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Composition optimization, high-temperature stability, and thermal cycling performance of Sc-doped Gd_(2)Zr_(2)O_(7) thermal barrier coatings: Theoretical and experimental studies

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Journal of Advanced Ceramics 2022年第3期11卷 454-469页

作者： Lei GUO Bowen LI yuxian cheng Lu WANG School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Advanced Joining Technology Key Lab of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin 300072China AECC Shenyang Liming Aero-Engine Co. Ltd.Shenyang 110043China

Sc was doped into Gd_(2)Zr_(2)O_(7) for expanding the potential for thermal barrier coating (TBC) applications. The solid solution mechanism of Sc in the Gd_(2)Zr_(2)O_(7) lattice, and the mechanical and thermophysical properties of the doped Gd_(2)Zr_(2)O_(7) were systematically studied by the first-principles method, based on which the Sc doping content was optimized. Additionally, Sc-doped Gd_(2)Zr_(2)O_(7) TBCs with the optimized composition were prepared by air plasma spraying using YSZ as a bottom ceramic coating (Gd-Sc/YSZ TBCs), and their sintering behavior and thermal cycling performance were examined. Results revealed that at low Sc doping levels, Sc has a large tendency to occupy the lattice interstitial sites, and when the doping content is above 11.11 at%, Sc substituting for Gd in the lattice becomes dominant. Among the doped Gd_(2)Zr_(2)O_(7), the composition with 16.67 at% Sc content has the lowest Pugh’s indicator (G/B) and the highest Poisson ratio (σ) indicative of the highest toughness, and the decreasing trends of Debye temperature and thermal conductivity slow down at this composition. By considering the mechanical and thermophysical properties comprehensively, the Sc doping content was optimized to be 16.67 at%. The fabricated Gd-Sc coatings remain phase and structural stability after sintering at 1400 ℃ for 100 h. Gd-Sc/YSZ TBCs exhibit excellent thermal shock resistance, which is related to the good thermal match between Gd-Sc and YSZ coatings, and the buffering effect of the YSZ coating during thermal cycling. These results revealed that Sc-doped Gd_(2)Zr_(2)O_(7) has a high potential for TBC applications, especially for the composition with 16.67 at% Sc content.

关键词： thermal barrier coating(TBC) first-principles calculation solid solution mechanism high-temperature stability thermal cycling

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MAGED4B Promotes Glioma Progression via Inactivation of the TNF-α-induced Apoptotic Pathway by Down-regulating TRIM27 Expression

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Neuroscience Bulletin 2023年第2期39卷 273-291页

作者： Can Liu Jun Liu Juntang Shao cheng Huang Xingliang Dai Yujun Shen Weishu Hou yuxian Shen Yongqiang Yu Department of Radiology The First Afliated Hospital of Anhui Medical UniversityHefei 230022China Biopharmaceutical Research Institute Anhui Medical UniversityHefei 230032China School of Basic Medical Sciences Anhui Medical UniversityHefei 230032China Department of Pathology The First Afliated Hospital of Anhui Medical UniversityHefei 230022China Department of Neurosurgery The First Afliated Hospital of Anhui Medical UniversityHefei 230022China

MAGED4B belongs to the melanoma-associated antigen family;originally found in melanoma,it is expressed in various types of cancer,and is especially enriched in glioblastoma.However,the functional role and molecular mechanisms of MAGED4B in glioma are still unclear.In this study,we found that the MAGED4B level was higher in glioma tissue than that in non-cancer tissue,and the level was positively correlated with glioma grade,tumor diameter,Ki-67 level,and patient age.The patients with higher levels had a worse prognosis than those with lower MAGED4B levels.In glioma cells,MAGED4B overexpression promoted proliferation,invasion,and migration,as well as decreasing apoptosis and the chemosensitivity to cisplatin and temozolomide.On the contrary,MAGED4B knockdown in glioma cells inhibited proliferation,invasion,and migration,as well as increasing apoptosis and the chemosensitivity to cisplatin and temozolomide.MAGED4B knockdown also inhibited the growth of gliomas implanted into the rat brain.The interaction between MAGED4B and tripartite motif-containing 27(TRIM27)in glioma cells was detected by co-immunoprecipitation assay,which showed that MAGED4B was co-localized with TRIM27.In addition,MAGED4B overexpression down-regulated the TRIM27 protein level,and this was blocked by carbobenzoxyl-L-leucyl-L-leucyl-L-leucine(MG132),an inhibitor of the proteasome.On the contrary,MAGED4B knockdown up-regulated the TRIM27 level.Furthermore,MAGED4B overexpression increased TRIM27 ubiquitination in the presence of MG132.Accordingly,MAGED4B down-regulated the protein levels of genes downstream of ubiquitin-specific protease 7(USP7)involved in the tumor necrosis factor-alpha(TNF-α)-induced apoptotic pathway.These findings indicate that MAGED4B promotes glioma growth via a TRIM27/USP7/receptor-interacting serine/threonine-protein kinase 1(RIP1)-dependent TNF-α-induced apoptotic pathway,which suggests that MAGED4B is a potential target for glioma diagnosis and treatment.

