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Hydrogen peroxide-activatable iodoBodipy-phthalhydrazid conjugate nanoparticles for cancer therapy

Nano Research 2023年第10期16卷 12294-12303页

作者： Haijun Ning yuxin yang Chengyuan Lv Danhong Zhou Saran Long Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China

The dependence on outer light source strongly hinders clinical applications of photodynamic therapy(PDT)to the deep-seated ***,the majority of documented PDT systems that function without the external light source rely on either the chemiluminescence resonance energy transfer(CRET)or fluorescence resonance energy transfer(FRET)mechanism,which decreases the energy transfer efficiency and reproducibility of ***,we developed a novel single-molecule triplet photosensitizer(iodoBodipy(IBDP)-L)that can be chemiexcited to triplet excited state to generate reactive oxygen species instead of outer light *** direct bonding of phthalhydrazid moiety to iodoBodipy fluorophore evoked valid intramolecular energy transfer(IET),and once phthalhydrazid part is activated by hydrogen peroxide,the released reaction energy could excite the iodoBodipy-phthalhydrazid conjugate as a *** product IBDP-L-COOH showed high triplet state quantum yield(ΦT=65%)and large spin-orbit coupling.A large amount of reactive oxygen species(ROS)was produced in MCF-7 cells,thus inhibiting the cell growth both in vitro and in vivo after IBDP-L was formulated into nanoparticles(NPs)via *** believe that the synthesized IodoBodipy-phthalhydrazid conjugate based on the IET mechanism will open a new door in the molecular design of efficient triplet photosensitizers for treating deeply seated tumors in the future.

关键词： luminol chemiexcited triplet photosensitizer cancer therapy intramolecular energy transfer(IET)mechanism

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Multi-omics revealed the mechanism of feed efficiency in sheep by the combined action of the host and rumen microbiota

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Animal Nutrition 2024年第3期18卷 367-379页

作者： Guangchen Zhou Junda Li Xuhui Liang Bohua yang Ximeng He Hongyu Tang Hongran Guo Gongwei Liu Wenyuan Cui Yulin Chen yuxin yang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China

This study was conducted to investigate potential regulatory mechanisms of feed efficiency(FE)in sheep by linking rumen microbiota with its host by the multi-omics *** hundred and ninety-eight hybrid female sheep(initial body weight=30.88±4.57 kg;4-month-old)were selected as candidate *** test sheep was fed in an individual pen for 60 days,and the residual feed intake(RFI)was *** ten candidate sheep with the highest RFI were divided into the Low-FE group,and the ten with the lowest RFI were divided into the High-FE group,all selected for sample *** RFI,average daily gain and average daily feed intake were highly significantly different between the two experimental groups(P<0.05).Compared with Low-FE group,the insulin-like growth factor-1 and very low-density lipoprotein in serum and the propionate in rumen significantly increased in High-FE group(P<0.01),but the acetate:propionate ratio in rumen significantly decreased in High-FE group(P=0.034).Metagenomics revealed Selenomonas ruminantium,Selenomonas *** Faecalibacterium prausnitzii were key bacteria,and increased abundance of the genes encoding the enzymes for cellulose degradation and production of propionate in High-FE *** results of proteomics and section showed the rumen papilla length and expression of carbonic anhydrase and Na^(+)/K^(+)-ATPase were significantly higher in High-FE group(P<0.05).On the other hand,the acetyl-CoA content significantly increased in the liver of High-FE group(P=0.002).The relative expression levels of insulin-like growth factor-1 and apolipoprotein A4 genes were significantly up-regulated in the liver of High-FE group(P<0.05),but relative expression level of monoacylglycerol O-acyltransferase 3 gene was significantly down-regulated(P=0.037).These findings provide the mechanism by which the collaborative interaction between rumen microbiota fermentation and host uptake and metabolism of fermentation products impacts feed efficiency tr

关键词： Residual feed intake Sheep Microbial composition Rumen proteome Liver transcriptome Metabolite

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A Modified Luenberger Observer for SOC Estimation of Lithium-Ion Battery 36

A Modified Luenberger Observer for SOC Estimation of Lithium...

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第36届中国控制会议

作者： Ting He Donghai Li Zhenlong Wu Yali Xue yuxin yang State Key Lab of Power Systems Department of Thermal EngineeringTsinghua University

ISBN: (纸本)9781538629185

State of Charge（SOC） estimation has always been a key issue in the Battery Management System（BMS）.This paper proposes a simple modified Luenberger observer to estimate the state of charge of the lithium-ion *** of battery equivalent circuit model is approximated at each *** results show that this simple modified Luenberger observer achieves satisfactory estimation accuracy,while still remains the advantage of low computational *** robustness of this proposed estimation algorithm is demonstrated by Monte-Carlo method,and the estimation output sensitivity to model parameters variations is also revealed through sensitivity analysis.

