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玉米须总黄酮抗大鼠高尿酸血症及肾脏保护作用

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郑州大学学报（医学版） 2024年第1期59卷 45-50页

作者：黄宇涵徐莎房伟宋玮贺雅静张玉霞马振勇商丘医学高等专科学校药学院河南商丘476005 商丘医学高等专科学校基础医学院河南商丘476005 河南中医药大学第一附属医院药学部郑州450000 商丘市第一人民医院病理科河南商丘476100 商丘医学高等专科学校临床医学院河南商丘476005

目的:探讨玉米须总黄酮(TFCS)抗大鼠高尿酸血症(HUA)及肾脏保护的价值。方法:将60只SD大鼠随机分成正常对照组,模型组,别嘌呤醇组和TFCS低、中、高剂量组,每组10只。除正常对照组外,其余各组给予250 mg/(kg·d)乙胺丁醇和100 mg/(kg·d... 详细信息

目的:探讨玉米须总黄酮(TFCS)抗大鼠高尿酸血症(HUA)及肾脏保护的价值。方法:将60只SD大鼠随机分成正常对照组,模型组,别嘌呤醇组和TFCS低、中、高剂量组,每组10只。除正常对照组外,其余各组给予250 mg/(kg·d)乙胺丁醇和100 mg/(kg·d)腺嘌呤的混悬液灌胃14 d,构建大鼠HUA模型。造模后别嘌呤醇组给予50 mg/(kg·d)别嘌呤醇,TFCS低、中、高剂量组分别给予0.5、1.0、2.0 mg/(kg·d)TFCS灌胃14 d。观察并记录大鼠的一般状态和体重;检测大鼠血清中尿酸(UA)、肌酐(Cr)、尿素氮(BUN)、黄嘌呤氧化酶(XOD)水平及尿液中UA水平;HE染色观察肾组织病理形态变化;免疫组化法检测大鼠肾组织尿酸转运体1(URAT1)蛋白的表达;qRT-PCR法检测大鼠肾组织葡萄糖转运体9(GLUT9)mRNA的表达。结果:与正常对照组比较,模型组大鼠精神状态萎靡、排尿增多;血清UA、Cr、BUN、XOD水平升高,尿液UA水平降低(P<0.05);肾小管上皮边界模糊,细胞肿胀变性,肾间质炎性细胞浸润;肾组织URAT1蛋白和GLUT9 mRNA表达水平升高(P<0.05)。与模型组比较,别嘌呤醇组和TFCS低、中、高剂量组大鼠精神状态及排尿情况好转;血清UA、Cr、BUN、XOD水平降低,尿液UA水平升高(P<0.05);肾组织损伤减轻,URAT1蛋白和GLUT9 mRNA表达水平降低(P<0.05)。结论:TFCS可有效降低HUA大鼠UA水平,并对肾脏有一定保护作用,其作用机制可能与抑制UA合成关键酶活性及调节UA转运蛋白表达有关。

关键词：玉米须总黄酮高尿酸血症大鼠 URAT1 GLUT9

基于“目为心之使”探讨视网膜动脉硬化与心血管疾病及中医辨证的关系

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中华中医药杂志 2024年第1期39卷 478-481页

作者：朱洁张书萌陈宇霞罗佳敏肖清玄陈伶利李杰湖南中医药大学长沙410208

目前,全球心血管疾病患病率和病死率与日俱增。研究发现,心血管的病情演变与视网膜动脉的硬化程度紧密相连,通过眼底血管的表现,能够了解到全身的血管病变。文章基于中医“目为心之使”理论探讨视网膜动脉硬化与心血管疾病的关系,从中... 详细信息

目前,全球心血管疾病患病率和病死率与日俱增。研究发现,心血管的病情演变与视网膜动脉的硬化程度紧密相连,通过眼底血管的表现,能够了解到全身的血管病变。文章基于中医“目为心之使”理论探讨视网膜动脉硬化与心血管疾病的关系,从中医“目为心之使”的理论基础、眼部症状当责之于心、视网膜动脉硬化与心血管疾病关系、视网膜动脉硬化与心病辨证论治关系等方面进行论述,阐述眼底血管的微观病变与心血管疾病中医宏观辨证的相关性,以期为心血管疾病的临床防治提供新思路和方法。

关键词：目为心之使视网膜动脉硬化心血管疾病眼底疾病高血压中医辨证

改良版Cubbin&Jackson量表诊断ICU患者压力性损伤最佳界值的多中心研究

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中华护理杂志 2024年第12期59卷 1436-1442页

作者：杨庄裴菊红杨秋霞吕琳魏育婷陶红霞张红燕马玉霞韩琳兰州大学护理学院兰州市730000 兰州大学第一临床医学院兰州市730000 甘肃省人民医院伤口造口治疗中心甘肃省人民医院护理部

目的探讨改良版Cubbin&Jackson量表诊断国内ICU患者压力性损伤的适用性和最佳界值。方法采用便利抽样法,选取2021年4月—2022年10月在甘肃省35所三级医院住院的6203例ICU患者作为调查对象,由经过规范化培训的ICU护士检查患者全身皮肤并... 详细信息

目的探讨改良版Cubbin&Jackson量表诊断国内ICU患者压力性损伤的适用性和最佳界值。方法采用便利抽样法,选取2021年4月—2022年10月在甘肃省35所三级医院住院的6203例ICU患者作为调查对象,由经过规范化培训的ICU护士检查患者全身皮肤并收集相关资料,判定是否存在压力性损伤及其分期,同时采用改良版Cubbin&Jackson量表进行压力性损伤风险评估。使用软件统计分析改良版Cubbin&Jackson量表诊断ICU患者压力性损伤的受试者工作特征曲线下面积(area under the curve,AUC)、约登指数、灵敏度和特异度等指标。结果6203例ICU患者住院期间共有79例发生压力性损伤,发生率为1.27%。分层分析显示,改良版Cubbin&Jackson量表预测诊断不同性别、年龄、ICU住院天数、是否机械通气和是否手术的ICU患者压力性损伤的AUC为0.74~0.92,约登指数为0.40~0.74,灵敏度和特异度分别为77.27%~94.44%、62.44%~82.63%。总分≤28分时,改良版Cubbin&Jackson量表的AUC最大(0.86),其约登指数、灵敏度、特异度、阳性预测值、阴性预测值、阳性似然比和阴性似然比分别为0.60、92.41%、67.26%、3.50%、99.86%、2.82、0.11。结论改良版Cubbin&Jackson量表可作为有效预测、诊断国内ICU患者压力性损伤的适用工具,最佳界值以≤28分为宜。

关键词：压力性损伤改良版Cubbin & Jackson量表重症监护病房风险评估预测界值护理

Chemical diversity of scleractinian corals revealed by untargeted metabolomics and molecular networking

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Acta Oceanologica Sinica 2023年第11期42卷 127-135页

作者： Jiying Pei yuxia Zhou Shiguo Chen Kefu Yu Zhenjun Qin Ruijie zhang Yitong Wang Coral Reef Research Center of China Guangxi Laboratory on the Study of Coral Reefs in the South China SeaSchool of Marine SciencesGuangxi UniversityNanning 530000China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai 519080China

The chemical diversity of scleractinian corals is closely related to their physiological,ecological,and evolutionary status,and can be influenced by both genetic background and environmental variables.To investigate intraspecific variation in the metabolites of these corals,the metabolomes of four species(Pocillopora meandrina,Seriatopora hystrix,Acropora formosa,and Fungia fungites)from the South China Sea were analyzed using untargeted mass spectrometry-based metabolomics.The results showed that a variety of metabolites,including amino acids,peptides,lipids,and other small molecules,were differentially distributed among the four species,leading to their significant separation in principal component analysis and hierarchical clustering plots.The higher content of storage lipids in branching corals(P.meandrina,S.hystrix,and A.formosa)compared to the solitary coral(F.fungites)may be due to the high densities of zooxanthellae in their tissues.The high content of aromatic amino acids in P.meandrina may help the coral protect against ultraviolet damage and promote growth in shallow seawater,while nitrogen-rich compounds may enable S.hystrix to survive in various challenging environments.The metabolites enriched in F.fungites,including amino acids,dipeptides,phospholipids,and other small molecules,may be related to the composition of the coral's mucus and its life-history,such as its ability to move freely and live solitarily.Studying the chemical diversity of scleractinian corals not only provides insight into their environmental adaptation,but also holds potential for the chemotaxonomy of corals and the discovery of novel bioactive natural products.

关键词： scleractinian coral chemical diversity metabolomics molecular networking environmental adaptation

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海南热带水果芒果重金属含量特征分析

食品安全导刊 2024年第7期 44-46页

作者：梁琼张玉霞林树秀谷满屯海南省检验检测研究院海南海口570311 海南省工商职业学院海南海口570203 海南省食品检验检测中心(海南省实验动物中心) 国家市场监管重点实验室(热带果蔬质量与安全)海南海口570314

目的:了解海南热带水果芒果中重金属含量特征以及受污染程度。方法:采用微波消解-电感耦合等离子体质谱技术对海南热带水果芒果中重金属的含量进行检测,然后采用污染指数对其受污染程度进行评价分析。结果:建立的检测方法在0~50μg·L^(... 详细信息

目的:了解海南热带水果芒果中重金属含量特征以及受污染程度。方法:采用微波消解-电感耦合等离子体质谱技术对海南热带水果芒果中重金属的含量进行检测,然后采用污染指数对其受污染程度进行评价分析。结果:建立的检测方法在0~50μg·L^(-1)线性关系良好,相关系数大于0.995;在加标水平为5μg·mL^(-1)时,回收率为91.2%~108.0%,RSD为0.14%~4.53%。芒果中重金属含量变化范围较宽,重金属Cu平均含量最高,为2.72 mg·kg^(-1),Hg和As未检出。结论:所建立的方法精密度高,操作简单、快速,可同时测定芒果中多种重金属含量。所测芒果样品重金属含量均低于相应的规定限值,没有超标现象,属于清洁安全食品。

关键词：芒果微波消解-电感耦合等离子体质谱重金属污染指数

NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4284-4304页

作者： Cheng Cheng Jie zhang Xiaodong Li Fei Xue Lei Cao Linlin Meng Wenhai Sui Meng zhang yuxia Zhao Bo Xi Xiao Yu Feng Xu Jianmin Yang Yun zhang Cheng zhang National Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinanChina Department of Cardiology Shengjing Hospital of China Medical UniversityShenyangLiaoning Province 110004China Department of Traditional Chinese Medicine Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012 ShandongChina Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinanChina Key Laboratory Experimental Teratology of the Ministry of Education Department of PhysiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanChina Department of Emergency Medicine Chest Pain CenterShandong Provincial Clinical Research Center for Emergency and Critical Care MedicineQilu HospitalShandong UniversityJinanChina Cardiovascular Disease Research Center of Shandong First Medical University Central Hospital Affiliated to Shandong First Medical UniversityJinanChina

Previous studies suggested a beneficial effect of natriuretic peptides in animal models of cardiovascular disease,but the role of natriuretic peptide receptor C(NPRC)in the pathogenesis of atherosclerosis(AS)remains unknown.This study was designed to test the hypothesis that NPRC may promote AS lesion formation and instability by enhancing oxidative stress,inflammation,and apoptosis via protein kinase A(PKA)signaling.ApoE^(−/−)mice were fed chow or Western diet for 12 weeks and NPRC expression was significantly increased in the aortic tissues of Western diet-fed mice.Systemic NPRC knockout mice were crossed with ApoE^(−/−)mice to generate ApoE^(−/−)NPRC^(−/−)mice,and NPRC deletion resulted in a significant decrease in the size and instability of aortic atherosclerotic lesions in ApoE^(−/−)NPRC^(−/−)versus ApoE^(−/−)mice.In addition,endothelial cell-specific NPRC knockout attenuated atherosclerotic lesions in mice.In contrast,endothelial cell overexpression of NPRC aggravated the size and instability of atherosclerotic aortic lesions in mice.Experiments in vitro showed that NPRC knockdown in human aortic endothelial cells(HAECs)inhibited ROS production,pro-inflammatory cytokine expression and endothelial cell apoptosis,and increased eNOS expression.Furthermore,NPRC knockdown in HAECs suppressed macrophage migration,cytokine expression,and phagocytosis via its effects on endothelial cells.On the contrary,NPRC overexpression in endothelial cells resulted in opposite effects.Mechanistically,the anti-inflammation and anti-atherosclerosis effects of NPRC deletion involved activation of cAMP/PKA pathway,leading to downstream upregulated AKT1 pathway and downregulated NF-κB pathway.In conclusion,NPRC deletion reduced the size and instability of atherosclerotic lesions in ApoE^(−/−)mice via attenuating inflammation and endothelial cell apoptosis and increasing eNOS expression by modulating cAMP/PKA-AKT1 and NF-κB pathways.Thus,targeting NPRC may provide a promising approach to the prevention and treatment of atheroscleros

关键词： inflammation atherosclerosis prevention

Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1205-1215页

作者： Xiaoyan Liu Zhe Li Shuai Liu Jing Sun zhanghua Chen Min Jiang Qingling zhang Yinghua Wei Xin Wang Yi-You Huang Yinyi Shi Yanhui Xu Huifang Xian Fan Bai Changxing Ou Bei Xiong Andrew M.Lew Jun Cui Rongli Fang Hui Huang Jincun Zhao Xuechuan Hong yuxia zhang Fuling Zhou Hai-Bin Luo Department of Hematology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Dawu County People’s Hospital Xiaogan 432826China State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Guangzhou Institute of Pediatrics Guangzhou Women and Children’s Medical CenterState Key Laboratory of Respiratory DiseasesGuangzhou Medical UniversityGuangzhou 510623China Biomedical Pioneering Innovation Center(BIOPIC) School of Life SciencesPeking UniversityBeijing 100871China Department of Infectious Disease and Department of Pediatrics The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Center for Innovative Marine Drug Screening&Evaluation(QNLM) School of Medicine and PharmacyOcean University of ChinaQingdao 266100China Walter and Eliza Hall Institute of Medical Research and Department of Microbiology&Immunology University of MelbourneParkvilleVic 3052Australia School of Life Sciences Sun Yat-sen UniversityGuangzhou 510006China Cardiovascular Department The Eighth Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China State Key Laboratory of Virology College of ScienceInnovation Center for Traditional Tibetan Medicine Modernization and Quality ControlMedical CollegeTibet UniversityLhasa 850000China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE) Hubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan University School of Pharmaceutical SciencesWuhan 430071China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can cause acute respiratory distress syndrome,hypercoagulability,hypertension,and multiorgan dysfunction.Effective antivirals with safe clinical profile are urgently needed to improve the overall prognosis.In an analysis of a randomly collected cohort of 124 patients with COVID-19,we found that hypercoagulability as indicated by elevated concentrations of D-dimers was associated with disease severity.By virtual screening of a U.S.FDA approved drug library,we identified an anticoagulation agent dipyridamole(DIP)in silico,which suppressed SARS-CoV-2 replication in vitro.In a proof-of-concept trial involving 31 patients with COVID-19,DIP supplementation was associated with significantly decreased concentrations of D-dimers(P<0.05),increased lymphocyte and platelet recovery in the circulation,and markedly improved clinical outcomes in comparison to the control patients.In particular,all 8 of the DIP-treated severely ill patients showed remarkable improvement:7 patients(87.5%)achieved clinical cure and were discharged from the hospitals while the remaining 1 patient(12.5%)was in clinical remission.

关键词： Dipyridamole SARS-CoV-2 COVID-19 Treatment D-dimer Severe cases

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“秩边透水道”针法源流探析及优势病谱

中国针灸 2024年第2期44卷 200-203页

作者：张艳林王海军曹玉霞任帅娣段林余郝健亨闫敏金晓飞冀来喜天津中医药大学针灸推拿学院天津301617 山西中医药大学第二临床学院晋中030619 山西省针灸医院针灸三科成都中医药大学针灸推拿学院

从芒针的历史沿革、秩边穴的争议和定位、操作方法的形成及要领3个方面对“秩边透水道”针法的源流进行梳理,对该针法现有的优势病谱归类,并从得气和起效的神经机制入手推测该针法潜在的优势病谱,阐述“秩边透水道”针法研究的不足,以... 详细信息

从芒针的历史沿革、秩边穴的争议和定位、操作方法的形成及要领3个方面对“秩边透水道”针法的源流进行梳理,对该针法现有的优势病谱归类,并从得气和起效的神经机制入手推测该针法潜在的优势病谱,阐述“秩边透水道”针法研究的不足,以期为该针法的全方位认识及进一步研究提供参考。

关键词： “秩边透水道”针法源流优势病谱

Visfatin and 25-Hydroxyvitamin D_(3) Levels Affect Coronary Collateral Circulation Development in Patients with Chronic Coronary Total Occlusion

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Cardiovascular Innovations and Applications 2022年第1期6卷 161-169页

作者： Xiaoling Ji Shuqi Jin yuxia wang Yumiao Chen Jing zhang Department of Cardiology China Aerospace Science and Industry Corporation 731 Hospital100074 BeijingChina Department of Cardiology Shenzhen Bao‘an Disteict Songgang People’s HospitalShenzhen518105China

Background:Coronary collateral circulation(CCC)plays a vital role in the myocardial blood supply,especially for ischemic myocardium.Evidence suggests that the visfatin and 25-hydroxyvitamin D_(3)[25(OH)D_(3)]levels are related to the degree and incidence of vascular stenosis associated with coronary artery disease;however,few studies have evaluated the effect of visfatin and 25(OH)D_(3) on CCC development in patients with chronic total occlusion(CTO).This study aimed to evaluate the relationship between the serum visfatin and 25(OH)D_(3) levels and CCC in patients with CTO.Methods:A total of 189 patients with CTO confirmed by coronary angiography were included.CCC was graded from 0 to 3 according to the Rentrop-Cohen classification.Patients with grade 0 or grade 1 collateral development were in-cluded in the poor CCC group(n=82),whereas patients with grade 2 or grade 3 collateral development were included in the good CCC group(n=107).The serum visfatin and 25(OH)D_(3) levels were measured by ELISA.Results:The visfatin level was significantly higher in the poor CCC group than in the good CCC group,and the 25(OH)D_(3) level was significantly lower in the poor CCC group than in the good CCC group(P=0.000).Correlation analysis showed that the Rentrop grade was negatively correlated with the visfatin level(r=−0.692,P=0.000)but positively correlated with the 25(OH)D_(3) level(r=0.635,P=0.000).Logistic regression analysis showed that the vis-fatin and 25(OH)D_(3) levels were independent risk factors for CCC(odds ratio 1.597,95%confidence interval 1.300-1.961,P=0.000 and odds ratio 0.566,95%confidence interval 0.444-0.722,P=0.000,respectively).The visfatin and 25(OH)D_(3) levels can effectively predict the CCC status.Conclusion:Serum visfatin and 25(OH)D_(3) levels are related to CCC development and are independent predictors of poor CCC.

关键词： 25-Hydroxyvitamin D_(3) coronary collateral circulation chronic total occlusion