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Acupotomy ameliorates subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis by regulating bone morphogenetic protein 2-Smad1 pathway

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Journal of Traditional Chinese Medicine 2023年第4期43卷 734-743页

作者： Chen Xilin GUO Yan LU Juan QIN Luxue HU Tingyao ZENG Xin WANG Xinyue ZHANG Anran zhuang yuxin ZHONG Honggang GUO Changqing School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Acupuncture and Moxibustion Department Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical UniversityBeijing 100010China Shenzhen Hospital of Southern Medical University Shenzhen 518000China Institute of Bone Injury China Academy of Chinese Medical SciencesBeijing 100010China

OBJECTIVE:To investigate the effects of acupotomy on the subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis(KOA).METHODS:The rabbits were divided into blank control,model,acupotomy and electroacupuncture(EA)groups,with 12 rabbits in *** Videman's method was used to prepare KOA *** acupotomy and EA group were given indicated intervention for 3 *** behavior of rabbits in each group was ***,cartilage–subchondral bone units were obtained and morphological changes were observed by optical microscope and micro computed *** test was used to detect the mechanical properties of subchondral bone,Western blot and real-time polymerase chain reaction(RT-PCR)were applied to detect the expression of bone morphogenetic protein 2-Smad1(BMP2-Smad1)pathway in subchondral ***:Compared with the control group,rabbits in the KOA group showed lameness,knee pain,and cartilage degradation;the subchondral bone showed active resorption,the mechanical properties decreased significantly and the BMP2-Smad1 pathway downregulated *** acupotomy and EA intervention could increase the thickness of trabecular bone(***),the bone volume fraction(BV/TV)and the thickness of subchondral bone plate,reduce the separation of trabecular bone(***),improve the maximum load and elastic modulus of subchondral bone,and effectively delay cartilage degeneration in KOA *** process may be achieved through upregulation the related proteins of BMP2-Smad1 *** maximum load and elastic modulus of subchondral bone in the acupotomy group were slightly better than those in the EA ***:Acupotomy could effectively protect cartilage by inhibiting abnormal bone resorption and improving mechanical properties of subchondral bone thorough the related proteins of BMP2-Smad1 pathway in KOA rabbits.

关键词： acupuncture therapy osteoarthritis knee subchondral bone mechanical properties bone morphogenetic protein 2 Smad1 protein

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Fabrication and photoluminescence of GaN nanowires prepared by ammoniating GaeO3/BN films on Si substrate

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Chinese Science Bulletin 2006年第14期51卷 1662-1665页

作者： XUE Chengshan WU yuxin zhuang Huizhao TIAN Deheng LIU Yi'an HE Jianting AI Yujie SUN Lili WANG Fuxue Institute of Semiconductors College of Physics and Electronics Shandong Normal University Jinan 250014 China

GaN nanowires were successfully pre-pared on Si(111) substrate through ammoniating Ga2O3/BN films deposited by radio frequency mag-netron sputtering system. The synthesized nanowires were confirmed as hexagonal wurtzite GaN by X-ray diffraction, selected-area electron diffraction and Fourier transform infrared spectra. Scanning electron microscopy and transmission electron microscopy revealed that the grown GaN nanowires have a smooth and clean surface with diameters ranging from 40 to 160 nm and lengths typically up to several tens of micrometers. The representative photolumi-nescence spectrum at room temperature exhibited a strong UV light emission band centered at 363 nm and a relative weak purple light emission peak at 422 nm. The growth mechanism is discussed briefly.