关键词： Glioma MAGE family member D4B Tripartite motif-containing Apoptosis

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生物电阻抗法测量18~42岁成人四肢骨骼肌质量的准确性评价

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实用医学杂志 2024年第4期40卷 549-553页

作者：郑伊迎程红邝玉娴马振新陈伟业卢可缘米杰刘丽广东药科大学公共卫生学院流行病与卫生统计学系广州510310 首都儿科研究所流行病学研究室北京100020 国家儿童医学中心、首都医科大学附属北京儿童医院儿童慢病管理中心北京100045

目的评价生物电阻抗法(bioelectrical impedance analysis,BIA)测量成人四肢骨骼肌质量(appendicular skeletal muscle mass,ASM)的准确性。方法采用方便抽样法,于2021年4月至2022年9月在广州全市招募836名18~42岁成人,采用BIA与双能X线吸收法(dual-energy X-ray absorptiometry,DXA)同步检测ASM。以DXA为标准方法,通过组内相关系数以及在对数变换数据中进行Bland-Altman分析判断BIA与DXA所测值的一致性,以此评价BIA测量ASM的准确性。绘制受试者工作特征曲线,评价BIA识别低肌肉质量的诊断价值。结果最终纳入774名研究对象。男、女性中两法所测ASM组内相关系数分别为0.774和0.667。男、女性中BIA与DXA所测ASM比值均值(一致性限)分别为0.94(0.80~1.10)和0.91(0.78~1.05)。BIA识别男、女性低肌肉质量的曲线下面积分别0.91和0.94。BIA判断男、女性低肌肉质量的Z值最佳界值分别为-0.57和-0.66,男性中BIA识别低肌肉质量的灵敏度、特异度分别为82.5%、86.0%,女性中分别为86.8%、93.8%。结论BIA与DXA所测成人四肢骨骼肌质量的一致性尚可,且BIA识别18~42岁成人低肌肉质量的诊断价值较好。

关键词：生物电阻抗法双能X线吸收法四肢骨骼肌质量低肌肉质量

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学习压力源对全日制体育硕士研究生学习倦怠的影响机制

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湖北体育科技 2024年第1期43卷 64-71页

作者：黄威陈志军龙腾辉张玉娴成波锦深圳市龙华区教育科学研究院第二附属学校广东深圳518110 广东财贸职业学院广东广州511500 广东南华工商职业学院广东清远511510 广州体育学院体育教育学院广东广州510500

目的基于压力源二维结构理论,探讨挑战性压力源与阻碍性压力源这两种压力源和全日制体育硕士研究生学习倦怠的关系及其作用机制。方法采用挑战性和阻碍性压力源量表、学习倦怠量表、应对方式量表和心理弹性量表,对广东省地区415名全日... 详细信息

目的基于压力源二维结构理论,探讨挑战性压力源与阻碍性压力源这两种压力源和全日制体育硕士研究生学习倦怠的关系及其作用机制。方法采用挑战性和阻碍性压力源量表、学习倦怠量表、应对方式量表和心理弹性量表,对广东省地区415名全日制体育硕士研究生进行调查。结论1)挑战性学习压力源对学习倦怠无显著影响,而阻碍性学习压力源对学习倦怠具有显著正向影响。2)挑战性学习压力源通过积极应对方式的完全中介作用对学习倦怠有负向影响,阻碍性学习压力源通过消极应对方式的部分中介作用对学习倦怠有正向影响。3)心理弹性负向调节阻碍性学习压力源与学习倦怠的关系,相对于高心理弹性的学生,低心理弹性的学生其阻碍性学习压力源对学习倦怠的正向影响更强。本研究扩宽了压力源二维结构理论的应用范围,为高校对体育硕士研究生学习倦怠的干预提供参考借鉴。

关键词：学习倦怠挑战性压力源阻碍性压力源应对方式心理弹性

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Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

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Acta Pharmaceutica Sinica B 2022年第1期12卷 149-166页

作者： Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo cheng Xianjia Qi yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun State Key Laboratory of Pharmaceutical Biotechnology Chemistry and Biomedicine Innovation Center(Chem BIC)School of Life SciencesNanjing UniversityNanjin 210023China Biopharmaceutical Research Institute School of Basic Medical SciencesAnhui Medical UniversityHefei 230032China Department of Colorectal Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China The First Clinical College of Nanjing University of Chinese Medicine Nanjing 210023China Shanghai Xu Ran Biotechnology Co. Ltd.Shanghai 201109China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy.

关键词： Tumor microenvironment PTPN11 SHP099 STING Type I interferon Colorectal cancer scRNA-seq Macrophage

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膨润土基封孔材料界面改性及长效封孔功能研究

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煤炭工程 2024年第2期56卷 157-164页

作者：赵建斌程健维山西煤炭运销集团孟县恒泰皇后煤业有限公司山西阳泉045100 中国矿业大学安全工程学院江苏徐州221116

针对煤矿瓦斯抽采平均浓度低、持续时间短的技术难题和工程实践的现场需求,选择机械改性法、有机活化改性法等界面改性方法,以膨润土为基础材料,提高保水性、稳定性和触变性,研发得到瓦斯抽采钻孔液相封孔材料。采用“液封气”思想实现... 详细信息

针对煤矿瓦斯抽采平均浓度低、持续时间短的技术难题和工程实践的现场需求,选择机械改性法、有机活化改性法等界面改性方法,以膨润土为基础材料,提高保水性、稳定性和触变性,研发得到瓦斯抽采钻孔液相封孔材料。采用“液封气”思想实现全周期触变封堵新生裂隙。现场应用结果表明:新材料封堵效果良好,平均抽采浓度41.66%,较传统材料提高15.27%,浓度衰减系数降低48%,补浆提升系数提高22%,可实现废孔利用。

关键词：瓦斯抽采钻孔封孔膨润土表面改性

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AlCr(Si)N和CrAl(Si)N涂层对TiAl合金900℃循环氧化性能的影响

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中国表面工程 2023年第4期36卷 185-195页

作者：章凯辛丽程玉贤彭新王博中国航发沈阳黎明航空发动机有限责任公司沈阳110043 中国科学院金属研究所沈阳110016 空装驻沈阳地区第二军事代表室沈阳110042

TiAl合金作为新型高温结构材料在航空航天和汽车工业领域已获应用,然而在850℃及以上温度服役时抗氧化性不足,施加氮化物涂层在提高TiAl合金抗氧化性和耐磨性等综合性能方面独具优势,目前关于氮化物涂层对TiAl基合金抗氧化性影响的研究... 详细信息

TiAl合金作为新型高温结构材料在航空航天和汽车工业领域已获应用,然而在850℃及以上温度服役时抗氧化性不足,施加氮化物涂层在提高TiAl合金抗氧化性和耐磨性等综合性能方面独具优势,目前关于氮化物涂层对TiAl基合金抗氧化性影响的研究有限。采用多弧离子镀方法在TiAl合金表面分别制备AlCrN涂层、AlCrSiN涂层、CrAlN涂层和CrAlSiN涂层,研究涂层对TiAl合金900℃循环氧化行为的影响。XRD结果表明,AlCrN和AlCrSiN涂层主要呈现AlN结构,而CrAlN和CrAlSiN涂层为CrN结构。在AlCrSiN和CrAlSiN涂层中,Si可能固溶于晶格中形成(Al,Cr,Si)N和(Cr,Al,Si)N固溶体。在900℃经过300个周期的循环氧化,AlCrN和AlCrSiN涂层表面氧化膜主要由Al2O3组成,热循环过程中涂层中形成大量裂纹。CrAlN和CrAlSiN涂层表面氧化膜主要由Cr_(2)O_(3)组成,连续致密,无开裂剥落。其中CrAlN涂层表面Cr_(2)O_(3)膜下面形成了Al的内氧化物,其氧化增重高于CrAlSiN涂层。此外,CrAlN和CrAlSiN涂层均与TiAl合金发生较严重的互扩散,在CrAlN/TiAl界面和CrAlSiN/TiAl界面处形成较厚的互扩散层。可见,CrAlN和CrAlSiN涂层显著提高了TiAl合金的抗高温氧化性能,而涂层中Si的添加使得涂层抗氧化性得到进一步的提升。研究结果可为TiAl合金施加氮化物涂层高温防护提供潜在可能。

关键词：氮化物涂层金属间化合物高温氧化互扩散

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小型化高密度可调控电感耦合等离子体发生器性能研究

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电子科技大学学报 2022年第5期51卷 715-720页

作者：袁野张岩郭成刘玉献薄勇赵青电子科技大学资源与环境学院成都610054 上海空间推进研究所上海闵行区201112

根据理论分析和磁场仿真结果设计并加工了一款用于黑障通信实验的电感耦合等离子体发生器,该装置能产生具有形状为半球形、厚度小于5 cm、等离子体密度为1×10^(18)m^(-3)量级等黑障典型等离子体鞘层特征的等离子体薄层。采用等离子体... 详细信息

