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NIR-triggered on-site NO/ROS/RNS nanoreactor:Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation

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Opto-Electronic Advances 2024年第6期7卷 58-73页

作者： Ziqing Xu Yakun Kang Jie Zhang Jiajia tang Hanyao Sun Yang Li Doudou He Xuan Sha yuxia tang Ziyi Fu Feiyun Wu Shouju Wang Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Women&Children Research Center The First Affiliated HospitalNanjing Medical UniversityNanjing 210029China

Photothermal and photodynamic therapies(PTT/PDT)hold promise for localized tumor treatment,yet their full potential is hampered by limitations such as the hypoxic tumor microenvironment and inadequate systemic immune *** these challenges,we present a novel near-infrared(NIR)-triggered RNS nanoreactor(PBNO-Ce6)to amplify the photodynamic and photothermal therapy efficacy against triple-negative breast cancer(TNBC).The designed PBNOCe6 combines sodium nitroprusside-doped Prussian Blue nanoparticles with Chlorin e6 to enable on-site RNS production through NIR-induced concurrent NO release and ROS *** not only enhances tumor cell eradication but also potentiates local and systemic antitumor immune responses,protecting mice from tumor *** in vivo evaluations revealed that treatment with PBNO-Ce6 leads to a remarkable 2.7-fold increase in cytotoxic T lymphocytes and a 62%decrease in regulatory T cells in comparison to the control PB-Ce6(Prussian Blue nanoparticles loaded with Chlorin e6),marking a substantial improvement over traditional PTT/*** such,the PBNO-Ce6 nanoreactor represents a transformative approach for improving outcomes in TNBC and potentially other malignancies affected by similar barriers.

关键词： photothermal therapy photodynamic therapy nitric oxide reactive nitrogen species triple-negative breast cancer immune response nanoreactor

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Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 544-547页

作者： Min Dong Rui tang Jing Li Jiajia Zhao Yu Wang Lin Ouyang Wei Lu Jun Tao Meng Dang yuxia tang Zhaogang Teng Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Post and TelecommunicationsNanjing 210023China Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Radiology The 909th HospitalSoutheast HospitalSchool of MedicineXiamen UniversityZhangzhou 363000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

Photodynamic therapy(PDT)is an effective treatment method for *** the specifically accumulated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of ***,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and *** confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of *** revealed the modification of CTPP significantly improves the targeting ability of the *** vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60μg/mL JPMO-Pt-CTPP-ZnPc was only 3%.Simultaneously,compared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

关键词： Mesoporous materials Janus particle Photodynamic therapy Mitochondria targeting Tumor treatment

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聚多巴胺/壳聚糖改性棉织物的茶色素染色及其抗菌和防紫外线性能

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纺织学报 2024年第3期45卷 106-113页

作者：李丽丽袁亮唐雨霞杨文菊王浩安徽农业大学材料与化学学院安徽合肥230036 马鞍山市纤维检验所安徽马鞍山243011

为提高棉织物的天然色素染色性和多功能性,利用CuSO_(4)/H_(2)O_(2)氧化体系下多巴胺(DA)在织物表面快速聚合沉积后,采用壳聚糖(CS)整理制备聚多巴胺/壳聚糖(PDA/CS)改性棉织物,再用茶色素对其进行染色处理。探究了DA快速聚合沉积过程... 详细信息

为提高棉织物的天然色素染色性和多功能性,利用CuSO_(4)/H_(2)O_(2)氧化体系下多巴胺(DA)在织物表面快速聚合沉积后,采用壳聚糖(CS)整理制备聚多巴胺/壳聚糖(PDA/CS)改性棉织物,再用茶色素对其进行染色处理。探究了DA快速聚合沉积过程中各因素对改性棉织物染色性能的影响,得到较佳工艺条件:CuSO_(4)浓度为3 mmol/L,DA质量浓度为2.0 mg/mL,H_(2)O_(2)浓度为13 mmol/L,沉积时间为2 h。在此条件下,PDA/CS改性棉织物染色后的K/S值达到6.21。研究结果表明:CuSO_(4)/H_(2)O_(2)氧化体系下DA在棉织物表面形成PDA层,可与CS产生氢键作用在织物表面均匀成膜;茶色素染色PDA/CS改性棉织物的耐摩擦色牢度、耐皂洗色牢度(沾色)和耐人造光色牢度均达到4级及以上;PDA/CS改性织物染色后的UPF值为312,对金黄色葡萄球菌与大肠杆菌的抑菌率达到90%以上,具备抗菌和防紫外线的双重功效。