关键词： State of Charge Modified Luenberger Observer Monte Carlo Method Sensitivity Analysis

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Development and accuracy of artificial intelligence-generated prediction of facial changes in orthodontic treatment:a scoping review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第11期24卷 974-984页

作者： Jiajun ZHU yuxin yang Hai Ming WONG Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityEngineering Research Center of Oral Biomaterials and Devices of Zhejiang ProvinceHangzhou310000China Faculty of Dentistry The University of Hong KongHong KongChina

Artificial intelligence(AI)has been utilized in soft-tissue analysis and prediction in orthodontic treatment planning,although its reliability has not been systematically *** scoping review was conducted to outline the development of AI in terms of predicting soft-tissue changes after orthodontic treatment,as well as to comprehensively evaluate its prediction *** electronic databases(PubMed,EBSCOhost,Web of Science,Embase,Cochrane Library,and Scopus)were searched up to March 14,*** studies investigating the performance of AI-based systems in predicting post-orthodontic soft-tissue alterations were *** Quality Assessment of Diagnostic Accuracy Studies-2(QUADAS-2)and Joanna Briggs Institute(JBI)appraisal checklist for diagnostic test accuracy studies were applied to assess risk of bias,while the Grading of Recommendation,Assessment,Development,and Evaluation(GRADE)assessment was conducted to evaluate the certainty of *** screening 2500 studies,four non-randomized clinical trials were finally included for full-text *** found a low level of evidence indicating an estimated high overall accuracy of AI-generated prediction,whereas the lower lip and chin seemed to be the least predictable ***,the facial morphology simulated by AI via the fusion of multimodality images was considered to be reasonably *** all of the included studies that were not randomized clinical trials(non-RCTs)showed a moderate to high risk of bias,more well-designed clinical trials with sufficient sample size are needed in future work.

关键词： Facial morphology Soft-tissue changes Artificial intelligence(AI) Orthodontic treatment

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Triple-induced gardenia fruit extract-enriched gelatin/polysaccharides microgels for O/W emulsions,and food 3D printing

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Food Bioscience 2023年第3期53卷 1360-1371页

作者： Zhiying Ouyang Juncheng Zhu yang Cheng Liangzhe Chen yuxin yang Liang Ma Hankun Zhu Yong Yu Yuhao Zhang Hongxia Wang State Key Laboratory of Silkworm Genome Biology College of Food ScienceSouthwest UniversityChongqing400715PR China Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing Chongqing400715PR China Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationChongqing400715PR China Key Laboratory of Quality and Safety Control of Citrus Fruits Ministry of Agriculture and Rural AffairsSouthwest UniversityChongqing400712PR China Key Laboratory of Condiment Supervision Technology for State Market Regulation Chongqing400715PR China Jingchu University of Technology Jingmen448000PR China

Gardenia fruit extract like gardenia blue is untable under light exposure and its application need *** blue was proposed to be stabilized in triple-induced microgels from cooperative effects of gelatin,β-cyclodextrin and chitooligosaccharide,and its emulsifying ability and 3D printing potential were sub-esequently *** synergetic effects on gardenia blue due to the intermolecular interactions including hydrogen bonding and electrostatic interaction,contributed to the high UV irradiation stability of *** complex microgels could absorb onto oil-water interface with emulsifying property,and the obtained high internal phase emulsions(HIPEs)illustrated outstanding centrifugal stability and great storage stability with low and uniform optical microscopic droplet *** obtained HIPEs possessed excellent shearing thinning properties,excellent structure reversibility,high-degree reticulation,outstanding thixotropy,great elasticity,high cohesive energy and mechanical strength.3D printing of HIPEs onto food also demonstrated high shape fidelity with low *** findings illustrate the way of stabilizing gardenia blue in microgels by triple synergies,demonstrate the potential as stabilizer for developing HIPEs,and offered reference for highly-addedvalue utilization in the personalized 3D food products.

