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Realtime observation of “spring fracture” like AlGaN/GaN HEMT failure under bias

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Science China(Information Sciences) 2024年第1期67卷 303-305页

作者： Qing ZHU Zhenni wang yuxiang WEI Ling YANG Xiaoli LU Jiejie ZHU Peng ZHONG Yimin LEI Xiaohua MA School of Microelectronics Xidian University State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology Xidian University School of Advanced Materials and Nanotechnology Xidian University

The AlGaN/GaN HEMTs have been considered promising candidates for high-frequency and high-power applications,while the reliability issues greatly limit the commercialization of AlGaN/GaN HEMTs. In the past, the research on the reliability of devices was often based on Raman spectroscopy, cathodoluminescence, and TEM after failure of the devices, which is often considered to be the laborious and complicated “archaeological” kind of analysis [1].

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多级地震作用下LRB隔震多层结构抗震性能分析

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建筑结构学报 2023年第11期44卷 1-14页

作者：王昱翔叶昆华中科技大学土木与水利工程学院湖北武汉430074

随着GB 18036—2015《中国地震动参数区划图》中引入了极罕遇地震作用、GB/T 51408—2021《建筑隔震设计标准》中提出了基于直接设计法的隔震结构设计理念以及《基于保持建筑正常使用功能的抗震技术导则(报批稿)》中对保证结构正常使用... 详细信息

随着GB 18036—2015《中国地震动参数区划图》中引入了极罕遇地震作用、GB/T 51408—2021《建筑隔震设计标准》中提出了基于直接设计法的隔震结构设计理念以及《基于保持建筑正常使用功能的抗震技术导则(报批稿)》中对保证结构正常使用功能提出了相应指标,有必要对基于直接设计法的基础隔震结构在设防、罕遇和极罕遇地震等多级地震作用下能否保证安全性及正常使用功能展开研究。将基础隔震结构简化为集中质量的多自由度体系并采用直接设计法完成结构设计,采用非线性时程分析方法研究上部结构自振周期、水平侧向刚度竖向分布及隔震系统力学性能参数对基础隔震结构在多级地震作用下安全性和正常使用功能的影响规律。研究结果表明:上部结构自振周期和隔震系统屈重比的变化对于基础隔震结构在设防和罕遇地震作用下的安全性及正常使用功能有较大的影响;极罕遇地震作用下基于直接设计法的基础隔震结构基本能够满足保证结构安全性的要求,但是同等条件下增大上部结构自振周期、减小隔震系统周期和屈重比均会对保证结构安全性带来不利影响;在隔震层与基坑挡墙发生碰撞的情况下基础隔震结构将难以保证安全性和正常使用功能,因此为有效降低基础隔震结构在极罕遇地震作用下与周边基坑挡墙发生碰撞,同时也避免过大的隔离空间,建议隔离缝的宽度取为罕遇地震作用下隔震层水平变形值的两倍。

关键词：基础隔震结构铅芯橡胶隔震支座直接设计法多级地震作用抗震性能碰撞

Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kαinhibitors

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2315-2328页

作者： Xu Zhang yuxiang wang Xi Zhang Yanyan Shen Kang Yang Qingyang Ma Yuemei Qiao Jiajie Shi Yi wang Lan Xu Biyu Yang Gaoxiang Ge Landian Hu Xiangyin Kong Chunhao Yang Yi Chen Jian Ding Linghua Meng Division of Anti-tumor Pharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai200031China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai200031China Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina

Phosphatidylinositol 3-kinase alpha(PI3Kα)inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma(ESCC).It is of great importance to identify potential biomarkers to predict or monitor the efficacy of PI3Kαinhibitors in an aim to improve the clinical responsive rate in ***,ESCC PDXs with CCND1 amplification were found to be more sensitive to CYH33,a novel PI3Kα-selective inhibitor currently in clinical trials for the treatment of advanced solid tumors including *** level of cyclin D1,p21 and Rb was found in CYH33-sensitive ESCC cells compared to those in resistant ***33 significantly arrested sensitive cells but not resistant cells at G1 phase,which was associated with accumulation of p21 and suppression of Rb phosphorylation by CDK4/6 and ***-phosphorylation of Rb attenuated the transcriptional activation of SKP2 by E2F1,which in turn hindered SKP2-mediated degradation of p21 and reinforced accumulation of ***,CDK4/6 inhibitors sensitized resistant ESCC cells and PDXs to *** findings provided mechanistic rationale to evaluate PI3Kαinhibitors in ESCC patients harboring amplified CCND1 and the combined regimen with CDK4/6 inhibitors in ESCC with proficient Rb.

