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同位素内标稀释-液相色谱-串联质谱法测定化妆品中大麻二酚和四氢大麻酚的含量

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香料香精化妆品 2024年第3期 17-22页

作者：薛峰杨晋青顾宇翔上海市质量监督检验技术研究院上海200233

采用液相色谱-串联质谱法(LC-MS/MS)联用检测技术和内标标准曲线法定量方式,建立了化妆品中大麻二酚(CBD)和四氢大麻酚(THC)的检测方法。样品采用加入内标后经甲醇萃取,稀释定容,通过高效液相色谱分离,串联质谱定性和定量检测,由C18柱(1... 详细信息

采用液相色谱-串联质谱法(LC-MS/MS)联用检测技术和内标标准曲线法定量方式,建立了化妆品中大麻二酚(CBD)和四氢大麻酚(THC)的检测方法。样品采用加入内标后经甲醇萃取,稀释定容,通过高效液相色谱分离,串联质谱定性和定量检测,由C18柱(100 mm×2.1 mm×3μm)分离,多反应监测(MRM)检测,内标标准曲线法定量。结果发现,CBD和THC的线性范围为0.5~50μg/L,相关系数≥0.999,方法的检出限为5μg/kg,定量限为10μg/kg。CBD和THC的平均回收率为83.8%~112.3%,相对标准偏差(RSD)<10.0%。该方法稳定、可靠,样品前处理简单,耗时短,同时具备较高的灵敏度和准确性。在化妆品监管中,填补了CBD和THC准确定性和定量分析的空白,适用于化妆品中CBD和THC的快速筛查。

关键词：液相色谱-串联质谱法化妆品大麻二酚四氢大麻酚

Antidiabetic effects of multi-species probiotic and its fermented milk in mice via restoring gut microbiota and intestinal barrier

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Food Bioscience 2022年第3期47卷 316-326页

作者： yuxiang gu Xing Li Haoran Chen Yue Sun Lin Yang Ying Ma Eric Chun Yong Chan School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbinHeilongjiang150001China Department of Pharmacy Faculty of ScienceNational University of Singapore18 Science Drive 4Singapore117543Singapore

Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM).In this study,the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM,Lactobacillus rhamnosus GG,Bifidobacterium lactis HN019 and Streptococcus thermophilus ST447) and its fermented yoghurt on the symptoms of high fat diet and streptozotocin induced T2DM mice were investigated,and the underlying mechanisms were ***-species probiotic and probiotic yoghurt elicited similar but varying efficacy in decreasing the body weight loss,improving organ weight,glucose tolerance and insulin resistance,regulating the levels of blood glucose,HbA1c,insulin and lipid as well as protecting the pancreatic *** tangible antidiabetic effects may be ascribed to the mutual promotion between the repair of the intestinal barrier/permeability and the optimization of gut microbiota ***,the intestinal flora-short chain fatty acids-intestinal hormones/inflammatory pathway was activated and thereby conferring healthy benefits to the *** proposed probiotic combination appears to provide a viable approach to alleviate T2DM.

关键词： Type 2 diabetes Probiotic Probiotic yoghurt gut microbiota Intestinal barrier Inflammation

Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms

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Stroke & Vascular Neurology 2023年第4期8卷 327-334页

作者： Yangyang Zhou Wenqiang Li Chao Wang Ruhang Xie Yongnan Zhu Qichen Peng Limin Zhang Hongqi Zhang yuxiang gu Shiqing Mu Jian Liu Xinjian Yang Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Clinical Diagnosis Laboratory Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina

Background and purpose Light transmission aggregometry(LTA)and CYP2C19 genotype analysis are commonly used to evaluate the antiplatelet effects of clopidogrel during the interventional treatment of intracranial *** aim of this study was to determine which test can predict ischaemic events during these *** Patient demographic information,imaging data,laboratory data and ischaemic complications were *** and CYP2C19 genotype results were compared,and multiple linear regression was performed to examine factors related to platelet *** regression analysis was performed to determine whether LTA and CYP2C19 could predict ischaemic complications and to identify other clinical risk *** operating characteristic curve analysis was conducted to calculate the cut-off value for predicting ischaemic complications.A subgroup analysis was also performed for different CYP2C19 genotype metabolisers,as well as for patients with flow diverters and traditional *** A total of 379 patients were included,of which 22 developed ischaemic *** platelet aggregation induced by ADP(ADP-MPA)could predict ischaemic events(p10 years(p=0.022)were independent risk factors for ischaemic events,while the CYP2C19 genotype was not associated with ischaemic *** the subgroup analysis,ADP-MPA could predict ischaemic events in fast metabolisers(p=0.004)and intermediate metabolisers(p=0.003).The cut-off value for ischaemic events was lower in patients with flow diverters(ADP-MPA=36.4%)than in patients with traditional stents(ADP-MPA=42.9%).Conclusions ADP-MPA can predict ischaemic complications during endovascular treatment of intracranial *** with flow diverters require stronger antiplatelet medication than patients with traditional stents.

关键词： CYP2C19 ischaemic intracranial

Endovascular treatment for basilar artery occlusion:a meta-analysis

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Stroke & Vascular Neurology 2023年第1期8卷 1-3页

作者： Jiawen Xu Xi Chen Shidong Chen Wenjie Cao Hongchen Zhao Wei Ni Yanrong Zhang Chao Gao yuxiang gu Xin Cheng Yi Dong Qiang Dong Department of Neurology Huashan Hospital Fudan UniversityShanghaiChina Department of Neurosurgery Huashan Hospital Fudan UniversityShanghaiChina Department of Nursing Huashan Hospital Fudan UniversityShanghaiChina

Acute basilar artery occlusion(BAO)may lead to severe disability or death in about 70%of patients.12 Previous studies have estab-lished endovascular treatment(EVT)as the standard treatment for patients with acute ante... 详细信息

关键词： treatment artery death

Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1677-1692页

作者： Dongsheng Bai Jiawei Zhao Runde Wang Jiaying Du Chen Zhou Chunyang gu yuxiang Wang Lulu Zhang Yue Zhao Na Lu State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionDepartment of PhysiologySchool of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal *** identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is *** our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus *** enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory ***,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy ***,*** up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRNA and an increase in mucin synthesis in goblet *** espe-cially significant finding is that *** activates the AhR pathway,thereby promoting the expression of *** summary,our results strongly indicate that *** enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRNA stability.

关键词： Chemotherapy Mucositis Eubacterium coprostanoligenes MUC2 AUF1

Absence of metallicity and bias-dependent resistivity in low-carrier-density EuCd_(2)As_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 119-125页

作者： yuxiang Wang Jianwen Ma Jian Yuan Wenbin Wu Yong Zhang Yicheng Mou Jiaming gu Peihong Cheng Wu Shi Xiang Yuan Jinglei Zhang Yanfeng guo Cheng Zhang State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of SciencesHefei 230031China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics Shanghai 201210China

EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet ***,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments prevent direct identification of the semimetal ***,we present a comprehensive magneto-transport study of high-quality Eu Cd_(2)As_(2)crystals with ultralow bulk carrier density(10^(13)cm^(-3)).In contrast to the general expectation of a Weyl semimetal phase,Eu Cd_(2)As_(2)shows insulating behavior in both antiferromagnetic and ferromagnetic states as well as surface-dominated conduction from band ***,the application of a dc bias current can dramatically modulate the resistance by over one order of magnitude,and induce a periodic resistance oscillation due to the geometric *** nonlinear transport results from the high nonequilibrium state induced by an electrical field near the band *** results suggest an insulating phase in Eu Cd_(2)As_(2)and put a strong constraint on the underlying mechanism of anomalous transport properties in this system.