关键词：棉织物聚多巴胺壳聚糖茶色素染色天然染料功能整理

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片层状Zn-Cu复合氧化物的制备及抗菌性能研究

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化学与生物工程 2024年第7期41卷 50-55页

作者：汤钰霞谢佳琴李传强陆军军医大学第二附属医院输血科重庆400037 重庆交通大学材料科学与工程学院重庆400074

采用煅烧金属有机框架(MOFs)前驱体的方法制备了Zn-Cu复合氧化物,通过TG、XRD、SEM、EDS、HRTEM和SAED等手段表征了其物相组成、微观结构等特性,以革兰氏阴性细菌大肠杆菌和革兰氏阳性细菌金黄色葡萄球菌为模型研究了Zn-Cu复合氧化物的... 详细信息

采用煅烧金属有机框架(MOFs)前驱体的方法制备了Zn-Cu复合氧化物,通过TG、XRD、SEM、EDS、HRTEM和SAED等手段表征了其物相组成、微观结构等特性,以革兰氏阴性细菌大肠杆菌和革兰氏阳性细菌金黄色葡萄球菌为模型研究了Zn-Cu复合氧化物的抗菌性能,并初步探究了其细胞毒性。结果表明,Zn-Cu复合氧化物具有良好的片层状结构,ZnO在CuO表面均匀分散,且ZnO的加入可能使部分CuO转变为Cu_(2)O;Zn-Cu复合氧化物对大肠杆菌和金黄色葡萄球菌均有较好的抗菌效果,随着CuO含量的增加,抗菌效果增强,但同时对成纤维细胞的毒性增强。

关键词： Zn-Cu复合氧化物片层状结构抗菌性能

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腘窝坐骨神经联合股神经阻滞在膝关节镜中的应用研究

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中国伤残医学 2024年第6期32卷 41-45页

作者：唐玉霞孙强赖金明安远县人民医院麻醉科江西赣州342100 安远县人民医院泌尿外科

目的:研究腘窝坐骨神经联合股神经阻滞在膝关节镜中的应用.方法:选取2020年1月-2022年6月在安远县人民医院进行膝关节镜手术的60例患者,随机将患者分为神经阻滞组和硬外膜组,每组各30例,硬膜外组患者采用连续硬膜外麻醉后进行手术,神经... 详细信息

目的:研究腘窝坐骨神经联合股神经阻滞在膝关节镜中的应用.方法:选取2020年1月-2022年6月在安远县人民医院进行膝关节镜手术的60例患者,随机将患者分为神经阻滞组和硬外膜组,每组各30例,硬膜外组患者采用连续硬膜外麻醉后进行手术,神经阻滞组患者采用腘窝坐骨神经联合股神经阻滞麻醉后进行手术.比较2组患者麻醉效果,比较2组患者麻醉前(T_(0))、麻醉后15分钟(T_(1))、麻醉后60分钟(T_(2))、手术结束时(T_(3))的心率(HR)和平均动脉压(MAP),比较2组患者感觉和运动神经阻滞起效时间、持续时间,比较2组患者术后各时间点膝关节主动屈曲角度,比较2组患者股四头肌肌力,比较2组患者不良反应发生情况.结果:神经阻滞组和硬膜外组患者T_(0)、T_(1)、T_(2)、T_(3)时HR水平比较,差异无统计学意义(P>0.05);神经阻滞组和硬膜外组患者T_(0)时MAP比较,差异无统计学意义(P>0.05);T_(1)、T_(2)、T_(3)时,神经阻滞组患者MAP水平均高于硬膜外组,差异有统计学意义(P0.05);术后3天、7天神经阻滞组患者膝关节主动屈曲角度大于硬膜外组患者,差异有统计学意义(P0.05).结论:腘窝坐骨神经联合股神经阻滞麻醉能够减轻膝关节镜手术患者应激反应,缩短麻醉起效时间,并延长麻醉作用时间.