关键词：磁控溅射 GaN纳米线光致发光 GaeO3/BN薄膜 Si

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对《爱情的牙齿》进行自我拆卸

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北京电影学院学报 2007年第3期 50-53页

作者：庄宇新北京电影学院文学系

钱叶红是一位三十多岁的美貌少妇，由于常去看牙，和青年牙科医生刘军熟了起来。钱告诉刘军自己背上受过伤，一阴天下雨就会疼痛发作，比天气预报还灵。刘军问起受伤的原委．引起了钱叶红对往事的回忆。

关键词：拆卸牙齿爱情天气预报刘军少妇美貌医生

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IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα

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Acta Pharmaceutica Sinica B 2022年第2期12卷 651-664,F0004页

作者： Juan Liu yuxin zhuang Jianlin Wu Qiang Wu Meixian Liu Yue Zhao Zhongqiu Liu Caiyan Wang Linlin Lu Yingjiao Meng Kawai Lei Xiaojuan Li Qibiao Wu Elaine Lai-Han Leung Zhengyang Guo Liang Liu Ting Li State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao SAR 999078China International Institute for Translational Chinese Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China Guangdong Provincial Key Laboratory of New Drug Screening/Laboratory of Anti-inflammatory and Immunomodulatory Pharmacology School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease Macao University of Science and TechnologyMacao SAR 999078China Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China Macao University of Science and TechnologyMacao SAR 999078China

Inhibitor of nuclear factor kappa-B kinase subunit beta(IKKβ)is one of important kinases in inflammation to phosphorylate inhibitor of nuclear factor kappa-B(IκBα)and then activate nuclear factor kappa-B(NF-κB).Inhibition of IKKβhas been a therapeutic strategy for inflammatory and autoimmune *** we report that IKKβis constitutively activated in healthy donors and healthy Ikkβ^(C46A)(cysteine 46 mutated to alanine)knock-in mice although they possess intensive IKKβ-IκBα-NF-κB signaling *** indicate that IKKβactivation probably plays homeostatic role instead of causing *** to IkkβWTlittermates,lipopolysaccharides(LPS)could induce high mortality rate in Ikkβ^(C46A) mice which is correlated to breaking the homeostasis by intensively activating p-IκBα-NF-κB signaling and inhibiting phosphorylation of 5’adenosine monophosphate-activated protein kinase(p-AMPK)*** then demonstrated that IKKβkinase domain(KD)phosphorylates AMPKa1 via interacting with residues Thr183,Ser184,and Thr388,while IKKβhelix-loop-helix motifs is essential to phosphorylate IκBαaccording to the previous *** assay further demonstrated that IKKβsimultaneously catalyzes phosphorylation of AMPK and IκBαto mediate ***,activation of AMPK rather than inhibition of IKKβcould substantially rescue LPS-induced mortality in Ikkβ^(C46A) mice by rebuilding the *** conclude that IKKβactivates AMPK to restrict inflammation and IKKβmediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα.

关键词： IKKβ Homeostasis Kinase domain AMPK Inflammation IκBα Anti-inflammatory drug Phosphorylation

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真菌几丁质酶研究进展

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微生物学报 2024年第11期64卷 4022-4035页

作者：庄钰鑫刘慧泉许铭西北农林科技大学植物保护学院作物抗逆与高效生产全国重点实验室陕西杨凌712100

几丁质是一种由N-乙酰葡萄糖胺通过β-1,4糖苷键连接聚合而成的多糖,在全球陆地和水生生态系统中普遍存在,是地球上最丰富的有机大分子多聚物之一。几丁质酶是一类催化几丁质降解的酶类,其不仅是基础研究的研究重点,而且在农业、医药和... 详细信息

几丁质是一种由N-乙酰葡萄糖胺通过β-1,4糖苷键连接聚合而成的多糖,在全球陆地和水生生态系统中普遍存在,是地球上最丰富的有机大分子多聚物之一。几丁质酶是一类催化几丁质降解的酶类,其不仅是基础研究的研究重点,而且在农业、医药和环境科学等多个领域展现出广泛的应用潜力。本文系统地概括了真菌几丁质酶的分类体系,探讨了它们在不同真菌类群中的分布特征,以及在酵母和丝状真菌等中的生物学功能。本文还详细分析了几丁质酶的酶学特性,并介绍了其在农业病虫害防治、疾病治疗和几丁质寡糖生产等方面的应用,还讨论了未来真菌几丁质酶研究方向。本文将为真菌几丁质酶的研究提供新的视角。