关键词： esophageal squamous render

Study on Local Resistance of non-Newtonian Power Law Fluid in Elbow Pipes

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Journal of Thermal Science 2016年第3期25卷 287-291页

作者： ZHANG Hao XU Tiantian ZHANG Xinxin wang yuxiang wang Yuancheng LIU Xueting School of Thermal Energy Engineering Shandong Jianzhu University Key Laboratory of Renewable Energy Utilization Technologies in Buildings Ministry of Education Department of Thermal Engineering University of Science and Technology Beijing

This paper focuses on the flow characteristic and local resistance of non-Newtonian power law fluid in a curved 90° bend pipe with circular cross-sections, which are widely used in industrial applications. By employing nu- merical simulation and theoretical analysis the properties of the flow and local resistance of power law fluid under different working conditions are obtained. To explore the change rule the experiment is carried out by changing the Reynolds number, the wall roughness and differcnt diameter ratio of elbow pipe. The variation of the local resistance coefficient with the Reynolds number, the diameter ratio and the wall roughness is presented comprehensively in the paper. The results show that the local resistance force coefficient hardly changes with Reynolds number of the power law fluid; the wall roughness has a significant impact on the local resistance coefficicnt. As the pipe wall roughness increasing, the coefficient of local resistance force will increase. The main reason of the influence of the roughness on the local resistance coefficient is the increase of the eddy current region in the power law fluid flow, which increases the kinetic energy dissipation of the main flow. This paper provides theoretical and numerical methods to understand the local resistance property of non-Newtonian power law fluid in elbow pipes.

关键词： non-Newtonian fluid Local resistance coefficient Reynolds number Bend diameter ratio Roughness

Actively Reconfigurable Valley Topological Edge and Corner States in Photonic Crystals Based on Phase Change Material Ge2Sb2Te5

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激光与光电子学进展 2024年第5期61卷 557-571页

作者： Li Wei Peng yuxiang Su Peihao Li Jianbo wang Kaijun Liu Exian Liu Jianqiang He Mengdong College of Science Hunan Province Key Laboratory of Materials Surface&Interface Science and TechnologyCentral South University of Forestry and TechnologyChangsha 410004HunanChina College of Science Jiujiang UniversityJiujiang 332005JiangxiChina

The immunity of topological states against backscattering and structural defects provides them with a unique advantage in the exploration and design of high-precision low-loss optical ***,the operating bandwidth of the topological states in certain photonic structures is difficult to actively tune and flexibly *** this study,we propose a valley topological photonic crystal(TPC)comprising two inverse honeycomb photonic crystals,consisting of hexagonal silicon and Ge2Sb2Te5(GST)*** GST transitions from the amorphous phase to the crystalline phase,the edge band of the TPC appears as a significant redshift and is inversed from a“∪”to an“∩”shape with topological phase transition,which enables active tuning of the operating bandwidth and propagation direction of topological edge *** the topological edge and corner states in a triangular structure constructed using TPCs can be simultaneously adjusted and reconfigured via GST phase transition,along with a change in the group number of corner *** the adjustability of topological edge states and electromagnetic coupling between two different topological bearded interfaces,we develop a multichannel optical router with a high tuning degree of freedom,where channels can be actively reconfigured and their on/off states can be freely *** study provides a strategy for the active regulation of topological states and may be beneficial for the development of reconfigurable topological optical devices.

关键词： topological edge states topological corner states phase change material active reconfiguration topological photonic crystal

Bi_(2)O_(3)/g-C_(3)N_(4)hollow core–shell Z-scheme heterojunction for photocatalytic uranium extraction

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Nano Research 2024年第7期17卷 5845-5855页

作者： Hao Fu Yuehua Pan Zhenyu Cai yuxiang Deng Minchen Hou Yuezhou Wei Toyohisa Fujita Shunyan Ning Youbin wang Shaolong Zhang Xinpeng wang School of Chemistry&Chemical Engineering Guangxi UniversityNanning 530004China School of Resources Environment and MaterialsGuangxi UniversityState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China School of Materials Sun Yat-sen UniversityShenzhen 518107China School of Nuclear Science and Technology University of South ChinaHengyang 421001China

Photocatalytic uranium extraction from radioactive nuclear wastewater and seawater is critical for promoting the sustainable advancement of nuclear industry,but the complexity of real-world environments,particularly the occurrence of anoxic and oxygen-enriched states,presents significant challenges to effective uranium ***,a layered hollow core–shell structure of Bi_(2)O_(3)/g-C_(3)N_(4)Z-scheme heterojunction photocatalyst has been designed and successfully applied for photocatalytic uranium extraction in both aerobic and oxygen-free conditions,and the extraction efficiency of uranium can reach 98.4%and 99.0%,***,the photocatalyst still has ultra-high extraction efficiency under the influence of pH,inorganic ions,and other *** exceptional capability for uranium extraction is on the one hand due to the distinctive hollow core–shell architecture,which furnishes an abundant quantity of active *** the other hand,benefiting from the suitable band gap structure brought by the construction of Z-scheme heterojunction,Bi_(2)O_(3)/g-C_(3)N_(4)exhibits current densities(1.00μA/cm^(2))that are 5.26 and 3.85 times greater than Bi_(2)O_(3)and g-C_(3)N_(4),respectively,and the directional migration mode of Z-scheme carriers significantly prolongs the lifetime of photogenerated charges(1.53 ns),which separately surpass the pure samples by factors of 5.10 and ***,the reaction mechanism and reaction process of photocatalytic uranium extraction are investigated in the presence and absence of oxygen,respectively.