关键词：股神经阻滞麻醉腘窝坐骨神经阻滞麻醉连续硬膜外麻醉膝关节镜

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DCG复合气凝胶的制备及对刚果红的吸附性能

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印染 2024年第4期50卷 53-57页

作者：唐雨霞程士润陈卫麒金海军王浩安徽农业大学材料与化学学院安徽合肥230036 安徽省产品质量监督检验研究院安徽合肥230051

微晶纤维素(MCC)通过选择性氧化得到二醛纤维素(DAC),再与壳聚糖(CS)、葡萄糖(G)交联制备DAC/CS/G(DCG)复合气凝胶。采用SEM、FTIR对DCG气凝胶进行表征,并考察其对刚果红(CR)的吸附作用。结果表明,MCC被高碘酸钠氧化后引入活性基团醛基... 详细信息

微晶纤维素(MCC)通过选择性氧化得到二醛纤维素(DAC),再与壳聚糖(CS)、葡萄糖(G)交联制备DAC/CS/G(DCG)复合气凝胶。采用SEM、FTIR对DCG气凝胶进行表征,并考察其对刚果红(CR)的吸附作用。结果表明,MCC被高碘酸钠氧化后引入活性基团醛基,可与CS、G发生化学交联和氢键键合,提高了对刚果红的吸附效果。与原MCC相比,DCG呈现较均匀密集的多孔结构;DCG的吸附过程均遵循准二级动力学模型和Langmuir等温模型;不同氧化度的DCG相比,DCG-0.06的吸附速率和容量更佳,当染料初始质量浓度为600 mg/L时,其单分子层理论最大吸附量可达到649.35 mg/g。

关键词：微晶纤维素壳聚糖高碘酸钠吸附刚果红

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Controllable and switchable chiral near-fields in symmetric graphene metasurfaces

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Chinese Physics B 2021年第12期30卷 563-570页

作者： Li Hu Hongxia Dai Fayin Cheng yuxia tang Chongqing Key Laboratory of Intelligent Perception and BlockChain Technology Chongqing Technology and Business UniversityChongqing 400067China Department of Applied Physics School of Computer Science and Information EngineeringChongqing Technology and Business UniversityChongqing 400067China Soft Matter and Interdisciplinary Research Center College of PhysicsChongqing UniversityChongqing 400044China

A strong chiral near-field plays significant roles in the detection,separation and sensing of chiral *** this paper,a simple and symmetric metasurface is proposed to generate strong chiral near-fields with both circularly polarized light and linearly polarized light illuminations in the mid-infrared *** to the near-field interaction between plasmonic resonant modes of two nanosheets excited by circularly polarized light,there is a strong single-handed chiral near-field in the gap between the two graphene nanosheets and the maximum enhancement of the optical chirality could reach two orders of *** expected,the intensity and the response wavelength of the chiral near-fields could be controlled by the Fermi level and geometrical parameters of the graphene nanosheets,as well as the permittivity of the ***,based on the interaction between the incident field and scattered field,the one-handed chiral nearfield in the gap also could be generated by the linearly polarized light *** the two cases,the handedness of the chiral near-field could be switched by the polarized direction of the incident *** results have potential opportunities for applications in molecular detection and sensing.

关键词： plasmonic resonance chiral near-field graphene metasurface

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Light focusing in linear arranged symmetric nanoparticle trimer on metal film system

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Chinese Physics B 2022年第1期31卷 540-546页

作者： yuxia tang Shuxia Wang Yingzhou Huang Yurui Fang State Key Laboratory of Coal Mine Disaster Dynamics and Control and Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials College of PhysicsChongqing UniversityChongqing 400044China Applied Physics School of Computer Science and Information EngineeringChongqing Technology and Business UniversityChongqing 400067China Key Laboratory of Materials Modification by Laser Electronand Ion Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024China

Benefiting from the induced image charge on film surface,the nanoparticle aggregating on metal exhibits interesting optical *** this work,a linear metal nanoparticle trimer on metal film system has been investigated to explore the novel optical *** the electric field and surface charge distributions demonstrate the light is focused on film greatly by the nanoparticles at two sides,which could be strongly modulated by the wavelength of incident *** the influence of nanoparticle in middle on this light focusing ability has also been studied here,which is explained by the plasmon hybridization *** finding about light focusing in nanoparticle aggregating on metal film not only enlarges the novel phenomenon of surface plasmon but also has great application prospect in the field of surface-enhanced spectra,surface catalysis,solar cells,water splitting,etc.

