间的关系,并利用现有颜填料数据库,开发出五种深色系的具有近红外高反射的颜填料。实验结果为:浅色系涂料的优化配方为(质量分数)金红石钛白粉25%,白色陶瓷微珠13%,重钙10%;颜填料折光指数越大,热反射性能越好;添加高反射颜填料制得的节能涂料与同色系普通涂料相比,平衡温度下降了10～20℃,表面吸收的热量大幅降低。

关键词：颜填料节能涂料近红外热反射

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信息不对称背景下过度自信的零售商融资策略

中国科学技术大学学报 2021年第9期51卷 671-689页

作者：杨锋常雨昕毕辰中国科学技术大学管理学院安徽合肥230026

过度自信的零售商对于随机事件的结果的认知比实际情况更确定.我们研究了包含一个利润最大化的银行和一个过度自信的零售商的系统.其中,零售商受到资金约束,可能需要使用银行贷款.基于零售商的初始资金,我们将零售商分为严重贫困、中等... 详细信息

过度自信的零售商对于随机事件的结果的认知比实际情况更确定.我们研究了包含一个利润最大化的银行和一个过度自信的零售商的系统.其中,零售商受到资金约束,可能需要使用银行贷款.基于零售商的初始资金,我们将零售商分为严重贫困、中等贫困和富裕三类.在信息对称和信息不对称的情况下,得到了零售商的均衡订货量和银行利率.在信息对称的情况下,资金受限的零售商总是使用银行贷款.在信息不对称的情况下,当零售商严重贫困时,他会向银行贷款.然而,当零售商中等贫困时,他会使用全部的初始资金,但不使用银行贷款.资金受限的零售商愿意向银行披露其对市场需求的认知.在某些情况下,信息不对称会减少双边界化效应造成的系统利润损失.

关键词：斯塔克伯格博弈银行融资过度自信的零售商信息不对称

A CRISPR/Cas12a-based platform for rapid on-site bovine viral diarrhea virus diagnostics

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Journal of Integrative Agriculture 2024年第8期23卷 2872-2876页

作者： Meixi Wang Jitao chang yuxin Han Chaonan Wang Songkang Qin Jun Wang Lulu Zhang Yuanmao Zhu Fei Xue Fang Wang Hongliang Chai Yulong Wang Xinjie Wang Xin Yin State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China Institute of Western Agriculture Chinese Academy of Agricultural SciencesChangji 831100China

Bovine viral diarrhea virus(BVDV)is a positive-sense single-stranded RNA virus,belonging to the genus Pestivirus in the Flaviviridae family(Riitho et al.2020).Currently,BVDV is divided into 3 main genotypes,BVDV-1,BVD... 详细信息

关键词： BVDV CRISPR/Cas diarrhea

Effect of heat treatment on microstructure and mechanical properties of selective laser-melted PH13-8Mo stainless steel

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Journal of Iron and Steel Research International 2024年第4期31卷 945-955页

作者： Yuan Zhang Xiang Liu chang-jun Wang chang Liu School of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Central Iron&Steel Research Institute Co. Ltd.Beijing 100081China

PH13-8Mo stainless steel powder with high sphericity and well fluidity was prepared by the plasma rotating electrode *** formed parts with ultra-high purity were manufactured by selective laser *** tensile and impact mechanical properties of the printed parts under three heat treatment regimes were compared to those without heat *** microstructure,grain orientation and phase composition were characterized by electron-backscatter diffraction,X-ray diffraction and transmission electron *** characterization results reveal that the addition of heat treatment makes the grains enlarge,and after different heat treatments,the average grain size from 1.51μm in the printed state increases to 2.78,3.09 and 2.06μm,*** formed parts are mainly composed of martensite and retained ***,the NiAl and M23C precipitates form,which are the major strengthening phases of PH13-8Mo stainless *** optimal heat treatment process is 925℃×1 h water cooling(WC)+0℃×2 h air cooling(AC)+540℃×4 h *** this heat treatment process,PH13-8Mo formed parts have the optimal comprehensive mechanical properties:the tensile strength,yield strength and impact energy KU2 are 1492 MPa,1432 MPa and 63 J,*** strengthening and toughening via heat treatment are mainly attributed to dislocation strengthening,the formation of NiAl and M23Co precipitates and the change of volume fraction of the retained austenite.

关键词： High-strength stainless steel-Selective laser melting-Heat treatment Microstructure Mechanical property