根据理论分析和磁场仿真结果设计并加工了一款用于黑障通信实验的电感耦合等离子体发生器,该装置能产生具有形状为半球形、厚度小于5 cm、等离子体密度为1×10^(18)m^(-3)量级等黑障典型等离子体鞘层特征的等离子体薄层。采用等离子体发射光谱诊断的方法,研究了等离子体发生器产生等离子体的电子激发温度和电子数密度,并分析了线圈功率对等离子体特性的影响规律,对等离子体发生器乃至对电小天线辐射调控系统的进一步优化有参考作用。

关键词：黑障电感耦合等离子体等离子体发生器光谱诊断

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Distribution Assessment and Source Identification Using Multivariate Statistical Analyses and Artificial Neutral Networks for Trace Elements in Agricultural Soils in Xinzhou of Shanxi Province, China

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Pedosphere 2018年第3期28卷 542-554页

作者： SHANGGUAN yuxian cheng Bin ZHAO Long HOU Hong MA Jin SUN Zaijin XU Yafei ZHAO Ruifen ZHANG Yigong HUA Xiaozan HUO Xiaolan ZHAO Xiufeng State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012( China) Institute of Agricultural Environment and Resources Shanxi Academy of Sciences Key Laboratory of Soil Environment and Nutrient Resources of Shanxi Province Taiyuan 030031( China)

Multivariate statistical analyses were used to assess the contents and distributions of trace elements in agricultural soils in Xinzhou of Shanxi Province, China, and to identify their sources. Samples with high levels of trace elements were concentrated in eastern Xinzhou, with contents declining from the east to west. Principal component and redundancy analyses revealed strong correlations among Co, Cu, Mn, Ni, Se, V, and Zn contents, suggesting that these elements were derived from similar parent materials. There were also strong correlations between the contents of these elements and soil properties. Contents of Cd and Pb were significantly higher in the agricultural soil samples than in the background soil samples(P < 0.05), and were higher in areas with higher levels of gross domestic product but decreased with distance to the nearest road. Therefore, human activities appear to have a strong influence on the Cd and Pb distribution patterns. A novel artificial neural network(ANN) model, using environmental input data, was used to predict the soil Cd and Pb contents of specified test dates. The performances of the ANN model and a traditional multilinear model were compared. The ANN model could successfully predict Cd and Pb content distributions, projecting that soil Cd and Pb contents will increase by 128% and 25%, respectively, by 2020. The results thus indicated that the economic condition of an area has a greater effect on trace element contents and distributions in the soil than the scale of the economy itself.

关键词：农业土壤统计分析分发模式神经网络迹元素山西省人工中国

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Dissecting the genome of star fruit(Averrhoa carambola L.)

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Horticulture Research 2020年第1期7卷 1626-1635页

作者： Yannan Fan Sunil Kumar Sahu Ting Yang Weixue Mu Jinpu Wei Le cheng Jinlong Yang Ranchang Mu Jie Liu Jianming Zhao yuxian Zhao Xun Xu Xin Liu Huan Liu State Key Laboratory of Agricultural Genomics China National GeneBankBGIShenzhen518120 ShenzhenChina BGI-Yunnan BGI-Shenzhen650106 KunmingChina Forestry Bureau of Ruili Yunnan Dehong678600 RuiliChina Chinese Academy of Forestry BeijingChina Guangdong Provincial Key Laboratory of Genome Read and Write 518120 ShenzhenChina BGI-Fuyang BGI-Shenzhen236009 FuyangChina Department of Biology University of CopenhagenCopenhagenDenmark

Averrhoa carambola is commonly known as star fruit because of its peculiar shape,and its fruit is a rich source of minerals and vitamins.It is also used in traditional medicines in countries such as India,China,the Philippines,and Brazil for treating various ailments,including fever,diarrhea,vomiting,and skin disease.Here,we present the first draft genome of the Oxalidaceae family,with an assembled genome size of 470.51 Mb.In total,24,726 protein-coding genes were identified,and 16,490 genes were annotated using various well-known databases.The phylogenomic analysis confirmed the evolutionary position of the Oxalidaceae family.Based on the gene functional annotations,we also identified enzymes that may be involved in important nutritional pathways in the star fruit genome.Overall,the data from this first sequenced genome in the Oxalidaceae family provide an essential resource for nutritional,medicinal,and cultivational studies of the economically important star-fruit plant.

关键词： vitamin Brazil cultivation

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