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脱细胞异体真皮与自体刃厚皮片联合移植修复足踝部非负重区创面的临床研究

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中华损伤与修复杂志（电子版） 2022年第5期17卷 399-404页

作者：任尊蔡伟杰张瑜博卢玉祥程鹏飞徐铮宇韩培上海交通大学医学院附属第六人民医院骨科 200233

目的探讨脱细胞异体真皮与自体刃厚皮片联合移植在足踝部非负重区创面修复中的疗效。方法采用回顾性队列研究方法,分析2015年1月至2021年3月上海交通大学医学院附属第六人民医院收治的51例足踝部非负重区创面患者。按照治疗方式不同进... 详细信息

目的探讨脱细胞异体真皮与自体刃厚皮片联合移植在足踝部非负重区创面修复中的疗效。方法采用回顾性队列研究方法,分析2015年1月至2021年3月上海交通大学医学院附属第六人民医院收治的51例足踝部非负重区创面患者。按照治疗方式不同进行分组,行复合皮移植治疗患者24例,设为复合皮移植组;采用自体全厚皮片移植治疗患者27例设为全厚皮移植组。患者创面清创后,复合皮移植组用脱细胞异体真皮覆盖创面,其上覆盖自体刃厚皮片联合移植,全厚皮移植组使用自体全厚皮片覆盖创面。术后评估2组患者的皮片成活率、再植皮率、创面愈合时间以及供皮区愈合时间。术后随访12个月,末次随访时进行美国足踝外科医师协会(AOFAS)踝关节功能评估及温哥华瘢痕量表(VSS)评分。数据比较采用t检验、Wilcoxon检验、卡方检验及Fisher精确检验。结果术后评估,复合皮移植组和全厚皮移植组的皮片最终均存活。全厚皮移植组因术后皮片部分坏死的再植皮率为22.2%(6/27),高于复合皮移植组的4.2%(1/24),但差异无统计学意义(P=0.103)。复合皮移植组创面愈合时间为17.0(15.8,18.0)d,显著短于全厚皮移植组的24.0(18.0,38.0)d,差异有统计学意义(Z=-4.222,P0.05)。复合皮移植组的AOFAS踝关节功能评分为93.0(92.0,95.0)分,显著优于全厚皮移植组的87.0(84.0,91.5)分,差异有统计学意义(Z=3.574,P<0.01)。复合皮移植组VSS评分为5.0(4.0,6.0)分,优于全厚皮移植组7.0(5.5,8.5)分,差异有统计学意义(Z=-3.823,P<0.01)。结论脱细胞异体真皮与自体刃厚皮片联合移植可有效修复足踝部非负重区皮肤软组织缺损,显著促进创面愈合,术后瘢痕较轻且可保持良好的踝关节功能。

关键词：脱细胞异体真皮复合皮移植全厚皮移植足踝部非负重区创面修复

猪流行性腹泻病毒Nsp8与宿主细胞互作蛋白的筛选及鉴定

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中国动物传染病学报 2021年第1期29卷 1-8页

作者：周书亭丁思嘉凌悦廖卓韵王子泓邹霭萱罗渝宵黄梓鑫陈宇翔袁聪俐朱建国崔立杨志彪上海交通大学农业与生物学院上海市兽医生物技术重点实验室上海200240

猪流行性腹泻病毒Nsp8是RNA依赖的RNA聚合酶辅助因子,在病毒基因组复制中具有重要作用。为了从宿主细胞蛋白角度了解PEDV Nsp8蛋白的作用,本研究以PEDV感染的宿主细胞LLC-PK1为研究对象,提取LLC-PK1细胞总RNA,利用SMART技术经过反转录... 详细信息

猪流行性腹泻病毒Nsp8是RNA依赖的RNA聚合酶辅助因子,在病毒基因组复制中具有重要作用。为了从宿主细胞蛋白角度了解PEDV Nsp8蛋白的作用,本研究以PEDV感染的宿主细胞LLC-PK1为研究对象,提取LLC-PK1细胞总RNA,利用SMART技术经过反转录、扩增和纯化获得双链cDNAs,将其与pGADT7-Rec和carrier DNA共同转化至酵母Y187菌株,构建LLC-PK1 cDNA酵母文库,对该文库容量及质量进行鉴定。结果显示:本研究构建的LLC-PK1 cDNA文库库容量为2.1×10^7 CFU/mL,插入cDNA片段长度为500~2500 bp;将构建的诱饵质粒pGBKT7-Nsp8与LLC-PK1 cDNA酵母表达文库进行杂交,筛选阳性克隆菌株并测序分析,共获得了8个潜在互作蛋白;将8个蛋白分别与诱饵质粒pGBKT7-Nsp8进行酵母回复杂交验证,有4种宿主蛋白与Nsp8蛋白共转化后能在含X-α-Gal的DDO/X/A和QDO/X/A选择培养基中形成蓝色菌落;选择其中出现频率最高的LDHB蛋白与Nsp8,分别构建含有Flag标签和HA标签的真核表达载体,利用不同的标签抗体进行Co-IP鉴定,发现Nsp8与LDHB蛋白可以发生免疫共沉淀;通过激光共聚焦显微镜观察发现,Nsp8和LDHB蛋白在细胞质中存在明显共定位。本研究结果表明,Nsp8与宿主蛋白LDHB存在相互作用,推测LDHB蛋白可能通过与PEDV Nsp8蛋白在细胞质中的相互作用参与病毒复制的生物学过程。