关键词： Bi_(2)O_(3)/g-C_(3)N_(4) Z-scheme photocatalytic uranium extraction

Machine learning-driven optimization of plasma-catalytic dry reforming of methane

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Journal of Energy Chemistry 2024年第9期96卷 153-163页

作者： yuxiang Cai Danhua Mei Yanzhen Chen Annemie Bogaerts Xin Tu Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK Research Group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1BE-2610 Wilrijk-AntwerpBelgium College of Electrical Engineering and Control Science Nanjing Tech UniversityNanjing 211816JiangsuChina

This study investigates the dry reformation of methane(DRM)over Ni/Al_(2)O_(3)catalysts in a dielectric barrier discharge(DBD)non-thermal plasma reactor.A novel hybrid machine learning(ML)model is developed to optimize the plasma-catalytic DRM reaction with limited experimental *** address the non-linear and complex nature of the plasma-catalytic DRM process,the hybrid ML model integrates three well-established algorithms:regression trees,support vector regression,and artificial neural networks.A genetic algorithm(GA)is then used to optimize the hyperparameters of each algorithm within the hybrid ML *** ML model achieved excellent agreement with the experimental data,demonstrating its efficacy in accurately predicting and optimizing the DRM *** model was subsequently used to investigate the impact of various operating parameters on the plasma-catalytic DRM *** found that the optimal discharge power(20 W),CO_(2)/CH_(4)molar ratio(1.5),and Ni loading(7.8 wt%)resulted in the maximum energy yield at a total flow rate of∼51 mL/***,we investigated the relative significance of each operating parameter on the performance of the plasma-catalytic DRM *** results show that the total flow rate had the greatest influence on the conversion,with a significance exceeding 35%for each output,while the Ni loading had the least impact on the overall reaction *** hybrid model demonstrates a remarkable ability to extract valuable insights from limited datasets,enabling the development and optimization of more efficient and selective plasma-catalytic chemical processes.

关键词： Plasma catalysis Machine learning Process optimization Dry reforming of methane Syngas production

Flexible and reusable cap-like thin Fe2O3 film for SERS applications

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Nano Research 2019年第2期12卷 381-388页

作者： Jiangtao Xu Xiaoting Li yuxiang wang Ronghui Guo Songmin Shang Shouxiang Jiang Institute of Textiles and Clothing The Hong Kong Polytechnic University Hong Kong 999077 Hong Kong China College of Light Industry Textile and Food Engineering Sichuan University Chengdu 610000 China

Cap-like α-Fe2O3 films are fabricated and deposited onto quartz fabric by using radio frequency magnetron sputtering and *** treated fabric sample in this study shows highly sensitive surface-enhanced Raman scattering (SERS) and excellent flexibility,reproducibility and *** addition,the sample can be recovered after a washing process with an organic solvent and repeatedly *** sensitive SERS performance is attributed to chemical enhancement through a charge transfer ***,the SERS performance is also found to be dependent on the light coupling *** the light absorbance rate of the α-Fe2O3 films increases at a wavelength near that of laser light,the film shows excellent sensitivity due to light coupling effect.

关键词： α-Fe2O3 quartz fabric flexible surface-enhanced Raman scattering (SERS) Raman sensor

Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1241-1248页

作者： Tingting Han yuxiang Xu Lin Sun Makoto Hashimoto Jianshe Wei Institute for Brain Sciences Research School of Life Sciences Henan University College of Chemistry and Molecular Sciences Henan University Department of Basic Technology Tokyo Metropolitan Institute of Medical Science

Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging; they have a great impact on the aging process and are the main risk factors for neurodegeneration. Reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases. This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including Alzheimer’s disease, Huntington’s chorea, and Parkinson’s disease. This review also describes the potential benefits of treating neurodegenerative diseases by modulating changes in microglial states. Therefore, inducing a shift from the neurotoxic to neuroprotective microglial state in neurodegenerative diseases induced by aging and chronic inflammation holds promise for the treatment of neurodegenerative diseases in the future.

关键词： aging Alzheimer's disease cytokines Huntington's disease microglia neurodegenerative diseases neuroinflammation neuroprotection neurotoxicity Parkinson's disease