关键词： electric field enhancement light focusing nanoparticle trimer on metal film system plasmonic hybridization

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Computed tomography and photoacoustic imaging guided photodynamic therapy against breast cancer based on mesoporous platinum with insitu oxygen generation ability

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1719-1729页

作者： Lingyan Zhang Mifang Li Quan Zhou Meng Dang yuxia tang Shouju Wang Jijun Fu Zhaogang Teng Guangming Lu Department of Medical Imaging Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjing 210002China Department of Medical Imaging The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630China Key Laboratory for Organic Electronics&Information Displays and Institute of Advanced Materials Jiangsu Key Laboratory for BiosensorsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210046China Departm ent of Medical Imaging Jiangsu Province HospitalNanjing 210029China Key Laboratory of Molecular Target&Clinical Pharmacology School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Photodynamic therapy(PDT)has been widely used in cancer ***,hypoxia in most solid tumors seriously restricts the efficacy of *** improve the hypoxic microenvironment,we designed a novel mesoporous platinum(mPt)nanoplatform to catalyze hydrogen peroxide(H2 O2)within the tumor cells in situ without an extra *** the fabrication,the carboxy terminus of the photosensitizer chlorin e6(Ce6)was connected to the amino terminus of the bifunctional mercaptoaminopolyglycol(SH-PEG-NH2)by a condensation reaction,and then PEG-Ce6 was modified onto the mPt moiety via the mercapto terminal of ***,cellular and animal experiments demonstrated that Pt@PEG-Ce6 catalyzed H2 O2 to produce oxygen(O2)and that Ce6 transformed O2 to generate reactive oxygen species(ROS)upon laser *** Pt@PEG-Ce6 nanoplatform with uniform diameter presented good biocompatibility and efficient tumor *** to the high atomic number and good near-infrared absorption for Pt,this Pt@PEG-Ce6 nanoplatform showed computed tomography(CT)and photoacoustic(PA)dual-mode imaging ability,thus providing an important tool for monitoring the tumor hypoxic ***,the Pt@PEG-Ce6 nanoplatform reduced the expression of hypoxia-inducible factor-la(HIF-1α)and programmed death-1(PD-1)in tumors,discussing the relationship between hypoxia,PD-1,and PDT for the first time.

关键词： Mesoporous platinum Photodynamic therapy Tumor hypoxia Photoacoustic imaging Computed tomography imaging

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基于图分析算法的信用卡交易欺诈检测

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现代信息科技 2024年第15期8卷 138-141页

作者：袁立宁唐雨霞黄琬雁罗恒雨何佩遥广西警察学院信息技术学院广西南宁530028 广西警察学院公安大数据现代产业学院广西南宁530028 广西警察学院刑事科学技术学院广西南宁530028

当前,在线信用卡交易欺诈案件快速增加,作案手段和方法更加多变,信用卡交易欺诈检测已成为银行风险防控的重点内容。文章依托近年人工智能领域热门的图分析理论与算法,将信用卡交易数据转化为图结构数据,从而分析信用卡交易欺诈图的社... 详细信息

当前,在线信用卡交易欺诈案件快速增加,作案手段和方法更加多变,信用卡交易欺诈检测已成为银行风险防控的重点内容。文章依托近年人工智能领域热门的图分析理论与算法,将信用卡交易数据转化为图结构数据,从而分析信用卡交易欺诈图的社区信息。在此基础上,应用图表示学习算法Deepwalk和机器学习分类器,构建信用卡交易欺诈检测模型,用于预测欺诈行为。实验结果表示,该模型对欺诈行为的检测准确率达70%。

关键词：信用卡交易欺诈检测图分析算法图表示学习

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