关键词：几丁质酶 GH18 多糖基因功能

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DXY inhibits H-PAS activity to treat multiple sclerosis

DXY inhibits H-PAS activity to treat multiple sclerosis

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2019中国中西医结合学会临床药理与毒理专业委员会第三届学术研讨会

作者： yuxin zhuang Fen Yang Wei Qiu Jianlin Wu Meixian Liu Kawai Lei Liang Liu Ting Li State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology School of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Multiple Sclerosis Centre Department of NeurologyThird Affiliated HospitalSun Yat-sen University

Multiple sclerosis(MS) is a central nervous system(CNS) autoimmune disease caused by inflammation and *** the current study, we haveidentifiedDXY,a compound derived from Chinese medicinal herb,effectively ameliorated EAE symptoms via selectively suppressing Th17 in *** conducting metabolomics study, we foundthat PA production was decreased in Th17 treated with DXY and upregulated in MS patients and experimental autoimmune encephalomyelitis(EAE) mouse model. Fueling PS could further intensively and selectively up-regulate Th17 differentiation in vitro,suggesting that consumption of PS promoted Th17 differentiation. Importantly, the symptoms of EAE micein addition of PAare much more severity than vehicle treatment. We found that PA production is synthesized by H-PAS rather than L-PAS in T lymphocytes. DXY covalently bound to H-PAS rather than L-PAS to inhibit PA production, and in turn suppressed Th17 differentiation as well as EAE progression. Collectively, our identified a novelH-PAS inhibitor with inhibitory effect on Th17 differentiation and inhibition of H-PAS activity potential to be developed as a novel strategy to treat MS.

关键词： multiple sclerosis PA H-PAS Th17

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雅克·阿达玛的数学教育思想研究

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教育研究前沿（中英文版） 2024年第2期14卷 110-117页

作者：庄雨鑫内蒙古师范大学科学技术史研究院内蒙古自治区呼和浩特010022

雅克·阿达玛是20世纪法国著名的数学家、数学教育家,具有丰富的数学创造性经验,对于数学发明的心理过程有着深刻的体会和独到的见解。在继承和发扬庞加莱关于数学发明心理活动过程规律的基础上,进行深入研究,完成《数学领域中的发明心... 详细信息

雅克·阿达玛是20世纪法国著名的数学家、数学教育家,具有丰富的数学创造性经验,对于数学发明的心理过程有着深刻的体会和独到的见解。在继承和发扬庞加莱关于数学发明心理活动过程规律的基础上,进行深入研究,完成《数学领域中的发明心理学》一书并于1945年出版,创立和发展了数学发明的心理学说。本文以该书为落脚点,深入剖析以“无意识思维”为核心的数学发明心理过程,即“准备、酝酿、顿悟、整理”四个阶段,从不同角度分析直觉思维对数学发明创造发挥的重要作用,辅以名人事例证明直觉思维在发明创造过程中具有逻辑思维无法取代的作用。基于上述研究工作,分析阿达玛的数学教育思想,并总结其对当今数学教育具有的重要价值。

关键词：雅克·阿达玛《数学领域中的发明心理学》发明心理数学教育思想

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加强高校思想政治工作的必要性及其途径

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锦州医学院学报（社会科学版） 2005年第1期3卷 57-59页

作者：庄郁馨鞍山科技大学辽宁鞍山114044

21世纪的高校思想政治教育面临着一系列新的问题和挑战。面对急剧变化的时代,加强高校思想政治工作具有十分重要的意义。积极探索高校思想政治教育的有效途径,切实把思想政治教育真正落到实处,有助于提高思想政治教育的针对性和实效性。

关键词：高校思想政治教育必要性途径

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue zhuang Yanxin Qiao Yu Zhang Aihua Yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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