关键词： magnetic Weyl semimetal quantum transport Hall effect nonlinear resistivity

Application of 3.0T intraoperative high-field magnetic resonanceimaging guidance for the surgery of arteriovenous malformationwithin eloquent areas

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Chinese Medical Journal 2014年第6期127卷 1180-1182页

作者： Zhu Fengping Tian Yanlong Zhu Wei gu yuxiang Xu Bin Wu Jinsong Mao Ying Department of Neurosurgery Huashan Hospital Fudan UniversityShanghai 20040 China

Arteriovenous malformations(AVMs)are vascularabnormalities that consist of multiple fistulousconnections between arteries and veins without the normalintervening capillary *** resection is

关键词： intraoperative magnetic resonance imaging intraoperative neurophysiological monitoring arteriovenous maljormation

iTRAQ-based proteomics reveals the mechanism of action of Yinlai decoction in treating pneumonia in mice consuming a high-calorie diet

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 21-32页

作者： Qianqian Li Tiegang Liu Chen Bai Xueyan Ma Hui Liu Zi’an Zheng yuxiang Wan He Yu Yuling Ma Xiaohong gu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Institute of Chinese Medicine Epidemic Disease Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025China Department of Acupuncture and Mini-invasive Oncology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China OCMRC Center University of OxfordOxford OX13PTUnited Kingdom

Objective:To uncover the underlying mechanisms of action of the Yinlai decoction on high-calorie dietinduced pneumonia through proteomics ***:Based on the Gene Expression Omnibus(GEO)database,lung tissue samples from normal and high-fat diet(HFD)fed mice in the GSE16377 dataset were selected as test cohorts to identify differentially expressed genes and conduct bioinformatics *** the animal experiments,mice were randomly divided into the control(N),high-calorie diet pneumonia(M),and Yinlai decoction treatment(Y)*** in the M group received high-calorie feed and a 0.5 mg/mL lipopolysaccharide solution spray for 30 min for 3 *** mice in the Y group were intragastrically administered 2 mL/10 g Yinlai decoction twice daily for 3 *** evaluation of the lung tissue was *** expressed proteins(DEPs)in the lung tissue were identified using quantitative proteomics and bioinformatics *** drug-target relationships between Yinlai decoction and core DEPs in the lung tissue were verified using AutoDock Vina and Molecular Graphics Laboratory(MGL)*** were verified by western ***:GEO data mining showed that an HFD altered oxidative phosphorylation in mouse lung *** Yinlai decoction alleviated pathological damage to lung tissue and pneumonia in mice that were fed a high-calorie diet.A total of 47 DEPs were identified between the Y and M *** analysis revealed their association with energy metabolism pathways such as the tricarboxylic acid cycle(TCA)and oxidative *** protein-protein interaction network revealed that Atp5a1,Pdha1,and Sdha were the target proteins mediating the therapeutic effects of Yinlai *** docking results suggested that the mechanism of the therapeutic effect of Yinlai decoction involves the binding of brassinolide,praeruptorin B,chrysoeriol,and other components in Yinlai decoction to ***:The Yinlai decoction allevia

关键词： Yinlai decoction High-calorie diet Pneumonia iTRAQ proteomics Energy metabolism

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视网膜神经节细胞的分类和功能研究进展

中华眼科杂志 2022年第5期58卷 390-395页

作者：顾钰香陈敏王凯军浙江大学医学院附属第二医院眼科中心杭州310009

视网膜神经节细胞(RGC)是视觉通路中最重要的一类神经细胞,其轴突组成的视神经是视觉信号传递到大脑的唯一通路,对RGC的形态学特性、基因表达特性、空间分布特性以及功能特性进行研究具有重要意义。本文汇总相关研究进展,对RGC的分类、... 详细信息

视网膜神经节细胞(RGC)是视觉通路中最重要的一类神经细胞,其轴突组成的视神经是视觉信号传递到大脑的唯一通路,对RGC的形态学特性、基因表达特性、空间分布特性以及功能特性进行研究具有重要意义。本文汇总相关研究进展,对RGC的分类、目前已明确的RGC类型以及不同损伤下不同类型RGC的损伤特点进行综述,为全面了解RGC的生理学、病理学特征和视神经损伤相关疾病提供参考。

关键词：视网膜神经节细胞树突视通路视神经损伤青光眼