关键词： Gelatin Gardenia fruit blue extract High internal phase emulsions Thixotropy Elasticity 3D printing

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Favorable haplotypes and associated genes for flowering time and photoperiod sensitivity identified by comparative selective signature analysis and GWAS in temperate and tropical maize

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The Crop Journal 2020年第2期8卷 227-242页

作者： Zhiwei Li Xiaogang Liu Xiaojie Xu Jiacheng Liu Zhiqin Sang Kanchao Yu yuxin yang Wenshuang Dai Xin Jin Yunbi Xu Institute of Crop Science Chinese Academy of Agricultural SciencesBeijing 100081China International Maize and Wheat Improvement Center(CIMMYT) El Batan 56130TexcocoMexico Xinjiang Academy of Agricultural Reclamation Shihezi 832000XinjiangChina Northeast Agricultural University Harbin 150030HeilongjiangChina

On the basis of growing environment,maize can largely be classified into temperate and tropical groups,leaving extensive genetic variation and evolutionary signatures in the maize *** identify candidate genes governing flowering time and photoperiod sensitivity,selective signature analysis and SNP-and haplotype-based GWAS were performed using 39,350 high-quality SNP markers in temperate and tropical maize groups consisting of 410 inbred lines phenotyped in three representative experiments in different *** signature analysis revealed 106 selective-sweep regions containing 423 candidate genes involved mainly in biological regulation and biosynthesis *** these genes,25 overlapped with known genes governing flowering time and photoperiod sensitivity and 37 were also detected by GWAS for days to tassel,anthesis-silk interval,and photoperiod sensitivity measured by days to *** two of the candidate genes governing flowering time overlapped selective *** haplotype alleles within significant haplotype loci showed the same direction of effect on flowering time and photoperiod *** inbred lines carrying GATT at HapL499(haplotype locus 499)on chromosome 1 had relatively short flowering *** carrying CA at HapL4054 on chromosome 10,TA at HapL4055 on chromosome 10,and GTTGT at HapL978 on chromosome 2 were less sensitive to photoperiod than lines carrying other haplotype *** loci associated with flowering time and photoperiod sensitivity explained respectively 17.5%–18.6%and 11.2%–15.5%of phenotypic *** genes and favorable haplotypes identified in this study may support the more efficient utilization of maize germplasm groups.

关键词： temperate signature GWAS

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Active Disturbance Rejection Control based Simplified Decoupling for Two-input-two-output Processes 36

Active Disturbance Rejection Control based Simplified Decoup...

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第36届中国控制会议

作者： Zhenlong Wu Yali Xue Lei Pan Donghai Li Ting He Li Sun yuxin yang State Key Lab of Power Systems Department of Thermal EngineeringTsinghua University Key Lab of Energy Thermal Conversion and Control of Ministry of Education Southeast University

ISBN: (纸本)9781538629185

In this paper, Maclaurin expansion and Padé approximation are utilized to handle the RHP zeros in the simplified decoupling control and the choosing strategy is given. To improve the robustness of each loop, Active Disturbance Rejection Control（ADRC） is adopted as a good solution which can estimate and compensate the total disturbances by the extended state observer（ESO）. Besides, the stability region of the closed loop with ADRC is calculated to benefit for the parameters tuning and P-analysis is used to analyze the robustness with different controllers. The simulation results demonstrate the advantage of ADRC based simplified decoupling in tracking performance and robustness.

关键词： Simplified decoupling Active disturbance rejection control Two-input-two-output processes

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INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE

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Frontiers of Agricultural Science and Engineering 2021年第3期8卷 447-459页

作者： yuxin yang He ZHANG Yuting FANG Ying LI Xinyue MEI Huichuan HUANG Fei DU Shusheng ZHU Min yang Yixiang LIU State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201China Key Laboratory for Agro-Biodiversity and Pest Control(Ministry of Education) College of Plant ProtectionYunnan Agricultural UniversityKunming 650201China Key Laboratory of Pest Monitoring and Green Management(Ministry of Agriculture and Rural Affairs of China) College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

Crop rotations are widely used because they can significantly reduce the incidence of pests and *** interactions between non-host roots and pathogens may be key in the inhibition of soilborne pathogens in crop *** between fennel(Foeniculum vulgare)roots/root exudates and Phytophthora nicotianae were investigated because of the known allelopathy between fennel and tobacco(Nicotiana tabacum).The effects of the key compounds in the fennel rhizosphere on the mycelial growth and zoospore behavior of *** were *** roots of fennel attracted *** zoospores and inhibited their motility and the germination of cystospores,with some cystospores rupturing.4-ethylacetophenone,vanillin and N-formylpiperidine were consistently identified in the fennel rhizosphere and were found to interfere with the infection of ***,especially *** treated with these compounds produced more abnormal branches and accumulated reactive oxygen *** interspecific interactions between non-host roots and pathogens were found to be an important factor in the inhibition by fennel of infection by ***.

关键词： fennel and tobacco rotation infection behavior Phytophthora nicotianae reactive oxygen species vanillin

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Generating a nanoscale blade-like optical field in a coupled nanofiber pair

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Photonics Research 2024年第1期12卷 154-162页

作者： yuxin yang JIAXIN GAO HAO WU ZHANKE ZHOU LIU yang XIN GUO PAN WANG LIMIN TONG Interdisciplinary Center for Quantum Information New Cornerstone Science LaboratoryState Key Laboratory of Extreme Photonics and InstrumentationCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Intelligent Optics&Photonics Research CenterJiaxing Research Institute Zhejiang UniversityJiaxing 314000China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

An optical field with sub-nm confinement is essential for exploring atomic-or molecular-level light-matter *** such fields demonstrated so far have typically point-like cross-sections,an optical field having a higher-dimensional cross-section may offer higher flexibility and/or efficiency in ***,we propose generating a nanoscale blade-like optical field in a coupled nanofiber pair(CNP)with a 1-nm-width central *** on a strong mode coupling-enabled slit waveguide mode,a sub-nm-thickness blade-like optical field can be generated with a cross-section down to~0.28 nm×38 nm at 1550 nm wavelength(i.e.,a thickness of~λ_(0)∕5000)and a peak-to-background intensity ratio(PBR)higher than 20 d *** slit waveguide mode of the CNP can be launched from one of the two nanofibers that are connected to a standard optical fiber via an adiabatical fiber taper,in which a fundamental waveguide mode of the fiber can be converted into a high-purity slit mode with high efficiency(>98%)within a CNP length of less than 10μm at 1550 nm *** wavelengthdependent behaviors and group velocity dispersion in mode converting processes are also investigated,showing that such a CNP-based design is also suitable for broadband and ultrafast pulsed *** results may open up new opportunities for studying light-matter interaction down to the sub-nm scale,as well as for exploring ultra-high-resolution optical technology ranging from super-resolution nanoscopy to chemical bond manipulation.

关键词： fiber waveguide optical

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Localized light-triggered release macrophage cytopharmaceuticals containing O-nitrobenzyl group for enhanced solid tumor cell-chemotherapy

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Acta Pharmaceutica Sinica B 2024年第11期14卷 5053-5068页

作者： Jinhu Liu Han yang Xiao Sang Tong Gao Zipeng Zhang Shunli Fu Huizhen yang Lili Chang Xiaoqing Liu Shuang Liang Shijun Yuan Suyun Wei yuxin yang Xiaoxin Yan Xinke Zhang Weiwei Mu Yongjun Liu Na Zhang Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)NMPA Key Laboratory for Technology Research and Evaluation of Drug ProductsSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Cytopharmaceutical based on macrophages is a breakthrough in the field of targeted drug de-Cytopharmaceutical based on macrophages is a breakthrough in the field of targeted drug delivery. However, it remains a challenge to localize and control drug release while retaining macrophage activity and exerting its immunotherapeutic effect. Herein, a localized light-triggered release macrophage cytopharmaceutical (USIP@M) was proposed, which could utilize the tumor targeting and immunotherapy effects of macrophages to reverse the immune suppression of tumor microenvironment (TME). Amphiphilic block copolymers with ultraviolet (UV)-responsive o-nitrobenzyl groups were synthesized and co-loaded with sorafenib (SF), IMD-0354 (IMD), and upconverting nanoparticles (UCNPs), which were then taken up by macrophages, and the targeted delivery of drugs was realized by using the tumor tropism of macrophages. UCNPs converted near-infrared light with strong penetrability and high safety into UV light, which promoted the photoresponsive depolymerization of block copolymers and production of exosomes from USIP@M, accelerated drug efflux and maintained the activity of macrophages. IMD simultaneously polarized carrier macrophages and tumor-associated macrophages to exert the antitumor effect of macrophages, enhance T cell immunity, and alleviate the immunosuppressive state of TME. Synergistically with the chemotherapeutic effect of SF, it could effectively kill tumors. In conclusion, based on the localized light-triggered release strategy, this study constructed a novel macrophage cytopharmaceutical that could localize and control drug release while retaining the activity of macrophages and exerting its immunotherapeutic effect, which could effectively treat solid tumors.

关键词： Cytopharmaceutical Macrophage Light-triggered release Upconverting nanoparticle O-Nitrobenzyl Exosome Solid tumor Cell-chemotherapy

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