关键词：猪流行性腹泻病毒 Nsp8 cDNA文库蛋白相互作用

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中国极化电子离子对撞机计划

核技术 2020年第2期43卷 1-59页

作者：曹须常雷畅宁波陈旭荣陈卓俊崔钫戴凌云邓维天丁明慧龚畅桂龙成郭奉坤韩成栋何军黄虹霞黄银 Kaptari L P 李德民李衡讷李民祥李学潜梁羽铁梁作堂刘国明刘杰刘柳明刘翔罗晓峰吕准马伯强马伏马建平马余刚冒立军 Mezrag C 平加伦秦思学任航 Roberts C D 申国栋史潮宋勤涛孙昊王恩科王凡王倩王荣王睿儒王涛峰王伟王晓玉王晓云吴佳俊吴兴刚肖博文肖国青谢聚军谢亚平邢宏喜徐瑚珊许怒徐书生鄢文标闫文成闫新虎杨建成杨一玻杨智姚德良尹佩林詹文龙张建辉张金龙张鹏鸣张肇西张振宇赵红卫赵光达赵强赵宇翔赵政国郑亮周剑周详周小蓉邹冰松邹丽平中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 南开大学天津300071 信阳师范学院信阳464000 湖南大学长沙410082 南京大学南京210093 华中科技大学武汉430074 European Centre for Theoretical Studies in Nuclear Physics and Related Areas(ECT*)and Fondazione Bruno Kessler Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy 北京大学物理学院北京100871 湖南师范大学长沙410081 中国科学院理论物理研究所中国科学院理论物理前沿重点实验室北京100190 南京师范大学南京210023 西南交通大学成都610000 Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear ResearchDubna 141980Russia 郑州大学物理学院郑州450001 华南师范大学量子物质研究院广东省核物质科学与技术重点实验室广州510631 兰州大学物理科学与技术学院兰州730000 山东大学粒子物理与粒子辐照教育部重点实验室青岛266237 华中师范大学夸克与轻子教育部重点实验室和粒子物理研究所武汉430079 东南大学物理学院南京211189 复旦大学现代物理研究所核物理与离子束应用教育部重点实验室上海200433 中国科学院上海应用物理研究所上海201800 IRFU CEAUniversitéParis-SaclayF-91191 Gif-sur-YvetteFrance 重庆大学物理系重庆400044 南京航空航天大学核科学与技术系南京211106 大连理工大学大连116024 北京航空航天大学物理学院北京100191 上海交通大学上海200240 兰州理工大学兰州730050 南京邮电大学南京210023 中国科学技术大学合肥230026 黄山学院黄山245021 北京师范大学高等量子研究中心北京100875 Department of Physics and Astronomy Stony Brook UniversityStony BrookNY 11794USA 中山大学物理与天文学院珠海519082 武汉大学物理科学与技术学院武汉430072 中国科学院高能物理研究所中国科学院大科学装置理论中心北京100049 中国地质大学(武汉)数学与物理学院武汉430074

轻子散射实验是探索核子与原子核结构的理想工具。中国电子离子对撞机(Electron Ion Collider in China,EicC)建议书设想在已开建的强流重离子加速器装置(High Intensity heavy ion Accelerator Facility,HIAF)的基础上,升级质子束流为2... 详细信息

轻子散射实验是探索核子与原子核结构的理想工具。中国电子离子对撞机(Electron Ion Collider in China,EicC)建议书设想在已开建的强流重离子加速器装置(High Intensity heavy ion Accelerator Facility,HIAF)的基础上,升级质子束流为20 GeV的极化束流,并建造2.8~5 GeV极化电子束流,从而实现质心系能量为15~20 GeV的双极化电子-离子对撞。EicC设计的亮度为(2~4)×10^33cm^-2·s^-1,质子束流极化率达到70%,电子束流极化率达到80%。该装置除了能提供极化轻离子束流(例如:氦-3)外,也可产生非极化重离子束流(碳-12~铀-238)。EicC将聚焦核子海夸克部分子结构、原子核物质结构与性质、奇特强子态三个方面的物理研究。高亮度、高精度的对撞机有助于精确地测量核子结构函数并对核子进行三维成像,揭示强相互作用的动力学规律;原子核部分子分布包括核子短程关联以及原子核介质效应同样是该提案的重要科学目标;EicC能区接近重味夸克产生阈值,在研究重味强子谱方面拥有低背景的独特优势,有助于发现研究新的奇特强子态。质子质量起源问题也可以通过重味矢量介子的产生来研究。为了完成上述物理目标,我们将利用最先进的探测器技术建造接近全立体角覆盖的EicC对撞机谱仪。在准备EicC白皮书的过程中,我们得到世界各国专家的支持。EicC的物理与已有的实验和美国即将建设的EIC中的物理项目相互补充。EicC的建成及运行有望引领前沿的中高能核物理研究,使我国在加速器和探测器先进技术等领域实现跨越式发展,为我国核物理与强子物理以及相关科学领域提供大型综合实验平台与人才培养基地。

关键词：电子离子对撞机核子结构核子质量奇特强子态量子色动力学螺旋度横动量依赖部分子分布广义部分子分布深度虚康普顿散射深度虚介子散射能量回收型直线加速器极化度自旋旋转器三维成像

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector