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Journal of Advanced Ceramics 2020年第6期9卷 782-790页

作者： Yuan FANG Xiaohua LIU yuxia feng Jianfeng ZHU Wei JIANG School of Material Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science and TechnologyXi’an 710021China

In this study,Ti_(3)(Al,Ga)C_(2)/Al_(2)O_(3) composites were successfully synthesized by in situ hot pressing at 1350℃ for 2 h using Ti,Al,TiC,and Ga_(2)O_(3) as raw materials.X-ray diffraction and scanning electron microscopy were used for characterizing the phase identities and microstructures of the sintered composites.The dependence of the Vickers hardness and flexural strength on the Al_(2)O_(3) content was found to be in single-peak type.Ti_(3)(Al_(0.6),Ga_(0.4))C_(2)/10.3vol% Al_(2)O_(3) composite exhibited significantly improved mechanical properties.Vickers hardness and flexural strength of the composite reached 6.58 GPa and 527.11 MPa,which were 40% and 74% higher than those of Ti_(3)AlC_(2),respectively.Formation of solid solution and incorporation of second phase of Al_(2)O_(3) resulted in the opposite influence on the fracture toughness.Finally,the hardening and strengthening mechanisms were discussed in detail.

关键词： Ti_(3)AlC_(2) solid solution ceramic composites microstructure mechanical properties

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黏性骨在口腔种植及牙周领域中的研究进展

国际口腔医学杂志 2024年第4期51卷 433-440页

作者：张婧周思颖张新铎冯玉霞李健学联勤保障部队第940医院口腔科兰州730050 新疆医科大学第一附属医院(附属口腔医院)口腔正畸科乌鲁木齐830011 兰州市第一人民医院麻醉科兰州730000

黏性骨由自体血小板浓缩物与颗粒骨移植材料交联而成,具有良好的可塑性和稳定性,可以适应多种骨缺损区形态并维持成骨空间;同时,源于自体血小板浓缩物的白细胞和多种生长因子的释放促进了血管生成和组织愈合。目前,黏性骨已逐渐应用于... 详细信息

黏性骨由自体血小板浓缩物与颗粒骨移植材料交联而成,具有良好的可塑性和稳定性,可以适应多种骨缺损区形态并维持成骨空间;同时,源于自体血小板浓缩物的白细胞和多种生长因子的释放促进了血管生成和组织愈合。目前,黏性骨已逐渐应用于口腔种植和牙周领域并取得了积极效果。本文阐述了黏性骨的组成、制备方式和作用机制,并对其在牙槽骨增量、即刻种植、牙槽嵴保存、上颌窦底提升以及牙周手术中的应用进行综述,旨在为进一步的机制研究和临床应用提供参考。

关键词：黏性骨血小板浓缩物颗粒骨材料骨增量牙龈退缩

Function of Lactate Dehydrogenase in Cardiac and Skeletal Muscle of Phrynocephalus Lizard in Relation to High-Altitude Adaptation

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Asian Herpetological Research 2018年第4期9卷 258-274页

作者： Huihui WANG Xiaolong TANG Yan WANG yuxia feng Peng PU Shengkang MEN Youli ZHAO Zhennan PENG Qiang CHEN Institute of Biochemistry and Molecular Biology School of Life ScienceLanzhou UniversityLanzhou 730000China Lanzhou University Second Hospital Lanzhou 730000China School of Life Science Lanzhou UniversityLanzhou 730000China

Poikilothermic animals living in high-altitude environments can be greatly affected by the anaerobic metabolism and lactate recycling, which are catalyzed by an enzyme called lactate dehydrogenase(LDH). However, the function and possible regulatory mechanisms of their anaerobic glycolysis remained elusive. We compared the difference in LDH between a native high-altitude(4 353 m) lizard, Phrynocephalus erythrurus, and a closely related species, Phrynocephalus przewalskii that lives in intermediate altitude environment(1 400 m). The activity of LDH, the concentration of lactate, the distribution of isoenzyme, and the mRNA amounts of Ldh-A and Ldh-B were determined. In cardiac muscle, the lactate-forming activity of P. erythrurus in LDH was higher than of P. przewalskii LDH at all three temperatures tested(10 °C, 25 °C and 35 °C), while lactate-oxidation activity of LDH was significantly different between the two species only at 25 °C and 35 °C. In skeletal muscle, both lactate-forming and lactate-oxidation rates of P. erythrurus were lower than that of P. przewalskii. There was a higher proportion of H subunit and a significantly higher expression of Ldh-B, with a concomitant decrease of lactate concentration in P. erythrurus. These results indicate that P. erythrurus may have a strong potential for anaerobic metabolism, which is likely adapted to the hypoxic environment at high altitudes. Furthermore, P. erythrurus is capable of oxidizing more lactate than P. przewalskii. The Ldh-A cDNA of the two species consists of a 999 bp open reading frame(ORF), which encodes 332 amino acids, while Ldh-B cDNA consists of a 1 002 bp ORF encoding 333 amino acids. LDHA has the same amino acid sequence between the two species, but three amino acid substitutions(V12 I, N21S and N318K) were observed in LDHB. Structure analysis of LDH indicated that the substitutions of residues Val12 and Asp21 in P. erythrurus could be responsible for the highaltitude adaptation. The LDH characteristics of LDH in P. erythrurus suggest unique adapta

关键词： lactate dehydrogenase(LDH) high altitude adaptation anaerobic metabolism Phrynocephalus erythrurus

双胎妊娠产妇孕前BMI、孕期增重与围产母婴结局的关系

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中外医学研究 2024年第3期22卷 149-153页

作者：林志斌冯玉霞武威市凉州医院甘肃武威733000

目的:分析双胎妊娠产妇孕前体重指数(BMI)、孕期增重与围产母婴结局的关系。方法:回顾性收集2018年5月—2022年5月武威市凉州医院就诊的600例双胎妊娠产妇的临床资料,按照孕前BMI分为低体重组(n=278)、正常体重组(n=286)、超重组(n=28)... 详细信息

目的:分析双胎妊娠产妇孕前体重指数(BMI)、孕期增重与围产母婴结局的关系。方法:回顾性收集2018年5月—2022年5月武威市凉州医院就诊的600例双胎妊娠产妇的临床资料,按照孕前BMI分为低体重组(n=278)、正常体重组(n=286)、超重组(n=28)及肥胖组(n=8),按照孕期增重[BMI差值(∆BMI)]分为增重不足组(n=204)、增重适宜组(n=256)、增重过多组(n=140),探讨孕前BMI、孕期增重与围产母婴结局的关系。结果:低体重组产妇孕期增重不足比例高于超重组,孕期增重过多比例低于超重组,正常体重组产妇孕期增重不足比例高于超重组,差异有统计学意义(P<0.05);超重组及肥胖组产后出血、妊娠期高血压、妊娠期糖尿病、胎盘早剥、胎儿窘迫、巨大儿发生率及新生儿出生体重高于低体重组与正常体重组,且低体重组妊娠期高血压、妊娠期糖尿病、产后出血、胎儿窘迫发生率高于正常体重组,新生儿出生体重低于正常体重组,差异有统计学意义(P<0.05);增重过多组妊娠期高血压、妊娠期糖尿病、胎盘早剥、产后出血、胎儿窘迫、巨大儿发生率及新生儿出生体重高于增重适宜组与增重不足组,增重不足组妊娠期高血压、妊娠期糖尿病、产后出血、胎儿窘迫发生率高于增重适宜组,新生儿出生体重明显低于增重适宜组,差异有统计学意义(P<0.05)。结论:双胎妊娠产妇孕前BMI水平异常及孕期BMI变化异常可导致不良妊娠结局发生风险更高,因此临床对双胎妊娠者的体重需更加关注与重视,可采取有效手段对其孕前体重及妊娠期间体重变化进行干预与管理,达到降低不良妊娠结局发生风险的目的。

关键词：孕前不同体重指数双胎妊娠产妇孕期增重指数围产母婴结局

Low-temperature epitaxy of transferable high-quality Pd(111)films on hybrid graphene/Cu(111)substrate

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Nano Research 2019年第11期12卷 2712-2717页

作者： Zhihong Zhang Xiaozhi Xu Ruixi Qiao Junjiang Liu yuxia feng Zhibin Zhang Peizhao Song Muhong Wu Lan Zhu Xuelin Yang Peng Gao Lei Liu Jie Xiong Enge Wang Kaihui Liu State Key Laboratory for Mesoscopic Physics International Centre for Quantum MaterialsCollaborative Innovation Centre of Quantum MatteSchool of PhysicsAcademy for Advanced Interdisciplinary StudiesPeking UniversityBejing 100871China Physical Science Laboratory Huairou National Comprehensive Science CentreBeijing 101400China School of Physics and Telecommunication Engineering South China Normal UniversityGuangzhou 510631China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China Songshan Lake Materials Laboratory Institute of PhysicsChinese Academy of SciencesGuangdong 523808China Peking Union Medical College Hospital Beijing 100730China State Key Laboratory of Electroric Thin Films and ltegrated Devices University of Electronic Science and Teclmology of ChinaChengdu 610054China

The continuous pursuit of miniaturization in the electronics and optoelectronics industry demands all device components with smaller size and higher performance,in which thin metal film is one heart material as conductive electrodes.However,conventional metal filmns are typically polycrystalline with random domain orientations and various grain boundaries,which greatly degrade their mechanical,thermal and electrical properties.Hence,it is highly demanded to produce single-crystal metal films with epitaxy in an appealing route.Traditional epitaxy on non-metal single-crystal substrates has difficulty in exfoliating away due to the formation of chemical bonds.Newly developed epitaxy on single-crystal graphene enables the easy exfoliation of epilayers but the annealing temperature must be high(typical 500-1,000℃ and out of the tolerant range of integrated circuit technology)due to the relative weak intertacial interactions.Here we demonstrate the facile production of 6-inch transferable high-quality Pd(111)filims on single-crystal hybrid graphene/Cu(111)substrate with CMOS-compatible annealing temperature of 150℃ only.The interfacial interaction between Pd and hybrid graphene/Cu(111)substrate is strong enough to enable the low-temperature epitaxy of Pd(111)films and weak enough to facilitate the easy film release from substrate.The obtained Pd(111)films possess superior properties to polyrystalline ones with-0.25 eV higher work function and almost half sheet resistance.This technique is proved to be applicable to other metals,such as Au and Ag.As the single-crystal graphene/Cu(111)substrates are obtained from industrial Cu foils and accessible in meter scale,our work will promote the massive applications of large-area high-quality metal fims in the development of next-generation electronic and optoelectronic devices.

关键词： single-crystal metal film graphene/Cu(111)substrate intertacial interactions meter scale

武威市凉州区女性人乳头瘤病毒感染与子宫颈病变影响因素分析

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中国当代医药 2024年第14期31卷 45-48页

作者：林志斌冯玉霞蔡萌娜陈治川甘肃省武威市凉州医院妇产科甘肃武威733000

目的探讨武威市凉州区女性子宫颈人乳头瘤病毒(HPV)感染情况,对子宫颈发生病变与HPV感染行相关性分析。方法采用扩增的聚合酶链式反应(PCR)方法对2021年3月至2023年9月在甘肃省武威市凉州医院进行宫颈癌筛查的13000名妇女进行检查。检测... 详细信息

目的探讨武威市凉州区女性子宫颈人乳头瘤病毒(HPV)感染情况,对子宫颈发生病变与HPV感染行相关性分析。方法采用扩增的聚合酶链式反应(PCR)方法对2021年3月至2023年9月在甘肃省武威市凉州医院进行宫颈癌筛查的13000名妇女进行检查。检测出HPV感染患者有1200例,对其行阴道镜检查及阴道镜下子宫颈活检术。根据宫颈组织活检提示有无子宫颈病变的发生分为两组,分别为病变组(n=486)未病变组(n=714)。运用单因素分析其子宫颈病变发生的影响因素,并运用多因素logistic回归分析方法对单因素中P<0.05中的因素进行分析。结果单因素分析结果提示病变组在年龄、有无持续HPV的感染、子宫颈柱状上皮外移情况、性伴侣数和HPV感染类型上与非病变组具有显著差异,差异有统计学意义(P<0.05);多因素分析结果显示,年龄为<25岁或≥55岁(β=0.754,OR=2.126,95%CI:1.649~2.740)、持续HPV的感染(β=1.048,OR=2.853,95%CI:2.209~3.683)、子宫颈柱状上皮外移(β=0.625,OR=1.868,95%CI:1.453~2.401)、性伴侣数≥2名(β=0.625,OR=1.988,95%CI:1.546~2.556)和HPV感染类型为高危型(β=0.863,OR=2.371,95%CI:1.833~3.066)都是影响子宫颈病变发生的独立危险因素。结论HPV感染与子宫颈病变之间存在联系,且HPV16/HPV18型是子宫颈病变HPV感染的主要类型,倡导定期体检,根据不同女性实施针对性措施对降低女性子宫颈HPV感染发生病变,预防子宫颈癌具深远意义。

关键词：人乳头瘤病毒感染人乳头瘤病毒亚型子宫颈病变影响因素

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不同压力蒸汽爆破处理对绿豆淀粉品质的影响

食品研究与开发 2024年第13期45卷 32-38页

作者：曲美霖冯瑜霞胡俊君李云龙程哲山西农业大学山西功能食品研究院山西太原030031

为探究蒸汽爆破处理对绿豆淀粉理化性质以及结构的影响,以绿豆为原料,考察蒸汽爆破压力对绿豆淀粉中各组分含量、糊化特性、溶解度等理化性质的影响,并通过碘吸收曲线、X-射线衍射、傅里叶变换红外光谱进一步分析绿豆淀粉的微观结构的... 详细信息

为探究蒸汽爆破处理对绿豆淀粉理化性质以及结构的影响,以绿豆为原料,考察蒸汽爆破压力对绿豆淀粉中各组分含量、糊化特性、溶解度等理化性质的影响,并通过碘吸收曲线、X-射线衍射、傅里叶变换红外光谱进一步分析绿豆淀粉的微观结构的变化。结果表明,当蒸汽压力为0.30 MPa时,绿豆中直链淀粉和抗性淀粉的含量显著高于其他压力处理的样品(p<0.05);随着蒸汽压力的上升,慢消化淀粉含量逐渐增加,快消化淀粉含量逐渐降低;绿豆淀粉的溶解度逐渐下降,而膨润力逐渐提高;当蒸汽压力为0.60 MPa时,绿豆淀粉的糊化温度最高,峰值黏度最低。微观结构分析表明,蒸汽爆破处理后的绿豆淀粉颗粒形貌发生明显变化,相对结晶度、短程有序化以及双螺旋程度降低;同时淀粉晶型由A型向C型转变。蒸汽爆破处理可以改变淀粉的理化性质和结构,进而影响绿豆淀粉的品质。

关键词：蒸汽爆破压力绿豆淀粉糊化特性微观结构

Recovery of Flavor Perception and Umami Taste Sensitivity in Young Chinese Adults Following SARS-CoV-2 Omicron Infection: A Case-Control Series

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Food Science and Human Wellness 2024年

作者： Yiwen Zhu Xiaoxiao feng yuxia Fan Yin Zhang Ye Liu Yuan Liu Department of Food Science & Technology School of Agriculture & Biology Shanghai Jiao Tong University Key Laboratory of Meat Processing of Sichuan Chengdu University Beijing Engineering and Technology Research Center of Food Additives School of Food and Health Beijing Technology and Business University School of Food and Health Beijing Technology and Business University

SARS-CoV-2， particularly the Omicron variant， often leads to flavor perception dysfunction in infected individuals， making a comprehensive understanding of its duration and recovery patterns a critical part of disease management. This study surveyed a cohort of 199 mildly-to-moderately affected SARS-CoV-2 Omicron-infected patients， focusing on the alterations in their olfaction， taste， and chemesthesis perception. Further， a subset of 36 participants (18 healthy and 18 infected) underwent sensory evaluations to check the variation of umami taste sensitivity. The results demonstrated that most of the infected cohort experienced chemosensory disorders， with the recovery period varying between one week and over a month. Intriguingly， the severity of flavor perception changes during infection significantly correlated with the length of the recovery period. Furthermore， this study explored the specific manifestations of flavor perception dysfunction， potential contributing factors， and potential mechanistic explanations for chemosensory disorders. These include local damage， inflammatory responses， and virus-induced neural damage. However， this study revealed no significant change (P > 0.05) in umami taste sensitivity among infected patients 55 days post-infection. While this research faces limitations related to its self-reported， cross-sectional design， and regional focus， it offers valuable insights into the multifaceted impact of COVID-19， particularly the Omicron variant， on chemosensory perception.

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信息技术在高职音乐教学中的应用研究

数字通信世界 2023年第12期 101-104页

作者：冯玉霞西昌民族幼儿师范高等专科学校四川西昌615000

文章就信息技术在高职音乐教学中的应用进行了探究。从分析高职音乐教学现状、成因入手,提出了在课前、课中、课后和音乐艺术实践等环节中融入信息技术的措施与方法。实践研究发现,通过课前信息技术辅助备课、课中“互联网+”线上、线... 详细信息

文章就信息技术在高职音乐教学中的应用进行了探究。从分析高职音乐教学现状、成因入手,提出了在课前、课中、课后和音乐艺术实践等环节中融入信息技术的措施与方法。实践研究发现,通过课前信息技术辅助备课、课中“互联网+”线上、线下混合式教学模式开展教学,课后借助智能手机巩固、拓展,以及班级音乐会等多种学习形式,能够实现信息技术与教育教学的深度融合,转变传统音乐教与学的方式,丰富教学内容、方法和手段,增加教学互动,激发学生学习积极性主动性,提高学生音乐素质,促进高职音乐教学质量、效率的有效提升。

关键词：信息技术高职音乐教学应用

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苦荞叶营养价值分析及其应用的研究现状

食品研究与开发 2023年第20期44卷 207-211页

作者：冯瑜霞程哲李云龙山西农业大学山西功能食品研究院山西太原030031

苦荞是我国古老的栽培作物之一,有较高的营养价值和药用价值,随着人们生活水平的不断提高,苦荞保健功能食品受到越来越多的青睐。苦荞叶中富含黄酮化合物和膳食纤维等营养成分,具有降血脂、降血糖、抗氧化、抗癌等多种功效,该文对苦荞... 详细信息

苦荞是我国古老的栽培作物之一,有较高的营养价值和药用价值,随着人们生活水平的不断提高,苦荞保健功能食品受到越来越多的青睐。苦荞叶中富含黄酮化合物和膳食纤维等营养成分,具有降血脂、降血糖、抗氧化、抗癌等多种功效,该文对苦荞叶的营养价值及其在食品中的应用进行综述,为苦荞叶的充分利用提供参考。

关键词：苦荞苦荞叶营养价值食品应用